Search Results - "Judkins, Alexander R."

Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion by Zhang, Ji, Fan, Jing, Venneti, Sriram, Cross, Justin R., Takagi, Toshimitsu, Bhinder, Bhavneet, Djaballah, Hakim, Kanai, Masayuki, Cheng, Emily H., Judkins, Alexander R., Pawel, Bruce, Baggs, Julie, Cherry, Sara, Rabinowitz, Joshua D., Thompson, Craig B.

“…Many cancer cells consume large quantities of glutamine to maintain TCA cycle anaplerosis and support cell survival. It was therefore surprising when RNAi…”
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Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development by Vitte, Jeremie, Gao, Fuying, Coppola, Giovanni, Judkins, Alexander R., Giovannini, Marco

“…Germline mutations of the SMARCB1 gene predispose to two distinct tumor syndromes: rhabdoid tumor predisposition syndrome, with malignant pediatric tumors…”
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Hypoxia Induces Production of L-2-Hydroxyglutarate by Intlekofer, Andrew M., Dematteo, Raymond G., Venneti, Sriram, Finley, Lydia W.S., Lu, Chao, Judkins, Alexander R., Rustenburg, Ariën S., Grinaway, Patrick B., Chodera, John D., Cross, Justin R., Thompson, Craig B.

“…Somatic mutations in isocitrate dehydrogenase 1 or 2 (IDH1/2) contribute to the pathogenesis of cancer via production of the “oncometabolite”…”
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Efficacy of High-Dose Chemotherapy and Three-Dimensional Conformal Radiation for Atypical Teratoid/Rhabdoid Tumor: A Report From the Children's Oncology Group Trial ACNS0333 by Reddy, Alyssa T, Strother, Douglas R, Judkins, Alexander R, Burger, Peter C, Pollack, Ian F, Krailo, Mark D, Buxton, Allen B, Williams-Hughes, Chris, Fouladi, Maryam, Mahajan, Anita, Merchant, Thomas E, Ho, Ben, Mazewski, Claire M, Lewis, Victor A, Gajjar, Amar, Vezina, Louis-Gilbert, Booth, Timothy N, Parsons, Kerry W, Poss, Vicky L, Zhou, Tianni, Biegel, Jaclyn A, Huang, Annie

“…Atypical teratoid/rhabdoid tumor (AT/RT) is an aggressive, early-childhood brain tumor without standard effective treatment. To our knowledge, we conducted the…”
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Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas by Chung, Chan, Sweha, Stefan R., Pratt, Drew, Tamrazi, Benita, Panwalkar, Pooja, Banda, Adam, Bayliss, Jill, Hawes, Debra, Yang, Fusheng, Lee, Ho-Joon, Shan, Mengrou, Cieslik, Marcin, Qin, Tingting, Werner, Christian K., Wahl, Daniel R., Lyssiotis, Costas A., Bian, Zhiguo, Shotwell, J. Brad, Yadav, Viveka Nand, Koschmann, Carl, Chinnaiyan, Arul M., Blüml, Stefan, Judkins, Alexander R., Venneti, Sriram

“…H3K27M diffuse intrinsic pontine gliomas (DIPGs) are fatal and lack treatments. They mainly harbor H3.3K27M mutations resulting in H3K27me3 reduction…”
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SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer by Xue, Yibo, Meehan, Brian, Fu, Zheng, Wang, Xue Qing D., Fiset, Pierre Olivier, Rieker, Ralf, Levins, Cameron, Kong, Tim, Zhu, Xianbing, Morin, Geneviève, Skerritt, Lashanda, Herpel, Esther, Venneti, Sriram, Martinez, Daniel, Judkins, Alexander R., Jung, Sungmi, Camilleri-Broet, Sophie, Gonzalez, Anne V., Guiot, Marie-Christine, Lockwood, William W., Spicer, Jonathan D., Agaimy, Abbas, Pastor, William A., Dostie, Josée, Rak, Janusz, Foulkes, William D., Huang, Sidong

“…Tumor suppressor SMARCA4 (BRG1) , a key SWI/SNF chromatin remodeling gene, is frequently inactivated in cancers and is not directly druggable. We recently…”
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Evaluation of Histone 3 Lysine 27 Trimethylation (H3K27me3) and Enhancer of Zest 2 (EZH2) in Pediatric Glial and Glioneuronal Tumors Shows Decreased H3K27me3 in H3F3A K27M Mutant Glioblastomas by Venneti, Sriram, Garimella, Mihir T., Sullivan, Lisa M., Martinez, Daniel, Huse, Jason T., Heguy, Adriana, Santi, Mariarita, Thompson, Craig B., Judkins, Alexander R.

