Search Results - "Jungmann, Andreas"

Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy by Hu, Jiong, Dziumbla, Sarah, Lin, Jihong, Bibli, Sofia-Iris, Zukunft, Sven, de Mos, Julian, Awwad, Khader, Frömel, Timo, Jungmann, Andreas, Devraj, Kavi, Cheng, Zhixing, Wang, Liya, Fauser, Sascha, Eberhart, Charles G., Sodhi, Akrit, Hammock, Bruce D., Liebner, Stefan, Müller, Oliver J., Glaubitz, Clemens, Hammes, Hans-Peter, Popp, Rüdiger, Fleming, Ingrid

“…A product of the soluble epoxide hydrolase enzyme, 19,20-dihydroxydocosapentaenoic acid (19,20-DHDP), is implicated in the pathogenesis of diabetic…”
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Secretome Analysis of Cardiomyocytes Identifies PCSK6 (Proprotein Convertase Subtilisin/Kexin Type 6) as a Novel Player in Cardiac Remodeling After Myocardial Infarction by Kuhn, Tim Christian, Knobel, Johannes, Burkert-Rettenmaier, Sonja, Li, Xue, Meyer, Ingmar Sören, Jungmann, Andreas, Sicklinger, Florian, Backs, Johannes, Lasitschka, Felix, Müller, Oliver J., Katus, Hugo A., Krijgsveld, Jeroen, Leuschner, Florian

“…BACKGROUND:Acute occlusion of a coronary artery results in swift tissue necrosis. Bordering areas of the infarcted myocardium may also experience impaired…”
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Critical role of RAGE and HMGB1 in inflammatory heart disease by Bangert, Anna, Andrassy, Martin, Müller, Anna-Maria, Bockstahler, Mariella, Fischer, Andrea, Volz, Christian H., Leib, Christoph, Göser, Stefan, Korkmaz-Icöz, Sevil, Zittrich, Stefan, Jungmann, Andreas, Lasitschka, Felix, Pfitzer, Gabriele, Müller, Oliver J., Katus, Hugo A., Kaya, Ziya

“…Autoimmune response to cardiac troponin I (TnI) induces inflammation and fibrosis in the myocardium. High-mobility group box 1 (HMGB1) is a multifunctional…”
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Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution by Yap, Yann W., Rusu, Patricia M., Chan, Andrea Y., Fam, Barbara C., Jungmann, Andreas, Solon-Biet, Samantha M., Barlow, Christopher K., Creek, Darren J., Huang, Cheng, Schittenhelm, Ralf B., Morgan, Bruce, Schmoll, Dieter, Kiens, Bente, Piper, Matthew D. W., Heikenwälder, Mathias, Simpson, Stephen J., Bröer, Stefan, Andrikopoulos, Sofianos, Müller, Oliver J., Rose, Adam J.

“…Dietary protein dilution (DPD) promotes metabolic-remodelling and -health but the precise nutritional components driving this response remain elusive. Here, by…”
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CaMKII activation participates in doxorubicin cardiotoxicity and is attenuated by moderate GRP78 overexpression by Tscheschner, Henrike, Meinhardt, Eric, Schlegel, Philipp, Jungmann, Andreas, Lehmann, Lorenz H, Müller, Oliver J, Most, Patrick, Katus, Hugo A, Raake, Philip W

“…The clinical use of the chemotherapeutic doxorubicin (Dox) is limited by cardiotoxic side-effects. One of the early Dox effects is induction of a sarcoplasmic…”
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Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis by Lorenzen, Johan M, Schauerte, Celina, Hübner, Anika, Kölling, Malte, Martino, Filippo, Scherf, Kristian, Batkai, Sandor, Zimmer, Karina, Foinquinos, Ariana, Kaucsar, Tamas, Fiedler, Jan, Kumarswamy, Regalla, Bang, Claudia, Hartmann, Dorothee, Gupta, Shashi K, Kielstein, Jan, Jungmann, Andreas, Katus, Hugo A, Weidemann, Frank, Müller, Oliver J, Haller, Hermann, Thum, Thomas

“…Osteopontin (OPN) is a multifunctional cytokine critically involved in cardiac fibrosis. However, the underlying mechanisms are unresolved. Non-coding RNAs are…”
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Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling by Liu, Wei, Ruiz-Velasco, Andrea, Wang, Shoubao, Khan, Saba, Zi, Min, Jungmann, Andreas, Dolores Camacho-Muñoz, Maria, Guo, Jing, Du, Guanhua, Xie, Liping, Oceandy, Delvac, Nicolaou, Anna, Galli, Gina, Müller, Oliver J., Cartwright, Elizabeth J., Ji, Yong, Wang, Xin

