Search Results - "Jun, Sujung"

The impact of lipids, lipid oxidation, and inflammation on AMD, and the potential role of miRNAs on lipid metabolism in the RPE by Jun, Sujung, Datta, Sayantan, Wang, Lei, Pegany, Roma, Cano, Marisol, Handa, James T.

“…The accumulation of lipids within drusen, the epidemiologic link of a high fat diet, and the identification of polymorphisms in genes involved in lipid…”
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Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis by Brichacek, Allison L., Benkovic, Stanley A., Chakraborty, Sreeparna, Nwafor, Divine C., Wang, Wei, Jun, Sujung, Dakhlallah, Duaa, Geldenhuys, Werner J., Pinkerton, Anthony B., Millán, José Luis, Brown, Candice M.

“…Tissue-nonspecific alkaline phosphatase (TNAP) is a ubiquitous enzyme present in many cells and tissues, including the central nervous system. Yet its…”
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Hypoxia-reoxygenation of primary astrocytes results in a redistribution of mitochondrial size and mitophagy by Quintana, Dominic D, Garcia, Jorge A, Sarkar, Saumyendra N, Jun, Sujung, Engler-Chiurazzi, Elizabeth B, Russell, Ashley E, Cavendish, John Z, Simpkins, James W

“…Astrocytes serve to maintain proper neuronal function and support neuronal viability, but remain largely understudied in research of cerebral ischemia…”
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Stem cell-derived three-dimensional (organoid) models of Alzheimer's disease: a precision medicine approach by Kim, Sujung Jun, Li, Jiaxin, Mahairaki, Vasiliki

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Characterization of the Pro-Inflammatory and Pruritogenic Transcriptome in Skin Lesions of the Experimental Canine Atopic Acute IgE-Mediated Late Phase Reactions Model and Correlation to Acute Skin Lesions of Human Atopic Dermatitis by Blubaugh, Amanda, Hoover, Kathleen, Kim, Sujung Jun, Fogle, Jonathan E, Sow, Fatoumata B, Banovic, Frane

“…Intradermal injection of anti-immunoglobulin E (IgE) antibodies in dogs grossly and histologically resemble naturally occurring atopic dermatitis (AD)…”
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Establishment of an Intradermal Canine IL-31-Induced Pruritus Model to Evaluate Therapeutic Candidates in Atopic Dermatitis by Pearson, Jason, Leon, Renato, Starr, Haley, Kim, Sujung Jun, Fogle, Jonathan E, Banovic, Frane

“…Pruritic models in healthy dogs utilizing intravenous administration of interleukin 31 (IL-31) bypass the "natural" itch sensation in AD, which is initiated by…”
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Extracellular Vesicles Secreted in Response to Cytokine Exposure Increase Mitochondrial Oxygen Consumption in Recipient Cells by Russell, Ashley E, Jun, Sujung, Sarkar, Saumyendra, Geldenhuys, Werner J, Lewis, Sara E, Rellick, Stephanie L, Simpkins, James W

“…Extracellular vesicles (EVs) are small, membrane-bound nanoparticles released from most, if not all cells, and can carry functionally active cargo (proteins,…”
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Extracellular superoxide dismutase inhibits innate immune responses and clearance of an intracellular bacterial infection by Break, Timothy J, Jun, Sujung, Indramohan, Mohanalaxmi, Carr, Karen D, Sieve, Amy N, Dory, Ladislav, Berg, Rance E

“…Reactive oxygen species and reactive nitrogen species play important roles during immune responses to bacterial pathogens. Extracellular superoxide dismutase…”
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Estrogen amelioration of Aβ-induced defects in mitochondria is mediated by mitochondrial signaling pathway involving ERβ, AKAP and Drp1 by Sarkar, Saumyendra, Jun, Sujung, Simpkins, James W

“…Abstract Perturbations in dynamic properties of mitochondria including fission, fusion, and movement lead to disruption of energy supply to synapses…”
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Biomarkers and Precision Medicine in Alzheimer's Disease by Sagar, Ram, Pathak, Pujita, Pandur, Balint, Kim, Sujung Jun, Li, Jiaxin, Mahairaki, Vasiliki

