Search Results - "Juan P Casas"

Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records by Bell, Steven, Daskalopoulou, Marina, Rapsomaniki, Eleni, George, Julie, Britton, Annie, Bobak, Martin, Casas, Juan P, Dale, Caroline E, Denaxas, Spiros, Shah, Anoop D, Hemingway, Harry

“…Objectives To investigate the association between alcohol consumption and cardiovascular disease at higher resolution by examining the initial lifetime…”
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Comparative Effectiveness of BNT162b2 and mRNA-1273 Vaccines in U.S. Veterans by Dickerman, Barbra A, Gerlovin, Hanna, Madenci, Arin L, Kurgansky, Katherine E, Ferolito, Brian R, Figueroa Muñiz, Michael J, Gagnon, David R, Gaziano, J. Michael, Cho, Kelly, Casas, Juan P, Hernán, Miguel A

“…In an observational study involving nearly 440,000 veterans, both the BNT162b2 vaccine and the mRNA-1273 vaccine were highly effective at preventing infection,…”
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The druggable genome and support for target identification and validation in drug development by Finan, Chris, Gaulton, Anna, Kruger, Felix A, Lumbers, R Thomas, Shah, Tina, Engmann, Jorgen, Galver, Luana, Kelley, Ryan, Karlsson, Anneli, Santos, Rita, Overington, John P, Hingorani, Aroon D, Casas, Juan P

“…Target identification (determining the correct drug targets for a disease) and target validation (demonstrating an effect of target perturbation on disease…”
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Selecting instruments for Mendelian randomization in the wake of genome-wide association studies by Swerdlow, Daniel I, Kuchenbaecker, Karoline B, Shah, Sonia, Sofat, Reecha, Holmes, Michael V, White, Jon, Mindell, Jennifer S, Kivimaki, Mika, Brunner, Eric J, Whittaker, John C, Casas, Juan P, Hingorani, Aroon D

“…Mendelian randomization (MR) studies typically assess the pathogenic relevance of environmental exposures or disease biomarkers, using genetic variants that…”
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Genetic architecture of host proteins involved in SARS-CoV-2 infection by Pietzner, Maik, Wheeler, Eleanor, Carrasco-Zanini, Julia, Raffler, Johannes, Kerrison, Nicola D., Oerton, Erin, Auyeung, Victoria P. W., Luan, Jian’an, Finan, Chris, Casas, Juan P., Ostroff, Rachel, Williams, Steve A., Kastenmüller, Gabi, Ralser, Markus, Gamazon, Eric R., Wareham, Nicholas J., Hingorani, Aroon D., Langenberg, Claudia

“…Understanding the genetic architecture of host proteins interacting with SARS-CoV-2 or mediating the maladaptive host response to COVID-19 can help to identify…”
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Tackling non-communicable diseases in low- and middle-income countries: is the evidence from high-income countries all we need? by Ebrahim, Shah, Pearce, Neil, Smeeth, Liam, Casas, Juan P, Jaffar, Shabbar, Piot, Peter

“…Shah Ebrahim and colleagues argue that more research on non-communicable diseases (NCDs) in both high-income countries and low- and middle-income countries can…”
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A chronological map of 308 physical and mental health conditions from 4 million individuals in the English National Health Service by Kuan, Valerie, Denaxas, Spiros, Gonzalez-Izquierdo, Arturo, Direk, Kenan, Bhatti, Osman, Husain, Shanaz, Sutaria, Shailen, Hingorani, Melanie, Nitsch, Dorothea, Parisinos, Constantinos A, Lumbers, R Thomas, Mathur, Rohini, Sofat, Reecha, Casas, Juan P, Wong, Ian C K, Hemingway, Harry, Hingorani, Aroon D

“…To effectively prevent, detect, and treat health conditions that affect people during their lifecourse, health-care professionals and researchers need to know…”
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Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysis by Casas, Juan P, Chua, Weiliang, Loukogeorgakis, Stavros, Vallance, Patrick, Smeeth, Liam, Hingorani, Aroon D, MacAllister, Raymond J

“…A consensus has emerged that angiotensin-converting-enzyme (ACE) inhibitors and angiotensin-II receptor blockers (ARBs) have specific renoprotective effects…”
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Genetic architecture of heart failure with preserved versus reduced ejection fraction by Joseph, Jacob, Liu, Chang, Hui, Qin, Aragam, Krishna, Wang, Zeyuan, Charest, Brian, Huffman, Jennifer E., Keaton, Jacob M., Edwards, Todd L., Demissie, Serkalem, Djousse, Luc, Casas, Juan P., Gaziano, J. Michael, Cho, Kelly, Wilson, Peter W. F., Phillips, Lawrence S., O’Donnell, Christopher J., Sun, Yan V.