“…The prevalence of cardiomyopathy from metabolic stress has increased dramatically; however, its molecular mechanisms remain elusive. Here, we show that…”
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Rapid and highly efficient inducible cardiac gene knockout in adult mice using AAV-mediated expression of Cre recombinase by Werfel, Stanislas, Jungmann, Andreas, Lehmann, Lorenz, Ksienzyk, Jan, Bekeredjian, Raffi, Kaya, Ziya, Leuchs, Barbara, Nordheim, Alfred, Backs, Johannes, Engelhardt, Stefan, Katus, Hugo A, Müller, Oliver J

“…Inducible gene targeting in mice using the Cre/LoxP system has become a valuable tool to analyse the roles of specific genes in the adult heart. However, the…”
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The cardiac microenvironment uses non‐canonical WNT signaling to activate monocytes after myocardial infarction by Meyer, Ingmar Sören, Jungmann, Andreas, Dieterich, Christoph, Zhang, Min, Lasitschka, Felix, Werkmeister, Susann, Haas, Jan, Müller, Oliver J, Boutros, Michael, Nahrendorf, Matthias, Katus, Hugo A, Hardt, Stefan E, Leuschner, Florian

“…A disturbed inflammatory response following myocardial infarction (MI) is associated with poor prognosis and increased tissue damage. Monocytes are key players…”
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CaM Kinase II mediates maladaptive post‐infarct remodeling and pro‐inflammatory chemoattractant signaling but not acute myocardial ischemia/reperfusion injury by Weinreuter, Martin, Kreusser, Michael M, Beckendorf, Jan, Schreiter, Friederike C, Leuschner, Florian, Lehmann, Lorenz H, Hofmann, Kai P, Rostosky, Julia S, Diemert, Nathalie, Xu, Chang, Volz, Hans Christian, Jungmann, Andreas, Nickel, Alexander, Sticht, Carsten, Gretz, Norbert, Maack, Christoph, Schneider, Michael D, Gröne, Hermann‐Josef, Müller, Oliver J, Katus, Hugo A, Backs, Johannes

“…CaMKII was suggested to mediate ischemic myocardial injury and adverse cardiac remodeling. Here, we investigated the roles of different CaMKII isoforms and…”
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Inducible cardiomyocyte-specific deletion of CaM kinase II protects from pressure overload-induced heart failure by Kreusser, Michael M., Lehmann, Lorenz H., Wolf, Nora, Keranov, Stanislav, Jungmann, Andreas, Gröne, Hermann-Josef, Müller, Oliver J., Katus, Hugo A., Backs, Johannes

“…CaM kinase II (CaMKII) has been suggested to drive pathological cardiac remodeling and heart failure. However, the evidence provided so far is based on…”
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TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation by Grund, Andrea, Szaroszyk, Malgorzata, Korf‐Klingebiel, Mortimer, Malek Mohammadi, Mona, Trogisch, Felix A, Schrameck, Ulrike, Gigina, Anna, Tiedje, Christopher, Gaestel, Matthias, Kraft, Theresia, Hegermann, Jan, Batkai, Sandor, Thum, Thomas, Perrot, Andreas, Remedios, Cris dos, Riechert, Eva, Völkers, Mirko, Doroudgar, Shirin, Jungmann, Andreas, Bauer, Ralf, Yin, Xiaoke, Mayr, Manuel, Wollert, Kai C, Pich, Andreas, Xiao, Hua, Katus, Hugo A, Bauersachs, Johann, Müller, Oliver J, Heineke, Joerg

“…Pathological cardiac overload induces myocardial protein synthesis and hypertrophy, which predisposes to heart failure. To inhibit hypertrophy therapeutically,…”
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AAV-Mediated Expression of AP-1-Neutralizing RNA Decoy Oligonucleotides Attenuates Transplant Vasculopathy in Mouse Aortic Allografts by Remes, Anca, Franz, Maximilian, Mohr, Franziska, Weber, Antje, Rapti, Kleopatra, Jungmann, Andreas, Karck, Matthias, Hecker, Markus, Kallenbach, Klaus, Müller, Oliver J., Arif, Rawa, Wagner, Andreas H.

