Search Results - "Juan, Todd"

FusionMap: detecting fusion genes from next-generation sequencing data at base-pair resolution by Ge, Huanying, Liu, Kejun, Juan, Todd, Fang, Fang, Newman, Matthew, Hoeck, Wolfgang

“…Motivation: Next generation sequencing technology generates high-throughput data, which allows us to detect fusion genes at both transcript and genomic levels…”
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Wild-Type KRAS Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer by AMADO, Rafael G, WOLF, Michael, PATTERSON, Scott D, CHANG, David D, PEETERS, Marc, VAN CUTSEM, Eric, SIENA, Salvatore, FREEMAN, Daniel J, JUAN, Todd, SIKORSKI, Robert, SUGGS, Sid, RADINSKY, Robert

“…Panitumumab, a fully human antibody against the epidermal growth factor receptor (EGFR), has activity in a subset of patients with metastatic colorectal cancer…”
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Limited differential expression of miRNAs and other small RNAs in LPS-stimulated human monocytes by Lu, Daniel, Yamawaki, Tracy, Zhou, Hong, Chou, Wen-Yu, Chhoa, Mark, Lamas, Edwin, Escobar, Sabine S, Arnett, Heather A, Ge, Huanying, Juan, Todd, Wang, Songli, Li, Chi-Ming

“…Monocytes are a distinct subset of myeloid cells with diverse functions in early inflammatory immune modulation. While previous studies have surveyed the role…”
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Motesanib Diphosphate in Progressive Differentiated Thyroid Cancer by Sherman, Steven I, Wirth, Lori J, Droz, Jean-Pierre, Hofmann, Michael, Bastholt, Lars, Martins, Renato G, Licitra, Lisa, Eschenberg, Michael J, Sun, Yu-Nien, Juan, Todd, Stepan, Daniel E, Schlumberger, Martin J

“…This phase 2 trial investigated the efficacy of motesanib diphosphate, an orally active inhibitor of VEGF receptors, in patients with advanced differentiated…”
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Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia by Sasu, Barbra J., Cooke, Keegan S., Arvedson, Tara L., Plewa, Cherylene, Ellison, Aaron R., Sheng, Jackie, Winters, Aaron, Juan, Todd, Li, Hongyan, Begley, C. Glenn, Molineux, Graham

“…Iron maldistribution has been implicated in multiple diseases, including the anemia of inflammation (AI), atherosclerosis, diabetes, and neurodegenerative…”
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Phase II Study of Safety and Efficacy of Motesanib in Patients With Progressive or Symptomatic, Advanced or Metastatic Medullary Thyroid Cancer by SCHLUMBERGER, Martin J, ELISEI, Rossella, ESCHENBERG, Michael J, SUN, Yu-Nien, JUAN, Todd, STEPAN, Daniel E, SHERMAN, Steven I, BASTHOLT, Lars, WIRTH, Lori J, MARTINS, Renato G, LOCATI, Laura D, JARZAB, Barbara, PACINI, Furio, DAUMERIE, Chantal, DROZ, Jean-Pierre

“…This phase II study investigated the efficacy and tolerability of motesanib, an investigational, highly selective inhibitor of vascular endothelial growth…”
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Biochemical characterization of AMG 102: a neutralizing, fully human monoclonal antibody to human and nonhuman primate hepatocyte growth factor by Burgess, Teresa L, Sun, Jan, Meyer, Susanne, Tsuruda, Trace S, Sun, Jilin, Elliott, Gary, Chen, Qing, Haniu, Mitsuru, Barron, Will F, Juan, Todd, Zhang, Ke, Coxon, Angela, Kendall, Richard L

“…AMG 102 is a fully human monoclonal antibody that selectively targets and neutralizes hepatocyte growth factor/scatter factor (HGF/SF). A detailed biochemical…”
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Pharmacological effects of nonselective and subtype-selective nicotinic acetylcholine receptor agonists in animal models of persistent pain by Gao, BaoXi, Hierl, Markus, Clarkin, Kristie, Juan, Todd, Nguyen, Hung, Valk, Marissa van der, Deng, Hong, Guo, Wenhong, Lehto, Sonya G., Matson, David, McDermott, Jeff S., Knop, Johannes, Gaida, Kevin, Cao, Lei, Waldon, Dan, Albrecht, Brian K., Boezio, Alessandro A., Copeland, Katrina W., Harmange, Jean-Christophe, Springer, Stephanie K., Malmberg, Annika B., McDonough, Stefan I.

“…Nicotinic acetylcholine receptors (nAChRs) are longstanding targets for a next generation of pain therapeutics, but the nAChR subtypes that govern analgesia…”
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A comparability study of 5 commercial KRAS tests by Oliner, Kelly, Juan, Todd, Suggs, Sid, Wolf, Michael, Sarosi, Ildiko, Freeman, Daniel J, Gyuris, Tibor, Baron, Will, Bakker, Andreas, Parker, Alex, Patterson, Scott D

“…Activating mutations in the KRAS gene occur frequently in human tumors, including colorectal carcinomas; most mutations occur in codons 12 and 13. Mutations in…”
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Activity of panitumumab alone or with chemotherapy in non-small cell lung carcinoma cell lines expressing mutant epidermal growth factor receptor by Freeman, Daniel J, Bush, Tammy, Ogbagabriel, Selam, Belmontes, Brian, Juan, Todd, Plewa, Cherylene, Van, Gwyneth, Johnson, Carol, Radinsky, Robert

