Development of oral CTL vaccine using a CTP-integrated Sabin 1 poliovirus-based vector system

Highlights • Poliovirus Sabin1-derived CTL vaccine vector RPS-CTP is proposed. • RPS-CTP vector contains cytoplasmic transduction peptide (CTP). • HIV-1 p24-expressing recombinant poliovirus (rec-PV) was produced. • Rec-PV efficiently induced p24-specific CTL in PVR-Tg mice vaccinated orally. • Vacc...

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Bibliographic Details
Published in:	Vaccine Vol. 33; no. 38; pp. 4827 - 4836
Main Authors:	Han, Seung-Soo, Lee, Jinjoo, Jung, Yideul, Kang, Myeong-Ho, Hong, Jung-Hyub, Cha, Min-Suk, Park, Yu-Jin, Lee, Ezra, Yoon, Cheol-Hee, Bae, Yong-Soo
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 11-09-2015 Elsevier Limited
Subjects:	Acquired immune deficiency syndrome Administration, Oral AIDS AIDS Vaccines - administration & dosage AIDS Vaccines - genetics AIDS Vaccines - immunology Allergy and Immunology Animals Genes Genetic Vectors HIV HIV Core Protein p24 - genetics HIV Core Protein p24 - immunology HIV-1 - genetics HIV-1 - immunology HIV-1 p24 Human immunodeficiency virus Human immunodeficiency virus 1 Immunization Infectious diseases Mice, Inbred ICR Mice, Transgenic Oral CTL vaccine p24-specific CTL Plasmids Poliovirus Poliovirus - genetics Poliovirus Sabin 1 vector Recombinant poliovirus RPS-CTP CTL vector Survival Analysis T-Lymphocytes, Cytotoxic - immunology Vaccines Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Vaccinia - prevention & control Vaccinia virus Oral CTL vaccine Recombinant poliovirus HIV-1 p24 p24-specific CTL Poliovirus Sabin 1 vector RPS-CTP CTL vector
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Summary:	Highlights • Poliovirus Sabin1-derived CTL vaccine vector RPS-CTP is proposed. • RPS-CTP vector contains cytoplasmic transduction peptide (CTP). • HIV-1 p24-expressing recombinant poliovirus (rec-PV) was produced. • Rec-PV efficiently induced p24-specific CTL in PVR-Tg mice vaccinated orally. • Vaccinated mice were resistant to challenge with p24-expressing vaccinia virus.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.07.072