“…Transplant vasculopathy (TV), characterized by obstructive lesions in affected vessels, represents one of the long-term complications of cardiac…”
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S100A1's single cysteine is an indispensable redox switch for the protection against diastolic calcium waves in cardiomyocytes by Seitz, Andreas, Busch, Martin, Kroemer, Jasmin, Schneider, Andrea, Simon, Stephanie, Jungmann, Andreas, Katus, Hugo A, Most, Patrick, Ritterhoff, Julia

“…The EF-hand calcium (Ca ) sensor protein S100A1 combines inotropic with antiarrhythmic potency in cardiomyocytes (CMs). Oxidative posttranslational…”
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Abstract P2026: S100a1 Protects Cardiomyocytes From Hypertrophic Growth By Controlling The De-novo Synthesis Of Contractile And Mitochondrial Protein Programs by Egger, Michael, Glaser, Manuel, Jungmann, Andreas, Syed, Azmal A, Krijgsveld, Jeroen, Busch, Martin, Wade, Rebecca, Most, Patrick

“…Background and HypothesisLoss of S100A1 expression in heart failure contributes to adverse cardiomyocyte (CM) remodeling via an unknown molecular mechanism…”
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Cell-Based Measurement of Neutralizing Antibodies Against Adeno-Associated Virus (AAV) by Jungmann, Andreas, Müller, Oliver, Rapti, Kleopatra

“…In recent years gene therapy using adeno-associated viral (AAV) vectors to treat cardiac disease has seen an unprecedented surge, owing to its safety, low…”
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Abstract P3020: Chronic Heart Failure As A Sequel After Severe Burn Injury - First Insight Into A Novel Pathological Heart-skin Axis by Hundeshagen, Gabriel, Mertin, Victoria, Thiele, Philipp, Jungmann, Andreas, Trogisch, Felix A, Drews, Oliver, Heineke, Joerg, Van Linthout, Sophie, Fielitz, Jens, Mayr, Manuel, Busch, Martin, Kneser, Ulrich, Most, Patrick

“…BackgroundWe described chronic heart failure with preserved ejection fraction (HFpEF) as a long-term sequel in survivors of severe pediatric burn injury (BI)…”
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Abstract 528: Restricted Proteasome Heterogeneity Promotes Premature Heart Failure and Deterioration of Associated Protein Levels Upon Continuous β-Adrenergic Stimulation by Trogisch, Felix A, Koser, Franziska, Jungmann, Andreas, Müller, Oliver J, Hecker, Markus, Drews, Oliver

“…Abstract only Introduction: The ubiquitin proteasome-system is a main contributor to cellular proteostasis. The dynamic regulation of proteasome composition…”
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A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway by Lehmann, Lorenz H, Jebessa, Zegeye H, Kreusser, Michael M, Horsch, Axel, He, Tao, Kronlage, Mariya, Dewenter, Matthias, Sramek, Viviana, Oehl, Ulrike, Krebs-Haupenthal, Jutta, von der Lieth, Albert H, Schmidt, Andrea, Sun, Qiang, Ritterhoff, Julia, Finke, Daniel, Völkers, Mirko, Jungmann, Andreas, Sauer, Sven W, Thiel, Christian, Nickel, Alexander, Kohlhaas, Michael, Schäfer, Michaela, Sticht, Carsten, Maack, Christoph, Gretz, Norbert, Wagner, Michael, El-Armouche, Ali, Maier, Lars S, Londoño, Juan E Camacho, Meder, Benjamin, Freichel, Marc, Gröne, Hermann-Josef, Most, Patrick, Müller, Oliver J, Herzig, Stephan, Furlong, Eileen E M, Katus, Hugo A, Backs, Johannes

“…A proteolytically derived fragment of the epigenetic regulator HDAC4 protects the heart through transcriptional repression of the hexosamine biosynthetic…”
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AAV-mediated AP-1 decoy oligonucleotide expression inhibits aortic elastolysis in a mouse model of Marfan syndrome by Remes, Anca, Arif, Rawa, Franz, Maximilian, Jungmann, Andreas, Zaradzki, Marcin, Puehler, Thomas, Heckmann, Markus B, Frey, Norbert, Karck, Matthias, Kallenbach, Klaus, Hecker, Markus, Müller, Oliver J, Wagner, Andreas H

“…Marfan syndrome is one of the most common inherited disorders of connective tissue caused by fibrillin-1 mutations, characterized by enhanced transcription…”
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