Search Results - "Jullien, Jerome"

Analysis of nuclear reprogramming following nuclear transfer to Xenopus oocyte by Jullien, Jerome

“…Germinal vesicle of stage V-VI Xenopus Laevis oocytes (at the prophase I stage of meiosis) can be used to transplant mammalian nuclei. In this type of…”
Get more information

Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes by Miyamoto, Kei, Pasque, Vincent, Jullien, Jerome, Gurdon, John B

“…Amphibian oocytes can rapidly and efficiently reprogram the transcription of transplanted somatic nuclei. To explore the factors and mechanisms involved, we…”
Get full text

H3K4 Methylation-Dependent Memory of Somatic Cell Identity Inhibits Reprogramming and Development of Nuclear Transfer Embryos by Hörmanseder, Eva, Simeone, Angela, Allen, George E., Bradshaw, Charles R., Figlmüller, Magdalena, Gurdon, John, Jullien, Jerome

“…Vertebrate eggs can induce the nuclear reprogramming of somatic cells to enable production of cloned animals. Nuclear reprogramming is relatively inefficient,…”
Get full text

Secreted inhibitors drive the loss of regeneration competence in Xenopus limbs by Aztekin, Can, Hiscock, Tom W, Gurdon, John, Jullien, Jerome, Marioni, John, Simons, Benjamin David

“…Absence of a specialized wound epidermis is hypothesized to block limb regeneration in higher vertebrates. However, the factors preventing its formation in…”
Get full text

Sperm is epigenetically programmed to regulate gene transcription in embryos by Teperek, Marta, Simeone, Angela, Gaggioli, Vincent, Miyamoto, Kei, Allen, George E, Erkek, Serap, Kwon, Taejoon, Marcotte, Edward M, Zegerman, Philip, Bradshaw, Charles R, Peters, Antoine H F M, Gurdon, John B, Jullien, Jerome

“…For a long time, it has been assumed that the only role of sperm at fertilization is to introduce the male genome into the egg. Recently, ideas have emerged…”
Get full text

The myeloid lineage is required for the emergence of a regeneration-permissive environment following Xenopus tail amputation by Aztekin, Can, Hiscock, Tom W, Butler, Richard, De Jesús Andino, Francisco, Robert, Jacques, Gurdon, John B, Jullien, Jerome

“…Regeneration-competent vertebrates are considered to suppress inflammation faster than non-regenerating ones. Hence, understanding the cellular mechanisms…”
Get full text

Mitosis gives a brief window of opportunity for a change in gene transcription by Halley-Stott, Richard P, Jullien, Jerome, Pasque, Vincent, Gurdon, John

“…Cell differentiation is remarkably stable but can be reversed by somatic cell nuclear transfer, cell fusion, and iPS. Nuclear transfer to amphibian oocytes…”
Get full text

Mechanisms of nuclear reprogramming by eggs and oocytes: a deterministic process? by Gurdon, J. B, Jullien, Jerome, Pasque, Vincent, Halley-Stott, Richard P, Miyamoto, Kei

“…Differentiated cells can become pluripotent through reprogramming by nuclear transfer, cell fusion and induced pluripotent stem cell technology. The…”
Get full text

Gene Resistance to Transcriptional Reprogramming following Nuclear Transfer Is Directly Mediated by Multiple Chromatin-Repressive Pathways by Jullien, Jerome, Vodnala, Munender, Pasque, Vincent, Oikawa, Mami, Miyamoto, Kei, Allen, George, David, Sarah Anne, Brochard, Vincent, Wang, Stan, Bradshaw, Charles, Koseki, Haruhiko, Sartorelli, Vittorio, Beaujean, Nathalie, Gurdon, John

“…Understanding the mechanism of resistance of genes to reactivation will help improve the success of nuclear reprogramming. Using mouse embryonic fibroblast…”
Get full text

Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes by Miyamoto, Kei, Nguyen, Khoi T., Allen, George E., Jullien, Jerome, Kumar, Dinesh, Otani, Tomoki, Bradshaw, Charles R., Livesey, Frederick J., Kellis, Manolis, Gurdon, John B.

