Search Results - "June, C. H."

Generation and Large‐Scale Expansion of Human Inducible Regulatory T Cells That Suppress Graft‐Versus‐Host Disease by Hippen, K. L., Merkel, S. C., Schirm, D. K., Nelson, C., Tennis, N. C., Riley, J. L., June, C. H., Miller, J. S., Wagner, J. E., Blazar, B. R.

“…Adoptive transfer of thymus‐derived natural regulatory T cells (nTregs) effectively suppresses disease in murine models of autoimmunity and graft‐versus‐host…”
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CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia by Kenderian, S S, Ruella, M, Shestova, O, Klichinsky, M, Aikawa, V, Morrissette, J J D, Scholler, J, Song, D, Porter, D L, Carroll, M, June, C H, Gill, S

“…Patients with chemo-refractory acute myeloid leukemia (AML) have a dismal prognosis. Chimeric antigen receptor T (CART) cell therapy has produced exciting…”
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T-cell reconstitution and expansion after hematopoietic stem cell transplantation: 'T' it up by PORTER, D. L, JUNE, C. H

“…Adoptive immunotherapy is the isolation and infusion of antigen-specific or nonspecific lymphocytes. Adoptive therapy with T cells may have a role in…”
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Kinase inhibitor ibrutinib to prevent cytokine-release syndrome after anti-CD19 chimeric antigen receptor T cells for B-cell neoplasms by Ruella, M, Kenderian, S S, Shestova, O, Klichinsky, M, Melenhorst, J J, Wasik, M A, Lacey, S F, June, C H, Gill, S

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Human Naive and Memory T Lymphocytes Differ in Telomeric Length and Replicative Potential by Weng, Nan-Ping, Levine, Bruce L., June, Carl H., Hodes, Richard J.

“…The present study has assessed the replicative history and the residual replicative potential of human naive and memory T cells. Telomeres are unique terminal…”
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Suppression of HIV-1 infection in primary CD4 T cells transduced with a self-inactivating lentiviral vector encoding a membrane expressed gp41-derived fusion inhibitor by Perez, E.E., Riley, J.L., Carroll, R.G., von Laer, D., June, C.H.

“…Peptidomimetics of HIV-1 gp41 sequences required for membrane fusion are potent inhibitors of HIV-1 entry. We hypothesize that expression of a membrane-bound…”
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CD28 Activation Pathway Regulates the Production of Multiple T-Cell-Derived Lymphokines/Cytokines by Thompson, Craig B., Lindsten, Tullia, Ledbetter, Jeffrey A., Kunkel, Steven L., Young, Howard A., Emerson, Stephen G., Leiden, Jeffrey M., June, Carl H.

“…CD28 is a 44-kDa glycoprotein expressed as a homodimer on the surface of a major subset of human T cells. Previous studies have demonstrated that the binding…”
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ICOS Costimulation Requires IL-2 and Can Be Prevented by CTLA-4 Engagement by Riley, James L, Blair, Patrick J, Musser, John T, Abe, Ryo, Tezuka, Katsunari, Tsuji, Takashi, June, Carl H

“…We investigated the relationship between ICOS, CD28, CTLA-4, and IL-2 to gain a better understanding of this family of costimulatory receptors in the immune…”
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Inhibition of Tyrosine Phosphorylation Prevents T-Cell Receptor-Mediated Signal Transduction by June, Carl H., Fletcher, Mary C., Ledbetter, Jeffrey A., Schieven, Gary L., Siegel, Jeffrey N., Phillips, Andrew F., Samelson, Lawrence E.

“…The binding of antigen to the multicomponent T-cell receptor (TCR) activates several signal transduction pathways via coupling mechanisms that are poorly…”
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Molecular remission of CML after autotransplantation followed by adoptive transfer of costimulated autologous T cells by RAPOPORT, A. P, LEVINE, B. L, MANN, D, JUNE, C. H, BADROS, A, MEISENBERG, B, RUEHLE, K, NANDI, A, ROLLINS, S, NATT, S, RATTERREE, B, WESTPHAL, S

“…Four patients with chronic myelogenous leukemia (CML) that was refractory to interferon alpha (two patients) or imatinib mesylate (two patients), and who…”
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Lipopolysaccharide-induced protein tyrosine phosphorylation in human macrophages is mediated by CD14 by Weinstein, SL, June, CH, DeFranco, AL

“…Induced protein tyrosine phosphorylation is an early intracellular event in LPS-stimulated murine macrophages that appears to play a role in signal…”
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Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway by Lindsten, Tullia, June, Carl H., Ledbetter, Jeffrey A., Stella, Gregory, Thompson, Craig B.

“…Quiescent T cells can be induced to express many genes by mitogen or antigen stimulation. The messenger RNAs of some of these genes undergo relatively rapid…”
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Improved anti-leukemia activities of adoptively transferred T cells expressing bispecific T-cell engager in mice by Liu, X, Barrett, D M, Jiang, S, Fang, C, Kalos, M, Grupp, S A, June, C H, Zhao, Y

“…Despite the impressive clinical efficacy of T cells engineered to express chimeric antigen receptors (CAR-Ts), the current applications of CAR-T cell therapy…”
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CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis by Perrin, PJ, Maldonado, JH, Davis, TA, June, CH, Racke, MK

“…The B7 family of cell surface molecules expressed on APC provides accessory signals to T cells via either CD28 or CTLA-4. However, while CD28 transduces a…”
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T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression by JUNE, C. H, LEDBETTER, J. A, GILLESPIE, M. M, LINDSTEN, T, THOMPSON, C. B

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An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA by BOHJANEN, P. R, PETRYNIAK, B, JUNE, C. H, THOMPSON, C. B, LINDSTEN, T

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Monosomy 1p36 uncovers a role for OX40 in survival of activated CD4+ T cells by Suhoski, M.M, Perez, E.E, Heltzer, M.L, Laney, A, Shaffer, L.G, Saitta, S, Nachman, S, Spinner, N.B, June, C.H, Orange, J.S

“…Abstract Monosomy 1p36 is a subtelomeric deletion syndrome associated with congenital anomalies presumably due to haploinsufficiency of multiple genes…”
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In Vitro Induction of Human Regulatory T Cells Using Conditions of Low Tryptophan Plus Kynurenines by Hippen, K. L., O'Connor, R. S., Lemire, A. M., Saha, A., Hanse, E. A., Tennis, N. C., Merkel, S. C., Kelekar, A., Riley, J. L., Levine, B. L., June, C. H., Turka, L. A., Kean, L. S., MacMillan, M. L., Miller, J. S., Wagner, J. E., Munn, D. H., Blazar, B. R.

“…Thymic regulatory T cells (tTregs) and induced regulatory T cells (iTregs) suppress murine acute graft‐versus‐host disease (GVHD). Previously, we demonstrated…”
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Isolation of a New Herpesvirus from Human CD4+T Cells by Frenkel, Niza, Schirmer, Eric C., Wyatt, Linda S., Katsafanas, George, Roffman, Ehud, Danovich, Robert M., June, Carl H.

“…A new human herpesvirus has been isolated from CD4+T cells purified from peripheral blood mononuclear cells of a healthy individual (RK), following incubation…”
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The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB by BOISE, L. H, PETRYNIAK, B, XIAOHONG MAO, JUNE, C. H, CHUNG-YIH WANG, LINDSTEN, T, BRAVO, R, KOVARY, K, LEIDEN, J. M, THOMPSON, C. B

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