Search Results - "Juan C. Gómez-Fernández"

Signaling through C2 domains: More than one lipid target by Corbalan-Garcia, Senena, Gómez-Fernández, Juan C.

“…C2 domains are membrane-binding modules that share a common overall fold: a single compact Greek-key motif organized as an eight-stranded anti-parallel…”
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Functions of the C-terminal domains of apoptosis-related proteins of the Bcl-2 family by Gómez-Fernández, Juan C.

“…Bcl-2 family proteins are involved in cell homeostasis, where they regulate cell death. Some of these proteins are pro-apoptotic and others pro-survival…”
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Phenolic Group of α‑Tocopherol Anchors at the Lipid–Water Interface of Fully Saturated Membranes by Ausili, Alessio, Torrecillas, Alejandro, de Godos, Ana M, Corbalán-García, Senena, Gómez-Fernández, Juan C

“…α-Tocopherol is considered to carry on a very important role as an antioxidant for membranes and lipoproteins and other biological roles as membrane…”
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The vertical location of α-tocopherol in phosphatidylcholine membranes is not altered as a function of the degree of unsaturation of the fatty acyl chains by Ausili, Alessio, de Godos, Ana M, Torrecillas, Alejandro, Aranda, Francisco J, Corbalán-García, Senena, Gómez-Fernández, Juan C

“…α-Tocopherol is a natural preservative that prevents free radical chain oxidations in biomembranes. We have studied the location of α-tocopherol in model…”
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Anticancer Agent Edelfosine Exhibits a High Affinity for Cholesterol and Disorganizes Liquid-Ordered Membrane Structures by Ausili, Alessio, Martínez-Valera, Pablo, Torrecillas, Alejandro, Gómez-Murcia, Victoria, de Godos, Ana M, Corbalán-García, Senena, Teruel, José A, Gómez Fernández, Juan C

“…Edelfosine is an anticancer drug with an asymmetric structure because, being a derivative of glycerol, it possesses two hydrophobic substituents of very…”
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Lamellar Gel (Lβ) Phases of Ternary Lipid Composition Containing Ceramide and Cholesterol by Busto, Jon V., García-Arribas, Aritz B., Sot, Jesús, Torrecillas, Alejandro, Gómez-Fernández, Juan C., Goñi, Félix M., Alonso, Alicia

“…Lipid lateral segregation into specific domains in cellular membranes is associated with cell signaling and metabolic regulation. This phenomenon partially…”
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Deciphering the Role and Signaling Pathways of PKCα in Luminal A Breast Cancer Cells by Serrano-López, Emilio M, Coronado-Parra, Teresa, Marín-Vicente, Consuelo, Szallasi, Zoltan, Gómez-Abellán, Victoria, López-Andreo, María José, Gragera, Marcos, Gómez-Fernández, Juan C, López-Nicolás, Rubén, Corbalán-García, Senena

“…Protein kinase C (PKC) comprises a family of highly related serine/threonine protein kinases involved in multiple signaling pathways, which control cell…”
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The Myth of The Annular Lipids by Gómez-Fernández, Juan C, Goñi, Félix M

“…In the early 1970s, the existence of a “lipid annulus” stably surrounding the individual intrinsic protein molecules was proposed by several authors. They…”
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Clotrimazole Fluidizes Phospholipid Membranes and Localizes at the Hydrophobic Part near the Polar Part of the Membrane by Ausili, Alessio, Yakymenko, Illya, Teruel, José A, Gómez-Fernández, Juan C

“…Clotrimazole (1-[(2-chlorophenyl)-diphenylmethyl]-imidazole) is an azole antifungal drug belonging to the imidazole subclass that is widely used in…”
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Protein kinase C regulatory domains: The art of decoding many different signals in membranes by Corbalán-García, Senena, Gómez-Fernández, Juan C.

