Search Results - "Juncadella, Ignacio J."

Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo by Lee, Chang Sup, Penberthy, Kristen K., Wheeler, Karen M., Juncadella, Ignacio J., Vandenabeele, Peter, Lysiak, Jeffrey J., Ravichandran, Kodi S.

“…Few apoptotic corpses are seen even in tissues with high cellular turnover, leading to the notion that the capacity for engulfment in vivo is vast. Whether…”
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Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation by Han, Claudia Z., Juncadella, Ignacio J., Kinchen, Jason M., Buckley, Monica W., Klibanov, Alexander L., Dryden, Kelly, Onengut-Gumuscu, Suna, Erdbrügger, Uta, Turner, Stephen D., Shim, Yun M., Tung, Kenneth S., Ravichandran, Kodi S.

“…Macrophage-derived insulin-like growth factor enhances the uptake of microvesicles by non-professional phagocytes, such as airway epithelial cells and…”
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Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation by Juncadella, Ignacio J., Kadl, Alexandra, Sharma, Ashish K., Shim, Yun M., Hochreiter-Hufford, Amelia, Borish, Larry, Ravichandran, Kodi S.

“…Airway epithelial cells are important in immune homeostasis in that they dampen immune activation by clearing dying cells and producing anti-inflammatory…”
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Unexpected link between an antibiotic, pannexin channels and apoptosis by Poon, Ivan K. H., Chiu, Yu-Hsin, Armstrong, Allison J., Kinchen, Jason M., Juncadella, Ignacio J., Bayliss, Douglas A., Ravichandran, Kodi S.

“…Plasma membrane pannexin 1 channels (PANX1) release nucleotide find-me signals from apoptotic cells to attract phagocytes. Here we show that the quinolone…”
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RNAi Screen and Proteomics Reveal NXF1 as a Novel Regulator of IRF5 Signaling by Fu, Bishi, Zhao, Mengmeng, Wang, Lingyan, Patil, Girish, Smith, Jennifer A., Juncadella, Ignacio J., Zuvela-Jelaska, Ljiljana, Dorf, Martin E., Li, Shitao

“…Interferon regulatory factor 5 (IRF5) is a key transcription factor of innate immunity, which plays an important role in host restriction to viral infection…”
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Cutting Edge: CD4 Is the Receptor for the Tick Saliva Immunosuppressor, Salp15 by Garg, Renu, Juncadella, Ignacio J, Ramamoorthi, Nandhini, Ashish, Ananthanarayanan, Shobana K, Thomas, Venetta, Rincon, Mercedes, Krueger, Joanna K, Fikrig, Erol, Yengo, Christopher M, Anguita, Juan

“…Salp15 is an Ixodes scapularis salivary protein that inhibits CD4+ T cell activation through the repression of TCR ligation-triggered calcium fluxes and IL-2…”
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Conformational Rearrangement within the Soluble Domains of the CD4 Receptor Is Ligand-specific by Ashish, Juncadella, Ignacio J., Garg, Renu, Boone, Christopher D., Anguita, Juan, Krueger, Joanna K.

“…Ligand binding induces shape changes within the four modular ectodomains (D1–D4) of the CD4 receptor, an important receptor in immune signaling. Small angle…”
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Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo by Lysiak, Jeffrey J, Ravichandran, Kodi S, Elliott, Michael R, Zheng, Shuqiu, Park, Daeho, Woodson, Robin I, Reardon, Michael A, Juncadella, Ignacio J, Kinchen, Jason M, Zhang, Jun

“…Apoptosis and the subsequent clearance of dying cells occurs throughout development and adult life in many tissues. Failure to promptly clear apoptotic cells…”
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Apoptosis and engulfment by bronchial epithelial cells. Implications for allergic airway inflammation by Penberthy, Kristen K, Juncadella, Ignacio J, Ravichandran, Kodi S

“…Insult or injury to the lung epithelial cells from pathogens, pollutants, and allergens can initiate the process of apoptotic cell death. Although "Creola…”
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The Ixodes scapularis salivary protein, salp15, prevents the association of HIV-1 gp120 and CD4 by Juncadella, Ignacio J., Garg, Renu, Bates, Tonya C., Olivera, Elias R., Anguita, Juan

“…Ixodes scapularis salivary protein, Salp15, inhibits CD4 + T cell activation by binding to the most-extracellular domains of the CD4 molecule, potentially…”
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Brain angiogenesis inhibitor 1 is expressed by gastric phagocytes during infection with Helicobacter pylori and mediates the recognition and engulfment of human apoptotic gastric epithelial cells by Das, Soumita, Sarkar, Arup, Ryan, Kieran A., Fox, Sarah, Berger, Alice H., Juncadella, Ignacio J., Bimczok, Diane, Smythies, Lesley E., Harris, Paul R., Ravichandran, Kodi S., Crowe, Sheila E., Smith, Phillip D., Ernst, Peter B.