“…Oocytes have a remarkable ability to reactivate silenced genes in somatic cells. However, it is not clear how the chromatin architecture of somatic cells…”
Get full text

Characterization of somatic cell nuclear reprogramming by oocytes in which a linker histone is required for pluripotency gene reactivation by Jullien, Jerome, Åstrand, Carolina, Halley-Stott, Richard P, Garrett, Nigel, Gurdon, John B

“…When transplanted into Xenopus oocytes, the nuclei of mammalian somatic cells are reprogrammed to express stem cell genes such as Oct4, Nanog, and Sox2. We now…”
Get full text

Epigenetic factors influencing resistance to nuclear reprogramming by Pasque, Vincent, Jullien, Jerome, Miyamoto, Kei, Halley-Stott, Richard P, Gurdon, J.B

“…Patient-specific somatic cell reprogramming is likely to have a large impact on medicine by providing a source of cells for disease modelling and regenerative…”
Get full text

HIRA dependent H3.3 deposition is required for transcriptional reprogramming following nuclear transfer to Xenopus oocytes by Jullien, Jerome, Astrand, Carolina, Szenker, Emmanuelle, Garrett, Nigel, Almouzni, Genevieve, Gurdon, John B

“…Nuclear reprogramming is potentially important as a route to cell replacement and drug discovery, but little is known about its mechanism. Nuclear transfer to…”
Get full text

Hierarchical Molecular Events Driven by Oocyte-Specific Factors Lead to Rapid and Extensive Reprogramming by Jullien, Jerome, Miyamoto, Kei, Pasque, Vincent, Allen, George E., Bradshaw, Charles R., Garrett, Nigel J., Halley-Stott, Richard P., Kimura, Hiroshi, Ohsumi, Keita, Gurdon, John B.

“…Nuclear transfer to oocytes is an efficient way to transcriptionally reprogram somatic nuclei, but its mechanisms remain unclear. Here, we identify a sequence…”
Get full text

Morphogen gradient interpretation by a regulated trafficking step during ligand-receptor transduction by Jullien, Jerome, Gurdon, John

“…Morphogen gradients are important in early development, but how cells recognize their position in such a gradient is not well understood. Cells need to…”
Get full text

The Expression of TALEN before Fertilization Provides a Rapid Knock-Out Phenotype in Xenopus laevis Founder Embryos by Miyamoto, Kei, Suzuki, Ken-Ichi T, Suzuki, Miyuki, Sakane, Yuto, Sakuma, Tetsushi, Herberg, Sarah, Simeone, Angela, Simpson, David, Jullien, Jerome, Yamamoto, Takashi, Gurdon, J B

“…Recent advances in genome editing using programmable nucleases have revolutionized gene targeting in various organisms. Successful gene knock-out has been…”
Get full text

Histone H3 lysine 9 trimethylation is required for suppressing the expression of an embryonically activated retrotransposon in Xenopus laevis by Herberg, Sarah, Simeone, Angela, Oikawa, Mami, Jullien, Jerome, Bradshaw, Charles R, Teperek, Marta, Gurdon, John, Miyamoto, Kei

“…Transposable elements in the genome are generally silenced in differentiated somatic cells. However, increasing evidence indicates that some of them are…”
Get full text

Reprogramming towards totipotency is greatly facilitated by synergistic effects of small molecules by Miyamoto, Kei, Tajima, Yosuke, Yoshida, Koki, Oikawa, Mami, Azuma, Rika, Allen, George E, Tsujikawa, Tomomi, Tsukaguchi, Tomomasa, Bradshaw, Charles R, Jullien, Jerome, Yamagata, Kazuo, Matsumoto, Kazuya, Anzai, Masayuki, Imai, Hiroshi, Gurdon, John B, Yamada, Masayasu

“…Animal cloning has been achieved in many species by transplanting differentiated cell nuclei to unfertilized oocytes. However, the low efficiencies of cloning…”
Get full text

A natural oocyte component required for the reprogramming of somatic cell nuclei by Jullien, Jerome, Gurdon, John B.

“…Comment on: Jullien J, et al. Proc Natl Acad Sci USA 2010; 107:5483-8…”
Get full text

Sperm and spermatids contain different proteins and bind distinct egg factors by Teperek, Marta, Miyamoto, Kei, Simeone, Angela, Feret, Renata, Deery, Michael J, Gurdon, John B, Jullien, Jerome

“…Spermatozoa are more efficient at supporting normal embryonic development than spermatids, their immature, immediate precursors. This suggests that the sperm…”
Get full text