Search Results - "Juergens, Uwe R."

New Perspectives for Mucolytic, Anti-inflammatory and Adjunctive Therapy with 1,8-Cineole in COPD and Asthma: Review on the New Therapeutic Approach by Juergens, Lisa Joy, Worth, Heinrich, Juergens, Uwe R.

“…The mucolytic monoterpene 1,8-cineole (eucalyptol), the major constituent of eucalyptus species, is well known for its anti-inflammatory, antioxidant,…”
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Inhibitory activity of 1,8-cineol (eucalyptol) on cytokine production in cultured human lymphocytes and monocytes by Juergens, Uwe R., Engelen, Tanja, Racké, Kurt, Stöber, Meinolf, Gillissen, Adrian, Vetter, Hans

“…The therapeutic value of secretolytic agents in COPD and asthma is still disputed. For this reason, in a preclinical study we aimed to test the potential…”
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Inhibition of NADPH oxidase by apocynin inhibits lipopolysaccharide (LPS) induced up-regulation of arginase in rat alveolar macrophages by Matthiesen, Sonja, Lindemann, Dirk, Warnken, Mareille, Juergens, Uwe R., Racké, Kurt

“…Reactive oxygen species participate in the pathogenesis of inflammatory airway diseases, in which increased arginase may play a role by interfering with nitric…”
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COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE therapy by Weckmann, Markus, Bahmer, Thomas, Sand, Jannie Marie, Rank Rønnow, Sarah, Pech, Martin, Vermeulen, Cornelis, Faiz, Alen, Leeming, Diana Julie, Karsdal, Morten Asser, Lunding, Lars, Oliver, Brian George G, Wegmann, Michael, Ulrich-Merzenich, Gudrun, Juergens, Uwe R, Duhn, Jannis, Laumonnier, Yves, Danov, Olga, Sewald, Katherina, Zissler, Ulrich, Jonker, Marnix, König, Inke, Hansen, Gesine, von Mutius, Erika, Fuchs, Oliver, Dittrich, Anna-Maria, Schaub, Bianca, Happle, Christine, Rabe, Klaus F, van de Berge, Maarten, Burgess, Janette Kay, Kopp, Matthias Volkmar

“…Asthma is a heterogeneous syndrome substantiating the urgent requirement for endotype-specific biomarkers. Dysbalance of fibrosis and fibrolysis in asthmatic…”
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Inflammatory responses after endothelin B (ETB ) receptor activation in human monocytes: New evidence for beneficial anti-inflammatory potency of ETB -receptor antagonism by Juergens, Uwe R, Racké, Kurt, Uen, Sakir, Haag, Susanne, Lamyel, Fathi, Stöber, Meinolf, Gillissen, Adrian, Novak, Natalija, Vetter, Hans

“…Abstract Endothelin (ET) stimulates potent ETA /ETB receptors important in the pathogenesis of pulmonary arterial hypertension (PAH) and fibrosis. Though…”
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Pulmonary arterial hypertension in patients with sarcoidosis: the Pulsar single center experience by Pabst, Stefan, Hammerstingl, Christoph, Grau, Natalie, Kreuz, Jens, Grohe, Christian, Juergens, Uwe R, Nickenig, Georg, Skowasch, Dirk

“…Sarcoidosis is a systemic granulomatous disease with unknown etiology. Lungs and lymph nodes are commonly affected. Also, cases of pulmonary hypertension (PH)…”
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Control by cholinergic mechanisms by Racké, Kurt, Juergens, Uwe R., Matthiesen, Sonja

“…In the respiratory tract acetylcholine is neurotransmitter in ganglia and postganglionic parasympathetic nerves, but in addition is paracrine mediator released…”
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Muscarinic Receptors Mediate Stimulation of Human Lung Fibroblast Proliferation by Matthiesen, Sonja, Bahulayan, Amit, Kempkens, Susanne, Haag, Susanne, Fuhrmann, Margarita, Stichnote, Christine, Juergens, Uwe R, Racke, Kurt

“…Airway remodeling is a structural alteration associated with chronic inflammatory and obstructive airway diseases, wherein fibroblasts are crucially involved…”
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β2-adrenoceptors and muscarinic receptors mediate opposing effects on endothelin-1 expression in human lung fibroblasts by Ahmedat, Ahmedat S., Warnken, Mareille, Juergens, Uwe R., Paul Pieper, Michael, Racké, Kurt

“…Human lung fibroblasts are a potential source of endothelin-1 (ET-1), a pro-fibrotic mediator. The present study explored possible muscarinic and β-adrenergic…”
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Extrinsic allergic alveolitis due to inhaled molds in occupational onion and potato processing: onion- and potato-sorter alveolitis by Sennekamp, Joachim, Juergens, Lisa-Joy, Sturm, Matthias, Juergens, Uwe R.

