Search Results - "Juan Manuel O'Connor"

Third- or Later-line Therapy for Metastatic Colorectal Cancer: Reviewing Best Practice by Bekaii-Saab, Tanios, Kim, Richard, Kim, Tae Won, O’Connor, Juan Manuel, Strickler, John H., Malka, David, Sartore-Bianchi, Andrea, Bi, Feng, Yamaguchi, Kensei, Yoshino, Takayuki, Prager, Gerald W.

“…An increasing number of patients with metastatic colorectal cancer (mCRC) are able to receive 3 or more lines of therapy. Treatments in this setting can…”
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The LEGACy study: a European and Latin American consortium to identify risk factors and molecular phenotypes in gastric cancer to improve prevention strategies and personalized clinical decision making globally by van Schooten, Tessa Suzanne, Derks, Sarah, Jiménez-Martí, Elena, Carneiro, Fatima, Figueiredo, Ceu, Ruiz, Erika, Alsina, Maria, Molero, Cristina, Garrido, Marcelo, Riquelme, Arnoldo, Caballero, Carmelo, Lezcano, Eva, O'Connor, Juan Manuel, Esteso, Federico, Farrés, Judith, Mas, José Manuel, Lordick, Florian, Vogt, Jeannette, Cardone, Antonella, Girvalaki, Charis, Cervantes, Andrés, Fleitas, Tania

“…Gastric Cancer (GC) is the fourth most deadly cancer worldwide. Enhanced understanding of its key epidemiological and molecular drivers is urgently needed to…”
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Phase II Study of Adjuvant Immunotherapy with the CSF-470 Vaccine Plus Bacillus Calmette-Guerin Plus Recombinant Human Granulocyte Macrophage-Colony Stimulating Factor vs Medium-Dose Interferon Alpha 2B in Stages IIB, IIC, and III Cutaneous Melanoma Patients: A Single Institution, Randomized Study by Mordoh, José, Pampena, María Betina, Aris, Mariana, Blanco, Paula Alejandra, Lombardo, Mónica, von Euw, Erika María, Mac Keon, Soledad, Yépez Crow, Michelle, Bravo, Alicia Inés, O'Connor, Juan Manuel, Orlando, Ana Gabriela, Ramello, Franco, Levy, Estrella Mariel, Barrio, María Marcela

“…The irradiated, allogeneic, cellular CSF-470 vaccine plus Bacillus Calmette-Guerin (BCG) and recombinant human granulocyte macrophage-colony stimulating factor…”
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Atypical pattern of response in rectal cancer after neoadjuvant pembrolizumab treatment: a case report, literature review, and proposed management model by Tissera, Natalia S, Esteso, Federico, Luca, Romina, Enrico, Diego, Waisberg, Federico, Rodriguez, Andrés, Bruno, Luisina, Kucharczyk, Mariana, Amat, Mora, García, Ximena, Pombo, Teresa, Salazar, Ivana Pedraza, Loria, Fernando Sanchez, Huertas, Eduardo, Galli, Mariana, Chacón, Matías, O'Connor, Juan Manuel

“…Immunotherapy is the first-line treatment in patients with advanced microsatellite instability-high (MSI-H) or deficient mismatch repair (dMMR) colorectal…”
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Observational study of patients with gastroenteropancreatic and bronchial neuroendocrine tumors in Argentina: Results from the large database of a multidisciplinary group clinical multicenter study by O'CONNOR, JUAN MANUEL, MARMISSOLLE, FABIANA, BESTANI, CLAUDIA, PESCE, VERONICA, BELLI, SUSANA, DOMINICHINI, ENZO, MENDEZ, GUILLERMO, PRICE, PAOLA, GIACOMI, NORA, PAIROLA, ALEJANDRO, LORIA, FERNANDO SÁNCHEZ, HUERTAS, EDUARDO, MARTIN, CLAUDIO, PATANE, KARINA, POLERI, CLAUDIA, ROSENBERG, MOISES, CABANNE, ANA, KUJARUK, MIRTA, CAINO, ANALIA, ZAMORA, VICTOR, MARIANI, JAVIER, DIOCA, MARIANO, PARMA, PATRICIA, PODESTA, GUSTAVO, ANDRIANI, OSCAR, GONDOLESI, GABRIEL, ROCA, ENRIQUE

“…Neuroendocrine tumors (NET) include a spectrum of malignancies arising from neuroendocrine cells throughout the body. The objective of this clinical…”
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Safety and effectiveness of regorafenib in patients with metastatic colorectal cancer in routine clinical practice in the prospective, observational CORRELATE study by Ducreux, Michel, Petersen, Lone Nørgård, Öhler, Leopold, Bergamo, Francesca, Metges, Jean-Philippe, de Groot, Jan Willem, Wang, Jaw-Yuan, García Paredes, Beatriz, Dochy, Emmanuelle, Fiala-Buskies, Sabine, Cervantes, Andrés, O'Connor, Juan Manuel, Falcone, Alfredo

