Search Results - "Juliano, L"

The delivery of therapeutic oligonucleotides by Juliano, Rudolph L

“…The oligonucleotide therapeutics field has seen remarkable progress over the last few years with the approval of the first antisense drug and with promising…”
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Caveolin-1 is a critical determinant of autophagy, metabolic switching, and oxidative stress in vascular endothelium by Shiroto, Takashi, Romero, Natalia, Sugiyama, Toru, Sartoretto, Juliano L, Kalwa, Hermann, Yan, Zhonghua, Shimokawa, Hiroaki, Michel, Thomas

“…Caveolin-1 is a scaffolding/regulatory protein that interacts with diverse signaling molecules. Caveolin-1(null) mice have marked metabolic abnormalities, yet…”
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Cellular Uptake and Intracellular Trafficking of Antisense and siRNA Oligonucleotides by Juliano, Rudolph L, Ming, Xin, Nakagawa, Osamu

“…Significant progress is being made concerning the development of oligonucleotides as therapeutic agents. Studies with antisense, siRNA, and other forms of…”
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Targeted Albumin-Based Nanoparticles for Delivery of Amphipathic Drugs by Xu, Rongzuo, Fisher, Michael, Juliano, R. L

“…We report the preparation and physical and biological characterization of human serum albumin-based micelles of approximately 30 nm diameter for the delivery…”
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The Chemistry and Biology of Oligonucleotide Conjugates by Juliano, R. L, Ming, Xin, Nakagawa, Osamu

“…Short DNA or RNA oligonucleotides have tremendous potential as therapeutic agents. Because of their ability to engage in Watson–Crick base pairing, they can…”
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Diffusion MRI and the detection of alterations following traumatic brain injury by Hutchinson, Elizabeth B., Schwerin, Susan C., Avram, Alexandru V., Juliano, Sharon L., Pierpaoli, Carlo

“…This article provides a review of brain tissue alterations that may be detectable using diffusion magnetic resonance imaging MRI (dMRI) approaches and an…”
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Chemical Manipulation of the Endosome Trafficking Machinery: Implications for Oligonucleotide Delivery by Juliano, Rudolph L.

“…Antisense oligonucleotides (ASOs), siRNA and splice switching oligonucleotides (SSOs) all have immense potential as therapeutic agents, potential that is now…”
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Endothelial PGC-1α Mediates Vascular Dysfunction in Diabetes by Sawada, Naoki, Jiang, Aihua, Takizawa, Fumihiko, Safdar, Adeel, Manika, Andre, Tesmenitsky, Yevgenia, Kang, Kyu-Tae, Bischoff, Joyce, Kalwa, Hermann, Sartoretto, Juliano L., Kamei, Yasutomi, Benjamin, Laura E., Watada, Hirotaka, Ogawa, Yoshihiro, Higashikuni, Yasutomi, Kessinger, Chase W., Jaffer, Farouc A., Michel, Thomas, Sata, Masataka, Croce, Kevin, Tanaka, Rica, Arany, Zolt

“…Endothelial dysfunction is a central hallmark of diabetes. The transcriptional coactivator PGC-1α is a powerful regulator of metabolism, but its role in…”
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Multiclonal human origin and global expansion of an endemic bacterial pathogen of livestock by Yebra, Gonzalo, Harling-Lee, Joshua D, Lycett, Samantha, Aarestrup, Frank M, Larsen, Gunhild, Cavaco, Lina M, Seo, Keun Seok, Abraham, Sam, Norris, Jacqueline M, Schmidt, Tracy, Ehlers, Marthie M, Sordelli, Daniel O, Buzzola, Fernanda R, Gebreyes, Wondwossen A, Gonçalves, Juliano L, Dos Santos, Marcos V, Zakaria, Zunita, Rall, Vera L M, Keane, Orla M, Niedziela, Dagmara A, Paterson, Gavin K, Holmes, Mark A, Freeman, Tom C, Fitzgerald, J Ross

“…Most new pathogens of humans and animals arise via switching events from distinct host species. However, our understanding of the evolutionary and ecological…”
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Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members by Juliano, R L

“…Cellular interactions with the extracellular matrix and with neighboring cells profoundly influence a variety of signaling events including those involved in…”
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Ingestion of plastic debris by commercially important marine fish in southeast-south Brazil by Neto, J. Gabriel B., Rodrigues, Fábio L., Ortega, Ileana, Rodrigues, Lucas dos S., Lacerda, Ana L.d.F., Coletto, Juliano L., Kessler, Felipe, Cardoso, Luis G., Madureira, Lauro, Proietti, Maíra C.