“…Background: Only one case of occupational extrinsic allergic alveolitis due to mold inhaled during the sorting and transportation of onions and potatoes has…”
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Obstructive sleep apnoea as a risk factor for atherosclerosis – implication for preventive and personalised treatment by Tuleta, Izabela, Pabst, Stefan, Juergens, Uwe R., Nickenig, Georg, Skowasch, Dirk

“…Atherosclerosis with its manifestations and associated diseases is a main cause of morbidity and mortality in industrial countries. The pathomechanisms…”
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Human and rat alveolar macrophages express multiple EDG receptors by Hornuß, Cyrill, Hammermann, Rainer, Fuhrmann, Margarita, Juergens, Uwe R, Racké, Kurt

“…Endothelial differentiation gene (EDG) receptors are a new family of eight G protein-coupled receptors for the lysophospholipids lysophosphatitic acid and…”
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New evidence of H1-receptor independent COX-2 inhibition by fexofenadine HCl in vitro by Juergens, Uwe R, Gillissen, Adrian, Uen, Sakir, Racké, Kurt, Stöber, Meinolf, Darlath, Wilfried, Vetter, Hans

“…Fexofenadine HCl (FEX) has previously been shown to have anti-inflammatory properties in relieving nasal congestion in allergic rhinitis. The objective of this…”
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Diagnostics and therapy of idiopathic pulmonary hemosiderosis by Willms, Hinrich, Gutjahr, Kathleen, Juergens, Uwe R, Hammerschmidt, Stefan, Gessner, Christian, Hoheisel, Gerhard, Wirtz, Hubert, Gillissen, Adrian

“…Idiopathic pulmonary hemosiderosis (IPH) is a rare clinical entity characterized by recurrent episodes of diffuse alveolar hemorrhage. The disease--also called…”
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Differential effects of fexofenadine on arachidonic acid metabolism in cultured human monocytes by Juergens, Uwe R, Darlath, Wilfried, Stober, Meinolf, Racké, Kurt, Tasci, Selcuk, Gillissen, Adrian, Vetter, Hans

“…The relief of nasal congestion with the antihistamine fexofenadine in seasonal allergic rhinitis is thought to be due to its additional anti-inflammatory…”
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Anti-inflammatory effects of 1,8-cineole (eucalyptol) improve glucocorticoid effects in vitro: A novel approach of steroid-sparing add-on therapy for COPD and asthma? by Juergens, Lisa Joy, Racké, Kurt, Tuleta, Izabella, Stoeber, Meinolf, Juergens, Uwe R.

“…[Display omitted] Add-on therapies with the monoterpene 1,8-cineole were shown to be effective in controlled studies, on asthma and chronic obstructive…”
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Regulation of monocyte redox balance by 1,8-cineole (eucalyptol) controls oxidative stress and pro-inflammatory responses in vitro: A new option to increase the antioxidant effects of combined respiratory therapy with budesonide and formoterol? by Juergens, Lisa Joy, Tuleta, Izabela, Stoeber, Meinolf, Racké, Kurt, Juergens, Uwe R.

“…Airway mucus hypersecretion is the typical feature of COPD and asthma. Hypersecretion is caused by reactive oxygen species (ROS) and links the COPD-bronchitis…”
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Reproterol--A monomolecular combination of orciprenaline and theophylline: novel aspects of its mode of action in asthma by Juergens, U R, Stöber, M, Vetter, H

“…Reproterol is a monomolecular combination of orciprenaline and theophylline used as beta-adrenergic agonist to induce bronchodilation in bronchial asthma…”
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Anti-inflammatory activity of 1.8-cineol (eucalyptol) in bronchial asthma: a double-blind placebo-controlled trial by JUERGENS, U.R, DETHLEFSEN, U, STEINKAMP, G, GILLISSEN, A, REPGES, R, VETTER, H

“…Airway hypersecretion is mediated by increased release of inflammatory mediators and can be improved by inhibition of mediator production. We have recently…”
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Control by cholinergic mechanisms: The Pharmacology of the Respiratory Tract by RACKE, Kurt, JUERGENS, Uwe R, MATTHIESEN, Sonja

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