Search Results - "Jubb, AM"

Methylation and colorectal cancer by Jubb, A. M., Bell, S. M., Quirke, P.

“…Statistics rate colorectal adenocarcinoma as the most common cause of cancer death on exclusion of smoking‐related neoplasia. However, the reported…”
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Association of k-ras, b-raf, and p53 Status With the Treatment Effect of Bevacizumab by Ince, William L., Jubb, Adrian M., Holden, Scott N., Holmgren, Eric B., Tobin, Patti, Sridhar, Meera, Hurwitz, Herbert I., Kabbinavar, Fairooz, Novotny, William F., Hillan, Kenneth J., Koeppen, Hartmut

“…Background: A recent phase III trial showed that the addition of bevacizumab, a monoclonal antibody to vascular endothelial growth factor-A, to first-line…”
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Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers by GRAY, Daniel, JUBB, Adrian M, DE SAUVAGE, Frederic J, DAVIS, David P, HOGUE, Deborah, DOWD, Patrick, KLJAVIN, Noelyn, YI, Sothy, WEI BAI, FRANTZ, Gretchen, ZEMIN ZHANG, KOEPPEN, Hartmut

“…To identify genes that could serve as targets for novel cancer therapeutics, we used a bioinformatic analysis of microarray data comparing gene expression…”
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Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia by JUBB, A. M, CHALASANI, S, FRANTZ, G. D, SMITS, R, GRABSCH, H. I, KAVI, V, MAUGHAN, N. J, HILLAN, K. J, QUIRKE, P, KOEPPEN, H

“…Achaete-scute like (ASCL)2 is a basic helix-loop-helix transcription factor essential for the maintenance of proliferating trophoblasts during placental…”
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Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF) by Strickland, Laura A, Jubb, Adrian M, Hongo, Jo-Anne, Zhong, Fiona, Burwick, Jennifer, Fu, Ling, Frantz, Gretchen D, Koeppen, Hartmut

“…Vascular endothelial growth factor‐A (VEGF) is an important regulator of vascular permeability. In preclinical studies, VEGF induces endothelial fenestrations…”
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EphB2 is a Prognostic Factor in Colorectal Cancer by JUBB, Adrian M, ZHONG, Fiona, BHEDDAH, Sheila, GRABSCH, Heike I, FRANTZ, Gretchen D, MUELLER, Wolfram, KAVI, Vidya, QUIRKE, Phil, POLAKIS, Paul, KOEPPEN, Hartmut

“…A receptor tyrosine kinase for ephrin ligands, EphB2 is expressed in colorectal cancer and has been proposed as a target for immunoconjugate therapy. The aim…”
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Expression of vascular endothelial growth factor, hypoxia inducible factor 1α, and carbonic anhydrase IX in human tumours by Jubb, A M, Pham, T Q, Hanby, A M, Frantz, G D, Peale, F V, Wu, T D, Koeppen, H W, Hillan, K J

“…Aims: To measure vascular endothelial growth factor (VEGF-A) mRNA in a large, diverse cohort of tumours and to investigate whether VEGF-A expression is…”
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Palliative care research: trading ethics for an evidence base by Jubb, A M

“…Good medical practice requires evidence of effectiveness to address deficits in care, strive for further improvements, and justly apportion finite resources…”
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DNA Methylation, a Biomarker for Colorectal Cancer by JUBB, ADRIAN M., QUIRKE, PHIL, OATES, ADAM J.

“…: Currently up to one‐third of colorectal cancer patients present with locally advanced or metastatic disease that precludes a surgical cure. Performance…”
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Quantitative analysis of colorectal tissue microarrays by immunofluorescence and in situ hybridization by Jubb, AM, Landon, TH, Burwick, J, Pham, TQ, Frantz, GD, Cairns, B, Quirke, P, Peale, FV, Hillan, KJ

“…The accuracy and reliability of in situ studies may be compromised by qualitative interpretations. Quantitation imposes a greater degree of objectivity, is…”
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