Search Results - "Jun Ninomiya"

Neoadjuvant Endocrine Therapy for Operable Breast Cancer: A Retrospective Analysis of Real-World Use by Iwamoto, Miki, Takei, Hiroyuki, Ninomiya, Jun, Asakawa, Hideki, Kurita, Tomoko, Yanagihara, Keiko, Iida, Shinya, Sakatani, Takashi, Ohashi, Ryuji

“…Background: A retrospective study of the real-world use of neoadjuvant endocrine therapy (NET) is important for standardizing the role of NET in breast cancer…”
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Optimal Treatment Duration of Neoadjuvant Endocrine Therapy for Women Aged 60 Years or Older with Estrogen Receptor-Positive, HER2-Negative Invasive Breast Cancer by Hayashi, Yuji, Takei, Hiroyuki, Saito, Tsuyoshi, Kai, Toshihiro, Inoue, Kenichi, Kurosumi, Masafumi, Ninomiya, Jun, on behalf of Saitama Breast Cancer Clinical Study Group (SBCCSG)

“…Background: Neoadjuvant endocrine therapy is not the standard of care for breast cancer, primarily because the optimal treatment duration remains unclear. This…”
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Induction therapy with paclitaxel and bevacizumab followed by switch maintenance therapy with eribulin in Japanese patients with HER2-negative metastatic breast cancer: a multicenter, collaborative, open-label, phase II clinical study for the SBCCSG 35 investigators by Inoue, Kenichi, Ninomiya, Jun, Saito, Tsuyoshi, Kimizuka, Kei, Kurosumi, Masafumi

“…To examine the efficacy and safety of induction therapy with paclitaxel and bevacizumab followed by switch maintenance therapy with eribulin (ISMT) in Japanese…”
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Compound mutations in Bmpr1a and Tak1 synergize facial deformities via increased cell death by Liu, Xia, Hayano, Satoru, Pan, Haichun, Inagaki, Maiko, Ninomiya‐Tsuji, Jun, Sun, Hongchen, Mishina, Yuji

“…Summary BMP signaling plays a critical role in craniofacial development. Augmentation of BMPR1A signaling through neural crest‐specific expression of…”
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Coordinating Tissue Regeneration Through Transforming Growth Factor‐β Activated Kinase 1 Inactivation and Reactivation by Hsieh, Hsiao Hsin Sung, Agarwal, Shailesh, Cholok, David J., Loder, Shawn J., Kaneko, Kieko, Huber, Amanda, Chung, Michael T., Ranganathan, Kavitha, Habbouche, Joe, Li, John, Butts, Jonathan, Reimer, Jonathan, Kaura, Arminder, Drake, James, Breuler, Christopher, Priest, Caitlin R., Nguyen, Joe, Brownley, Cameron, Peterson, Jonathan, Ozgurel, Serra Ucer, Niknafs, Yashar S., Li, Shuli, Inagaki, Maiko, Scott, Greg, Krebsbach, Paul H., Longaker, Michael T., Westover, Kenneth, Gray, Nathanael, Ninomiya‐Tsuji, Jun, Mishina, Yuji, Levi, Benjamin

“…Aberrant wound healing presents as inappropriate or insufficient tissue formation. Using a model of musculoskeletal injury, we demonstrate that loss of…”
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TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1 by Hashimoto, Kazunori, Simmons, Alicia N, Kajino-Sakamoto, Rie, Tsuji, Yoshiaki, Ninomiya-Tsuji, Jun

“…Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is the master transcriptional regulator of antioxidant gene expression. On increased oxidative…”
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TAK1 regulates resident macrophages by protecting lysosomal integrity by Sakamachi, Yosuke, Morioka, Sho, Mihaly, September R, Takaesu, Giichi, Foley, Julie F, Fessler, Michael B, Ninomiya-Tsuji, Jun

“…Hematopoietic cell survival and death is critical for development of a functional immune system. Here, we report that a protein kinase, TAK1, is selectively…”
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TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation by Morioka, Sho, Broglie, Peter, Omori, Emily, Ikeda, Yuka, Takaesu, Giichi, Matsumoto, Kunihiro, Ninomiya-Tsuji, Jun

“…TNF activates three distinct intracellular signaling cascades leading to cell survival, caspase-8-mediated apoptosis, or receptor interacting protein kinase 3…”
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Essential function for the kinase TAK1 in innate and adaptive immune responses by Akira, Shizuo, Sato, Shintaro, Sanjo, Hideki, Takeda, Kiyoshi, Ninomiya-Tsuji, Jun, Yamamoto, Masahiro, Kawai, Taro, Matsumoto, Kunihiro, Takeuchi, Osamu

“…Transforming growth factor-beta-activated kinase 1 (TAK1) has been linked to interleukin 1 receptor and tumor necrosis factor receptor signaling. Here we…”
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Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation by Takeda, Kohsuke, Matsuzawa, Atsushi, Nishitoh, Hideki, Tobiume, Kei, Kishida, Satoshi, Ninomiya-Tsuji, Jun, Matsumoto, Kunihiro, Ichijo, Hidenori

