Search Results - "Ju, Zhenlin"

PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness by Shen, Jianfeng, Zhao, Wei, Ju, Zhenlin, Wang, Lulu, Peng, Yang, Labrie, Marilyne, Yap, Timothy A, Mills, Gordon B, Peng, Guang

“…PARP inhibitors (PARPi) have shown remarkable therapeutic efficacy against -mutant cancers through a synthetic lethal interaction. PARPi exert their…”
Get full text

Clinical relevance of TP53 hotspot mutations in high-grade serous ovarian cancers by Tuna, Musaffe, Ju, Zhenlin, Yoshihara, Kosuke, Amos, Christopher I., Tanyi, Janos L., Mills, Gordon B.

“…Background Mutation of TP53 is the most frequent genetic alteration in high-grade serous ovarian cancer (HGSOC). The impact of hotspot mutations of TP53 and…”
Get full text

ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade by Shen, Jianfeng, Ju, Zhenlin, Zhao, Wei, Wang, Lulu, Peng, Yang, Ge, Zhongqi, Nagel, Zachary D., Zou, Jun, Wang, Chen, Kapoor, Prabodh, Ma, Xiangyi, Ma, Ding, Liang, Jiyong, Song, Shumei, Liu, Jinsong, Samson, Leona D., Ajani, Jaffer A., Li, Guo-Min, Liang, Han, Shen, Xuetong, Mills, Gordon B., Peng, Guang

“…ARID1A (the AT-rich interaction domain 1A, also known as BAF250a ) is one of the most commonly mutated genes in cancer 1 , 2 . The majority of ARID1A mutations…”
Get full text

TCPA: a resource for cancer functional proteomics data by Li, Jun, Lu, Yiling, Akbani, Rehan, Ju, Zhenlin, Roebuck, Paul L, Liu, Wenbin, Yang, Ji-Yeon, Broom, Bradley M, Verhaak, Roeland G W, Kane, David W, Wakefield, Chris, Weinstein, John N, Mills, Gordon B, Liang, Han

Get full text

ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors by Shen, Jianfeng, Peng, Yang, Wei, Leizhen, Zhang, Wei, Yang, Lin, Lan, Li, Kapoor, Prabodh, Ju, Zhenlin, Mo, Qianxing, Shih, Ie-Ming, Uray, Ivan P, Wu, Xiangwei, Brown, Powel H, Shen, Xuetong, Mills, Gordon B, Peng, Guang

“…ARID1A, SWI/SNF chromatin remodeling complex subunit, is a recently identified tumor suppressor that is mutated in a broad spectrum of human cancers. Thus, it…”
Get more information

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers by Han, Leng, Diao, Lixia, Yu, Shuangxing, Xu, Xiaoyan, Li, Jie, Zhang, Rui, Yang, Yang, Werner, Henrica M.J., Eterovic, A. Karina, Yuan, Yuan, Li, Jun, Nair, Nikitha, Minelli, Rosalba, Tsang, Yiu Huen, Cheung, Lydia W.T., Jeong, Kang Jin, Roszik, Jason, Ju, Zhenlin, Woodman, Scott E., Lu, Yiling, Scott, Kenneth L., Li, Jin Billy, Mills, Gordon B., Liang, Han

“…Adenosine-to-inosine (A-to-I) RNA editing is a widespread post-transcriptional mechanism, but its genomic landscape and clinical relevance in cancer have not…”
Get full text

Immuno-genomic landscape of osteosarcoma by Wu, Chia-Chin, Beird, Hannah C., Andrew Livingston, J., Advani, Shailesh, Mitra, Akash, Cao, Shaolong, Reuben, Alexandre, Ingram, Davis, Wang, Wei-Lien, Ju, Zhenlin, Hong Leung, Cheuk, Lin, Heather, Zheng, Youyun, Roszik, Jason, Wang, Wenyi, Patel, Shreyaskumar, Benjamin, Robert S., Somaiah, Neeta, Conley, Anthony P., Mills, Gordon B., Hwu, Patrick, Gorlick, Richard, Lazar, Alexander, Daw, Najat C., Lewis, Valerae, Futreal, P. Andrew

“…Limited clinical activity has been seen in osteosarcoma (OS) patients treated with immune checkpoint inhibitors (ICI). To gain insights into the immunogenic…”
Get full text

YAP/TAZ-Mediated Upregulation of GAB2 Leads to Increased Sensitivity to Growth Factor-Induced Activation of the PI3K Pathway by Wang, Chao, Gu, Chao, Jeong, Kang Jin, Zhang, Dong, Guo, Wei, Lu, Yiling, Ju, Zhenlin, Panupinthu, Nattapon, Yang, Ji Yeon, Gagea, Mihai Mike, Ng, Patrick Kwok Shing, Zhang, Fan, Mills, Gordon B

