Search Results - "Jung, MinKyo"
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Contact-ID, a tool for profiling organelle contact sites, reveals regulatory proteins of mitochondrial-associated membrane formation
Published in Proceedings of the National Academy of Sciences - PNAS (02-06-2020)“…The mitochondria-associated membrane (MAM) has emerged as a cellular signaling hub regulating various cellular processes. However, its molecular components…”
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Monoclonal antibody Y01 prevents tauopathy progression induced by lysine 280-acetylated tau in cell and mouse models
Published in The Journal of clinical investigation (17-04-2023)“…The spatiotemporal pattern of the spread of pathologically modified tau through brain regions in Alzheimer's disease (AD) can be explained by prion-like…”
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Direct Visualization of Actin Filaments and Actin-Binding Proteins in Neuronal Cells
Published in Frontiers in cell and developmental biology (26-11-2020)“…Actin networks and actin-binding proteins (ABPs) are most abundant in the cytoskeleton of neurons. The function of ABPs in neurons is nucleation of actin…”
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Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice
Published in Nature communications (23-06-2023)“…Brown adipose tissue (BAT) has abundant mitochondria with the unique capability of generating heat via uncoupled respiration. Mitochondrial uncoupling protein…”
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The autophagy research in electron microscopy
Published in Applied microscopy (06-11-2019)“…Autophagy, a highly conserved process of eukaryotic cellular recycling, plays an important role in cell survival and maintenance. Dysfunctional autophagy…”
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Super-resolution proximity labeling reveals anti-viral protein network and its structural changes against SARS-CoV-2 viral proteins
Published in Cell reports (Cambridge) (29-08-2023)“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in human cells by interacting with host factors following infection. To understand the…”
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Leucine-induced localization of Leucyl-tRNA synthetase in lysosome membrane
Published in Biochemical and biophysical research communications (18-11-2017)“…Leucyl-tRNA synthetase (LRS) plays major roles in providing leucine-tRNA and activating mechanistic target of rapamycin complex 1 (mTORC1) through…”
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Urinary Exosomal Cystatin C and Lipopolysaccharide Binding Protein as Biomarkers for Antibody−Mediated Rejection after Kidney Transplantation
Published in Biomedicines (21-09-2022)“…We aimed to discover and validate urinary exosomal proteins as biomarkers for antibody−mediated rejection (ABMR) after kidney transplantation. Urine and…”
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Dual-color Correlative Light and Electron Microscopy for the Visualization of Interactions between Mitochondria and Lysosomes
Published in Journal of visualized experiments (27-09-2024)“…Cellular organelles, such as mitochondria and lysosomes, display dynamic structures. Despite the higher resolution of transmission electron microscopy for…”
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A multifunctional peroxidase-based reaction for imaging, sensing and networking of spatial biology
Published in Biochimica et biophysica acta. Molecular cell research (01-03-2023)“…Peroxidase is a heme-containing enzyme that reduces hydrogen peroxide to water by extracting electron(s) from aromatic compounds via a sequential turnover…”
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L-serine restored lysosomal failure in cells derived from patients with BPAN reducing iron accumulation with eliminating lipofuscin
Published in Free radical biology & medicine (20-08-2024)“…Defective mitochondria and autophagy, as well as accumulation of lipid and iron in WDR45 mutant fibroblasts, is related to beta-propeller protein-associated…”
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Hybrid engineered dental composites by multiscale reinforcements with chitosan-integrated halloysite nanotubes and S-glass fibers
Published in Composites. Part B, Engineering (01-12-2020)“…Novel combinations of mechanical and biological properties are required when developing new polymer-based restorative dental composites. This study reports a…”
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SHISA5/SCOTIN restrains spontaneous autophagy induction by blocking contact between the ERES and phagophores
Published in Autophagy (03-07-2022)“…The phagophore expands into autophagosomes in close proximity to endoplasmic reticulum (ER) exit sites (ERESs). Here, we propose that a single-pass ER…”
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Correlative Light and Transmission Electron Microscopy Showed Details of Mitophagy by Mitochondria Quality Control in Propionic Acid Treated SH-SY5Y Cell
Published in Materials (29-09-2020)“…Propionic acid is a metabolite of the microbiome and can be transported to the brain. Previous data show that propionic acid changes mitochondrial biogenesis…”
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Immuno-gold Techniques in Biomedical Sciences
Published in Advances in experimental medicine and biology (01-01-2021)“…Since their development in the 1960s, immuno-gold techniques have been steadily used in biomedical science, because these techniques are applicable to all…”
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Intrinsically disordered region-mediated condensation of IFN-inducible SCOTIN/SHISA-5 inhibits ER-to-Golgi vesicle transport
Published in Developmental cell (09-10-2023)“…Newly synthesized proteins in the endoplasmic reticulum (ER) are sorted by coat protein complex II (COPII) at the ER exit site en route to the Golgi. Under…”
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Mitochondrial matrix RTN4IP1/OPA10 is an oxidoreductase for coenzyme Q synthesis
Published in Nature chemical biology (01-02-2024)“…Targeting proximity-labeling enzymes to specific cellular locations is a viable strategy for profiling subcellular proteomes. Here, we generated transgenic…”
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Clusterin Binding Modulates the Aggregation and Neurotoxicity of Amyloid-β(1–42)
Published in Molecular neurobiology (01-10-2022)“…Alzheimer’s disease (AD) is the most common neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) aggregates in the brain. Clusterin…”
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Neuromyelitis optica (NMO)‐IgG‐driven organelle reorganization in human iPSC‐derived astrocytes
Published in The FASEB journal (01-10-2021)“…Neuromyelitis optica (NMO) is an autoimmune disease that primarily targets astrocytes. Autoantibodies (NMO‐IgG) against the water channel protein, aquaporin 4…”
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Genome-wide kinase-MAM interactome screening reveals the role of CK2A1 in MAM Ca 2+ dynamics linked to DEE66
Published in Proceedings of the National Academy of Sciences - PNAS (08-08-2023)“…The endoplasmic reticulum (ER) and mitochondria form a unique subcellular compartment called mitochondria-associated ER membranes (MAMs). Disruption of MAMs…”
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