“…Rising concentrations of plastics in the oceans are leading to increasing negative interactions with marine biota, including ingestion by endangered and/or…”
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Optimization of limonene biotransformation for the production of bulk amounts of α-terpineol by Molina, Gustavo, Pessôa, Marina G., Bicas, Juliano L., Fontanille, Pierre, Larroche, Christian, Pastore, Gláucia M.

“…[Display omitted] •Bioprocess for α-terpineol production, a commercially important monoterpene alcohol.•Effect of medium composition and cultivation conditions…”
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Pathogen effects on milk yield and composition in chronic subclinical mastitis in dairy cows by Gonçalves, J.L., Kamphuis, C., Vernooij, H., Araújo, J.P., Grenfell, R.C., Juliano, L., Anderson, K.L., Hogeveen, H., dos Santos, M.V.

“…•Milk loss and composition alteration depended on the pathogen causing mastitis.•Chronic quarters produced less milk than healthy quarters.•Infection with…”
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Clinging to life: cell to matrix adhesion and cell survival by Reddig, Peter J, Juliano, Rudy L

“…Cell to matrix adhesion regulates cellular homeostasis in multiple ways. Integrin attachment to the extracellular matrix mediates this regulation through…”
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MALDI–TOF bacterial subtyping for rapid detection of biomarkers in Staphylococcus aureus from subclinical bovine mastitis by Lopes, Thainara, Fidelis, Carlos E, Silva, Amanda T F, Mota, Rinaldo A, Rall, Vera L M, dos Santos, Marcos V, Gonçalves, Juliano L

“…Abstract Aims This study aimed to evaluate matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) bacterial subtyping for…”
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Intracellular Trafficking and Endosomal Release of Oligonucleotides: What We Know and What We Don't by Juliano, R L

“…Understanding the cellular uptake and intracellular trafficking of oligonucleotides provides an important basic underpinning for the developing field of…”
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Short communication: Association between the accessory gene regulator (agr) group and the severity of bovine mastitis caused by Staphylococcus aureus by Rossi, Bruna F, Bonsaglia, Erika C R, Pantoja, Jose C F, Santos, Marcos V, Gonçalves, Juliano L, Fernandes Júnior, Ary, Rall, Vera L M

“…Staphylococcus aureus can elicit mild to more severe degrees of mastitis in cattle, depending on the response of the host's immune system and the virulence…”
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Isotope-based inferences of skipjack tuna feeding ecology and movement in the southwestern Atlantic Ocean by Coletto, Juliano L., Botta, Silvina, Fischer, Luciano G., Newsome, Seth D., Madureira, Lauro S.P.

“…Skipjack tuna (Katsuwonus pelamis) sustain a large-scale fishery in the southwest Atlantic Ocean (SWA), but information about its foraging ecology in this…”
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Addressing cancer signal transduction pathways with antisense and siRNA oligonucleotides by Juliano, Rudolph L

“…Signal transduction pathways play key roles in the initiation, progression and dissemination of cancer. Thus, signaling molecules are attractive targets for…”
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Insulin-dependent metabolic and inotropic responses in the heart are modulated by hydrogen peroxide from NADPH-oxidase isoforms NOX2 and NOX4 by Steinhorn, Benjamin, Sartoretto, Juliano L., Sorrentino, Andrea, Romero, Natalia, Kalwa, Hermann, Abel, E. Dale, Michel, Thomas

“…Hydrogen peroxide (H2O2) is a stable reactive oxygen species (ROS) that has long been implicated in insulin signal transduction in adipocytes. However, H2O2's…”
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