Search Results - "Judithann Lee"

A Potent and Selective Nonpeptide Antagonist of CXCR2 Inhibits Acute and Chronic Models of Arthritis in the Rabbit by Podolin, Patricia L, Bolognese, Brian J, Foley, James J, Schmidt, Dulcie B, Buckley, Peter T, Widdowson, Katherine L, Jin, Qi, White, John R, Lee, Judithann M, Goodman, Richard B, Hagen, Tonja R, Kajikawa, Osamu, Marshall, Lisa A, Hay, Douglas W. P, Sarau, Henry M

“…Much evidence implicates IL-8 as a major mediator of inflammation and joint destruction in rheumatoid arthritis. The effects of IL-8 and its related ligands…”
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Combination therapy with ofatumumab and bendamustine in xenograft model of chronic lymphocytic leukaemia by Haskova, Zdenka, Whitacre, Margaret N., Dede, Kimberly A., Lee, Judithann M., Trulli, Stephen H., Ciucci, Marc, Toso, John F., White, John R., Jonak, Zdenka L.

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Evaluation of Potent and Selective Small-Molecule Antagonists for the CXCR2 Chemokine Receptor by Widdowson, Katherine L, Elliott, John D, Veber, Daniel F, Nie, Hong, Rutledge, Melvin C, McCleland, Brent W, Xiang, Jia-Ning, Jurewicz, Anthony J, Hertzberg, Robert P, Foley, James J, Griswold, Don E, Martin, Lenox, Lee, Judithann M, White, John R, Sarau, Henry M

“…N,N‘-Diarylureas were prepared, and the structure−activity relationship relative to the CXCR2 receptor was examined. This led to the identification of a potent…”
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Identification of a Potent, Selective Non-peptide CXCR2 Antagonist That Inhibits Interleukin-8-induced Neutrophil Migration by White, John R., Lee, Judithann M., Young, Peter R., Hertzberg, Robert P., Jurewicz, Anthony J., Chaikin, Margery A., Widdowson, Katherine, Foley, James J., Martin, Lenox D., Griswold, Don E., Sarau, Henry M.

“…Interleukin-8 (IL-8) and closely related Glu-Leu-Arg (ELR) containing CXC chemokines, including growth-related oncogene (GRO)α, GROβ, GROγ, and epithelial…”
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Identification of Potent, Selective Non-peptide CC Chemokine Receptor-3 Antagonist That Inhibits Eotaxin-, Eotaxin-2-, and Monocyte Chemotactic Protein-4-induced Eosinophil Migration by White, John R., Lee, Judithann M., Dede, Kimberly, Imburgia, Christina S., Jurewicz, Anthony J., Chan, George, Fornwald, James A., Dhanak, Dashyant, Christmann, Lisa T., Darcy, Michael G., Widdowson, Katherine L., Foley, James J., Schmidt, Dulcie B., Sarau, Henry M.

“…Eosinophils have been implicated in the pathogenesis of asthma and other allergic diseases. Several CC chemokines including eotaxin (CCL-11), eotaxin-2…”
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Abstract LB-317: Combination therapy with ofatumumab and bendamustine in xenograft model of chronic lymphocytic leukemia by Haskova, Zdenka, Whitacre, Margaret, Dede, Kimberly, Lee, Judithann M., Trulli, Stephen H., Ciucci, Marc, Toso, John, White, John, Jonak, Zdenka L.

“…Abstract Ofatumumab (OFA) is a fully human CD20 monoclonal antibody (mAb) recently approved for treatment of patients with fludarabine- and…”
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Design and evaluation of small peptides mapping the exposed surface of IL-8 by Thompson, S K, Veber, D F, Jurewicz, A J, Peishoff, C E, Lee, J M, White, J R

“…In an effort to determine which regions of IL-8 are involved in interactions with its receptors, eight peptides were designed to correspond to distinct exposed…”
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Cystine Uptake by Cultured Cells Originating from Dog Proximal Tubule Segments by Beatrice States, Reynolds, Robert, Judithann Lee, Segal, Stanton

