Search Results - "Jung, Mankil"

Acetylcholinesterase inhibition by flavonoids from Agrimonia pilosa by Jung, Mankil, Park, Moonso

“…In a bioassay-guided search for acetylcholinesterase (AChE) inhibitors from 180 medicinal plants, an ethyl acetate extract of whole plants of Agrimonia pilosa…”
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Practical Synthesis of Chalcone Derivatives and Their Biological Activities by Jung, Jae-Chul, Lee, Yongnam, Min, Dongguk, Jung, Mankil, Oh, Seikwan

“…Practical synthesis and biological activities of 4-hydroxy-3-methoxy-2-propene derivatives are described. The novel chalcone derivatives were prepared by acid…”
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Antidiabetic agents from medicinal plants by Jung, Mankil, Park, Moonsoo, Lee, Hyun Chul, Kang, Yoon-Ho, Kang, Eun Seok, Kim, Sang Ki

“…Currently available therapeutic options for non-insulin-dependent diabetes mellitus, such as dietary modification, oral hypoglycemics, and insulin, have…”
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First total synthesis of natural pulsatilla saponin D via highly stereospecific glycosylation by Kim, Minkyu, Lim, Eunyoung, Jung, Mankil

“…The first total synthesis of pulsatilla saponin D, a potent anti-lung cancer natural product was accomplished in eight steps from l-arabinopyranoside in high…”
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Artemisinin-Daumone Hybrid Inhibits Cancer Cell-Mediated Osteolysis by Targeting Cancer Cells and Osteoclasts by Ma, Gwang Taek, Lee, Sun Kyoung, Park, Kwang-Kyun, Park, Junhee, Son, Seung Hwa, Jung, Mankil, Chung, Won-Yoon 

“…Background/Aims: Bone metastasis of cancer cells decreases patient survival and quality of life. Hybridization via the covalent coupling of two bioactive…”
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Total Synthesis and Anticancer Activity of Novel Pulsatilla Saponin D Analogues by Kim, Minkyu, Park, Yongseo, Chung, Won-Yoon, Park, Kwang-Kyun, Jung, Mankil

“…Novel saponins that retain a free carboxyl group at the C-17 position and various sugars linked at the C-3 position of hederagenin aglycone were synthesized…”
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Daumone fed late in life improves survival and reduces hepatic inflammation and fibrosis in mice by Park, Jong Hee, Chung, Hae Young, Kim, Minkyu, Lee, Jung Hwa, Jung, Mankil, Ha, Hunjoo

“…Summary The liver is one of the most susceptible organs to aging, and hepatic inflammation and fibrosis increase with age. Chronic inflammation has been…”
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First Synthesis of Novel Aminophenyl Pyridinium-5-(hydroxybenzoyl)-hydrazonomethyl-2-oxothiazol-3-ide Derivatives and Evaluation of Their Anticancer Activities by Min, Dongguk, Han, Moon Hi, Lee, Seulki, Jung, Mankil

“…The first total synthesis for large-scale production and anticancer activity of novel…”
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Simple synthesis of modafinil derivatives and their anti-inflammatory activity by Jung, Jae-Chul, Lee, Yeonju, Son, Jee-Young, Lim, Eunyoung, Jung, Mankil, Oh, Seikwan

“…Simple synthesis of modafinil derivatives and their biological activity are described. The key synthetic strategies involve substitution and coupling…”
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Protective effects of magnesium lithospermate B against diabetic atherosclerosis via Nrf2-ARE-NQO1 transcriptional pathway by Hur, Kyu Yeon, Kim, Soo Hyun, Choi, Min-Ah, Williams, Darren R, Lee, Yong-ho, Kang, Sang Won, Yadav, Umesh C.S, Srivastava, Satish K, Jung, Mankil, Cho, Jin Won, Kim, Sang Geon, Kang, Eun Seok, Lee, Eun Jig, Lee, Hyun Chul

“…Abstract Hyperglycemia-induced oxidative stress is known to play an important role in the development of several diabetic complications, including…”
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Synthesis of a dual-labeled probe of dimethyl lithospermate B with photochemical and fluorescent properties by Lim, Eunyoung, Ricci, Jeremy, Jung, Mankil

