Search Results - "Junien"

Placental contribution to nutritional programming of health and diseases: epigenetics and sexual dimorphism by Tarrade, Anne, Panchenko, Polina, Junien, Claudine, Gabory, Anne

“…The recent and rapid worldwide increase in non-communicable diseases challenges the assumption that genetic factors are the primary contributors to such…”
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A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in NASH by Francque, Sven M, Bedossa, Pierre, Ratziu, Vlad, Anstee, Quentin M, Bugianesi, Elisabetta, Sanyal, Arun J, Loomba, Rohit, Harrison, Stephen A, Balabanska, Rozalina, Mateva, Lyudmila, Lanthier, Nicolas, Alkhouri, Naim, Moreno, Christophe, Schattenberg, Jörn M, Stefanova-Petrova, Diana, Vonghia, Luisa, Rouzier, Régine, Guillaume, Maeva, Hodge, Alexander, Romero-Gómez, Manuel, Huot-Marchand, Philippe, Baudin, Martine, Richard, Marie-Paule, Abitbol, Jean-Louis, Broqua, Pierre, Junien, Jean-Louis, Abdelmalek, Manal F

“…Lanifibranor is a pan–peroxisome proliferator–activated receptor agonist that modulates metabolic and inflammatory pathways. In this 24-week, phase 2b,…”
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Pan-PPAR agonist lanifibranor improves portal hypertension and hepatic fibrosis in experimental advanced chronic liver disease by Boyer-Diaz, Zoe, Aristu-Zabalza, Peio, Andrés-Rozas, María, Robert, Claude, Ortega-Ribera, Martí, Fernández-Iglesias, Anabel, Broqua, Pierre, Junien, Jean-Louis, Wettstein, Guillaume, Bosch, Jaime, Gracia-Sancho, Jordi

“…In advanced chronic liver disease (ACLD), deregulated hepatic necroinflammatory processes play a key role in the development of liver microvascular…”
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Pan-PPAR agonist IVA337 is effective in experimental lung fibrosis and pulmonary hypertension by Avouac, Jerome, Konstantinova, Irena, Guignabert, Christophe, Pezet, Sonia, Sadoine, Jeremy, Guilbert, Thomas, Cauvet, Anne, Tu, Ly, Luccarini, Jean-Michel, Junien, Jean-Louis, Broqua, Pierre, Allanore, Yannick

“…To evaluate the antifibrotic effects of the pan-peroxisome proliferator-activated receptor (PPAR) agonist IVA337 in preclinical mouse models of pulmonary…”
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Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis by Ruzehaji, Nadira, Frantz, Camelia, Ponsoye, Matthieu, Avouac, Jerome, Pezet, Sonia, Guilbert, Thomas, Luccarini, Jean-Michel, Broqua, Pierre, Junien, Jean-Louis, Allanore, Yannick

“…The pathogenesis of systemic sclerosis (SSc) involves a distinctive triad of autoimmune, vascular and inflammatory alterations resulting in fibrosis. Evidence…”
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Developmental programming and epigenetics by GABORY, Anne, ATTIG, Linda, JUNIEN, Claudine

“…The ways in which epigenetic modifications fix the effects of early environmental events, ensuring sustained responses to transient stimuli that result in…”
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The new‐generation pan‐peroxisome proliferator‐activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis by Wettstein, Guillaume, Luccarini, Jean‐Michel, Poekes, Laurence, Faye, Patrick, Kupkowski, Francine, Adarbes, Vanessa, Defrêne, Evelyne, Estivalet, Céline, Gawronski, Xavier, Jantzen, Ingrid, Philippot, Alain, Tessier, Julien, Tuyaa‐Boustugue, Pascale, Oakley, Fiona, Mann, Derek A., Leclercq, Isabelle, Francque, Sven, Konstantinova, Irena, Broqua, Pierre, Junien, Jean‐Louis

“…IVA337 is a pan‐peroxisome proliferator‐activated receptor (PPAR) agonist with moderate and well‐balanced activity on the three PPAR isoforms (α, γ, δ). PPARs…”
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Child Health, Developmental Plasticity, and Epigenetic Programming by Hochberg, Z, Feil, R, Constancia, M, Fraga, M, Junien, C, Carel, J.-C, Boileau, P, Le Bouc, Y, Deal, C. L, Lillycrop, K, Scharfmann, R, Sheppard, A, Skinner, M, Szyf, M, Waterland, R. A, Waxman, D. J, Whitelaw, E, Ong, K, Albertsson-Wikland, K

“…Plasticity in developmental programming has evolved to provide the best chances of survival and reproductive success to the organism under changing…”
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Sexual dimorphism in environmental epigenetic programming by Gabory, Anne, Attig, Linda, Junien, Claudine

“…The phenotype of an individual is the result of complex interactions between genotype and current, past and ancestral environment leading to a lifelong…”
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Odiparcil, a potential glycosaminoglycans clearance therapy in mucopolysaccharidosis VI-Evidence from in vitro and in vivo models by Entchev, Eugeni, Jantzen, Ingrid, Masson, Philippe, Bocart, Stephanie, Bournique, Bruno, Luccarini, Jean-Michel, Bouchot, Andre, Lacombe, Olivier, Junien, Jean-Louis, Broqua, Pierre, Tallandier, Mireille

“…Mucopolysaccharidoses are a class of lysosomal storage diseases, characterized by enzymatic deficiency in the degradation of specific glycosaminoglycans (GAG)…”
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Nutritional epigenomics of metabolic syndrome : New perspective against the epidemic by GALLOU-KABANI, Catherine, JUNIEN, Claudine

“…Human epidemiological studies and appropriately designed dietary interventions in animal models have provided considerable evidence to suggest that maternal…”
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The pan-PPAR agonist lanifibranor improves cardiometabolic health in patients with metabolic dysfunction-associated steatohepatitis by Cooreman, Michael P., Butler, Javed, Giugliano, Robert P., Zannad, Faiez, Dzen, Lucile, Huot-Marchand, Philippe, Baudin, Martine, Beard, Daniel R., Junien, Jean-Louis, Broqua, Pierre, Abdelmalek, Manal F., Francque, Sven M.

