Search Results - "June-Yong Lee"

Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease by Lee, June-Yong, Hall, Jason A., Kroehling, Lina, Wu, Lin, Najar, Tariq, Nguyen, Henry H., Lin, Woan-Yu, Yeung, Stephen T., Silva, Hernandez Moura, Li, Dayi, Hine, Ashley, Loke, P’ng, Hudesman, David, Martin, Jerome C., Kenigsberg, Ephraim, Merad, Miriam, Khanna, Kamal M., Littman, Dan R.

“…Lymphoid cells that produce interleukin (IL)-17 cytokines protect barrier tissues from pathogenic microbes but are also prominent effectors of inflammation and…”
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An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses by Sano, Teruyuki, Huang, Wendy, Hall, Jason A., Yang, Yi, Chen, Alessandra, Gavzy, Samuel J., Lee, June-Yong, Ziel, Joshua W., Miraldi, Emily R., Domingos, Ana I., Bonneau, Richard, Littman, Dan R.

“…RORγt+ Th17 cells are important for mucosal defenses but also contribute to autoimmune disease. They accumulate in the intestine in response to microbiota and…”
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Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation by Cheung, Ka Lung, Zhang, Fan, Jaganathan, Anbalagan, Sharma, Rajal, Zhang, Qiang, Konuma, Tsuyoshi, Shen, Tong, Lee, June-Yong, Ren, Chunyan, Chen, Chih-Hung, Lu, Geming, Olson, Matthew R., Zhang, Weijia, Kaplan, Mark H., Littman, Dan R., Walsh, Martin J., Xiong, Huabao, Zeng, Lei, Zhou, Ming-Ming

“…The BET proteins are major transcriptional regulators and have emerged as new drug targets, but their functional distinction has remained elusive. In this…”
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SARS-CoV-2 Infection of Microglia Elicits Proinflammatory Activation and Apoptotic Cell Death by Jeong, Gi Uk, Lyu, Jaemyun, Kim, Kyun-Do, Chung, Young Cheul, Yoon, Gun Young, Lee, Sumin, Hwang, Insu, Shin, Won-Ho, Ko, Junsu, Lee, June-Yong, Kwon, Young-Chan

“…Accumulating evidence suggests that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes various neurological symptoms in patients…”
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Virtual memory CD8 T cells display unique functional properties by Lee, June-Yong, Hamilton, Sara E., Akue, Adovi D., Hogquist, Kristin A., Jameson, Stephen C.

“…Previous studies revealed the existence of foreign antigen-specific memory phenotype CD8 T cells in unimmunized mice. Considerable evidence suggests this…”
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Context-Dependent Regulation of Type17 Immunity by Microbiota at the Intestinal Barrier by Akuzum, Begum, Lee, June-Yong

“…T-helper-17 (Th17) cells and related IL-17-producing (type17) lymphocytes are abundant at the epithelial barrier. In response to bacterial and fungal…”
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IgSF11 deficiency alleviates osteoarthritis in mice by suppressing early subchondral bone changes by Kim, Gyeong Min, Kim, Jihee, Lee, June-Yong, Park, Min-Chan, Lee, Soo Young

“…Osteoarthritis (OA) is a degenerative joint disease. While it is classically characterized by articular cartilage destruction, OA affects all tissues in the…”
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TREGking From Gut to Brain: The Control of Regulatory T Cells Along the Gut-Brain Axis by Choi, Juli, Kim, Bo-Ram, Akuzum, Begum, Chang, Leechung, Lee, June-Yong, Kwon, Ho-Keun

“…The human gastrointestinal tract has an enormous and diverse microbial community, termed microbiota, that is necessary for the development of the immune system…”
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5-aminosalicylic acid suppresses osteoarthritis through the OSCAR-PPARγ axis by Kim, Jihee, Ryu, Gina, Seo, Jeongmin, Go, Miyeon, Kim, Gyungmin, Yi, Sol, Kim, Suwon, Lee, Hana, Lee, June-Yong, Kim, Han Sung, Park, Min-Chan, Shin, Dong Hae, Shim, Hyunbo, Kim, Wankyu, Lee, Soo Young

“…Osteoarthritis (OA) is a progressive and irreversible degenerative joint disease that is characterized by cartilage destruction, osteophyte formation,…”
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SPNS2 enables T cell egress from lymph nodes during an immune response by Okuniewska, Martyna, Fang, Victoria, Baeyens, Audrey, Raghavan, Varsha, Lee, June-Yong, Littman, Dan R., Schwab, Susan R.

