Search Results - "Ju, Zhenyu"

GPX4 and vitamin E cooperatively protect hematopoietic stem and progenitor cells from lipid peroxidation and ferroptosis by Hu, Qian, Zhang, Yifan, Lou, Huiling, Ou, Zexian, Liu, Jin, Duan, Wentao, Wang, Hao, Ge, Yuanlong, Min, Junxia, Wang, Fudi, Ju, Zhenyu

“…Ferroptosis, a newly defined mode of regulated cell death caused by unbalanced lipid redox metabolism, is implicated in various tissue injuries and…”
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Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention by Zhu, Xudong, Chen, Zhiyang, Shen, Weiyan, Huang, Gang, Sedivy, John M., Wang, Hu, Ju, Zhenyu

“…Remarkable progress in ageing research has been achieved over the past decades. General perceptions and experimental evidence pinpoint that the decline of…”
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Mitochondrial sirtuins in stem cells and cancer by Jaiswal, Amit, Xudong, Zhu, Zhenyu, Ju, Saretzki, Gabriele

“…The mammalian sirtuin family consists of seven proteins, three of which (SIRT3, SIRT4, and SIRT5) localise specifically within mitochondria and preserve…”
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Histone H3K4me3 modification is a transgenerational epigenetic signal for lipid metabolism in Caenorhabditis elegans by Wan, Qin-Li, Meng, Xiao, Wang, Chongyang, Dai, Wenyu, Luo, Zhenhuan, Yin, Zhinan, Ju, Zhenyu, Fu, Xiaodie, Yang, Jing, Ye, Qunshan, Zhang, Zhan-Hui, Zhou, Qinghua

“…As a major risk factor to human health, obesity presents a massive burden to people and society. Interestingly, the obese status of parents can cause progeny’s…”
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Gastric Lgr5＋ stem cells are the cellular origin of invasive intestinal-type gastric cancer in mice by Li, Xiu-Bin, Yang, Guan, Zhu, Liang, Tang, Yu-Ling, Zhang, Chong, Ju, Zhenyu, Yang, Xiao, Teng, Yan

“…The cellular origin of gastric cancer remains elusive. Leucine-rich repeat-containing G-protein-coupled receptor 5 （Lgr5） is the first identified marker of…”
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Microglial PGC-1α protects against ischemic brain injury by suppressing neuroinflammation by Han, Bin, Jiang, Wei, Cui, Pan, Zheng, Kai, Dang, Chun, Wang, Junjie, Li, He, Chen, Lin, Zhang, Rongxin, Wang, Qing Mei, Ju, Zhenyu, Hao, Junwei

“…Neuroinflammation and immune responses occurring minutes to hours after stroke are associated with brain injury after acute ischemic stroke (AIS). PPARγ…”
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Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing by Ma, Xiao-Ru, Zhu, Xudong, Xiao, Yujie, Gu, Hui-Min, Zheng, Shuang-Shuang, Li, Liang, Wang, Fan, Dong, Zhao-Jun, Wang, Di-Xian, Wu, Yang, Yang, Chenyu, Jiang, Wenhong, Yao, Ke, Yin, Yue, Zhang, Yang, Peng, Chao, Gao, Lixia, Meng, Zhuoxian, Hu, Zeping, Liu, Chong, Li, Li, Chen, Hou-Zao, Shu, Yousheng, Ju, Zhenyu, Zhao, Jing-Wei

“…The age-dependent decline in remyelination potential of the central nervous system during ageing is associated with a declined differentiation capacity of…”
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Metabolomic profiling of single enlarged lysosomes by Zhu, Hongying, Li, Qianqian, Liao, Tiepeng, Yin, Xiang, Chen, Qi, Wang, Ziyi, Dai, Meifang, Yi, Lin, Ge, Siyuan, Miao, Chenjian, Zeng, Wenping, Qu, Lili, Ju, Zhenyu, Huang, Guangming, Cang, Chunlei, Xiong, Wei

“…Lysosomes are critical for cellular metabolism and are heterogeneously involved in various cellular processes. The ability to measure lysosomal metabolic…”
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Hepatic HuR modulates lipid homeostasis in response to high-fat diet by Zhang, Zhuojun, Zong, Chen, Jiang, Mingyang, Hu, Han, Cheng, Xiaolei, Ni, Juhua, Yi, Xia, Jiang, Bin, Tian, Feng, Chang, Ming-Wen, Su, Wen, Zhu, Lijun, Li, Jinfan, Xiang, Xueping, Miao, Congxiu, Gorospe, Myriam, de Cabo, Rafael, Dou, Yali, Ju, Zhenyu, Yang, Jichun, Jiang, Changtao, Yang, Zhongzhou, Wang, Wengong

“…Lipid transport and ATP synthesis are critical for the progression of non-alcoholic fatty liver disease (NAFLD), but the underlying mechanisms are largely…”
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SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2 by Pan, Huize, Guan, Di, Liu, Xiaomeng, Li, Jingyi, Wang, Lixia, Wu, Jun, Zhou, Junzhi, Zhang, Weizhou, Ren, Ruotong, Zhang, Weiqi, Li, Ying, Yang, Jiping, Hao, Ying, Yuan, Tingting, Yuan, Guohong, Wang, Hu, Ju, Zhenyu, Mao, Zhiyong, Li, Jian, Qu, Jing, Tang, Fuchou, Liu, Guang-Hui

