Analysis of MMP-3 polymorphism in osseointegrated implant failure

Polymorphisms in matrix metalloproteinases (MMPs) genes have been associated with several pathologies, including dental implant loss. MMP-3 is crucial to the connective tissue remodeling process. The objective of this study was to investigate the possible relationship between -1612 MMP-3 polymorphis...

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Bibliographic Details
Published in:	Brazilian journal of oral sciences Vol. 15; no. 4; p. 304
Main Authors:	Munhoz, Francielle Boçon de Araujo, Nogara, Paula Regina Bach, Junior, Francisco Rafael da Costa, Branco, Filipe Polese, Santos, Maria Cristina Leme Godoy dos
Format:	Journal Article
Language:	English
Published:	Universidade Estadual de Campinas 20-09-2017
Subjects:	Polymorphism. Metalloproteinase. Implant loss. Risk factor
Online Access:	Get full text
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Summary:	Polymorphisms in matrix metalloproteinases (MMPs) genes have been associated with several pathologies, including dental implant loss. MMP-3 is crucial to the connective tissue remodeling process. The objective of this study was to investigate the possible relationship between -1612 MMP-3 polymorphism and the early implant failure. A sample of 240 non-smokers was divided: test group 120 patients with one or more early failed implants and control group 120 patients with one or more healthy implants. Genomic DNA from oral mucosa was analyzed by PCR-RFLP. No association of early implant loss with genotypes and alleles of the -1612 polymorphism in MMP-3 were found by the Chi-squared test. Only the presence of the -1612 polymorphism of MMP-3 is not a genetic risk factor for early loss of implants.
ISSN:	1677-3225 1677-3225
DOI:	10.20396/bjos.v15i4.8650045