“…Alzheimer's disease (AD) is the most common form of dementia in the elderly, which is the fifth major cause of mortality for people over 65 years. While some…”
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Characterisation of the pruritus responses and pruritic behaviours in an interleukin 31‐induced canine model of pruritus by Pearson, Jason, Denley, Tara, Blubaugh, Amanda, Kim, Sujung Jun, Fogle, Jonathan E., Leon, Renato, Goss, Caleb, Banovic, Frane

“…Background Intravenous administration of interleukin (IL)‐31 in healthy dogs has been used as a model to assess antipruritic drugs. However, there is no known…”
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miR-146a Dysregulates Energy Metabolism During Neuroinflammation by Kim, Sujung Jun, Russell, Ashley E., Wang, Wei, Gemoets, Darren E., Sarkar, Saumyendra N., Simpkins, James W., Brown, Candice M.

“…Alzheimer’s disease (AD) and other neurodegenerative diseases are characterized by chronic neuroinflammation and a reduction in brain energy metabolism. An…”
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Allele-Specific Effects of ecSOD in Bacterial Infection by Jun, Sujung, Kim, Byung-Jin, Break, Timothy J, Berg, Rance E, Jones, Harlan P, Dory, Ladislav

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311 - Allele-Specific Effects of ecSOD in Bacterial Infection by Jun, Sujung, Kim, Byung-Jin, Break, Timothy J, Berg, Rance E, Jones, Harlan P, Dory, Ladislav

“…Extracellular superoxide dismutase (ecSOD) is the only enzyme that scavenges superoxide specifically in the extracellular compartment. Recent studies indicate…”
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Disruption of metabolic, sleep, and sensorimotor functional outcomes in a female transgenic mouse model of Alzheimer’s disease by Nwafor, Divine C., Chakraborty, Sreeparna, Jun, Sujung, Brichacek, Allison L., Dransfeld, Margaret, Gemoets, Darren E., Dakhlallah, Duaa, Brown, Candice M.

“…[Display omitted] •CVN-AD mice exhibit impaired metabolic activity.•Sleep-wake homeostasis is disrupted in CVN-AD mice.•CVN-AD mice exhibit sensorimotor…”
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Loss of tissue-nonspecific alkaline phosphatase (TNAP) enzyme activity in cerebral microvessels is coupled to persistent neuroinflammation and behavioral deficits in late sepsis by Nwafor, Divine C., Chakraborty, Sreeparna, Brichacek, Allison L., Jun, Sujung, Gambill, Catheryne A., Wang, Wei, Engler-Chiurazzi, Elizabeth B., Dakhlallah, Duaa, Pinkerton, Anthony B., Millán, José Luis, Benkovic, Stanley A., Brown, Candice M.

“…•Alkaline phosphatase activity in brain microvessels is diminished in sepsis.•Loss of alkaline phosphatase activity is coupled to the loss of barrier…”
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Extracellular superoxide dismutase polymorphism in mice: Allele-specific effects on phenotype by Jun, Sujung, Pierce, Anson, Dory, Ladislav

“…Extracellular superoxide dismutase (ecSOD) protects the extracellular matrix from oxidative stress. We previously reported a new allele for ecSOD, expressed in…”
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Abstract TP254: Effects of Inducible Nitric Oxide Synthase on Behavior and Functional Outcomes in a Novel “Humanized” Transgenic Mouse Model of Ischemic Stroke by Brichacek, Allison L, Jun, Sujung, Povroznik, Jessica M, Nwafor, Divine C, Benkovic, Stanley A, Wang, Wei, Quintana, Dominic D, Hu, Heng, Ren, Xuefang, Engler-Chiurazzi, Elizabeth B, Brown, Candice M

“…Abstract only Introduction: Inducible nitric oxide synthase (iNOS) is a critical regulator of brain and systemic inflammatory responses in many neurological…”
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Extracellular superoxide dismutase impairs neutrophil function and clearance of Listeria monocytogenes (118.4) by Break, Timothy, Jun, Sujung, Indramohan, Mohanalaxmi, Dory, Ladislav, Berg, Rance

“…Abstract It is well established that reactive oxygen species (ROS) play a critical role during immune responses against pathogens. Extracellular superoxide…”
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Exosomes and neuroinflammatory microRNAs: cytokine-specific profiles by Russell, Ashley, Jun, Sujung, Lewis, Sara, Rellick, Stephanie, Simpkins, James

“…Background: Evidence suggests that exosomes participate in the spread of pathology by transferring misfolded proteins and aberrant microRNAs (miR) from…”
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