Search Results - "Jubie, Selvaraj"

Acute oral toxicity study of novel polyherbal formulations by using wistar rats and Swiss albino mice as per OECD 425 TG by Jatoth, Ramkishan, Dhanabal, S.P, Senthil, V., Ganesh, T., Selvaraj, Jubie, Venkatesan, P.S.

“…Hydaljss08 is a new semisolid fermented hydroalcoholic polyherbal formulation containing crude drug substances. Immunoboost Tab is a novel polyherbal dosage…”
Get full text

Synthesis and Characterization of Dipeptide–Drug Conjugate: The Use of Linker Coupling Reaction by Ramamurthi, Deepthi, Selvaraj, Jubie, Patnaik, Sunil Kumar, Palathoti, Nagarjuna, Rajeshkumar, Raman, Chandrasekar, Moola Joghee Nanjan

“…Most of the effective anticancer drugs available in the market suffer from adverse effects due to their lack of target specificity. Therefore, so many delivery…”
Get full text

Modulation of Nrf2 by activation of estrogen receptor β as a therapeutic strategy to prevent cancer development and overcome inflammation-related drug resistance in breast cancer by Rymbai, Emdormi, Sugumar, Deepa, Selvaraj, Jubie, Kothandam, Ram, Selvaraj, Divakar

“…Despite the tremendous progress in breast cancer diagnosis and treatment, the mortality rate is expected to increase due to the emergence of drug resistance…”
Get full text

Identification of (2,3)-2-(3,4-dihydroxyphenyl)chroman-3-yl-3,4,5-trihydroxy benzoate as multiple inhibitors of SARS-CoV-2 targets; a systematic molecular modelling approach by Selvaraj, Jubie, Sundar P, Shyam, Rajan, Logesh, Selvaraj, Divakar, Palanisamy, Dhanabal, Namboori PK, Krishnan, Mohankumar, Suresh Kumar

“…Coronavirus disease of 2019 (COVID-19) is a zoonotic disease caused by a new severe acute respiratory syndrome (SARS-CoV-2) which has quickly resulted in a…”
Get full text

Plant Derived Immunomodulators; A Critical Review by Swaroop, Akey Krishna, Motamarri Venkata Naga Lalitha, Chaitanya, Shanmugam, Meena, Subramanian, Gomathy, Natarajan, Jawahar, Selvaraj, Jubie

“…The concept of immunomodulation was proposed by Edward Jenner, while working on polio vaccine in 1796. Many of the autoimmune diseases such as rheumatoid…”
Get full text

Thioredoxin Interacting Protein Inhibitors in Diabetes Mellitus: A Critical Review by Kar, Ayushi, Paramasivam, Balamurugan, Jayakumar, Darshini, Swaroop, Akey Krishna, Jubie, Selvaraj

“…Diabetes Mellitus (DM) is one of the highest contributors to global mortality, exceeding numbers of even the three major infectious diseases in the world,…”
Get more information

Phytochemical and in-vitro Biological Investigation of Indian Traditional Medicinal Plants for their Cytotoxicity and Hepatoprotective Potential by Chaitanya, Mvnl, Selvaraj, Jubie, Palanisamy, Dhanabal, Thangavelu, Prabha, Usamo, Firehiwot Belayneh

“…This study aimed to select 16 medicinal plants based on their folklore remedy for treating various diseases like inflammation, cancer, etc., and scientifically…”
Get more information

Coumarin-Fatty Acid Conjugates as Potential ERα/AKT-1 Antagonists for ER Positive Breast Cancer by Selvaraj, Jubie, John, Jameera B A, Joghee, Nanjan M, Antony, Justin, Wadhwani, Ashish, Natarajan, Jawahar

“…Current drugs used for the treatment of hormone-dependent breast cancer function as anti-estrogens in the breast, in addition to Estrogen Receptor (ER)…”
Get more information

Potential Pharmacological Inhibitors of Pim Kinase Under Clinical Trials by Jeyapal, Gomathi P, Chandrasekar, Moola J N, Krishnasamy, Rajendiran, Selvaraj, Jubie, Mohammad, Manal, Nanjan, Moola J

“…Pim kinases, also known as Serine/Threonine kinases, are intensively studied protein drug targets in cancer research. They play crucial role in the regulation…”
Get more information

Hybrid virtual screening and molecular dynamics approach for identification of allosteric modulator of EAAT2 by Manisha, Chennu, Palathoti, Nagarjuna, Chand, Jagdish, Krishna Swaroop, Akey, Selvaraj, Jubie, Kumar, B.R. Prashantha, Naveentha X, Prisil, Durairaj, Brindha, Justin, Antony