“…Large numbers of kidney epithelial cells were cultured successfully from isolated dog proximal tubule segments. Cells in primary culture and in first passage…”
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Discovery of potent and selective phenylalanine derived CCR3 receptor antagonists. Part 2 by Dhanak, Dashyant, Christmann, Lisa T, Darcy, Michael G, Keenan, Richard M, Knight, Steven D, Lee, Judithann, Ridgers, Lance H, Sarau, Henry M, Shah, Dinubhai H, White, John R, Zhang, Lily

“…Highly potent CCR3 antagonists have been developed from a previously reported series of phenylalanine ester-based leads. Solution-phase, parallel synthesis…”
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SB-265610, an Il-8 antagonist, is a potent inhibitor of PMN chemotaxis and is effective in the rabbit immune complex model of colitis by White, John R., Lee, Judithann M., Flanigan, Ann, Widdowson, Katherine L., Sarau, Henry M., Coppola, Domenico, Murthy, Sreekant

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Discovery of potent and selective phenylalanine derived CCR3 antagonists. Part 1 by Dhanak, Dashyant, Christmann, Lisa T., Darcy, Michael G., Jurewicz, Anthony J., Keenan, Richard M., Lee, Judithann, Sarau, Henry M., Widdowson, Katherine L., White, John R.

“…The discovery of a series of phenylalanine derived CCR3 antagonists is reported. Parallel, solution-phase library synthesis has been utilized to delineate the…”
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The role of the anionic groups in the receptor binding of interleukin-8 antagonists by Widdowson, Katherine, Nie, Hong, Jurewicz, Anthony J, Hertzberg, Robert P, Sarau, Henry M, Foley, James J, Lee, JudithAnn, White, John R, Veber, Daniel F

“…SummaryIn an effort to determine the role of the acidic group in the receptor binding ofN-(2-hydroxy-4-nitrophenyl)-N′-(phenyl) urea, an interleukin-8B…”
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EFFECT OF CYSTINE DIMETHYLESTER (CDM) ON RENAL TUBULAR FUNCTION, A MODEL OF FANCONI SYNDROME by Foreman, John W, Lee, Judithann, Bowring, Margaret Ann, Segal, Stanton

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Effect of cystine dimethylester on renal solute handling and isolated renal tubule transport in the rat: a new model of the Fanconi syndrome by Foreman, J W, Bowring, M A, Lee, J, States, B, Segal, S

“…The effect of cystine dimethylester on the renal handling of phosphate, glucose, alpha-amino nitrogen, amino acids, and protein in vivo and on the uptake of…”
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Characteristics of cystine uptake by cultured LLC-PK1 cells by Foreman, J W, Lee, J, Segal, S

“…The characteristics of the uptake of L-cystine by LLC-PK1 cells were examined. The uptake diminished with time in culture after passage of cells while the…”
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Cystine and lysine transport in cultured human renal epithelial cells by States, B, Foreman, J, Lee, J, Harris, D, Segal, S

“…The transport of the amino acids, cystine and lysine, was studied in epithelial cell lines propagated from human kidney cortex. Cystine uptake data were…”
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Characteristics of lysine transport by isolated rat renal cortical tubule fragments by Bowring, M A, Foreman, J W, Lee, J, Segal, S

“…The uptake of L-lysine was examined in isolated renal cortical tubules. Lysine was actively taken up by the renal tubule cells isolated from 7-week-old rats…”
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Cystine-glutamate transport interactions in rat renal cortical tubules, brushborder vesicles, and cultured renal tubule cells by Foreman, J W, McNamara, P D, Bowring, M A, Lee, J, Rea, C, Segal, S

“…Glutamate had no significant effect on the uptake of 0.025 mM cystine by isolated rat renal cortical tubules and brushborder membrane vesicles in contrast to…”
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Characteristics of cultured human renal cortical epithelia by States, B, Foreman, J, Lee, J, Segal, S

“…Nine human kidney epithelial cell lines, isolated from small biopsied material and from whole kidney, were propagated in both a hormonally defined medium and a…”
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