“…T cell expression of sphingosine 1-phosphate (S1P) receptor 1 (S1PR1) enables T cell exit from lymph nodes (LNs) into lymph, while endothelial S1PR1 expression…”
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Context-Dependent Regulation of Type17 Immunity by Microbiota at the Intestinal Barrier by Begum Akuzum, June-Yong Lee

“…T-helper-17 (Th17) cells and related IL-17-producing (type17) lymphocytes are abundant at the epithelial barrier. In response to bacterial and fungal…”
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Autophagy Protein Rubicon Mediates Phagocytic NADPH Oxidase Activation in Response to Microbial Infection or TLR Stimulation by Yang, Chul-Su, Lee, Jong-Soo, Rodgers, Mary, Min, Chan-Ki, Lee, June-Yong, Kim, Hee Jin, Lee, Kwang-Hoon, Kim, Chul-Joong, Oh, Byungha, Zandi, Ebrahim, Yue, Zhenyu, Kramnik, Igor, Liang, Chengyu, Jung, Jae U.

“…Phagocytosis and autophagy are two important and related arms of the host's first-line defense against microbial invasion. Rubicon is a RUN domain containing…”
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A Dual Role for UVRAG in Maintaining Chromosomal Stability Independent of Autophagy by Zhao, Zhen, Oh, Soohwan, Li, Dapeng, Ni, Duojiao, Pirooz, Sara Dolatshahi, Lee, Joo-Hyung, Yang, Shunhua, Lee, June-Yong, Ghozalli, Irene, Costanzo, Vincenzo, Stark, Jeremy M., Liang, Chengyu

“…Autophagy defects have recently been associated with chromosomal instability, a hallmark of human cancer. However, the functional specificity and mechanism of…”
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The Autophagy Regulator Rubicon Is a Feedback Inhibitor of CARD9-Mediated Host Innate Immunity by Yang, Chul-Su, Rodgers, Mary, Min, Chan-Ki, Lee, Jong-Soo, Kingeter, Lara, Lee, June-Yong, Jong, Ambrose, Kramnik, Igor, Lin, Xin, Jung, Jae U.

“…Assembly of a scaffold consisting of CARD9, BCL10, and MALT1 (CBM complex) is critical for effective signaling by multiple pattern recognition receptors (PRRs)…”
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Transcriptional and Epigenetic Regulation of Context-Dependent Plasticity in T-Helper Lineages by Meyer J. Friedman, Haram Lee, June-Yong Lee, Soohwan Oh

“…Th cell lineage determination and functional specialization are tightly linked to the activation of lineage-determining transcription factors (TFs) that bind…”
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Remembering to Be Tolerant by Lee, June-Yong, Jameson, Stephen C.

“…Self-tolerant T cells can be transiently reactivated. We avoid potentially lethal autoreactivity because our adaptive immune system ignores normal, healthy…”
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Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells by Skon, Cara N, Lee, June-Yong, Anderson, Kristin G, Masopust, David, Hogquist, Kristin A, Jameson, Stephen C

“…Jameson and colleagues show that the establishment of resident memory CD8 + T cells in nonlymphoid tissues requires transcriptional downregulation of the…”
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Dysfunctional interferon-alpha production by peripheral plasmacytoid dendritic cells upon Toll-like receptor-9 stimulation in patients with systemic lupus erythematosus by Kwok, Seung-Ki, Lee, June-Yong, Park, Se-Ho, Cho, Mi-La, Min, So-Youn, Park, Sung-Hwan, Kim, Ho-Youn, Cho, Young-Gyu

“…It is well known that interferon (IFN)-alpha is important to the pathogenesis of systemic lupus erythematosus (SLE). However, several reports have indicated…”
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Transcription factor RORα enforces stability of the Th17 cell effector program by binding to a Rorc cis-regulatory element by Hall, Jason A., Pokrovskii, Maria, Kroehling, Lina, Kim, Bo-Ram, Kim, Seung Yong, Wu, Lin, Lee, June-Yong, Littman, Dan R.

“…T helper 17 (Th17) cells regulate mucosal barrier defenses but also promote multiple autoinflammatory diseases. Although many molecular determinants of Th17…”
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Derivation and maintenance of virtual memory CD8 T cells by Akue, Adovi D, Lee, June-Yong, Jameson, Stephen C

“…Memory CD8(+) T cells are an important component of the adaptive immune response against many infections, and understanding how Ag-specific memory CD8(+) T…”
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