“…Lanifibranor, a pan-PPAR agonist, improves liver histology in patients with metabolic dysfunction-associated steatohepatitis (MASH), who have poor…”
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Maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta by Gabory, Anne, Ferry, Laure, Fajardy, Isabelle, Jouneau, Luc, Gothié, Jean-David, Vigé, Alexandre, Fleur, Cécile, Mayeur, Sylvain, Gallou-Kabani, Catherine, Gross, Marie-Sylvie, Attig, Linda, Vambergue, Anne, Lesage, Jean, Reusens, Brigitte, Vieau, Didier, Remacle, Claude, Jais, Jean-Philippe, Junien, Claudine

“…Males and females responses to gestational overnutrition set the stage for subsequent sex-specific differences in adult onset non communicable diseases…”
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Sex- and diet-specific changes of imprinted gene expression and DNA methylation in mouse placenta under a high-fat diet by Gallou-Kabani, Catherine, Gabory, Anne, Tost, Jörg, Karimi, Mohsen, Mayeur, Sylvain, Lesage, Jean, Boudadi, Elsa, Gross, Marie-Sylvie, Taurelle, Julien, Vigé, Alexandre, Breton, Christophe, Reusens, Brigitte, Remacle, Claude, Vieau, Didier, Ekström, Tomas J, Jais, Jean-Philippe, Junien, Claudine

“…Changes in imprinted gene dosage in the placenta may compromise the prenatal control of nutritional resources. Indeed monoallelic behaviour and sensitivity to…”
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Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) α/γ/δ Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate by Boubia, Benaïssa, Poupardin, Olivia, Barth, Martine, Binet, Jean, Peralba, Philippe, Mounier, Laurent, Jacquier, Elise, Gauthier, Emilie, Lepais, Valérie, Chatar, Maryline, Ferry, Stéphanie, Thourigny, Anne, Guillier, Fabrice, Llacer, Jonathan, Amaudrut, Jérome, Dodey, Pierre, Lacombe, Olivier, Masson, Philippe, Montalbetti, Christian, Wettstein, Guillaume, Luccarini, Jean-Michel, Legendre, Christiane, Junien, Jean-Louis, Broqua, Pierre

“…Here, we describe the identification and synthesis of novel indole sulfonamide derivatives that activate the three peroxisome proliferator activated receptor…”
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Depot- and sex-specific effects of maternal obesity in offspring’s adipose tissue by Lecoutre, Simon, Deracinois, Barbara, Laborie, Christine, Eberlé, Delphine, Guinez, Céline, Panchenko, Polina E, Lesage, Jean, Vieau, Didier, Junien, Claudine, Gabory, Anne, Breton, Christophe

“…According to the Developmental Origin of Health and Disease (DOHaD) concept, alterations of nutrient supply in the fetus or neonate result in long-term…”
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830-P: The Pan-PPAR Agonist Lanifibranor Improves Nonalcoholic Steatohepatitis (NASH) and Glycemic Control by COOREMAN, MICHAEL P., FRANCQUE, SVEN, DZEN, LUCILE, HUOT-MARCHAND, PHILIPPE, JUNIEN, JEAN L., BROQUA, PIERRE, ABDELMALEK, MANAL F.

“…Lanifibranor therapy resulted in both NASH resolution and fibrosis reduction in the phase 2b NATIVE study in patients with non-cirrhotic NASH, compared to…”
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Sex in basic research: concepts in the cardiovascular field by Ventura-Clapier, Renée, Dworatzek, Elke, Seeland, Ute, Kararigas, Georgios, Arnal, Jean-Francois, Brunelleschi, Sandra, Carpenter, Thomas C, Erdmann, Jeanette, Franconi, Flavia, Giannetta, Elisa, Glezerman, Marek, Hofmann, Susanna M, Junien, Claudine, Katai, Miyuki, Kublickiene, Karolina, König, Inke R, Majdic, Gregor, Malorni, Walter, Mieth, Christin, Miller, Virginia M, Reynolds, Rebecca M, Shimokawa, Hiroaki, Tannenbaum, Cara, D'Ursi, Anna Maria, Regitz-Zagrosek, Vera

“…Women and men, female and male animals and cells are biologically different, and acknowledgement of this fact is critical to advancing medicine. However,…”
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844-P: Lanifibranor Improves Markers of Cardiometabolic Health in Patients with NASH and Type 2 Diabetes, Correlated with Responses in Adiponectin Levels by GRIFFEL, LOUIS H., FRANCQUE, SVEN, ABDELMALEK, MANAL F., HUOT-MARCHAND, PHILIPPE, DZEN, LUCILE, BAUDIN, MARTINE, JUNIEN, JEAN L., BROQUA, PIERRE, COOREMAN, MICHAEL P.

“…Background: Lanifibranor, a pan-PPAR agonist, has shown efficacy on liver histology and metabolic-immune markers of NASH in the phase 2b NATIVE study. PPAR…”
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Placental contribution to the origins of sexual dimorphism in health and diseases: sex chromosomes and epigenetics by Gabory, Anne, Roseboom, Tessa J, Moore, Tom, Moore, Lorna G, Junien, Claudine

“…Sex differences occur in most non-communicable diseases, including metabolic diseases, hypertension, cardiovascular disease, psychiatric and neurological…”
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