“…H3F3A mutations are seen in ∼30% of pediatric glioblastoma (GBMs) and involve either the lysine residue at position 27 (K27M) or glycine at position 34…”
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Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas by Bayliss, Jill, Mukherjee, Piali, Lu, Chao, Jain, Siddhant U, Chung, Chan, Martinez, Daniel, Sabari, Benjamin, Margol, Ashley S, Panwalkar, Pooja, Parolia, Abhijit, Pekmezci, Melike, McEachin, Richard C, Cieslik, Marcin, Tamrazi, Benita, Garcia, Benjamin A, La Rocca, Gaspare, Santi, Mariarita, Lewis, Peter W, Hawkins, Cynthia, Melnick, Ari, David Allis, C, Thompson, Craig B, Chinnaiyan, Arul M, Judkins, Alexander R, Venneti, Sriram

“…Childhood posterior fossa (PF) ependymomas cause substantial morbidity and mortality. These tumors lack recurrent genetic mutations, but a subset of these…”
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CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary by Xue, Yibo, Meehan, Brian, Macdonald, Elizabeth, Venneti, Sriram, Wang, Xue Qing D., Witkowski, Leora, Jelinic, Petar, Kong, Tim, Martinez, Daniel, Morin, Geneviève, Firlit, Michelle, Abedini, Atefeh, Johnson, Radia M., Cencic, Regina, Patibandla, Jay, Chen, Hongbo, Papadakis, Andreas I., Auguste, Aurelie, de Rink, Iris, Kerkhoven, Ron M., Bertos, Nicholas, Gotlieb, Walter H., Clarke, Blaise A., Leary, Alexandra, Witcher, Michael, Guiot, Marie-Christine, Pelletier, Jerry, Dostie, Josée, Park, Morag, Judkins, Alexander R., Hass, Ralf, Levine, Douglas A., Rak, Janusz, Vanderhyden, Barbara, Foulkes, William D., Huang, Sidong

“…Inactivating mutations in SMARCA4 ( BRG1 ), a key SWI/SNF chromatin remodelling gene, underlie small cell carcinoma of the ovary, hypercalcemic type (SCCOHT)…”
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Targeting SWI/SNF ATPases in H3.3K27M diffuse intrinsic pontine gliomas by Mota, Mateus, Sweha, Stefan R, Pun, Matt, Natarajan, Siva Kumar, Ding, Yujie, Chung, Chan, Hawes, Debra, Yang, Fusheng, Judkins, Alexander R, Samajdar, Susanta, Cao, Xuhong, Xiao, Lanbo, Parolia, Abhijit, Chinnaiyan, Arul M, Venneti, Sriram

“…Diffuse midline gliomas (DMGs) including diffuse intrinsic pontine gliomas (DIPGs) bearing lysine-to-methionine mutations in histone H3 at lysine 27 (H3K27M)…”
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Genetic Landscape of the Childhood Cancer Medulloblastoma by Parsons, D. Williams, Li, Meng, Zhang, Xiaosong, Jones, Siân, Leary, Rebecca J, Lin, Jimmy Cheng-Ho, Boca, Simina M, Carter, Hannah, Samayoa, Josue, Bettegowda, Chetan, Gallia, Gary L, Jallo, George I, Binder, Zev A, Nikolsky, Yuri, Hartigan, James, Smith, Doug R, Gerhard, Daniela S, Fults, Daniel W, VandenBerg, Scott, Berger, Mitchel S, Marie, Suely Kazue Nagahashi, Shinjo, Sueli Mieko Oba, Clara, Carlos, Phillips, Peter C, Minturn, Jane E, Biegel, Jaclyn A, Judkins, Alexander R, Resnick, Adam C, Storm, Phillip B, Curran, Tom, He, Yiping, Rasheed, B. Ahmed, Friedman, Henry S, Keir, Stephen T, McLendon, Roger, Northcott, Paul A, Taylor, Michael D, Burger, Peter C, Riggins, Gregory J, Karchin, Rachel, Parmigiani, Giovanni, Bigner, Darell D, Yan, Hai, Papadopoulos, Nick, Vogelstein, Bert, Kinzler, Kenneth W, Velculescu, Victor E

“…Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number…”
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Spectrum of SMARCB1/INI1 mutations in familial and sporadic rhabdoid tumors by Eaton, Katherine W., Tooke, Laura S., Wainwright, Luanne M., Judkins, Alexander R., Biegel, Jaclyn A.

