Search Results - "June, Ronald K"

Emerging role of metabolic signaling in synovial joint remodeling and osteoarthritis by June, Ronald K., Liu-Bryan, Ru, Long, Fanxing, Griffin, Timothy M.

“…ABSTRACT Obesity and associated metabolic diseases collectively referred to as the metabolic syndrome increase the risk of skeletal and synovial joint…”
Get full text

Revised Role of Glycosaminoglycans in TAT Protein Transduction Domain-mediated Cellular Transduction by Gump, Jacob M., June, Ronald K., Dowdy, Steven F.

“…Cellular uptake of the human immunodeficiency virus TAT protein transduction domain (PTD), or cell-penetrating peptide, has previously been surmised to occur…”
Get full text

Cartilage Metabolism, Mitochondria, and Osteoarthritis by Blanco, Francisco J., June, Ronald K.

Get full text

Sex-specific effects of calving season on joint health and biomarkers in Montana ranchers by Thompson, Matthew A, Martin, Stephen A, Hislop, Brady D, Younkin, Roubie, Andrews, Tara M, Miller, Kaleena, June, Ronald K, Adams, Erik S

“…Agricultural workers have a higher incidence of osteoarthritis (OA), but the etiology behind this phenomenon is unclear. Calving season, which occurs in mid-…”
Get full text

Effects of mechanical stimulation on metabolomic profiles of SW1353 chondrocytes: shear and compression by Welhaven, Hope D, McCutchen, Carley N, June, Ronald K

“…Mechanotransduction is a biological phenomenon where mechanical stimuli are converted to biochemical responses. A model system for studying mechanotransduction…”
Get full text

Combining Targeted Metabolomic Data with a Model of Glucose Metabolism: Toward Progress in Chondrocyte Mechanotransduction by Salinas, Daniel, Minor, Cody A, Carlson, Ross P, McCutchen, Carley N, Mumey, Brendan M, June, Ronald K

“…Osteoarthritis is a debilitating disease likely involving altered metabolism of the chondrocytes in articular cartilage. Chondrocytes can respond metabolically…”
Get full text

Metabolomic Profiles and Pathways in Osteoarthritic Human Cartilage: A Comparative Analysis with Healthy Cartilage by Welhaven, Hope D, Welfley, Avery H, Brahmachary, Priyanka, Bergstrom, Annika R, Houske, Eden, Glimm, Matthew, Bothner, Brian, Hahn, Alyssa K, June, Ronald K

“…Osteoarthritis (OA) is a chronic joint disease with heterogenous metabolic pathology. To gain insight into OA-related metabolism, metabolite extracts from…”
Get full text

Metabolomic Profiling and Mechanotransduction of Single Chondrocytes Encapsulated in Alginate Microgels by Fredrikson, Jacob P, Brahmachary, Priyanka P, Erdoğan, Ayten E, Archambault, Zachary K, Wilking, James N, June, Ronald K, Chang, Connie B

“…Articular cartilage is comprised of two main components, the extracellular matrix (ECM) and the pericellular matrix (PCM). The PCM helps to protect…”
Get full text

Synthesis of a pH-Sensitive Nitrilotriacetic Linker to Peptide Transduction Domains To Enable Intracellular Delivery of Histidine Imidazole Ring-Containing Macromolecules by June, Ronald K, Gogoi, Khirud, Eguchi, Akiko, Cui, Xian-Shu, Dowdy, Steven F

“…Intracellular delivery of functional macromolecules using peptide transduction domains (PTDs) is an exciting technology with both experimental and therapeutic…”
Get full text

The Cortical Bone Metabolome of C57BL/6J Mice Is Sexually Dimorphic by Welhaven, Hope D., Vahidi, Ghazal, Walk, Seth T., Bothner, Brian, Martin, Stephen A., Heveran, Chelsea M., June, Ronald K.

