Search Results - "Judge, R"

Main group metal-mediated strategies for C-H and C-F bond activation and functionalisation of fluoroarenes by Judge, Neil, Logallo, Alessandra, Hevia, Eva

“…With fluoroaromatic compounds increasingly employed as scaffolds in agrochemicals and active pharmaceutical ingredients, the development of methods which…”
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Alkali‐Metal‐Alkoxide Powered Zincation of Fluoroarenes Employing Zinc Bis‐Amide Zn(TMP)2 by Judge, Neil R., Hevia, Eva

“…Reminiscent of Lochmann‐Schlosser superbase recipes, the addition of two molar equivalents of KOtBu to Zn(TMP)2 (TMP=2,2,6,6‐tetramethylpiperidide) transforms…”
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Loss of the inducible Hsp70 delays the inflammatory response to skeletal muscle injury and severely impairs muscle regeneration by Senf, Sarah M, Howard, Travis M, Ahn, Bumsoo, Ferreira, Leonardo F, Judge, Andrew R

“…Skeletal muscle regeneration following injury is a highly coordinated process that involves transient muscle inflammation, removal of necrotic cellular debris…”
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Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy by Reed, Sarah A., Sandesara, Pooja B., Senf, Sarah M., Judge, Andrew R.

“…Cachexia is characterized by inexorable muscle wasting that significantly affects patient prognosis and increases mortality. Therefore, understanding the…”
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p38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting by McClung, J M, Judge, A R, Powers, S K, Yan, Z

“…Oxidative stress is a primary trigger of cachectic muscle wasting, but the signaling pathway(s) that links it to the muscle wasting processes remains to be…”
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CrossTalk opposing view: The dominant mechanism causing disuse muscle atrophy is proteolysis by Reid, Michael B., Judge, Andrew R., Bodine, Sue C.

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FOXO signaling is required for disuse muscle atrophy and is directly regulated by Hsp70 by Senf, Sarah M, Dodd, Stephen L, Judge, Andrew R

“…The purpose of the current study was to determine whether heat shock protein 70 (Hsp70) directly regulates forkhead box O (FOXO) signaling in skeletal muscle…”
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Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy by Ebert, Scott M, Rasmussen, Blake B, Judge, Andrew R, Judge, Sarah M, Larsson, Lars, Wek, Ronald C, Anthony, Tracy G, Marcotte, George R, Miller, Matthew J, Yorek, Mark A, Vella, Adrian, Volpi, Elena, Stern, Jennifer I, Strub, Matthew D, Ryan, Zachary, Talley, John J, Adams, Christopher M

“…Activating transcription factor 4 (ATF4) is a multifunctional transcription regulatory protein in the basic leucine zipper superfamily. ATF4 can be expressed…”
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Full 3D finite element modelling of spiral strand cables by Judge, R., Yang, Z., Jones, S.W., Beattie, G.

“…► Full 3D elasto-plastic finite element models of multi-layer spiral strand cables are developed. ► A novel procedure to generate the complex geometry and FE…”
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Donor‐influenced Structure–Activity Correlations in Stoichiometric and Catalytic Reactions of Lithium Monoamido‐Monohydrido‐Dialkylaluminates by Lemmerz, Lara E., McLellan, Ross, Judge, Neil R., Kennedy, Alan R., Orr, Samantha A., Uzelac, Marina, Hevia, Eva, Robertson, Stuart D., Okuda, Jun, Mulvey, Robert E.