“…The transcription regulators YAP and TAZ function as effectors of the HIPPO signaling cascade, critical for organismal development, cell growth, and cellular…”
Get full text

Gene signature associated with resistance to fluvastatin chemoprevention for breast cancer by Bhardwaj, Anjana, Embury, Matthew D, Ju, Zhenlin, Wang, Jing, Bedrosian, Isabelle

“…Although targeting of the cholesterol pathway by statins prevents breast cancer development in mouse models, efficacy is not absolute. Therefore, the goal of…”
Get full text

DNA-Methyltransferase 1 Induces Dedifferentiation of Pancreatic Cancer Cells through Silencing of Krüppel-Like Factor 4 Expression by Xie, Victoria K, Li, Zhiwei, Yan, Yongmin, Jia, Zhiliang, Zuo, Xiangsheng, Ju, Zhenlin, Wang, Jing, Du, Jiawei, Xie, Dacheng, Xie, Keping, Wei, Daoyan

“…The dismal prognosis of pancreatic cancer has been linked to poor tumor differentiation. However, molecular basis of pancreatic cancer differentiation and…”
Get full text

The molecular heterogeneity of the precancerous breast affects drug efficacy by Bhardwaj, Anjana, Rojo, Raniv Dawey, Ju, Zhenlin, Koh, Alexander, Tachibana, Kazunoshin, Wang, Jing, Bedrosian, Isabelle

“…In the therapeutic domain, targeted therapies have been shown to be generally more effective when given to patients with tumors that harbor the targeted…”
Get full text

High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability by Cheung, Lydia W T, Hennessy, Bryan T, Li, Jie, Yu, Shuangxing, Myers, Andrea P, Djordjevic, Bojana, Lu, Yiling, Stemke-Hale, Katherine, Dyer, Mary D, Zhang, Fan, Ju, Zhenlin, Cantley, Lewis C, Scherer, Steven E, Liang, Han, Lu, Karen H, Broaddus, Russell R, Mills, Gordon B

“…We demonstrate that phosphatidylinositol 3-kinase (PI3K) pathway aberrations occur in >80% of endometrioid endometrial cancers, with coordinate mutations of…”
Get more information

Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis by Kiyama, Takae, Chen, Ching-Kang, Wang, Steven W, Pan, Ping, Ju, Zhenlin, Wang, Jing, Takada, Shinako, Klein, William H, Mao, Chai-An

“…Mitochondrial dysfunction has been implicated in the pathologies of a number of retinal degenerative diseases in both the outer and inner retina. In the outer…”
Get full text

Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies by Ip, Carman K. M., Ng, Patrick K. S., Jeong, Kang Jin, Shao, S. H., Ju, Zhenlin, Leonard, P. G., Hua, Xu, Vellano, Christopher P., Woessner, Richard, Sahni, Nidhi, Scott, Kenneth L., Mills, Gordon B.

“…Activation of platelet-derived growth factor receptor alpha (PDGFRA) by genomic aberrations contributes to tumor progression in several tumor types. In this…”
Get full text

Whole genome and reverse protein phase array landscapes of patient derived osteosarcoma xenograft models by Wu, Chia-Chin, Huang, Licai, Zhang, Zhongting, Ju, Zhenlin, Song, Xingzhi, Kolb, E. Anders, Zhang, Wendong, Gill, Jonathan, Ha, Min, Smith, Malcolm A., Houghton, Peter, Morton, Christopher L., Kurmasheva, Raushan, Maris, John, Mosse, Yael, Lu, Yiling, Gorlick, Richard, Futreal, P. Andrew, Beird, Hannah C.

“…Osteosarcoma is the most common primary bone malignancy in children and young adults, and it has few treatment options. As a result, there has been little…”
Get full text

Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma by DAVIES, Michael A, STEMKE-HALE, Katherine, PRIETO, Victor G, ALDAPE, Kenneth, MILLS, Gordon B, GERSHENWALD, Jeffrey E, LIN, E, TELLEZ, Carmen, WANLENG DENG, GOPAL, Yennu N, WOODMAN, Scott E, CALDERONE, Tiffany C, ZHENLIN JU, LAZAR, Alexander J

“…Purpose: Activation of the phosphoinositide 3-kinase (PI3K)-AKT pathway has been implicated in melanoma based primarily on the prevalence of mutations in PTEN…”
Get full text

Naturally Occurring Neomorphic PIK3R1 Mutations Activate the MAPK Pathway, