Search Results - "Jumde, Varsha R."

Pathoblockers or antivirulence drugs as a new option for the treatment of bacterial infections by Calvert, Matthew B, Jumde, Varsha R, Titz, Alexander

“…The rapid development of antimicrobial resistance is threatening mankind to such an extent that the World Health Organization expects more deaths from…”
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A Ruthenium-Based Catalytic System for a Mild Borrowing-Hydrogen Process by Jumde, Varsha R., Gonsalvi, Luca, Guerriero, Antonella, Peruzzini, Maurizio, Taddei, Maurizio

“…The alkylation of arylamines using stoichiometric amounts of aliphatic and benzylic alcohols in the presence of tBuOK was carried out at 55 °C using a low…”
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Domino Hydrogenation–Reductive Amination of Phenols, a Simple Process To Access Substituted Cyclohexylamines by Jumde, Varsha R, Petricci, Elena, Petrucci, Chiara, Santillo, Niccolò, Taddei, Maurizio, Vaccaro, Luigi

“…Phenols can be efficiently reduced by sodium formate and Pd/C as the catalyst in water and in the presence of amines to give the corresponding…”
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A Metal-Catalyzed Tandem 1,4-Benzodiazepine Synthesis Based on Two Hydrogen-Transfer Reactions by Jumde, Varsha R., Cini, Elena, Porcheddu, Andrea, Taddei, Maurizio

“…Starting from 2‐aminobenzyl alcohols and 1,2‐amino alcohols, 2,3,4,5‐tetrahydro‐1H‐1,4‐benzodiazepines (TH‐BDZ) can be prepared through a one‐pot…”
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Deoxycholic Acid-Derived Biaryl Phosphites as Versatile and Enantioselective Ligands in the Rhodium-Catalyzed Conjugate Addition of Arylboronic Acids to Nitroalkenes by Jumde, Varsha R., Iuliano, Anna

“…A highly enantioselective conjugate addition of arylboronic acids to cyclic as well as acyclic aromatic and aliphatic nitroalkenes is presented. The rhodium…”
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C3 Epimerization of Glucose, via Regioselective Oxidation and Reduction by Jumde, Varsha R, Eisink, Niek N. H. M, Witte, Martin D, Minnaard, Adriaan J

“…Palladium-catalyzed oxidation can single out the secondary hydroxyl group at C3 in glucose, circumventing the more readily accessible hydroxyl at C6 and the…”
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Steering Self-Assembly of Amphiphilic Molecular Nanostructures via Halogen Exchange by Kriete, Björn, Bondarenko, Anna S, Jumde, Varsha R, Franken, Linda E, Minnaard, Adriaan J, Jansen, Thomas L. C, Knoester, Jasper, Pshenichnikov, Maxim S

“…In the field of self-assembly, the quest for gaining control over the supramolecular architecture without affecting the functionality of the individual…”
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Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach by Konstantinidou, Markella, Magari, Francesca, Sutanto, Fandi, Haupenthal, Jörg, Jumde, Varsha R., Ünver, M. Yagiz, Heine, Andreas, Camacho, Carlos Jamie, Hirsch, Anna K. H., Klebe, Gerhard, Dömling, Alexander

“…Pharmacophore searches that include anchors, fragments contributing above average to receptor binding, combined with one‐step syntheses are a powerful approach…”
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Converting Escherichia coli into an archaebacterium with a hybrid heterochiral membrane by Caforio, Antonella, Siliakus, Melvin F., Exterkate, Marten, Jain, Samta, Jumde, Varsha R., Andringa, Ruben L. H., Kengen, Servé W. M., Minnaard, Adriaan J., Driessen, Arnold J. M., van der Oost, John

“…One of the main differences between bacteria and archaea concerns their membrane composition. Whereas bacterial membranes are made up of glycerol-3-phosphate…”
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Protein‐Templated Hit Identification through an Ugi Four‐Component Reaction by Mancini, Federica, Unver, M. Yagiz, Elgaher, Walid A. M., Jumde, Varsha R., Alhayek, Alaa, Lukat, Peer, Herrmann, Jennifer, Witte, Martin D., Köck, Matthias, Blankenfeldt, Wulf, Müller, Rolf, Hirsch, Anna K. H.

