Search Results - "Jung, Frederic H"

AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis by WILKINSON, Robert W, ODEDRA, Rajesh, BYTH, Kate F, BARRASS, Nigel C, MUNDT, Kirsten E, FOOTE, Kevin M, HERON, Nicola M, JUNG, Frederic H, MORTLOCK, Andrew A, BOYLE, F. Thomas, GREEN, Stephen, HEATON, Simon P, WEDGE, Stephen R, KEEN, Nicholas J, CRAFTER, Claire, FOSTER, John R, BRADY, Madeleine C, BIGLEY, Alison, BROWN, Elaine

“…Purpose: In the current study, we examined the in vivo effects of AZD1152, a novel and specific inhibitor of Aurora kinase activity (with selectivity for…”
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Diversity-orientated synthesis of 3,5-bis(arylamino)pyrazoles by Degorce, Sébastien, Jung, Frédéric H., Harris, Craig S., Koza, Patrice, Lecoq, Jonathan, Stevenin, Arnaud

“…The synthesis of differentially-substituted 3,5-bis(arylamino)pyrazoles has not yet been documented. During our investigation, we managed to develop a novel,…”
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Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: Selective inhibitors of Aurora B kinase with potent anti-tumor activity by Foote, Kevin M., Mortlock, Andrew A., Heron, Nicola M., Jung, Frédéric H., Hill, George B., Pasquet, Georges, Brady, Madeleine C., Green, Stephen, Heaton, Simon P., Kearney, Sarah, Keen, Nicholas J., Odedra, Rajesh, Wedge, Stephen R., Wilkinson, Robert W.

“…A new class of 1-acetanilide-4-aminopyrazole-substituted quinazoline Aurora kinase inhibitors has been discovered possessing highly potent cellular activity…”
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SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors by Heron, Nicola M., Anderson, Malcolm, Blowers, David P., Breed, Jason, Eden, Jonathan M., Green, Stephen, Hill, George B., Johnson, Trevor, Jung, Frederic H., McMiken, Helen H.J., Mortlock, Andrew A., Pannifer, Andrew D., Pauptit, Richard A., Pink, Jennifer, Roberts, Nicola J., Rowsell, Siân

“…The discovery, optimisation and subsequent structural determination of a novel class of Aurora kinase inhibitors are described. A novel series of…”
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Novel imidazo[1,2-a]pyridine based inhibitors of the IGF-1 receptor tyrosine kinase: Optimization of the aniline by Ducray, Richard, Jones, Clifford D., Jung, Frederic H., Simpson, Iain, Curwen, Jon, Pass, Martin

“…Following the discovery of imidazopyridine 1 as a potent IGF-1R tyrosine kinase inhibitor, the aniline part has been modified with the aim to optimize the…”
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Discovery, Synthesis, and in Vivo Activity of a New Class of Pyrazoloquinazolines as Selective Inhibitors of Aurora B Kinase by Mortlock, Andrew A, Foote, Kevin M, Heron, Nicola M, Jung, Frédéric H, Pasquet, Georges, Lohmann, Jean-Jacques M, Warin, Nicolas, Renaud, Fabrice, De Savi, Chris, Roberts, Nicola J, Johnson, Trevor, Dousson, Cyril B, Hill, George B, Perkins, David, Hatter, Glenn, Wilkinson, Robert W, Wedge, Stephen R, Heaton, Simon P, Odedra, Rajesh, Keen, Nicholas J, Crafter, Claire, Brown, Elaine, Thompson, Katherine, Brightwell, Stephen, Khatri, Liz, Brady, Madeleine C, Kearney, Sarah, McKillop, David, Rhead, Steve, Parry, Tony, Green, Stephen

“…The Aurora kinases have been the subject of considerable interest as targets for the development of new anticancer agents. While evidence suggests inhibition…”
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Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase by Ducray, Richard, Simpson, Iain, Jung, Frederic H., Nissink, J. Willem M., Kenny, Peter W., Fitzek, Martina, Walker, Graeme E., Ward, Lara T., Hudson, Kevin

“…Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase. We disclose a novel series of…”
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Progress in the development of selective inhibitors of aurora kinases by Mortlock, Andrew A, Keen, Nicholas J, Jung, Frederic H, Heron, Nicola M, Foote, Kevin M, Wilkinson, Robert W, Green, Stephen

“…Errors in the mitotic process are thought to be one of the principal sources of the genetic instability that hallmarks cancer. Unsurprisingly, many of the…”
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Progress in the development of selective inhibitors of Aurora kinases by Mortlock, Andrew, Keen, Nicholas J, Jung, Frederic H, Heron, Nicola M, Foote, Kevin M, Wilkinson, Robert, Green, Stephen

“…Errors in the mitotic process are thought to be one of the principal sources of the genetic instability that hallmarks cancer. Unsurprisingly, many of the…”
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Discovery of Novel and Potent Thiazoloquinazolines as Selective Aurora A and B Kinase Inhibitors by Jung, Frédéric H, Pasquet, Georges, Lambert-van der Brempt, Christine, Lohmann, Jean-Jacques M, Warin, Nicolas, Renaud, Fabrice, Germain, Hervé, De Savi, Chris, Roberts, Nicola, Johnson, Trevor, Dousson, Cyril, Hill, George B, Mortlock, Andrew A, Heron, Nicola, Wilkinson, Robert W, Wedge, Stephen R, Heaton, Simon P, Odedra, Rajesh, Keen, Nicholas J, Green, Stephen, Brown, Elaine, Thompson, Katherine, Brightwell, Stephen

“…The synthesis of a novel series of quinazolines substituted at C4 by five-membered ring aminoheterocycles is reported. Their in vitro structure−activity…”
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SARr and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors by HERON, Nicola M, ANDERSON, Malcolm, MORTLOCK, Andrew A, PANNIFER, Andrew D, PAUPTIT, Richard A, PINK, Jennifer, ROBERTS, Nicola J, ROWSELL, Sian, BLOWERS, David P, BREED, Jason, EDEN, Jonathan M, GREEN, Stephen, HILL, George B, JOHNSON, Trevor, JUNG, Frederic H, MCMIKEN, Helen H. J

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