“…Dimethyl lithosermate B (DLB) is a highly potent natural antioxidant and antidiabetic polyphenol with unknown mode of action. To determine its cellular…”
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Synthesis and Anticancer Activity of Novel Deoxoartemisinin–Glycolipid Hybrids by Min, Dongguk, Kim, Minkyu, Ricci, Jérémy, Jung, Sora, Kim, Kirim, Chung, Won-Yoon, Park, Kwang-Kyun, Jung, Mankil

“…The practical synthesis and anticancer activity of novel deoxoartemisinin–glycolipid hybrids, which incorporate two drugs into a single molecule and can impact…”
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Recent advances in artemisinin and its derivatives as antimalarial and antitumor agents by Jung, Mankil, Lee, Kyunghoon, Kim, Hanjo, Park, Moonsoo

“…Artemisinin, the first and last naturally occurring 1, 2, 4-trioxane originated from Artemisia annua, L. and its derivatives are a potent class of antimalarial…”
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Discovery of Artemisinin-Glycolipid Hybrids as Anti-oral Cancer Agents by Ricci, Jérémy, Kim, Minkyu, Chung, Won-Yoon, Park, Kwang-Kyun, Jung, Mankil

“…Novel artemisinin-glycolipid hybrids were directly synthesized from 12β (C–C)-type deoxoartemisinin and glycolipid and exhibited exceptional in vitro…”
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Synthesis and anticancer activity of novel amide derivatives of non-acetal deoxoartemisinin by Jung, Mankil, Park, Namsoo, Moon, Hyung-In, Lee, Yongnam, Chung, Won-Yoon, Park, Kwang-Kyun

“…Novel amide derivatives of non-acetal deoxoartemisinin were synthesized. Some of the derivatives had potent in vitro anticancer activity and the…”
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Total synthesis of flocoumafen via knoevenagel condensation and intramolecular ring cyclization: general access to natural products by Jung, Jae-Chul, Lim, Eunyoung, Lee, Yongnam, Min, Dongguk, Ricci, Jeremy, Park, Oe-Sook, Jung, Mankil

“…The total synthesis and structure determination of cis- and trans-flocoumafen was described. The key synthetic steps involve Knoevenagel condensation with…”
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Naturally occurring peroxides with biological activities by Jung, Mankil, Kim, Hanjo, Lee, Kyunghoon, Park, Moonsoo

“…New natural peroxides that have potent biological activities with novel diverse structures are reviewed with classification as secondary metabolites such as…”
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Lithospermic acid B ameliorates the development of diabetic nephropathy in OLETF rats by Kang, Eun Seok, Lee, Geun Taek, Kim, Beom Seok, Kim, Chul Hoon, Seo, Gi Ho, Han, Seung Jin, Hur, Kyu Yeon, Ahn, Chul Woo, Ha, Hunjoo, Jung, Mankil, Ahn, Young Soo, Cha, Bong Soo, Lee, Hyun Chul

“…Lithospermic acid B (LAB), an active component isolated from Salvia miltiorrhizae, has been reported to have renoprotective effects in type 1 diabetic animal…”
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Three-dimensional structure of Plasmodium falciparum Ca2+-ATPase(PfATP6) and docking of artemisinin derivatives to PfATP6 by JUNG, Mankil, KIM, Hanjo, KI YOUP NAM, KYOUNG TAI NO

“…Construction of the 3D structure of PfATP6 by homology modeling and docking simulation of artemisinin derivatives to this protein model are reported. Docking…”
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Antitumor Activity of Novel Deoxoartemisinin Monomers, Dimers, and Trimer by Jung, Mankil, Lee, Sangmin, Ham, Jungyeob, Lee, Kyunghoon, Kim, Hanjo, Kim, Soo Kie

“…The first primary amines 9 and bromoalkyl analogues 7 of deoxoartemisinin with nonacetal functionality at C-12 are prepared as versatile intermediates for the…”
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