“…Epidermal growth factor receptor (EGFR) kinase domain mutations cause hyperresponsiveness to ligand and hypersensitivity to small-molecule tyrosine kinase…”
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Motesanib inhibits Kit mutations associated with gastrointestinal stromal tumors by Caenepeel, Sean, Renshaw-Gegg, Lisa, Baher, Angelo, Bush, Tammy L, Baron, Will, Juan, Todd, Manoukian, Raffi, Tasker, Andrew S, Polverino, Anthony, Hughes, Paul E

“…Activating mutations in Kit receptor tyrosine kinase or the related platelet-derived growth factor receptor (PDGFR) play an important role in the pathogenesis…”
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The Dual Specificity JKAP Specifically Activates the c-Jun N-terminal Kinase Pathway by Chen, Alice J., Zhou, Guisheng, Juan, Todd, Colicos, Suzanne M., Cannon, John P., Cabriera-Hansen, Maria, Meyer, Christian F., Jurecic, Roland, Copeland, Neal G., Gilbert, Debra J., Jenkins, Nancy A., Fletcher, Fred, Tan, Tse-Hua, Belmont, John W.

“…The involvement of dual specificity phosphatases (DSPs) in the mitogen-activated protein kinase (MAPK) signaling has been mostly limited to the inactivation of…”
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Cloning and Characterization of a Specific Receptor for Mouse Oncostatin M by Lindberg, Richard A., Juan, Todd S.-C., Welcher, Andrew A., Sun, Yu, Cupples, Rod, Guthrie, Brenda, Fletcher, Frederick A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice by Juan, Todd, Véniant, Murielle M., Helmering, Joan, Babij, Philip, Baker, Daniel M., Damore, Michael A., Bass, Michael B., Gyuris, Tibor, Chhoa, Mark, Li, Chi-Ming, Ebeling, Chris, Amato, Julie, Carlson, George A., Lloyd, David J.

“…We conducted a genome-wide screen using the mutagen N-ethyl-N-nitrosourea to identify recessive mutations in genes that lead to altered lipid traits in mice…”
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Identification of a Lipopolysaccharide Binding Domain in CD14 between Amino Acids 57 and 64 (∗) by Juan, Todd S.-C., Hailman, Eric, Kelley, Michael J., Busse, Leigh A., Davy, Elyse, Empig, Cyril J., Narhi, Linda O., Wright, Samuel D., Lichenstein, Henri S.

“…CD14 is a 55-kDa glycoprotein which binds lipopolysaccharide (LPS) and enables LPS-dependent responses in a variety of cells. Recent limited proteolysis…”
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The Candidate Neuroprotective Agent Artemin Induces Autonomic Neural Dysplasia without Preventing Peripheral Nerve Dysfunction by Bolon, Brad, Jing, Shuqian, Asuncion, Frank, Scully, Sheila, Pisegna, Marlese, Van, Gwyneth Y., Zheng Hu, Yan Bin Yu, Min, Hosung, Wild, Ken, Rosenfeld, Robert D., Tarpley, John, Carnahan, Josette, Duryea, Diane, Hill, Dave, Kaufman, Steve, Yan, Xiao-Qiang, Juan, Todd, Christensen, Kathy, Mccabe, James, Simonet, W. Scott

“…Artemin (ART) signals through the GFRα—3/RET receptor complex to support sympathetic neuron development. Here we show that ART also influences autonomic…”
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Wild-Type KRAS Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer by Amado, Rafael G, Wolf, Michael, Peeters, Marc, Van Cutsem, Eric, Siena, Salvatore, Freeman, Daniel J, Juan, Todd, Sikorski, Robert, Suggs, Sid, Radinsky, Robert, Patterson, Scott D, Chang, David D

“…Panitumumab, a fully human antibody against the epidermal growth factor receptor (EGFR), has activity in a subset of patients with metastatic colorectal cancer…”
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Identification of a Domain in Soluble CD14 Essential for Lipopolysaccharide (LPS) Signaling but Not LPS Binding by Juan, Todd S.-C., Hailman, Eric, Kelley, Michael J., Wright, Samuel D., Lichenstein, Henri S.

“…CD14 is a 55-kDa glycoprotein that binds lipopolysaccharide (LPS) and enables LPS-dependent responses in a variety of cells. Monoclonal antibodies of CD14 such…”
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Soluble CD14 Truncated at Amino Acid 152 Binds Lipopolysaccharide (LPS) and Enables Cellular Response to LPS (∗) by Juan, Todd S.-C., Kelley, Michael J., Johnson, David A., Busse, Leigh A., Hailman, Eric, Wright, Samuel D., Lichenstein, Henri S.

“…CD14 is a 55-kDa glycoprotein which binds lipopolysaccharide (LPS) and enables LPS-dependent responses in a variety of cells. In order to identify the domains…”
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Pancreatic islet expression profiling in diabetes-prone C57BLKS/J mice reveals transcriptional differences contributed by DBA loci, including Plagl1 and Nnt by Anderson, Abraham A, Helmering, Joan, Juan, Todd, Li, Chi-Ming, McCormick, Jocelyn, Graham, Melissa, Baker, Daniel M, Damore, Michael A, Véniant, Murielle M, Lloyd, David J

“…C57BLKS/J (BLKS) mice are susceptible to islet exhaustion in insulin-resistant states as compared with C57BL6/J (B6) mice, as observed by the presence of the…”
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