Search Results - "Judge, Susan"

Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets by Nimmagadda, Vamshi K, Bever, Christopher T, Vattikunta, Narasimha R, Talat, Saifi, Ahmad, Vakas, Nagalla, Naveen K, Trisler, David, Judge, Susan I V, Royal, 3rd, Walter, Chandrasekaran, Krish, Russell, James W, Makar, Tapas K

“…Treatment of experimental autoimmune encephalomyelitis (EAE) with resveratrol, an activator of sirtuin 1 (SIRT1), reduces disease severity. This suggested that…”
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TrkB agonist, 7,8-dihydroxyflavone, reduces the clinical and pathological severity of a murine model of multiple sclerosis by Makar, Tapas K, Nimmagadda, Vamshi K.C, Singh, Ishwar S, Lam, Kristal, Mubariz, Fahad, Judge, Susan I.V, Trisler, David, Bever, Christopher T

“…Abstract 7,8-Dihydroxyflavone (DHF), is a recently described TrkB agonist that readily crosses the blood brain barrier. We treated C57Bl/6 mice with MOG —…”
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Unique amalgamation of primary and secondary structural elements transform peptaibols into potent bioactive cell-penetrating peptides by Du, Lin, Risinger, April L., Mitchell, Carter A., You, Jianlan, Stamps, Blake W., Pan, Ning, King, Jarrod B., Bopassa, Jean C., Judge, Susan I. V., Yang, Zhibo, Stevenson, Bradley S., Cichewicz, Robert H.

“…Mass-spectrometry-based metabolomics and molecular phylogeny data were used to identify a metabolically prolific strain of Tolypocladium that was obtained from…”
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Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment by Judge, Susan I V, Bever, Jr, Christopher T

“…Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) characterized by demyelination, with a relative sparing of axons. In MS…”
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The Voltage-Gated Potassium Channel Kv1.3 Is Highly Expressed on Inflammatory Infiltrates in Multiple Sclerosis Brain by Rus, Horea, Pardo, Carlos A., Hu, Lina, Darrah, Erika, Cudrici, Cornelia, Niculescu, Teodora, Niculescu, Florin, Mullen, Katharine M., Allie, Rameeza, Guo, Liping, Wulff, Heike, Beeton, Christine, Susan I. V. Judge, Kerr, Douglas A., Knaus, Hans-Gunther, Chandy, K. George, Calabresi, Peter A., Latorre, Ramon

“…Multiple Sclerosis (MS) is characterized by central nervous system perivenular and parenchymal mononuclear cell infiltrates consisting of activated T cells and…”
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Use of engineered bone marrow stem cells to deliver brain derived neurotrophic factor under the control of a tetracycline sensitive response element in experimental allergic encephalomyelitis by Makar, Tapas K, Nimmagadda, Vamshi K.C, Patibandla, Gopi K, Le, Toby, Judge, Susan I.V, Trisler, David, Bever, Christopher T

“…Abstract Brain derived neurotrophic factor (BDNF) has neuroprotective properties but its use has been limited by poor penetration of the blood brain barrier…”
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Potassium channels Kv1.3 and Kv1.5 are expressed on blood-derived dendritic cells in the central nervous system by Mullen, Katherine M., Rozycka, Monika, Rus, Horea, Hu, Lina, Cudrici, Cornelia, Zafranskaia, Ekaterina, Pennington, Michael W., Johns, David C., Judge, Susan I. V., Calabresi, Peter A.

“…Objective Potassium (K+) channels on immune cells have gained attention recently as promising targets of therapy for immune‐mediated neurological diseases such…”
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Sustained-release fampridine for multiple sclerosis by Bever, Christopher T, Judge, Susan Iv

“…Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system of unknown cause in which neurological impairment…”
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Evaluation of combination gene therapy with PTEN and antisense hTERT for malignant glioma in vitro and xenografts by You, Yongping, Geng, Xiaozeng, Zhao, Peng, Fu, Zhen, Wang, Cunzu, Chao, Shengwu, Liu, Ning, Lu, Ailing, Gardner, Kevin, Pu, Peiyu, Kong, Chunsheng, Ge, Yun, Judge, Susan I. V, Li, Qingdi Q

“…Telomerase activation is a critical event in cell immortalization, and an increase in human telomerase reverse transcriptase (hTERT) expression is the key step…”
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Voltage-gated potassium channels in multiple sclerosis: Overview and new implications for treatment of central nervous system inflammation and degeneration by Judge, Susan I V, Lee, Jennifer M, Bever, Jr, Christopher T, Hoffman, Paul M

“…Inflammatory tissue damage and the presence of reactive immunocompetent T lymphocytes, macrophages, microglia, and dendritic cells (DCs) are characteristic…”
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Potassium channel blockers and openers as CNS neurologic therapeutic agents by Judge, Susan I V, Smith, Paul J, Stewart, Peggy E, Bever, Jr, Christopher T