“…Regorafenib prolonged overall survival (OS) versus placebo in patients with treatment-refractory metastatic colorectal cancer (mCRC) in phase III trials. We…”
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Opportunistic and Serious Infections in Patients with Neuroendocrine Tumors Treated with Everolimus: A Multicenter Study of Real-World Patients by Mauro, Carine, de Jesus, Victor Hugo Fonseca, Barros, Milton, Costa, Frederico Perego, Weschenfelder, Rui F, D'Agustini, Nathalia, Angel, Martin, Luca, Romina, Nuñez, Jose Eduardo, O'Connor, Juan Manuel, Riechelmann, Rachel P

“…The incidence of infections is poorly studied in patients with neuroendocrine tumors (NET) treated with everolimus outside of clinical trials. We aimed to…”
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Performance of two prognostic scores that incorporate genetic information to predict long‐term outcomes following resection of colorectal cancer liver metastases: An external validation of the MD Anderson and JHH‐MSK scores by Sasaki, Kazunari, Gagnière, Johan, Dupré, Aurélien, Ardiles, Victoria, O'Connor, Juan Manuel, Wang, Jaeyun, Moro, Amika, Morioka, Daisuke, Buettner, Stefan, Gau, Laurence, Ribeiro, Mathieu, Wagner, Doris, Andreatos, Nikolaos, Løes, Inger Marie, Fitschek, Fabian, Kaczirek, Klaus, Lønning, Per Eystein, Kornprat, Peter, Poultsides, George, Kamphues, Carsten, Imai, Katsunori, Baba, Hideo, Endo, Itaru, Kwon, Choon Hyuck David, Aucejo, Federico N., Santibañes, Eduardo, Kreis, Martin E., Margonis, Georgios Antonios

“…Introduction Two novel clinical risk scores (CRS) that incorporate KRAS mutation status were developed: modified CRS (mCRS) and GAME score. However, they have…”
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Implementation of a virtual multicenter gastrointestinal tumor board to reduce cancer disparities in Argentina by Esteso, Federico, Tissera, Natalia Soledad, O'Connor, Juan Manuel, Luca, Romina, Huertas, Eduardo, Sánchez Loria, Fernando, Pedraza, Ivana, Pairola, Alejandro, Brancato, Fernando, Paganini, Lisandro, Kucharczyk, Mariana, Amat, Mora, Pombo, Maria Teresa, Galli, Mariana, Bruno, Luisina, Caro, Luis, Rodriguez, Andrés, Enrico, Diego, Waisberg, Federico, Chacón, Matías

“…Given the increasing complexity of cancer care, multidisciplinary tumor boards have become essential in daily clinical oncology practice. The Project Extension…”
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Towards precision medicine in colorectal cancer liver metastases by O’Connor, Juan Manuel, Loria, Fernando Sanchez

“…According to the data published by GLOBOCAN 2018 CRC incidence rates in developed countries are approximately threefoldhigher than in transitioning countries;…”
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Short-course radiotherapy for rectal cancer: real-world evidence in Argentina by Tissera, Natalia S, Freile, Berenice, Waisberg, Federico, Esteso, Federico, Galli, Mariana, Loria, Fernando Sanchez, Luca, Romina, Pedraza, Ivana Inés, Enrico, Diego Hernán, Chacón, Carolina, Huertas, Eduardo, Chacón, Matías Rodrigo, O'Connor, Juan Manuel

“…Short-course radiotherapy (SCRT) of 25 Gy in five daily fractions is a recommended strategy in the neoadjuvant setting for resectable locally advanced rectal…”
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Expert consensus for the management of advanced or metastatic pancreatic neuroendocrine and carcinoid tumors by Castellano, Daniel, Grande, Enrique, Valle, Juan, Capdevila, Jaume, Reidy-Lagunes, Diane, O’Connor, Juan Manuel, Raymond, Eric

“…Neuroendocrine tumors (NETs) are rare tumors that have been increasing in incidence over the last 30 years with no significant changes in survival. As survival…”
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Ibero-American Consensus Review and Incorporation of New Biomarkers for Clinical Practice in Colorectal Cancer by Bonilla, Carlos Eduardo, Montenegro, Paola, O’Connor, Juan Manuel, Hernando-Requejo, Ovidio, Aranda, Enrique, Pinto Llerena, José, Llontop, Alejandra, Gallardo Escobar, Jorge, Díaz Romero, María del Consuelo, Bautista Hernández, Yicel, Graña Suárez, Begoña, Batagelj, Emilio J, Wali Mushtaq, Ahmad, García-Foncillas, Jesús

“…Advances in genomic technologies have significantly improved the management of colorectal cancer (CRC). Several biomarkers have been identified in CRC that…”
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The Screening and COnsensus Based on Practices and Evidence (SCOPE) Program–Results of a Survey on Daily Practice Patterns for Patients with mCRC by Prager, Gerald, Köhne, Claus-Henning, O’Connor, Juan Manuel, Rivera, Fernando, Santini, Daniele, Wasan, Harpreet, Phelip, Jean Marc

