Search Results - "Jung, M. Katherine"

Alcohol,inflammation,and gut-liver-brain interactions in tissue damage and disease development by Wang, H Joe, Zakhari, Samir, Jung, M Katherine

“…Chronic inflammation is often associated with alcoholrelated medical conditions. The key inducer of such inflammation, and also the best understood, is gut…”
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The concise synthesis of chalcone, indanone and indenone analogues of combretastatin A4 by Kerr, Daniel J., Hamel, Ernest, Jung, M. Katherine, Flynn, Bernard L.

“…A series of aryl- and aroyl-substituted chalcone analogues of the tubulin binding agent combretastatin A4 ( 1) were prepared, using a recently introduced…”
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One-Pot Synthesis of Benzo[b]furan and Indole Inhibitors of Tubulin Polymerization by Flynn, Bernard L, Hamel, Ernest, Jung, M. Katherine

“…Benzo[b]furan and indole analogues of some recently identified benzo[b]thiophene inhibitors of tubulin polymerization have been prepared, and their biological…”
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Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly by Hamel, Ernest, Day, Billy W, Miller, John H, Jung, M Katherine, Northcote, Peter T, Ghosh, Arun K, Curran, Dennis P, Cushman, Mark, Nicolaou, K C, Paterson, Ian, Sorensen, Erik J

“…Previous studies on the drug content of pelleted tubulin polymers suggest that peloruside A binds in the laulimalide site, which is distinct from the taxoid…”
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Introduction to a special issue on wearable alcohol biosensors: Development, use, and state of the field by Jung, M. Katherine

“…•Dr. Jung reviews the history and state of the field for wearable alcohol biosensors.•Dr. Jung provides an overview of the research questions addressed in the…”
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Synthesis and Biological Evaluation of 2-Amino-3-(3‘,4‘,5‘-trimethoxybenzoyl)-5-aryl Thiophenes as a New Class of Potent Antitubulin Agents by Romagnoli, Romeo, Baraldi, Pier Giovanni, Pavani, Maria Giovanna, Tabrizi, Mojgan Aghazadeh, Preti, Delia, Fruttarolo, Francesca, Piccagli, Laura, Jung, M. Katherine, Hamel, Ernest, Borgatti, Monica, Gambari, Roberto

“…A new series of compounds in which the 2-amino-5-chlorophenyl ring of phenstatin analogue 7 was replaced with a 2-amino-5-aryl thiophene was synthesized and…”
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Antineoplastic Agents. 465. Structural Modification of Resveratrol:  Sodium Resverastatin Phosphate by Pettit, George R, Grealish, Matthew P, Jung, M. Katherine, Hamel, Ernest, Pettit, Robin K, Chapuis, J.-Charles, Schmidt, Jean M

“…As an extension of structure/activity investigations of resveratrol (1), phenstatin (2c), and the cancer antiangiogenesis drug sodium combretastatin A-4…”
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Demonstration of microtubule-like structures formed with (−)-rhazinilam from purified tubulin outside of cells and a simple tubulin-based assay for evaluation of analog activity by Edler, Michael C., Yang, Guangli, Katherine Jung, M., Bai, Ruoli, Bornmann, William G., Hamel, Ernest

“…(−)-Rhazinilam was spontaneously generated from a natural product during isolation. In cultured cells, it causes microtubule bundle formation, like those…”
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Alcohol Exposure and Mechanisms of Tissue Injury and Repair by Jung, M. Katherine, Callaci, John J., Lauing, Kristen L., Otis, Jeffrey S., Radek, Katherine A., Jones, Michael K., Kovacs, Elizabeth J.

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Trends in Premature Deaths From Alcoholic Liver Disease in the U.S., 1999–2018 by Yoon, Young-Hee, Chen, Chiung M., Slater, Megan E., Jung, M. Katherine, White, Aaron M.

“…So-called deaths of despair—those involving drug overdoses, alcohol-related liver disease, and suicide—have been rising in the U.S. among middle-aged white,…”
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The Need for Integrating Addiction Medicine and Hepatology by Leggio, Lorenzo, Jung, M Katherine

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Antineoplastic Agents. 487. Synthesis and Biological Evaluation of the Antineoplastic Agent 3,4-Methylenedioxy-5,4‘-dimethoxy-3‘-amino-Z-stilbene and Derived Amino Acid Amides by Pettit, George R, Anderson, Collin R, Herald, Delbert L, Jung, M. Katherine, Lee, Debbie J, Hamel, Ernest, Pettit, Robin K