“…Potassium (K+) channels are the most heterogeneous and widely distributed class of ion channels. K(+) channels are dynamic pore-forming transmembrane proteins…”
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The human WW45 protein enhances MST1-mediated apoptosis in vivo by Luo, Xuelai, Li, Zhaoming, Yan, Qun, Li, Xiaolan, Tao, Deding, Wang, Jing, Leng, Yan, Gardner, Kevin, Judge, Susan, Li, Qingdi, Hu, Junbo, Gong, Jianping

“…Mammalian sterile 20-like kinase 1 (MST1) is a serine/threonine protein kinase that is activated in response to a variety of apoptotic stimuli and causes…”
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Timing of apoptosis onset depends on cell cycle progression in peripheral blood lymphocytes and lymphocytic leukemia cells by YONGDONG FENG, JIANHONG WU, LI, Qingdi Q, JIANPING GONG, XIAOLAN FENG, DEDING TAO, JUNBO HU, JICHAO QIN, XIAOLAN LI, WET XIAO, GARDNER, Kevin, JUDGE, Susan I. V

“…Apoptosis results in cell death within 10 min after initiation by Bcl-2 family proteins and mitochondria; however, cells enter the apoptotic pathway at…”
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Dendritic cells are abundant in non-lesional gray matter in multiple sclerosis by Cudrici, Cornelia, Ito, Takahiro, Zafranskaia, Ekaterina, Niculescu, Florin, Mullen, Katherine M., Vlaicu, Sonia, Judge, Susan I.V., Calabresi, Peter A., Rus, Horea

“…We have analyzed the localization of dendritic cells (DCs) in non-lesional gray matter (NLGM) in comparison to non-lesional white matter (NLWM) and acute or…”
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C5b-9-activated, K(v)1.3 channels mediate oligodendrocyte cell cycle activation and dedifferentiation by Tegla, Cosmin A, Cudrici, Cornelia, Rozycka, Monika, Soloviova, Katerina, Ito, Takahiro, Singh, Anil K, Khan, Aamer, Azimzadeh, Philippe, Andrian-Albescu, Maria, Khan, Anver, Niculescu, Florin, Rus, Violeta, Judge, Susan I V, Rus, Horea

“…Voltage-gated potassium (K(v)) channels play an important role in the regulation of growth factor-induced cell proliferation. We have previously shown that…”
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C5b-9-activated, Kv1.3 channels mediate oligodendrocyte cell cycle activation and dedifferentiation by TEGLA, Cosmin A, CUDRICI, Cornelia, NICULESCU, Florin, RUS, Violeta, JUDGE, SusanI. V, RUS, Horea, ROZYCKA, Monika, SOLOVIOVA, Katerina, ITO, Takahiro, SINGH, Anil K, KHAN, Aamer, AZIMZADEH, Philippe, ANDRIAN-ALBESCU, Maria, KHAN, Anver

“…Voltage-gated potassium (K v ) channels play an important role in the regulation of growth factor-induced cell proliferation. We have previously shown that…”
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Determinants of 4-aminopyridine sensitivity in a human brain kv1.4 k(+) channel: phenylalanine substitutions in leucine heptad repeat region stabilize channel closed state by Judge, Susan I V, Yeh, Jay Z, Goolsby, James E, Monteiro, Mervyn J, Bever, Jr, Christopher T

“…The biophysical and pharmacological effects of individual phenylalanine-for-leucine (Phe-for-Leu) substitutions in the leucine heptad repeat region located at…”
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A Maurotoxin with Constrained Standard Disulfide Bridging by M'Barek, Sarrah, Lopez-Gonzalez, Ignacio, Andreotti, Nicolas, di Luccio, Eric, Visan, Violeta, Grissmer, Stephan, Judge, Susan, El Ayeb, Mohamed, Darbon, Hervé, Rochat, Hervé, Sampieri, François, Béraud, Evelyne, Fajloun, Ziad, De Waard, Michel, Sabatier, Jean-Marc

“…Maurotoxin (MTX) is a 34-residue toxin that has been isolated initially from the venom of the scorpion Scorpio maurus palmatus. It presents a large number of…”
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Inactivation gating and 4-AP sensitivity in human brain Kv1.4 potassium channel by Judge, Susan I.V, Monteiro, Mervyn J, Yeh, Jay Z, Bever, Christopher T

“…Voltage-gated K + channels vary in sensitivity to block by 4-aminopyridine (4-AP) over a 1000-fold range. Most K + channel phenotypes with leucine at the…”
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Treatment of Experimental Allergic Encephalomyelitis with 7,8 Dihydroxyflavone: Evidence for Neuroprotection (P2.187) by Nimmagadda, Vamshi, Makar, Tapas, Lam, Kristal, Judge, Susan, Trisler, David, Bever, Christopher

“…Abstract only…”
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