“…Kinetic target‐guided synthesis represents an efficient hit‐identification strategy, in which the protein assembles its own inhibitors from a pool of…”
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Frontispiece: Protein‐Templated Hit Identification through an Ugi Four‐Component Reaction by Mancini, Federica, Unver, M. Yagiz, Elgaher, Walid A. M., Jumde, Varsha R., Alhayek, Alaa, Lukat, Peer, Herrmann, Jennifer, Witte, Martin D., Köck, Matthias, Blankenfeldt, Wulf, Müller, Rolf, Hirsch, Anna K. H.

“…The Ugi four‐component reaction (Ugi‐4CR) was employed as a new reaction in kinetic target‐guided synthesis (KTGS). Applying the reaction on the bacterial β…”
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Potential Dental Biofilm Inhibitors: Dynamic Combinatorial Chemistry Affords Sugar‐Based Molecules that Target Bacterial Glucosyltransferase by Hartman, Alwin M., Jumde, Varsha R., Elgaher, Walid A. M., Te Poele, Evelien M., Dijkhuizen, Lubbert, Hirsch, Anna K. H.

“…We applied dynamic combinatorial chemistry (DCC) to find novel ligands of the bacterial virulence factor glucosyltransferase (GTF) 180. GTFs are the major…”
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Bile Acid Derived Tropos Vaulted Bi­naphth­ylphosphites: Synthesis, Stereo­chemical Characterization and Complexation to Rhodium by Jumde, Varsha R., Iuliano, Anna

“…Three different 2,2′‐binaphthylphosphites were synthesized, starting from suitable derivatives of cholic or deoxycholic acids and…”
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A chiral Rh–phosphite complex displaying high activity in the enantioselective Rh-catalyzed addition of arylboronic acids to carbonyl compounds: when and why atropos is better than tropos by Jumde, Varsha R., Facchetti, Sarah, Iuliano, Anna

“…The use of deoxycholic acid derived tropos and atropoisomeric phosphites as chiral ligands in the Rh-catalyzed enantioselective addition of arylboronic acids…”
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Design and Synthesis of Bioisosteres of Acylhydrazones as Stable Inhibitors of the Aspartic Protease Endothiapepsin by Jumde, Varsha R., Mondal, Milon, Gierse, Robin M., Unver, M. Yagiz, Magari, Francesca, van Lier, Roos C. W., Heine, Andreas, Klebe, Gerhard, Hirsch, Anna K. H.

“…Acylhydrazone‐based dynamic combinatorial chemistry (DCC) is a powerful strategy for the rapid identification of novel hits. Even though acylhydrazones are…”
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Deoxycholic acid derived monophosphites as chiral ligands in the asymmetric Suzuki–Miyaura cross-coupling by Jumde, Varsha R., Iuliano, Anna

“…Biaryl phosphites derived from deoxycholic acid were used as chiral ligands in the asymmetric Suzuki–Miyaura cross-coupling of arylboronic acids with aryl…”
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Cover Feature: Potential Dental Biofilm Inhibitors: Dynamic Combinatorial Chemistry Affords Sugar‐Based Molecules that Target Bacterial Glucosyltransferase (ChemMedChem 1/2021) by Hartman, Alwin M., Jumde, Varsha R., Elgaher, Walid A. M., Te Poele, Evelien M., Dijkhuizen, Lubbert, Hirsch, Anna K. H.

“…The Cover Feature shows the application of dynamic combinatorial chemistry (DCC) for the identification of potential inhibitors of bacterial…”
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Towards the Modulation of RNA-Binding Proteins: New Compounds Targeting Protein HuR by Serena Della Volpe, Rita Nasti, Michele Queirolo, Yagiz M. Unver, Varsha R. Jumde, Alexander Dömling, Francesca Vasile, Donatella Potenza, Francesca Alessandra Ambrosio, Giosué Costa, Stefano Alcaro, Chiara Zucal, Alessandro Provenzani, Marcello Di Giacomo, Daniela Rossi, Anna K. H. Hirsch, Simona Collina

“…RNA-binding proteins (RBPs) have been widely recognized for their pivotal role in the regulation of post-transcriptional processes. [...]…”
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