Search Results - "Judice, Wagner A. S"

Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-Like rCPB2.8 by Judice, Wagner A S, Manfredi, Marcella A, Souza, Gerson P, Sansevero, Thiago M, Almeida, Paulo C, Shida, Cláudio S, Gesteira, Tarsis F, Juliano, Luiz, Westrop, Gareth D, Sanderson, Sanya J, Coombs, Graham H, Tersariol, Ivarne L S

“…Cysteine protease B is considered crucial for the survival and infectivity of the Leishmania in its human host. Several microorganism pathogens bind to the…”
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Kosmotropic Salt Activation and Substrate Specificity of Poliovirus Protease 3C by Gouvea, Iuri E, Judice, Wagner A. S, Cezari, Maria H. S, Juliano, Maria A, Juhász, Tünde, Szeltner, Zoltán, Polgár, László, Juliano, Luiz

“…Picornaviruses produce a large polyprotein, which is cleaved by virally encoded cysteine peptidases, picornain-2A and -3C. Picornain-3C has characteristics of…”
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Leishmanicidal, antiproteolytic and antioxidant evaluation of natural biflavonoids isolated from Garcinia brasiliensis and their semisynthetic derivatives by Gontijo, Vanessa Silva, Judice, Wagner A.S., Codonho, Barbara, Pereira, Ivan Oliveira, Assis, Diego Magno, Januário, Jaqueline Pereira, Caroselli, Elide E., Juliano, Maria Aparecida, de Carvalho Dosatti, Amanda, Marques, Marcos José, Junior, Claudio Viegas, Henrique dos Santos, Marcelo

“…The natural biflavonoids morelloflavone-4‴-O-β-d-glycosyl (1), (±)-fukugiside (2) and morelloflavone (3) were isolated from the ethyl acetate extract (EAEE) of…”
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Endocytosis and the Participation of Glycosaminoglycans Are Important to the Mechanism of Cell Death Induced by β‑Hairpin Antimicrobial Peptides by Buri, Marcus Vinicius, Sperandio, Letícia Paulino, de Souza, Kamylla F. S, Antunes, Fernanda, Rezende, Marina Mastelaro, Melo, Carina Mucciolo, Pinhal, Maria A. S, Barros, Carlos C, Fernig, David G, Yates, Edwin A, Ide, Jaime S, Smaili, Soraya S, Riske, Karin A, Nader, Helena B, Luis dos Santos Tersariol, Ivarne, Lima, Marcelo Andrade, Judice, Wagner A. S, Miranda, Antonio, Paredes-Gamero, Edgar J

“…The cytotoxic mode of action of four antimicrobial peptides (AMPs) (gomesin, tachyplesin, protegrin, and polyphemusin) against a HeLa cell tumor model is…”
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Cytotoxicity of 4-substituted quinoline derivatives: Anticancer and antileishmanial potential by Costa, Claudia A., Lopes, Rayssa M., Ferraz, Leticia S., Esteves, Gabriela N.N., Di Iorio, Juliana F., Souza, Aline A., de Oliveira, Isadora M., Manarin, Flavia, Judice, Wagner A.S., Stefani, Helio A., Rodrigues, Tiago

“…[Display omitted] Chemical modifications of quinoline moiety have been recognized as a useful strategy to development of new drugs. Here, the cytotoxicity of a…”
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Cysteine proteases as potential targets for anti-trypanosomatid drug discovery by Judice, Wagner A.S., Ferraz, Letícia Silva, Lopes, Rayssa de Mello, Vianna, Luan dos Santos, Siqueira, Fábio da Silva, Di Iorio, Juliana F., Dalzoto, Laura de Azevedo Maffeis, Trujilho, Mariana Nascimento Romero, Santos, Taiz dos Reis, Machado, Maurício F.M., Rodrigues, Tiago

“…[Display omitted] Leishmaniasis and trypanosomiasis are endemic neglected disease in South America and Africa and considered a significant public health…”
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Repurposing of 5‐nitrofuran‐3,5‐disubstituted isoxazoles: A thriving scaffold to antitrypanosomal agents by Carvalho, Diego B., Neves, Amarith R., Portapilla, Gisele B., Soares, Ozildeia, Santos, Larissa B. B., Oliveira, Jefferson R. S., Vianna, Luan S., Judice, Wagner A. S., Cardoso, Iara A., Luccas, Pedro H., Nonato, M. Cristina, Lopes, Norberto P., Albuquerque, Sergio, Baroni, Adriano C. M.