“…Protein kinase C (PKC) is a member of a family of Ser/Thr phosphotransferases that are involved in many cellular signaling pathways. These enzymes possess two…”
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Edelfosine Is Incorporated into Rafts and Alters Their Organization by Ausili, Alessio, Torrecillas, Alejandro, Aranda, Francisco J, Mollinedo, Faustino, Gajate, Consuelo, Corbalán-García, Senena, de Godos, Ana, Gómez-Fernández, Juan C

“…The effect of edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine or ET-18-OCH3) on model membranes containing…”
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Liposome-Encapsulated Morphine Affords a Prolonged Analgesia While Facilitating Extinction of Reward and Aversive Memories by Gómez-Murcia, Victoria, Ribeiro Do Couto, Bruno, Gómez-Fernández, Juan C., Milanés, María V., Laorden, María L., Almela, Pilar

“…Morphine is thoroughly used for pain control; however, it has a high addictive potential. Opioid liposome formulations produce controlled drug release and have…”
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Curcumin Disorders 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine Membranes and Favors the Formation of Nonlamellar Structures by 1,2-Dielaidoyl-sn-glycero-3-phosphoethanolamine by Pérez-Lara, Angel, Ausili, Alessio, Aranda, Francisco J, Godos, Ana de, Torrecillas, Alejandro, Corbalán-García, Senena, Gómez-Fernández, Juan C

“…Curcumin is a polyphenol present in turmeric, a spice widely used in Asian traditional medicine and cooking. It has many and diverse biological effects and is…”
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Diethylstilbestrol Modifies the Structure of Model Membranes and Is Localized Close to the First Carbons of the Fatty Acyl Chains by Ausili, Alessio, Rodríguez-González, Inés, Torrecillas, Alejandro, Teruel, José A, Gómez-Fernández, Juan C

“…The synthetic estrogen diethylstilbestrol (DES) is used to treat metastatic carcinomas and prostate cancer. We studied its interaction with membranes and its…”
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The binding of different model membranes with PKCε C2 domain is not dependent on membrane curvature but affects the sequence of events during unfolding by Ausili, Alessio, Corbalán-García, Senena, Gómez-Fernández, Juan C.

“…The C2 domain of novel protein kinases C (nPKC) binds to membranes in a Ca2+-independent way contributing to the activation of these enzymes. We have studied…”
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Capsaicin Fluidifies the Membrane and Localizes Itself near the Lipid–Water Interface by Torrecillas, Alejandro, Schneider, Monika, Fernández-Martínez, Ana M, Ausili, Alessio, de Godos, Ana M, Corbalán-García, Senena, Gómez-Fernández, Juan C

“…Capsaicin is the chemical responsible for making some peppers spicy hot, but additionally it is used as a pharmaceutical to alleviate different pain…”
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Phosphatidylinositol 4,5-bisphosphate decreases the concentration of Ca2+, phosphatidylserine and diacylglycerol required for protein kinase C α to reach maximum activity by Egea-Jiménez, Antonio L, Pérez-Lara, Angel, Corbalán-García, Senena, Gómez-Fernández, Juan C

“…The C2 domain of PKCα possesses two different binding sites, one for Ca(2+) and phosphatidylserine and a second one that binds PIP2 with very high affinity…”
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Phosphatidylinositol-4,5-bisphosphate enhances anionic lipid demixing by the C2 domain of PKCα by Egea-Jiménez, Antonio L, Fernández-Martínez, Ana M, Pérez-Lara, Ángel, de Godos, Ana, Corbalán-García, Senena, Gómez-Fernández, Juan C

“…The C2 domain of PKCα (C2α) induces fluorescence self-quenching of NBD-PS in the presence of Ca2+, which is interpreted as the demixing of phosphatidylserine…”
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Redox State of Coenzyme Q10 Determines Its Membrane Localization by Ausili, Alessio, Torrecillas, Alejandro, Aranda, Francisco, de Godos, Ana, Sánchez-Bautista, Sonia, Corbalán-García, Senena, Gómez-Fernández, Juan C

“…The interaction between oxidized (ubiquinone-10) and reduced (ubiquinol-10) coenzyme Q10 with dimyristoylphosphatidylcholine has been examined by differential…”
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The C2 domains of classical and novel PKCs as versatile decoders of membrane signals by Corbalán-García, Senena, Gómez-Fernández, Juan C.

“…The C2 domains of classical and novel protein kinases C play a very important role in decoding signals, which trigger the translocation of these enzymes to the…”
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