Search Results - "Junichiro Irie"

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men by Irie, Junichiro, Inagaki, Emi, Fujita, Masataka, Nakaya, Hideaki, Mitsuishi, Masanori, Yamaguchi, Shintaro, Yamashita, Kazuya, Shigaki, Shuhei, Ono, Takashi, Yukioka, Hideo, Okano, Hideyuki, Nabeshima, Yo-ichi, Imai, Shin-ichiro, Yasui, Masato, Tsubota, Kazuo, Itoh, Hiroshi

“…Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+) levels causes aging-related disorders and therapeutic approaches…”
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Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids by Miyamoto, Junki, Igarashi, Miki, Watanabe, Keita, Karaki, Shin-ichiro, Mukouyama, Hiromi, Kishino, Shigenobu, Li, Xuan, Ichimura, Atsuhiko, Irie, Junichiro, Sugimoto, Yukihiko, Mizutani, Tetsuya, Sugawara, Tatsuya, Miki, Takashi, Ogawa, Jun, Drucker, Daniel J., Arita, Makoto, Itoh, Hiroshi, Kimura, Ikuo

“…Gut microbiota mediates the effects of diet, thereby modifying host metabolism and the incidence of metabolic disorders. Increased consumption of omega-6…”
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Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice by Kimura, Ikuo, Miyamoto, Junki, Ohue-Kitano, Ryuji, Watanabe, Keita, Yamada, Takahiro, Onuki, Masayoshi, Aoki, Ryo, Isobe, Yosuke, Kashihara, Daiji, Inoue, Daisuke, Inaba, Akihiko, Takamura, Yuta, Taira, Satsuki, Kumaki, Shunsuke, Watanabe, Masaki, Ito, Masato, Nakagawa, Fumiyuki, Irie, Junichiro, Kakuta, Hiroki, Shinohara, Masakazu, Iwatsuki, Ken, Tsujimoto, Gozoh, Ohno, Hiroaki, Arita, Makoto, Itoh, Hiroshi, Hase, Koji

“…Antibiotics and dietary habits can affect the gut microbial community, thus influencing disease susceptibility. Although the effect of microbiota on the…”
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Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians by Sato, Yuko, Atarashi, Koji, Plichta, Damian R., Arai, Yasumichi, Sasajima, Satoshi, Kearney, Sean M., Suda, Wataru, Takeshita, Kozue, Sasaki, Takahiro, Okamoto, Shoki, Skelly, Ashwin N., Okamura, Yuki, Vlamakis, Hera, Li, Youxian, Tanoue, Takeshi, Takei, Hajime, Nittono, Hiroshi, Narushima, Seiko, Irie, Junichiro, Itoh, Hiroshi, Moriya, Kyoji, Sugiura, Yuki, Suematsu, Makoto, Moritoki, Nobuko, Shibata, Shinsuke, Littman, Dan R., Fischbach, Michael A., Uwamino, Yoshifumi, Inoue, Takashi, Honda, Akira, Hattori, Masahira, Murai, Tsuyoshi, Xavier, Ramnik J., Hirose, Nobuyoshi, Honda, Kenya

“…Centenarians have a decreased susceptibility to ageing-associated illnesses, chronic inflammation and infectious diseases 1 – 3 . Here we show that…”
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Barley β-glucan improves metabolic condition via short-chain fatty acids produced by gut microbial fermentation in high fat diet fed mice by Miyamoto, Junki, Watanabe, Keita, Taira, Satsuki, Kasubuchi, Mayu, Li, Xuan, Irie, Junichiro, Itoh, Hiroshi, Kimura, Ikuo

“…Dietary intake of barley β-glucan (BG) is known to affect energy metabolism. However, its underlying mechanism remains poorly understood because studies have…”
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The short chain fatty acid receptor GPR43 regulates inflammatory signals in adipose tissue M2-type macrophages by Nakajima, Akira, Nakatani, Akiho, Hasegawa, Sae, Irie, Junichiro, Ozawa, Kentaro, Tsujimoto, Gozoh, Suganami, Takayoshi, Itoh, Hiroshi, Kimura, Ikuo

“…The regulation of inflammatory responses within adipose tissue by various types of immune cells is closely related to tissue homeostasis and progression of…”
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The role of short-chain fatty acid on blood pressure regulation by Miyamoto, Junki, Kasubuchi, Mayu, Nakajima, Akira, Irie, Junichiro, Itoh, Hiroshi, Kimura, Ikuo

“…PURPOSE OF REVIEWThe gut microbiota and its metabolites have been implicated in the regulation of host physiological functions such as inflammatory and…”
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Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions by Miyamoto, Junki, Ohue-Kitano, Ryuji, Mukouyama, Hiromi, Nishida, Akari, Watanabe, Keita, Igarashi, Miki, Irie, Junichiro, Tsujimoto, Gozoh, Satoh-Asahara, Noriko, Itoh, Hiroshi, Kimura, Ikuo

“…Ketone bodies, including β-hydroxybutyrate and acetoacetate, are important alternative energy sources during energy shortage. β-Hydroxybutyrate also acts as a…”
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Newly developed type 1 diabetes after coronavirus disease 2019 vaccination: A case report by Sasaki, Hironobu, Itoh, Arata, Watanabe, Yasuhiro, Nakajima, Yuya, Saisho, Yoshifumi, Irie, Junichiro, Meguro, Shu, Itoh, Hiroshi