“…Chagas disease (CD) is a neglected disease caused by the protozoan Trypanosoma cruzi. The two drugs used in the treatment schedules exhibit adverse effects and…”
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Hydrolytic Properties and Substrate Specificity of the Foot-and-Mouth Disease Leader Protease by Santos, Jorge A. N, Gouvea, Iuri E, Júdice, Wagner A. S, Izidoro, Mario A, Alves, Fabiana M, Melo, Robson L, Juliano, Maria A, Skern, Tim, Juliano, Luiz

“…Foot-and-mouth disease virus, a global animal pathogen, possesses a single-stranded RNA genome that, on release into the infected cell, is immediately…”
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Design, Synthesis, Biological Evaluation and Molecular Modeling Studies of Novel Eugenol Esters as Leishmanicidal Agents by Coelho, Camila, dos Santos, Thiago, Freitas, Poliany, Nunes, Juliana, Marques, Marcos, Padovani, Camila, Júdice, Wagner, Camps, Ihosvany, da Silveira, Nelson, Carvalho, Diogo, Veloso, Marcia

“…Leishmaniasis is a neglected pathology with a high incidence worldwide, and is a governmental health issue due to the increased morbidity and mortality…”
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4′-Hydroxy-6,7-methylenedioxy-3-methoxyflavone: A novel flavonoid from Dulacia egleri with potential inhibitory activity against cathepsins B and L by de Novais, Leice M.R., de Arueira, Cauane C.O., Ferreira, Luiz F., Ribeiro, Tereza A.N., Sousa, Paulo T., Jacinto, Marcos J., de Carvalho, Mário G., Judice, Wagner A.S., Jesus, Larissa O.P., de Souza, Aline A., Torquato, Heron F.V., Paredes-Gamero, Edgar J., Silva, Virginia C.

“…A new flavone, 4′-hydroxy-6,7-methylenedioxy-3-methoxyflavone 1, and two other nucleosides, ribavirin 2 and adenosine 3, were isolated from the leaves of…”
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The substrate specificity of cruzipain 2, a cysteine protease isoform from Trypanosoma cruzi by Dos Reis, Flavia C. G., Júdice, Wagner A. S., Juliano, Maria A., Juliano, Luiz, Scharfstein, Julio, De A. Lima, Ana Paula C.

“…Abstract Papain-like cysteine proteases are important for the survival of the flagellated protozoa Trypanosoma cruzi, the causative agent of Chagas' Disease…”
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A study of human furin specificity using synthetic peptides derived from natural substrates, and effects of potassium ions by Izidoro, Mario A., Gouvea, Iuri E., Santos, Jorge A.N., Assis, Diego M., Oliveira, Vitor, Judice, Wagner A.S., Juliano, Maria A., Lindberg, Iris, Juliano, Luiz

“…We explored furin substrate requirements in addition to the motif R-X-K/R-R using synthetic fluorescent resonance energy transfer (FRET) decapeptides. These…”
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Foot and mouth disease leader protease (Lbpro): Investigation of prime side specificity allows the synthesis of a potent inhibitor by Nogueira Santos, Jorge Alexandre, Assis, Diego M., Gouvea, Iuri Estrada, Júdice, Wagner A.S., Izidoro, Mario Augusto, Juliano, Maria Aparecida, Skern, Tim, Juliano, Luiz

“…Foot and mouth disease virus expresses its genetic information as a single polyprotein that is translated from the single-stranded RNA genome. Proteinases…”
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Synthesis, protease inhibition, and antileishmanial activity of new benzoxazoles derived from acetophenone or benzophenone and synthetic precursors by Folquitto, Laís R. S., Nogueira, Priscila F., Espuri, Patrícia F., Gontijo, Vanessa S., de Souza, Thiago B., Marques, Marcos J., Carvalho, Diogo T., Júdice, Wagner A. S., Dias, Danielle F.