“…ABSTRACT Cortical bone quality, which is sexually dimorphic, depends on bone turnover and therefore on the activities of remodeling bone cells. However, sex…”
Get full text

Non-Invasive Quantification of Cartilage Using a Novel In Vivo Bioluminescent Reporter Mouse by Mailhiot, Sarah E, Zignego, Donald L, Prigge, Justin R, Wardwell, Ella R, Schmidt, Edward E, June, Ronald K

“…Mouse models are common tools for examining post-traumatic osteoarthritis (OA), which involves cartilage deterioration following injury or stress. One…”
Get full text

In vivo mechanotransduction: Effect of acute exercise on the metabolomic profiles of mouse synovial fluid by Hahn, Alyssa K., Rawle, Rachel A., Bothner, Brian, Prado Lopes, Erika Barboza, Griffin, Timothy M., June, Ronald K.

“…Exercise is known to induce beneficial effects in synovial joints. However, the mechanisms underlying these are unclear. Synovial joints experience repeated…”
Get full text

Temperature effects in articular cartilage biomechanics by June, Ronald K, Fyhrie, David P

“…Articular cartilage is the soft tissue that covers contacting surfaces of bones in synovial joints. Cartilage is composed of chondrocytes and an extracellular…”
Get full text

Heat conduction simulation of chondrocyte-embedded agarose gels suggests negligible impact of viscoelastic dissipation on temperature change by Myers, Erik, Piazza, Molly, Owkes, Mark, June, Ronald K.

“…Agarose is commonly used for 3D cell culture and to mimic the stiffness of the pericellular matrix of articular chondrocytes. Although it is known that both…”
Get full text

Hydrodynamic delivery of Cre protein to lineage-mark or time-stamp mouse hepatocytes in situ by Sonsteng, Katherine M, Prigge, Justin R, Talago, Emily A, June, Ronald K, Schmidt, Edward E

“…Cre-responsive fluorescent marker alleles are powerful tools for cell lineage tracing in mice; however their utility is limited by regulation of Cre activity…”
Get full text

Application of global metabolomic profiling of synovial fluid for osteoarthritis biomarkers by Carlson, Alyssa K., Rawle, Rachel A., Adams, Erik, Greenwood, Mark C., Bothner, Brian, June, Ronald K.

“…Osteoarthritis affects over 250 million individuals worldwide. Currently, there are no options for early diagnosis of osteoarthritis, demonstrating the need…”
Get full text

Osteoarthritis Year in Review 2024: Molecular biomarkers of osteoarthritis by Welhaven, Hope D., Welfley, Avery H., June, Ronald K.

“…To provide a comprehensive and insightful summary of studies on molecular biomarkers at the gene, protein, and metabolite levels across different sample types…”
Get full text

Unraveling sex-specific risks of knee osteoarthritis before menopause: Do sex differences start early in life? by Hernandez, Paula A., Bradford, John Churchill, Brahmachary, Priyanka, Ulman, Sophia, Robinson, Jennifer L., June, Ronald K., Cucchiarini, Magali

“…Sufficient evidence within the past two decades have shown that osteoarthritis (OA) has a sex-specific component. However, efforts to reveal the biological…”
Get full text

Metabolomic profiles of cartilage and bone reflect tissue type, radiography-confirmed osteoarthritis, and spatial location within the joint by Welhaven, Hope D., Viles, Ethan, Starke, Jenna, Wallace, Cameron, Bothner, Brian, June, Ronald K., Hahn, Alyssa K.

“…Osteoarthritis is the most common chronic joint disease, characterized by the abnormal remodeling of joint tissues including articular cartilage and…”
Get full text

Utilizing metabolomics to identify potential biomarkers and perturbed metabolic pathways in osteoarthritis: A systematic review by Van Pevenage, Peyton M., Birchmier, Jaedyn T., June, Ronald K.

“…Osteoarthritis (OA) is a joint disease that is clinically diagnosed using components of history, physical exam, and characteristic radiographic findings, such…”
Get full text