“…ABSTRACT After Helicobacter pylori infection in humans, gastric epithelial cells (GECs) undergo apoptosis due to stimulation by the bacteria or inflammatory…”
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ShcA regulates late stages of T cell development and peripheral CD4+ T cell numbers by Buckley, Monica W, Trampont, Paul C, Arandjelovic, Sanja, Fond, Aaron M, Juncadella, Ignacio J, Ravichandran, Kodi S

“…T cell development in the thymus is a highly regulated process that critically depends upon productive signaling via the preTCR at the β-selection stage, as…”
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Delivery of the Immunosuppressive Antigen Salp15 to Antigen-Presenting Cells by Salmonella enterica Serovar Typhimurium aroA Mutants by Motameni, Amir-Reza T, Juncadella, Ignacio J, Ananthanarayanan, Shobana K, Hedrick, Michael N, Huet-Hudson, Yvette, Anguita, Juan

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The tick saliva immunosuppressor, Salp15, contributes to Th17-induced pathology during Experimental Autoimmune Encephalomyelitis by Juncadella, Ignacio J., Bates, Tonya C., Suleiman, Reem, Monteagudo-Mera, Andrea, Olson, Chris M., Navasa, Nicolás, Olivera, Elias R., Osborne, Barbara A., Anguita, Juan

“…► Treatment with the immunosuppressive protein, Salp15, during induction of murine EAE exacerbates pathology. ► Salp15 does not prevent the activation of…”
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The immunosuppresive tick salivary protein, Salp15 by Juncadella, Ignacio J, Anguita, Juan

“…The interaction between Ixodid ticks and their mammalian hosts is a complex relationship. While the mammalian host tries to avoid the completion of the feeding…”
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T-cell signaling pathways inhibited by the tick saliva immunosuppressor, Salp15 by Juncadella, Ignacio J, Garg, Renu, Ananthnarayanan, Shobana K, Yengo, Christopher M, Anguita, Juan

“…The Ixodes scapularis salivary protein Salp15 inhibits the activation of T cells through its interaction with the coreceptor CD4. Salp15 prevents the…”
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Distinct bacterial dissemination and disease outcome in mice subcutaneously infected with Borrelia burgdorferi in the midline of the back and the footpad by Motameni, Amir-Reza T., Bates, Tonya C., Juncadella, Ignacio J., Petty, Cynthia, Hedrick, Michael N., Anguita, Juan

“…Subcutaneous inoculation of mice with Borrelia burgdorferi, the causative agent of Lyme disease, results in established infection and the development of acute…”
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An essential role for calcium flux in phagocytes for apoptotic cell engulfment and the anti-inflammatory response by Gronski, M A, Kinchen, J M, Juncadella, I J, Franc, N C, Ravichandran, K S

“…Cells undergo programmed cell death/apoptosis throughout the lifespan of an organism. The subsequent immunologically silent removal of apoptotic cells plays a…”
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Unexpected requirement for ELMO1 in apoptotic germ cell clearance in vivo by Elliott, Michael R., Zheng, Shuqiu, Park, Daeho, Woodson, Robin I., Reardon, Michael A., Juncadella, Ignacio J., Kinchen, Jason M., Zhang, Jun, Lysiak, Jeffrey J., Ravichandran, Kodi S.

“…Apoptosis and the subsequent clearance of these dying cells occur throughout development and adult life in many tissues. Failure to promptly clear apoptotic…”
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Cutting Edge: CD4 Is the Receptor for the Tick Saliva Immunosuppressor, Salp151 by Garg, Renu, Juncadella, Ignacio J., Ramamoorthi, Nandhini, Ashish, Ananthanarayanan, Shobana K., Thomas, Venetta, Rincón, Mercedes, Krueger, Joanna K., Fikrig, Erol, Yengo, Christopher M., Anguita, Juan

“…Salp15 is an Ixodes scapularis salivary protein that inhibits CD4 + T cell activation through the repression of TCR ligation-triggered calcium fluxes and IL-2…”
Get full text