“…The mammalian mitogen‐activated protein (MAP) kinase kinase kinase apoptosis signal‐regulating kinase 1 (ASK1) is a pivotal component in cytokine‐ and…”
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Preparation of ruthenium-containing sheet composites using a papermaking technique for selective oxidation of alcohol by Fukahori, Shuji, Morikawa, Masaaki, Ninomiya, Jun-ichirou

“…Ruthenium (Ru) catalyst was introduced onto a glass fiber surface by ion-exchange, the treated fibers were made into Ru-containing sheet composites (referred…”
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Changing clinical and molecular characteristics of hepatitis E virus infection in Mie Prefecture, Japan: Disappearance of indigenous subtype 3e strains by Nakano, Tatsunori, Okano, Hiroshi, Takahashi, Masaharu, Nagashima, Shigeo, Shiraki, Katsuya, Oya, Yumi, Inoue, Hidekazu, Ohmori, Shigeru, Tsukimoto, Mone, Ishida, Satoshi, Fujimoto, Shino, Kobayashi, Makoto, Yamawaki, Makoto, Kumagai, Masanari, Ninomiya, Jun, Maegawa, Tadashi, Kojima, Yuji, Araki, Jun, Hamaoka, Shima, Horiike, Shinichiro, Yoshimura, Hitoshi, Takeuchi, Keisuke, Itoh, Keiichi, Akachi, Shigehiro, Uraki, Satoko, Yamamoto, Norihiko, Ogura, Suguru, Sugimoto, Kazushi, Yoshikawa, Kyoko, Hasegawa, Hiroshi, Iwasa, Motoh, Takei, Yoshiyuki, Okamoto, Hiroaki

“…Aim To evaluate the clinical and molecular characteristics of hepatitis E virus (HEV) infection in Mie Prefecture, Japan, from 2004 through 2018. Methods The…”
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TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells by Sato, Shintaro, Sanjo, Hideki, Tsujimura, Tohru, Ninomiya-Tsuji, Jun, Yamamoto, Masahiro, Kawai, Taro, Takeuchi, Osamu, Akira, Shizuo

“…Transforming growth factor (TGF)-β-activating kinase 1 (TAK1) is critical for Toll-like receptor- and tumor necrosis factor-mediated cellular responses. In B…”
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TAK1 Regulates Reactive Oxygen Species and Cell Death in Keratinocytes, Which Is Essential for Skin Integrity by Omori, Emily, Morioka, Sho, Matsumoto, Kunihiro, Ninomiya-Tsuji, Jun

“…Mice with a keratinocyte-specific deletion of Tak1 exhibit severe skin inflammation due to hypersensitivity to tumor necrosis factor (TNF) killing. Here we…”
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TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration by Morioka, Sho, Inagaki, Maiko, Komatsu, Yoshihiro, Mishina, Yuji, Matsumoto, Kunihiro, Ninomiya-Tsuji, Jun

“…TGF-β activated kinase 1 (TAK1) is a mediator of various cytokine signaling pathways. Germline deficiency of Tak1 causes multiple abnormalities, including…”
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Enterocyte-Derived TAK1 Signaling Prevents Epithelium Apoptosis and the Development of Ileitis and Colitis by Kajino-Sakamoto, Rie, Inagaki, Maiko, Lippert, Elisabeth, Akira, Shizuo, Robine, Sylvie, Matsumoto, Kunihiro, Jobin, Christian, Ninomiya-Tsuji, Jun

“…Recent studies have revealed that TAK1 kinase is an essential intermediate in several innate immune signaling pathways. In this study, we investigated the role…”
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Activated macrophage survival is coordinated by TAK1 binding proteins by Mihaly, September R, Morioka, Sho, Ninomiya-Tsuji, Jun, Takaesu, Giichi

“…Macrophages play diverse roles in tissue homeostasis and immunity, and canonically activated macrophages are critically associated with acute inflammatory…”
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Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development by Lane, Jamie, Yumoto, Kenji, Azhar, Mohamad, Ninomiya-Tsuji, Jun, Inagaki, Maiko, Hu, Yingling, Deng, Chu-Xia, Kim, Jieun, Mishina, Yuji, Kaartinen, Vesa

“…Transforming growth factor-beta3 (TGF-β3) plays a critical role in palatal epithelial cells by inducing palatal epithelial fusion, failure of which results in…”
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A Real-World Retrospective Cohort Study of Combined Therapy with Bevacizumab and Paclitaxel in Japanese Patients with Metastatic Breast Cancer by Yamada, Hirofumi, Inoue, Kenichi, Nagai, Shigenori E., Nakai, Maki, Arisawa, Fumio, Ueda, Hiroyuki, Saito, Tsuyoshi, Ninomiya, Jun, Kuroda, Toru, Sakurai, Takashi, Kodama, Hitomi, Kimizuka, Kei, Hata, Satoshi, Kai, Toshihiro, Kurosumi, Masafumi, investigators, for the SBCCSG

“…Objective: Combined therapy with bevacizumab and paclitaxel (BP regimen) as a first-line treatment has proven highly effective with good tolerance for patients…”
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Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species by Omori, Emily, Inagaki, Maiko, Mishina, Yuji, Matsumoto, Kunihiro, Ninomiya-Tsuji, Jun

“…Dysregulation in cellular redox systems results in accumulation of reactive oxygen species (ROS), which are causally associated with a number of disease…”
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