“…Pharmacologic clinical trials for heart failure with preserved ejection fraction have been largely unsuccessful as compared to those for heart failure with…”
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Interleukin-6 receptor pathways in abdominal aortic aneurysm by Harrison, Seamus C, Smith, Andrew J P, Jones, Gregory T, Swerdlow, Daniel I, Rampuri, Riaz, Bown, Matthew J, Folkersen, Lasse, Baas, Annette F, de Borst, Gert Jan, Blankensteijn, Jan D, Price, Jacqueline F, van der Graaf, Yolanda, McLachlan, Stela, Agu, Obi, Hofman, Albert, Uitterlinden, Andre G, Franco-Cereceda, Anders, Ruigrok, Ynte M, van't Hof, F N, Powell, Janet T, van Rij, Andre M, Casas, Juan P, Eriksson, Per, Holmes, Michael V, Asselbergs, Folkert W, Hingorani, Aroon D, Humphries, Steve E

“…We conducted a systematic review and meta-analysis of studies reporting circulating IL-6 in AAA, and new investigations of the association between a common…”
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Visualizing novel connections and genetic similarities across diseases using a network-medicine based approach by Ferolito, Brian, do Valle, Italo Faria, Gerlovin, Hanna, Costa, Lauren, Casas, Juan P., Gaziano, J. Michael, Gagnon, David R., Begoli, Edmon, Barabási, Albert-László, Cho, Kelly

“…Understanding the genetic relationships between human disorders could lead to better treatment and prevention strategies, especially for individuals with…”
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Uric acid and risk of pre-eclampsia: results from a large case–control study and meta-analysis of prospective studies by Colmenares-Mejia, Claudia C., Quintero-Lesmes, Doris C., Bautista-Niño, Paula K., Guío, Elizabeth, Paez, Maria C., Beltrán, Mónica, Williams, David, Gray, Kathryn J., Casas, Juan P., Serrano, Norma C.

“…To quantify the association between maternal uric acid levels and pre-eclampsia risk in a large collection of primigravid women. A case–control study (1365…”
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Association of pre-eclampsia risk with maternal levels of folate, homocysteine and vitamin B12 in Colombia: A case-control study by Serrano, Norma C, Quintero-Lesmes, Doris Cristina, Becerra-Bayona, Silvia, Guio, Elizabeth, Beltran, Mónica, Paez, María C, Ortiz, Ricardo, Saldarriaga, Wilmar, Diaz, Luis A, Monterrosa, Álvaro, Miranda, Jezid, Mesa, Clara M, Sanin, José E, Monsalve, German, Dudbridge, Frank, Hingorani, Aroon D, Casas, Juan P

“…Maternal serum concentrations of folate, homocysteine, and vitamin B12 have been associated with pre-eclampsia. Nevertheless, reported studies involve limited…”
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Association Between Genetic Variants on Chromosome 15q25 Locus and Objective Measures of Tobacco Exposure by MUNAFO, Marcus R, TIMOFEEVA, Maria N, WHINCUP, Peter H, CASAS, Juan P, UHL, George R, VINEIS, Paolo, PADMANABHAN, Sandosh, JEFFERIS, Barbara J, AMUZU, Antoinette, RIBOLI, Elio, UPTON, Mark N, AVEYARD, Paul, MORRIS, Richard W, EBRAHIM, Shah, HINGORANI, Aroon D, WATT, Graham, PALMER, Tom M, TIMPSON, Nicholas J, SMITH, George Davey, PRIETO-MERINO, David, SATTAR, Naveed, BRENNAN, Paul, JOHNSTONE, Elaine C, RELTON, Caroline, JOHNSON, Paul C. D, WALTHER, Donna