“…SIRT6 belongs to the mammalian homologs of Sir2 histone NAD＋-dependent deacylase family. In rodents, SIRT6 deficiency leads to aging-associated degeneration of…”
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Analysis of redox landscapes and dynamics in living cells and in vivo using genetically encoded fluorescent sensors by Zou, Yejun, Wang, Aoxue, Shi, Mei, Chen, Xianjun, Liu, Renmei, Li, Ting, Zhang, Chenxia, Zhang, Zhuo, Zhu, Linyong, Ju, Zhenyu, Loscalzo, Joseph, Yang, Yi, Zhao, Yuzheng

“…Cellular oxidation–reduction reactions are mainly regulated by pyridine nucleotides (NADPH/NADP + and NADH/NAD + ), thiols, and reactive oxygen species (ROS)…”
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The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice by Xu, Qixia, Fu, Qiang, Li, Zi, Liu, Hanxin, Wang, Ying, Lin, Xu, He, Ruikun, Zhang, Xuguang, Ju, Zhenyu, Campisi, Judith, Kirkland, James L., Sun, Yu

“…Ageing-associated functional decline of organs and increased risk for age-related chronic pathologies is driven in part by the accumulation of senescent cells,…”
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SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling by Wang, Hu, Diao, Daojun, Shi, Zhencan, Zhu, Xudong, Gao, Yawei, Gao, Shaorong, Liu, Xiaoyu, Wu, You, Rudolph, K. Lenhard, Liu, Guanghui, Li, Tangliang, Ju, Zhenyu

“…Proper regulation of Wnt signaling is critical for the maintenance of hematopoietic stem cell (HSC) homeostasis. The epigenetic regulation of Wnt signaling in…”
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A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability by Liu, Jiang, Wang, Ying, Song, Lizhi, Zeng, Linghua, Yi, Weiwei, Liu, Ting, Chen, Huanzhen, Wang, Miao, Ju, Zhenyu, Cong, Yu-Sheng

“…Disturbance of endoplasmic reticulum (ER) homoeostasis induces ER stress and leads to activation of the unfolded protein response (UPR), which is an adaptive…”
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Transferrin receptor 1-mediated iron uptake plays an essential role in hematopoiesis by Wang, Shufen, He, Xuyan, Wu, Qian, Jiang, Li, Chen, Liyun, Yu, Yingying, Zhang, Pan, Huang, Xin, Wang, Jia, Ju, Zhenyu, Min, Junxia, Wang, Fudi

“…Transferrin receptor 1 (Tfr1) mediates the endocytosis of diferric transferrin in order to transport iron, and Tfr1 has been suggested to play an important…”
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Illuminating NAD+ Metabolism in Live Cells and In Vivo Using a Genetically Encoded Fluorescent Sensor by Zou, Yejun, Wang, Aoxue, Huang, Li, Zhu, Xudong, Hu, Qingxun, Zhang, Yinan, Chen, Xianjun, Li, Fengwen, Wang, Qiaohui, Wang, Hu, Liu, Renmei, Zuo, Fangting, Li, Ting, Yao, Jing, Qian, Yajie, Shi, Mei, Yue, Xiao, Chen, Weicai, Zhang, Zhuo, Wang, Congrong, Zhou, Yong, Zhu, Linyong, Ju, Zhenyu, Loscalzo, Joseph, Yang, Yi, Zhao, Yuzheng

“…Understanding of NAD+ metabolism provides many critical insights into health and diseases, yet highly sensitive and specific detection of NAD+ metabolism in…”
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SETD2 mutations confer chemoresistance in acute myeloid leukemia partly through altered cell cycle checkpoints by Dong, Yunzhu, Zhao, Xinghui, Feng, Xiaomin, Zhou, Yile, Yan, Xiaomei, Zhang, Ya, Bu, Jiachen, Zhan, Di, Hayashi, Yoshihiro, Zhang, Yue, Xu, Zefeng, Huang, Rui, Wang, Jieyu, Zhao, Taoran, Xiao, Zhijian, Ju, Zhenyu, Andreassen, Paul R., Wang, Qian-fei, Chen, Wei, Huang, Gang

“…SETD2 , an epigenetic tumor suppressor, is frequently mutated in MLL-rearranged (MLLr) leukemia and relapsed acute leukemia (AL). To clarify the impact of…”
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Chemical screen identifies a geroprotective role of quercetin in premature aging by Geng, Lingling, Liu, Zunpeng, Zhang, Weiqi, Li, Wei, Wu, Zeming, Wang, Wei, Ren, Ruotong, Su, Yao, Wang, Peichang, Sun, Liang, Ju, Zhenyu, Chan, Piu, Song, Moshi, Qu, Jing, Liu, Guang-Hui

“…Aging increases the risk of various diseases. The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases…”
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The E3 ligase TRIM31 regulates hematopoietic stem cell homeostasis and MLL-AF9 leukemia by Zhang, Kai, Liu, Dingdong, Li, Yafei, Shi, Zhencan, Guo, Jun, Gao, Chengjiang, Wang, Hu, Ju, Zhenyu, Diao, Daojun

“…Hematopoietic stem cells (HSC) are kept in a quiescent state to maintain their self-renewal capacity. Proper regulation of cyclin-dependent kinases (CDK) and…”
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A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage by Wang, Jianwei, Sun, Qian, Morita, Yohei, Jiang, Hong, Groß, Alexander, Lechel, André, Hildner, Kai, Guachalla, Luis Miguel, Gompf, Anne, Hartmann, Daniel, Schambach, Axel, Wuestefeld, Torsten, Dauch, Daniel, Schrezenmeier, Hubert, Hofmann, Wolf-Karsten, Nakauchi, Hiromitsu, Ju, Zhenyu, Kestler, Hans A., Zender, Lars, Rudolph, K. Lenhard

“…Checkpoints that limit stem cell self-renewal in response to DNA damage can contribute to cancer protection but may also promote tissue aging. Molecular…”
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