“…A series of heteroleptic monoamido‐monohydrido‐dialkylaluminate complexes of general formula [iBu2AlTMPHLi⋅donor] were synthesized and characterised in…”
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Models of accelerated sarcopenia: Critical pieces for solving the puzzle of age-related muscle atrophy by Buford, Thomas W, Anton, Stephen D, Judge, Andrew R, Marzetti, Emanuele, Wohlgemuth, Stephanie E, Carter, Christy S, Leeuwenburgh, Christiaan, Pahor, Marco, Manini, Todd M

“…Abstract Sarcopenia, the age-related loss of skeletal muscle mass, is a significant public health concern that continues to grow in relevance as the population…”
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MYOD1 functions as a clock amplifier as well as a critical co-factor for downstream circadian gene expression in muscle by Hodge, Brian A, Zhang, Xiping, Gutierrez-Monreal, Miguel A, Cao, Yi, Hammers, David W, Yao, Zizhen, Wolff, Christopher A, Du, Ping, Kemler, Denise, Judge, Andrew R, Esser, Karyn A

“…In the present study we show that the master myogenic regulatory factor, MYOD1, is a positive modulator of molecular clock amplitude and functions with the…”
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Mas Receptor Activation Slows Tumor Growth and Attenuates Muscle Wasting in Cancer by Murphy, Kate T, Hossain, Mohammed I, Swiderski, Kristy, Chee, Annabel, Naim, Timur, Trieu, Jennifer, Haynes, Vanessa, Read, Suzannah J, Stapleton, David I, Judge, Sarah M, Trevino, Jose G, Judge, Andrew R, Lynch, Gordon S

“…Cancer cachexia is a multifactorial syndrome characterized by a progressive loss of skeletal muscle mass associated with significant functional impairment…”
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Tumour‐derived leukaemia inhibitory factor is a major driver of cancer cachexia and morbidity in C26 tumour‐bearing mice by Kandarian, Susan C., Nosacka, Rachel L., Delitto, Andrea E., Judge, Andrew R., Judge, Sarah M., Ganey, John D., Moreira, Jesse D., Jackman, Robert W.

“…Background Cancer cachexia is a metabolic wasting syndrome that is strongly associated with a poor prognosis. The initiating factors causing fat and muscle…”
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p300 Acetyltransferase activity differentially regulates the localization and activity of the FOXO homologues in skeletal muscle by Senf, Sarah M, Sandesara, Pooja B, Reed, Sarah A, Judge, Andrew R

“…The Forkhead Box O (FOXO) transcription factors regulate diverse cellular processes, and in skeletal muscle are both necessary and sufficient for muscle…”
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Identification of the Acetylation and Ubiquitin-Modified Proteome during the Progression of Skeletal Muscle Atrophy by Ryder, Daniel J, Judge, Sarah M, Beharry, Adam W, Farnsworth, Charles L, Silva, Jeffrey C, Judge, Andrew R

“…Skeletal muscle atrophy is a consequence of several physiological and pathophysiological conditions including muscle disuse, aging and diseases such as cancer…”
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Skeletal muscle interleukin-6 regulation in hyperthermia by Welc, Steven S, Judge, Andrew R, Clanton, Thomas L

“…We previously reported that IL-6 production is acutely elevated in skeletal muscles exposed to ≥41°C, but the regulatory pathways are poorly understood. The…”
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Calpain-1 is required for hydrogen peroxide-induced myotube atrophy by McClung, J M, Judge, A R, Talbert, E E, Powers, S K

“…Recent reports suggest numerous roles for cysteine proteases in the progression of skeletal muscle atrophy due to disuse or disease. Nonetheless, a specific…”
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Diaphragm and ventilatory dysfunction during cancer cachexia by Roberts, Brandon M., Ahn, Bumsoo, Smuder, Ashley J., Al‐Rajhi, Monsour, Gill, Luther C., Beharry, Adam W., Powers, Scott K., Fuller, David D., Ferreira, Leonardo F., Judge, Andrew R.

“…Cancer cachexia is characterized by a continuous loss of locomotor skeletal muscle mass, which causes profound muscle weakness. If this atrophy and weakness…”
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FoxP1 is a transcriptional repressor associated with cancer cachexia that induces skeletal muscle wasting and weakness by Neyroud, Daria, Nosacka, Rachel L., Callaway, Chandler S., Trevino, Jose G., Hu, Hui, Judge, Sarah M., Judge, Andrew R.

“…Background Skeletal muscle wasting is a devastating consequence of cancer that affects up to 80% of cancer patients and associates with reduced survival…”
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