“…Two single-nucleotide polymorphisms, rs1051730 and rs16969968, located within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are…”
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Data-driven identification of ageing-related diseases from electronic health records by Kuan, Valerie, Fraser, Helen C., Hingorani, Melanie, Denaxas, Spiros, Gonzalez-Izquierdo, Arturo, Direk, Kenan, Nitsch, Dorothea, Mathur, Rohini, Parisinos, Constantinos A., Lumbers, R. Thomas, Sofat, Reecha, Wong, Ian C. K., Casas, Juan P., Thornton, Janet M., Hemingway, Harry, Partridge, Linda, Hingorani, Aroon D.

“…Reducing the burden of late-life morbidity requires an understanding of the mechanisms of ageing-related diseases (ARDs), defined as diseases that accumulate…”
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Circulating Apolipoprotein E Concentration and Cardiovascular Disease Risk: Meta-analysis of Results from Three Studies by Sofat, Reecha, Cooper, Jackie A, Kumari, Meena, Casas, Juan P, Mitchell, Jacqueline P, Acharya, Jayshree, Thom, Simon, Hughes, Alun D, Humphries, Steve E, Hingorani, Aroon D

“…The association of APOE genotype with circulating apolipoprotein E (ApoE) concentration and cardiovascular disease (CVD) risk is well established. However, the…”
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Atrial fibrillation epidemiology, disparity and healthcare contacts: a population-wide study of 5.6 million individuals by Chung, Sheng-Chia, Sofat, Reecha, Acosta-Mena, Dionisio, Taylor, Julie A, Lambiase, Pier D, Casas, Juan P, Providencia, Rui

“…Background: We aimed to evaluate atrial fibrillation occurrence, reasons for healthcare visits, mortality, causes of death and examined patterns by relative…”
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Major cardiovascular risk factors in Latin America: a comparison with the United States. The Latin American Consortium of Studies in Obesity (LASO) by Miranda, J Jaime, Herrera, Victor M, Chirinos, Julio A, Gómez, Luis F, Perel, Pablo, Pichardo, Rafael, González, Angel, Sánchez, José R, Ferreccio, Catterina, Aguilera, Ximena, Silva, Eglé, Oróstegui, Myriam, Medina-Lezama, Josefina, Pérez, Cynthia M, Suárez, Erick, Ortiz, Ana P, Rosero, Luis, Schapochnik, Noberto, Ortiz, Zulma, Ferrante, Daniel, Casas, Juan P, Bautista, Leonelo E

“…Limited knowledge on the prevalence and distribution of risk factors impairs the planning and implementation of cardiovascular prevention programs in the Latin…”
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Million Veteran Program's response to COVID-19: Survey development and preliminary findings by Whitbourne, Stacey B, Nguyen, Xuan-Mai T, Song, Rebecca J, Lord, Emily, Lyden, Michelle, Harrington, Kelly M, Ward, Rachel, Li, Yanping, Brewer, Jessica V V, Cho, Kelly M, Djousse, Luc, Muralidhar, Sumitra, Tsao, Philip S, Gaziano, J Michael, Casas, Juan P

“…In response to the novel Coronavirus Disease 2019 (COVID-19) pandemic, the Department of Veterans Affairs (VA) Million Veteran Program (MVP) organized efforts…”
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PCSK9 loss of function is protective against extra-coronary atherosclerotic cardiovascular disease in a large multi-ethnic cohort by Small, Aeron M, Huffman, Jennifer E, Klarin, Derek, Lynch, Julie A, Assimes, Themistocles, DuVall, Scott, Sun, Yan V, Shere, Labiba, Natarajan, Pradeep, Gaziano, Michael, Rader, Daniel J, Wilson, Peter W F, Tsao, Philip S, Chang, Kyong-Mi, Cho, Kelly, O'Donnell, Christopher J, Casas, Juan P, Damrauer, Scott M

“…Therapeutic inhibition of PCSK9 protects against coronary artery disease (CAD) and ischemic stroke (IS). The impact on other diseases remains less well…”
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