“…Background Germline mutations and deletions of SMARCB1/INI1 in chromosome band 22q11.2 predispose patients to rhabdoid tumor and schwannomatosis. Previous…”
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Emerging variants of concern in SARS-CoV-2 membrane protein: a highly conserved target with potential pathological and therapeutic implications by Shen, Lishuang, Bard, Jennifer Dien, Triche, Timothy J., Judkins, Alexander R., Biegel, Jaclyn A., Gai, Xiaowu

“…Mutations in the SARS-CoV-2 Membrane (M) gene are relatively uncommon. The M gene encodes the most abundant viral structural protein, and is implicated in…”
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Nonsense Mutation and Inactivation of SMARCA4 (BRG1) in an Atypical Teratoid/Rhabdoid Tumor Showing Retained SMARCB1 (INI1) Expression by HASSELBLATT, Martin, GESK, Stefan, SCHNEPPENHEIM, Reinhard, SIEBERT, Reiner, PAULUS, Werner, OYEN, Florian, ROSSI, Sabrina, VISCARDI, Elisabetta, GIANGASPERO, Felice, GIANNINI, Caterina, JUDKINS, Alexander R, FRÜHWALD, Michael C, OBSER, Tobias

“…Atypical teratoid/rhabdoid tumors (AT/RTs) are highly aggressive brain tumors of early childhood poorly responding to therapy. The majority of cases show…”
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A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas by Venneti, Sriram, Santi, Mariarita, Felicella, Michelle Madden, Yarilin, Dmitry, Phillips, Joanna J., Sullivan, Lisa M., Martinez, Daniel, Perry, Arie, Lewis, Peter W., Thompson, Craig B., Judkins, Alexander R.

“…Pediatric glioblastomas (GBM) are highly aggressive and lethal tumors. Recent sequencing studies have shown that ~30 % of pediatric GBM and ~80 % of diffuse…”
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Increased viral variants in children and young adults with impaired humoral immunity and persistent SARS-CoV-2 infection: A consecutive case series by Truong, Thao T., Ryutov, Alex, Pandey, Utsav, Yee, Rebecca, Goldberg, Lior, Bhojwani, Deepa, Aguayo-Hiraldo, Paibel, Pinsky, Benjamin A., Pekosz, Andrew, Shen, Lishuang, Boyd, Scott D., Wirz, Oliver F., Röltgen, Katharina, Bootwalla, Moiz, Maglinte, Dennis T., Ostrow, Dejerianne, Ruble, David, Han, Jennifer H., Biegel, Jaclyn A., Li, Maggie, Huang, ChunHong, Sahoo, Malaya K., Pannaraj, Pia S., O'Gorman, Maurice, Judkins, Alexander R., Gai, Xiaowu, Dien Bard, Jennifer

“…There is increasing concern that persistent infection of SARS-CoV-2 within immunocompromised hosts could serve as a reservoir for mutation accumulation and…”
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Tumor-associated macrophages in SHH subgroup of medulloblastomas by Margol, Ashley S, Robison, Nathan J, Gnanachandran, Janahan, Hung, Long T, Kennedy, Rebekah J, Vali, Marzieh, Dhall, Girish, Finlay, Jonathan L, Erdreich-Epstein, Anat, Krieger, Mark D, Drissi, Rachid, Fouladi, Maryam, Gilles, Floyd H, Judkins, Alexander R, Sposto, Richard, Asgharzadeh, Shahab

“…Medulloblastoma in children can be categorized into at least four molecular subgroups, offering the potential for targeted therapeutic approaches to reduce…”
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Comprehensive Genome Analysis of 6,000 USA SARS-CoV-2 Isolates Reveals Haplotype Signatures and Localized Transmission Patterns by State and by Country by Shen, Lishuang, Dien Bard, Jennifer, Biegel, Jaclyn A, Judkins, Alexander R, Gai, Xiaowu

“…Genomic analysis of SARS-CoV-2 sequences is crucial in determining the effectiveness of prudent safer at home measures in the United States (US). By haplotype…”
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Pathology and diagnosis of SMARCB1-deficient tumors by Margol, Ashley S, Judkins, Alexander R

“…Malignant rhabdoid tumor (MRT) can occur in the kidney, central nervous system, or extracranial/extrarenal locations and is characterized by alterations in the…”
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Epigenetically defined therapeutic targeting in H3.3G34R/V high-grade gliomas by Sweha, Stefan R, Chung, Chan, Natarajan, Siva Kumar, Panwalkar, Pooja, Pun, Matthew, Ghali, Amer, Bayliss, Jill, Pratt, Drew, Shankar, Anand, Ravikumar, Visweswaran, Rao, Arvind, Cieslik, Marcin, Wilder-Romans, Kari, Scott, Andrew J, Wahl, Daniel R, Jessa, Selin, Kleinman, Claudia L, Jabado, Nada, Mackay, Alan, Jones, Chris, Martinez, Daniel, Santi, Mariarita, Judkins, Alexander R, Yadav, Viveka Nand, Qin, Tingting, Phoenix, Timothy N, Koschmann, Carl J, Baker, Suzanne J, Chinnaiyan, Arul M, Venneti, Sriram

“…High-grade gliomas with arginine or valine substitutions of the histone H3.3 glycine-34 residue (H3.3G34R/V) carry a dismal prognosis, and current treatments,…”
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