“…The SCOPE project aimed to better understand practice patterns, identify drivers for treatment goals, and determine third- and fourth-line treatment choices…”
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Implementation of a molecular tumour board in LATAM: the impact on treatment decisions for patients evaluated at Instituto Alexander Fleming, Argentina by Angel, Martín Osvaldo, Pupareli, Carmen, Soule, Tomas, Tsou, Florencia, Leiva, Mariano, Losco, Federico, Esteso, Federico, O Connor, Juan Manuel, Luca, Romina, Petracci, Fernando, Girotti, Romina, Mahmoud, Yamil Damián, Martín, Claudio, Chacón, Matías

“…The role of the molecular tumour board (MTB) is to recommend personalised therapy for patients with cancer beyond standard-of-care treatment. A comprehensive…”
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Unmet Medical Needs in Metastatic Lung and Digestive Neuroendocrine Neoplasms by Capdevila, Jaume, Bodei, Lisa, Davies, Philippa, Gorbounova, Vera, Jensen, Robert T, Knigge, Ulrich P, Krejs, Guenter J, Krenning, Eric, O'Connor, Juan Manuel, Peeters, Marc, Rindi, Guido, Salazar, Ramon, Vullierme, Marie-Pierre, Pavel, Marianne E

“…Unmet medical needs are not infrequent in oncology, and these needs are usually of higher magnitude in rare cancers. The field of neuroendocrine neoplasms…”
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Influence of proton pump inhibitors on the pathological response of rectal cancer: a multicentre study by Cesca, Marcelle G, Ruiz-Garcia, Erika, Weschenfelder, Rui, D'Agustini, Nathalia, Iseas, Soledad, Luca, Romina, O'Connor, Juan Manuel, D'Alpino, Renata, Pereira, Allan A, Mello, Celso A, Aguiar, Jr, Samuel, E Silva, Virgílio Souza, Riechelmann, Rachel P

“…The standard neoadjuvant therapy for rectal cancer involves fluoropyrimidines and radiotherapy and, most recently, total neoadjuvant therapy (TNT). A drug-drug…”
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Recommendations for the management of pancreatic cancer type adenocarcinoma: A consensus statement reached during the 2015 Latin American Symposium on Gastroenterological Oncology by Caglevic, Christian, Gallardo, Jorge, de la Torre, Marcela, Mahave, Mauricio, Müller, Bettina, Solé, Sebastián, Moscoso, Yuri, De La Fuente, Hernán, Roa, Juan Carlos, Hoefler, Sebastián, Butte, Jean M, González M, Pablo, O'Connor, Juan Manuel, Torres, Javiera, Pérez Encalada, Verónica, Alarcón Cano, Daniel, Ubillos, Luis, Rolfo, Christian, Lingua, Alejo, Díaz Romero, Consuelo, Padilla Rosciano, Alejandro, Cuartero, Viviana, Calderillo Ruiz, Germán, Schwartsmann, Gilberto, Kon Jara, Xavier, Andrade G, Andrés, Mas López, Luis, Barajas, Olga, Carballido, Marcela, Lembach, Hanns, Morillas G, Lena, Roca, Enrique, Lobatón, José, Montenegro B, Paola, Yepes, Andrés, Marsiglia, Hugo

“…Pancreatic cancer is a malignancy of great impact in developed countries and is having an increasing impact in Latin America. Incidence and mortality rates are…”
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Optimizing Regorafenib Dosing and Patient Management in Colorectal Cancer in Latin America: Perspectives from Argentina by Dioca, Mariano, O'Connor, Juan Manuel

“…Colorectal cancer (CRC) is one of the most commonly diagnosed cancers in Central and South America and one of the top causes of cancer death; however, these…”
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Using Artificial Intelligence to Find the Optimal Margin Width in Hepatectomy for Colorectal Cancer Liver Metastases by Bertsimas, Dimitris, Margonis, Georgios Antonios, Sujichantararat, Suleeporn, Boerner, Thomas, Ma, Yu, Wang, Jane, Kamphues, Carsten, Sasaki, Kazunari, Tang, Seehanah, Gagniere, Johan, Dupré, Aurelien, Løes, Inger Marie, Wagner, Doris, Stasinos, Georgios, Macher-Beer, Andrea, Burkhart, Richard, Morioka, Daisuke, Imai, Katsunori, Ardiles, Victoria, O'Connor, Juan Manuel, Pawlik, Timothy M, Poultsides, George, Seeliger, Hendrik, Beyer, Katharina, Kaczirek, Klaus, Kornprat, Peter, Aucejo, Federico N, de Santibañes, Eduardo, Baba, Hideo, Endo, Itaru, Lønning, Per Eystein, Kreis, Martin E, Weiss, Matthew J, Wolfgang, Christopher L, D'Angelica, Michael

“…In patients with resectable colorectal cancer liver metastases (CRLM), the choice of surgical technique and resection margin are the only variables that are…”
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