“…The vaccine for the coronavirus disease 2019 (COVID‐19) has been reported to potentially cause or worsen diabetes. A 73‐year‐old Japanese woman received two…”
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Intestinal Epithelial NAD+ Biosynthesis Regulates GLP-1 Production and Postprandial Glucose Metabolism in Mice by Nagahisa, Taichi, Yamaguchi, Shintaro, Kosugi, Shotaro, Homma, Koichiro, Miyashita, Kazutoshi, Irie, Junichiro, Yoshino, Jun, Itoh, Hiroshi

“…Obesity is associated with perturbations in incretin production and whole-body glucose metabolism, but the precise underlying mechanism remains unclear. Here,…”
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C-C motif chemokine receptor 9 regulates obesity-induced insulin resistance via inflammation of the small intestine in mice by Amiya, Takeru, Nakamoto, Nobuhiro, Irie, Junichiro, Taniki, Nobuhito, Chu, Po-Sung, Koda, Yuzo, Miyamoto, Kentaro, Yamaguchi, Akihiro, Shiba, Shunsuke, Morikawa, Rei, Itoh, Hiroshi, Kanai, Takanori

“…Aims/hypothesis Accumulation of adipose tissue macrophages is considered pivotal in the development of obesity-associated inflammation and insulin resistance…”
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Contribution of uremic dysbiosis to insulin resistance and sarcopenia by Uchiyama, Kiyotaka, Wakino, Shu, Irie, Junichiro, Miyamoto, Junki, Matsui, Ayumi, Tajima, Takaya, Itoh, Tomoaki, Oshima, Yoichi, Yoshifuji, Ayumi, Kimura, Ikuo, Itoh, Hiroshi

“…Abstract Background Chronic kidney disease (CKD) leads to insulin resistance (IR) and sarcopenia, which are associated with a high mortality risk in CKD…”
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A Non-calorie-restricted Low-carbohydrate Diet is Effective as an Alternative Therapy for Patients with Type 2 Diabetes by Yamada, Yoshifumi, Uchida, Junichi, Izumi, Hisa, Tsukamoto, Yoko, Inoue, Gaku, Watanabe, Yuichi, Irie, Junichiro, Yamada, Satoru

“…Objective Although caloric restriction is a widely used intervention to reduce body weight and insulin resistance, many patients are unable to comply with such…”
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Dysbiosis in the Pathophysiology of Coronary Artery Disease by Irie, Junichiro, Itoh, Hiroshi

“…[See article vol. 23: 908-921]Coronary artery disease (CAD) is the leading cause of worldwide mortality, but the incidence rate of CAD varies among countries,…”
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Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men by Yamaguchi, Shintaro, Irie, Junichiro, Mitsuishi, Masanori, Uchino, Yuichi, Nakaya, Hideaki, Takemura, Ryo, Inagaki, Emi, Kosugi, Shotaro, Okano, Hideyuki, Yasui, Masato, Tsubota, Kazuo, Hayashi, Kaori, Yoshino, Jun, Itoh, Hiroshi

“…Obesity and aging are major risk factors for several life-threatening diseases. Accumulating evidence from both rodents and humans suggests that the levels of…”
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Assessment of glycemic variability and lifestyle behaviors in healthy nondiabetic individuals according to the categories of body mass index by Kashiwagi, Kazuhiro, Inaishi, Jun, Kinoshita, Shotaro, Wada, Yasuyo, Hanashiro, Sayaka, Shiga, Kiko, Kitazawa, Momoko, Tsutsumi, Shiori, Yamakawa, Hiroyuki, Irie, Junichiro, Kishimoto, Taishiro

“…Background There are limited data about the association between body mass index (BMI), glycemic variability (GV), and life-related factors in healthy…”
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Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes by Kodama, Keiichi, Horikoshi, Momoko, Toda, Kyoko, Yamada, Satoru, Hara, Kazuo, Irie, Junichiro, Sirota, Marina, Morgan, Alexander A, Chen, Rong, Ohtsu, Hiroshi, Maeda, Shiro, Kadowaki, Takashi, Butte, Atul J

“…Type 2 diabetes (T2D) is a complex, polygenic disease affecting nearly 300 million people worldwide. T2D is primarily characterized by insulin resistance, and…”
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Canagliflozin protects the cardiovascular system through effects on the gut environment in non-diabetic nephrectomized rats by Matsui, Ayumi, Yoshifuji, Ayumi, Irie, Junichiro, Tajima, Takaya, Uchiyama, Kiyotaka, Itoh, Tomoaki, Wakino, Shu, Itoh, Hiroshi

“…Background The gut produces toxins that contribute to the cardiovascular complications of chronic kidney disease. Canagliflozin, a sodium glucose cotransporter…”
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CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake by Kobayashi, Nana, Okazaki, Shogo, Sampetrean, Oltea, Irie, Junichiro, Itoh, Hiroshi, Saya, Hideyuki

“…CD44 variant (CD44v) contributes to cancer stemness by stabilizing the xCT subunit of system xc(−) and thereby promoting its glutamate-cystine antiporter…”
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Author Correction: CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake by Kobayashi, Nana, Okazaki, Shogo, Sampetrean, Oltea, Irie, Junichiro, Itoh, Hiroshi, Saya, Hideyuki

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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