Search Results - "Jung, Rachel"
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Using Technology to Expand Communities of Practice and Support Culturally Sustaining Pedagogy in Music Education
Published in Music educators journal (01-12-2023)“…Technology can help expand communities of practice in music education and promote a democratic schooling process vital to culturally sustaining pedagogy…”
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High-resolution imaging and quantification of plasma membrane cholesterol by NanoSIMS
Published in Proceedings of the National Academy of Sciences - PNAS (21-02-2017)“…Cholesterol is a crucial lipid within the plasma membrane of mammalian cells. Recent biochemical studies showed that one pool of cholesterol in the plasma…”
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Lipoprotein lipase is active as a monomer
Published in Proceedings of the National Academy of Sciences - PNAS (26-03-2019)“…Lipoprotein lipase (LPL), the enzyme that hydrolyzes triglycerides in plasma lipoproteins, is assumed to be active only as a homodimer. In support of this…”
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Apolipoprotein C-III inhibits triglyceride hydrolysis by GPIHBP1-bound LPL[S]
Published in Journal of lipid research (01-09-2017)“…ApoC-III is often assumed to retard the intravascular processing of triglyceride-rich lipoproteins (TRLs) by inhibiting LPL, but that view is based largely on…”
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NanoSIMS Analysis of Intravascular Lipolysis and Lipid Movement across Capillaries and into Cardiomyocytes
Published in Cell metabolism (01-05-2018)“…The processing of triglyceride-rich lipoproteins (TRLs) in capillaries provides lipids for vital tissues, but our understanding of TRL metabolism is limited,…”
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Macrophages release plasma membrane-derived particles rich in accessible cholesterol
Published in Proceedings of the National Academy of Sciences - PNAS (04-09-2018)“…Macrophages are generally assumed to unload surplus cholesterol through direct interactions between ABC transporters on the plasma membrane and HDLs, but they…”
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Mobility of “HSPG-bound” LPL explains how LPL is able to reach GPIHBP1 on capillaries
Published in Journal of lipid research (01-01-2017)“…In mice lacking glycosylphosphatidylinositol-anchored high density lipoprotein binding protein 1 (GPIHBP1), the LPL secreted by adipocytes and myocytes remains…”
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Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia
Published in eLife (05-09-2019)“…Cultured mouse peritoneal macrophages release large numbers of ~30-nm cholesterol-rich particles. Here, we show that those particles represent fragments of the…”
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Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding
Published in Journal of lipid research (01-07-2017)“…Mutation of conserved cysteines in proteins of the Ly6 family cause human disease—chylomicronemia in the case of glycosylphosphatidylinositol-anchored HDL…”
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Impaired thermogenesis and sharp increases in plasma triglyceride levels in GPIHBP1-deficient mice during cold exposure
Published in Journal of lipid research (01-04-2018)“…Glycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1 (GPIHBP1), an endothelial cell protein, binds LPL in the subendothelial spaces…”
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NanoSIMS imaging reveals unexpected heterogeneity in nutrient uptake by brown adipocytes
Published in Biochemical and biophysical research communications (12-10-2018)“…Heterogeneity in the metabolic properties of adipocytes in white adipose tissue has been well documented. We sought to investigate metabolic heterogeneity in…”
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ZEB1 regulates glioma stemness through LIF repression
Published in Scientific reports (28-02-2017)“…The identification of a stem cell regulatory gene which is aberrantly expressed in glioma and associated with patient survival would increase the understanding…”
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Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL
Published in Journal of lipid research (01-01-2017)“…GPIHBP1, an endothelial cell protein, binds LPL in the interstitial spaces and shuttles it to its site of action inside blood vessels. For years, studies of…”
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An LPL–specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1[S]
Published in Journal of lipid research (01-10-2016)“…LPL contains two principal domains: an amino-terminal catalytic domain (residues 1–297) and a carboxyl-terminal domain (residues 298–448) that is important for…”
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Minimal expression of dysferlin prevents development of dysferlinopathy in dysferlin exon 40a knockout mice
Published in Acta neuropathologica communications (18-01-2023)“…Dysferlin is a Ca -activated lipid binding protein implicated in muscle membrane repair. Recessive variants in DYSF result in dysferlinopathy, a progressive…”
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GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients
Published in eLife (06-06-2019)“…GPIHBP1, a GPI-anchored protein of capillary endothelial cells, binds lipoprotein lipase (LPL) within the subendothelial spaces and shuttles it to the…”
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An upstream enhancer regulates Gpihbp1 expression in a tissue-specific manner[S]
Published in Journal of lipid research (01-04-2019)“…Glycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1 (GPIHBP1), the protein that shuttles LPL to the capillary lumen, is essential…”
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Lipoprotein lipase reaches the capillary lumen in chickens despite an apparent absence of GPIHBP1
Published in JCI insight (19-10-2017)“…In mammals, GPIHBP1 is absolutely essential for transporting lipoprotein lipase (LPL) to the lumen of capillaries, where it hydrolyzes the triglycerides in…”
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Peripheral and Central Bone Mineral Density in Charcot's Neuroarthropathy Compared in Diabetic and Nondiabetic Populations
Published in Journal of the American Podiatric Medical Association (01-05-2012)“…This prospective study was performed to compare calcaneal and lumbar bone mineral density (BMD) in individuals with and without diabetes mellitus. We compared…”
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Incidence of Talar Dome Lesions with Concomitant Peroneal Tendon Pathologic Features: A Magnetic Resonance Imaging Evaluation
Published in The Journal of foot and ankle surgery (01-09-2012)“…Abstract Few studies have evaluated the incidence of talar dome lesions and injuries to the peroneal tendons occurring concomitantly. The purpose of our…”
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