Search Results - "Julku, Ulrika H."

Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo by Svarcbahs, Reinis, Julku, Ulrika H., Norrbacka, Susanna, Myöhänen, Timo T.

“…Prolyl oligopeptidase (PREP) inhibition by small-molecule inhibitors can reduce alpha-synuclein (aSyn) aggregation, a key player in Parkinson’s disease…”
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Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner by Julku, Ulrika H, Jäntti, Maria, Svarcbahs, Reinis, Myöhänen, Timo T

“…Prolyl oligopeptidase (PREP) is a serine protease that binds to alpha-synuclein (aSyn) and induces its aggregation. PREP inhibitors have been shown to have…”
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Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the α-Synuclein Virus Vector-Based Parkinson's Disease Mouse Model by Decreasing α-Synuclein Oligomeric Species in Mouse Brain by Svarcbahs, Reinis, Julku, Ulrika H, Myöhänen, Timo T

“…Decreased clearance of α-synuclein (aSyn) and aSyn protein misfolding and aggregation are seen as major factors in the pathogenesis of Parkinson's disease (PD)…”
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Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A by Svarcbahs, Reinis, Jäntti, Maria, Kilpeläinen, Tommi, Julku, Ulrika H., Urvas, Lauri, Kivioja, Saara, Norrbacka, Susanna, Myöhänen, Timo T.

“…[Display omitted] Prolyl oligopeptidase (PREP) is a serine protease that has been studied particularly in the context of neurodegenerative diseases for decades…”
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Behavioural and dopaminergic changes in double mutated human A30PA53T alpha-synuclein transgenic mouse model of Parkinson´s disease by Kilpeläinen, Tommi, Julku, Ulrika H., Svarcbahs, Reinis, Myöhänen, Timo T.

“…Alpha-synuclein (aSyn) is the main component of Lewy bodies, the histopathological marker in Parkinson’s disease (PD), and point mutations and multiplications…”
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Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model by Eteläinen, Tony S., Kilpeläinen, Tommi P., Ignatius, Adele, Auno, Samuli, De Lorenzo, Francesca, Uhari-Väänänen, Johanna K., Julku, Ulrika H., Myöhänen, Timo T.

“…Parkinson's disease (PD) is characterized by degeneration of nigrostriatal dopaminergic neurons and accumulation of α-synuclein (αSyn) as Lewy bodies…”
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Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α‑Synuclein Mouse Models of Parkinson’s Disease by Kilpeläinen, Tommi P., Pätsi, Henri T., Svarcbahs, Reinis, Julku, Ulrika H., Eteläinen, Tony S., Cui, Hengjing, Auno, Samuli, Sipari, Nina, Norrbacka, Susanna, Leino, Teppo O., Jäntti, Maria, Myöhänen, Timo T., Wallén, Erik A. A.

“…Prolyl oligopeptidase (PREP) is a widely distributed serine protease in the human body cleaving proline-containing peptides; however, recent studies suggest…”
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A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy by Eteläinen, Tony S, Silva, M Catarina, Uhari-Väänänen, Johanna K, De Lorenzo, Francesca, Jäntti, Maria H, Cui, Hengjing, Chavero-Pieres, Marta, Kilpeläinen, Tommi, Mechtler, Christina, Svarcbahs, Reinis, Seppälä, Erin, Savinainen, Juha R, Puris, Elena, Fricker, Gert, Gynther, Mikko, Julku, Ulrika H, Huttunen, Henri J, Haggarty, Stephen J, Myöhänen, Timo T

“…Tauopathies are neurodegenerative diseases that are characterized by accumulation of hyperphosphorylated tau protein, higher-order aggregates, and tau…”
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Prolyl Oligopeptidase Regulates Dopamine Transporter Phosphorylation in the Nigrostriatal Pathway of Mouse by Julku, Ulrika H, Panhelainen, Anne E, Tiilikainen, Saija E, Svarcbahs, Reinis, Tammimäki, Anne E, Piepponen, T Petteri, Savolainen, Mari H, Myöhänen, Timo T

“…Alpha-synuclein is the main component of Lewy bodies, a histopathological finding of Parkinson’s disease. Prolyl oligopeptidase (PREP) is a serine protease…”
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Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the [alpha]-Synuclein Virus Vector-Based Parkinson's Disease Mouse Model by Decreasing [alpha]-Synuclein Oligomeric Species in Mouse Brain by Svarcbahs, Reinis, Julku, Ulrika H, Myohanen, Timo T

“…Decreased clearance of [alpha]-synuclein (aSyn) and aSyn protein misfolding and aggregation are seen as major factors in the pathogenesis of Parkinson's…”
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