“…This work reports the synthesis, protease inhibition, and antileishmanial activity of ten benzoxazole derivatives, which were obtained in a three-step…”
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Cyclopalladated compounds containing 2,6-lutidine: Synthesis, spectral and biological studies by da Cunha, Gislaine A., de Souza, Ronan F.F., de Farias, Renan L., Moreira, Mariete B., Silva, Débora E.S., Zanetti, Renan D., Garcia, Daniel M., Spindola, Daniel G., Michelin, Luis F.G., Bincoletto, Claudia, de Souza, Aline A., Antunes, Alyne A., Judice, Wagner A. de S., Leitao, Renan C.F., Deflon, Victor M., Mauro, Antônio E., Netto, Adelino V.G.

“…Bridge splitting reactions between [Pd(C2,N-dmba)(μ-X)]2 (dmba = N,N-dimethylbenzylamine; X = Cl, I, N3, NCO) and 2,6-lutidine (lut) in the 1:2 molar ratio at…”
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Antileishmanial activity and insights into the mechanisms of action of symmetric Au(I) benzyl and aryl-N-heterocyclic carbenes by Rosa, Letícia B., Galuppo, Carolina, Lima, Rochanna L.A., Fontes, Josielle V., Siqueira, Fábio S., Júdice, Wagner A.S., Abbehausen, Camilla, Miguel, Danilo C.

“…Leishmania amazonensis and L. braziliensis are the main etiological agents of the American Tegumentary Leishmaniasis (ATL). Taking into account the limited…”
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Carboxydipeptidase activities of recombinant cysteine peptidases. Cruzain of Trypanosoma cruzi and CPB of Leishmania mexicana by Judice, Wagner A S, Puzer, Luciano, Cotrin, Simone S, Carmona, Adriana K, Coombs, Graham H, Juliano, Luiz, Juliano, Maria A

“…The recombinant cysteine peptidases, cruzain from Trypanosoma cruzi and CPB2.8DeltaCTE from Leishmania mexicana, are cathepsin L-like and characteristically…”
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Leishmania (L.) amazonensis peptidase activities inside the living cells and in their lysates by Caroselli, Elide E., Assis, Diego M., Barbiéri, Clara L., Júdice, Wagner A.S., Juliano, Maria A., Gazarini, Marcos L., Juliano, Luiz

“…[Display omitted] ► Leishmania amastigotes incorporate only peptides containing positively charged amino acids. ► Leishmania express cysteine peptidases…”
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Differences in substrate specificities between cysteine protease CPB isoforms of Leishmania mexicana are mediated by a few amino acid changes by Juliano, Maria A., Brooks, Darren R., Selzer, Paul M., Pandolfo, Hector L., Judice, Wagner A. S., Juliano, Luiz, Meldal, Morten, Sanderson, Sanya J., Mottram, Jeremy C., Coombs, Graham H.

“…The CPB genes of the protozoan parasite Leishmania mexicana encode stage‐regulated cathepsin L‐like cysteine proteases that are important virulence factors and…”
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Eleocarpanthraquinone, a novel anthraquinone from Rhamnidium elaeocarpum (Rhamnaceae) by Kauffmann, Angélica C., Oliveira, Rhayssa G.S.P., Dourado, Thainara A., Soares, Iuri N., de Sousa, Paulo T., Ribeiro, Tereza A.N., Jacinto, Marcos J., de Souza, Gabriel L.C., Judice, Wagner A. de S., Emiliano, Marli de F.C., Vianna, Luan dos S., de Carvalho, Mário G., Silva, Virgínia C.P.

“…[Display omitted] •First report of new anthrone-anthraquinone from the stem bark of Rhamnidium elaeocarpum.•Eleocarpanthraquinone (1) exhibited inhibition of…”
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