“…[Display omitted] EAAT2, a glial protein that clears excess glutamate from synapses, regulates synaptic transmission, and prevents excitotoxicity in neurons is…”
Get full text

Relevance of Machine Learning to Predict the Inhibitory Activity of Small Thiazole Chemicals on Estrogen Receptor by Jayaprakash, Venkatesan, Saravanan, Thangavelu, Ravindran, Karuppaiyan, Prabha, Thangavelu, Selvaraj, Jubie, Jayapalan, Sudeepan, Chaitanya, M V N L, Sivakumar, Thangavel

“…Drug discovery requires the use of hybrid technologies for the discovery of new chemical substances. One of those interesting strategies is QSAR via applying…”
Get more information

Dual evaluation of some novel chalcone annulated pyrazolines as anti-inflammatory and antimicrobial agents via in-silico target study on cyclooxygenase-2 by Thangavelu Prabha, Selvaraj Jubie, Palanisamy Selvamani, Subbiah Latha, Thangavel Sivakumar

“…A novel series of chalcone bearing pyrazoline moieties were (P1 to P7) synthesized and characterized by various analytical techniques. The anti-inflammatory…”
Get full text

Hydroxychloroquine and curcumin conjugates as multifunctional co drugs for the potential treatment of COVID-19: An in-silico based study by Thangavelu Prabha, Palanisamy Dhanabal, Palanisamy Selvamani, Subbiah Latha, Thangavel Sivakumar, Selvaraj Jubie

“…The present study has been undertaken to search the novel co drugs for fighting against the COVID-19 disease through an in- silico approach. We have designed…”
Get full text

Synthesis and evaluation of coumate analogues as estrogen receptor inhibitors for breast cancer therapy by Selvaraj Jubie, Basheer A, Neetu Yadav, Ashish Wadhwani, Mohammed Afzal Azam

“…A sulphatase inhibitor 667 COUMATE is in clinical trials for estrogen-positive breast cancer therapy for postmenopausal women, while there are a number of…”
Get full text

Synthesis and Neuropharmacological Evaluation of Some Novel Quinoxaline 2, 3-Dione Derivatives by Jubie, Selvaraj, Gayathri, Rajamanickam, Kalirajan, Rajagopal

“…Quinoxaline-2, 3-dione obtained from cyclocondensation reaction of o-phenylene diamine with oxalic acid was reacted with three different ketones and…”
Get full text

Dual targeting DNA gyrase B (GyrB) and topoisomerse IV (ParE) inhibitors: A review by Azam, Mohammed Afzal, Thathan, Janarthanan, Jubie, Selvaraj

“…GyrB and ParE are type IIA topoisomerases and found in most bacteria. Its function is vital for DNA replication, repair and decatenation. The highly conserved…”
Get full text

The identification of cianidanol as a selective estrogen receptor beta agonist and evaluation of its neuroprotective effects on Parkinson's disease models by Rymbai, Emdormi, Sugumar, Deepa, Chakkittukandiyil, Amritha, Kothandan, Ram, Selvaraj, Jubie, Selvaraj, Divakar

“…The present study aims to identify selective estrogen receptor beta (ERβ) agonists and to evaluate the neuroprotective mechanism in Parkinson's disease (PD)…”
Get full text

Navigating IL-6: From molecular mechanisms to therapeutic breakthroughs by Swaroop, Akey Krishna, Negi, Preeya, Kar, Ayushi, Mariappan, Esakkimuthukumar, Natarajan, Jawahar, Namboori P.K., Krishnan, Selvaraj, Jubie

“…This concise review navigates the intricate realm of Interleukin-6 (IL-6), an important member of the cytokine family. Beginning with an introduction to…”
Get full text

Enhanced oral bioavailability of an antipsychotic drug through nanostructured lipid carriers by Jawahar, Natarajan, Hingarh, Prashant Kumar, Arun, Radhakrishnan, Selvaraj, Jubie, Anbarasan, Arigo, S, Sathianarayanan, G, Nagaraju

“…•Formulation of Nanostructured Lipid Carriers containing antipsychotic drug by solvent diffusion method.•Physico – chemical Characterization of the prepared…”
Get full text

"In-silico Design and Development of Novel Hydroxyurea Lipid Drug Conjugates for Breast Cancer Therapy Targeting PI3K/AKT/mTOR Pathway" by Dharmaraj, Saranya, Swaroop, Akey Krishna, Esakkimuthukumar, Mariappan, Negi, Preeya, Jubie, Selvaraj

“…Hydroxyurea (HU) has shown promise in breast cancer treatment, but its hydrophilic nature limits its efficacy. Therefore, conjugating HU with lipids could…”
Get more information