“…An efficient synthesis of 3,4-methylenedioxy-5,4‘-dimethoxy-3‘-amino-Z-stilbene (1c) and hydrochloride (1d) is reported. The nitrostilbene intermediate 6a was…”
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Discovery of 7-Hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a Tubulin Polymerization Inhibitor with Potent Antiproliferative and Tumor Vascular Disrupting Properties by Flynn, Bernard L, Gill, Gurmit S, Grobelny, Damian W, Chaplin, Jason H, Paul, Dharam, Leske, Annabell F, Lavranos, Tina C, Chalmers, David K, Charman, Susan A, Kostewicz, Edmund, Shackleford, David M, Morizzi, Julia, Hamel, Ernest, Jung, M. Katherine, Kremmidiotis, Gabriel

“…A structure–activity relationship (SAR) guided design of novel tubulin polymerization inhibitors has resulted in a series of benzo[b]furans with exceptional…”
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Alcohol Exposure and Mechanisms of Tissue Injury and Repair by Jung, M. Katherine, Callaci, John J., Lauing, Kristen L., Otis, Jeffrey S., Radek, Katherine A., Jones, Michael K., Kovacs, Elizabeth J.

“…Tissue injury owing to acute and chronic alcohol consumption has extensive medical consequences, with the level and duration of alcohol exposure affecting both…”
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The Microtubule Stabilizing Agent Laulimalide Does Not Bind in the Taxoid Site, Kills Cells Resistant to Paclitaxel and Epothilones, and May Not Require Its Epoxide Moiety for Activity by Pryor, Donald E, O'Brate, Aurora, Bilcer, Geoffrey, Díaz, J. Fernando, Wang, Yuefang, Wang, Yong, Kabaki, Mikio, Jung, M. Katherine, Andreu, José M, Ghosh, Arun K, Giannakakou, Paraskevi, Hamel, Ernest

“…Laulimalide is a cytotoxic natural product that stabilizes microtubules. The compound enhances tubulin assembly, and laulimalide is quantitatively comparable…”
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Heterocyclic and Phenyl Double-Bond-Locked Combretastatin Analogues Possessing Potent Apoptosis-Inducing Activity in HL60 and in MDR Cell Lines by Simoni, Daniele, Grisolia, Giuseppina, Giannini, Giuseppe, Roberti, Marinella, Rondanin, Riccardo, Piccagli, Laura, Baruchello, Riccardo, Rossi, Marcello, Romagnoli, Romeo, Invidiata, Francesco Paolo, Grimaudo, Stefania, Jung, M. Katherine, Hamel, Ernest, Gebbia, Nicola, Crosta, Lucia, Abbadessa, Vincenzo, Di Cristina, Antonietta, Dusonchet, Luisa, Meli, Maria, Tolomeo, Manlio

“…Two new series of combretastatin (CA-4) analogues have been prepared. The alkenyl motif of CA-4 was replaced either by a five-membered heterocyclic…”
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Benzoylphenylurea Sulfur Analogues with Potent Antitumor Activity by Hallur, Gurulingappa, Jimeno, Antonio, Dalrymple, Susan, Zhu, Tao, Jung, M. Katherine, Hidalgo, Manuel, Isaacs, John T, Sukumar, Saraswati, Hamel, Ernest, Khan, Saeed R

“…A novel series of BPU analogues were synthesized and evaluated for antitumor activity. In particular, BPU sulfur analogues 6n and 7d were shown to possess up…”
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Antineoplastic agents. 509. Synthesis of fluorcombstatin phosphate and related 3-halostilbenes by Pettit, G.R, Minardi, M.D, Rosenberg, H.J, Hamel, E, Bibby, M.C, Martin, S.W, Jung, M.K, Pettit, R.K, Cuthbertson, T.J, Chapuis, J.C

“…The present SAR study of combretastatin A-3 (3a) focused on replacement of the 3-hydroxyl group by a series of halogens. That approach with Z-stilbenes…”
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Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles by Romagnoli, Romeo, Baraldi, Pier Giovanni, Jung, M. Katherine, Iaconinoto, Maria Antonietta, Carrion, Maria Dora, Remusat, Vincent, Preti, Delia, Tabrizi, Mojgan Aghazadeh, Francesca, Fruttarolo, De Clercq, Erik, Balzarini, Jan, Hamel, Ernest

“…A new series of compounds, in which the 2-amino-4-methoxyphenyl ring of phenstatin analogue 5 was replaced with 2- or 3-amino-benzoheterocycles, was…”
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Antitumor Agents 238. Anti-tubulin and in vitro Cytotoxic Effects of N-Substituted Allocolchicinoids by Lee, Kuo-Hsiung, Nakagawa-Goto, Kyoko, Katherine Jung, M., Hamel, Ernest, Wu, Chin-Chung, F. Bastow, Kenneth, Brossi, Arnold, Ohta, Shunsaku

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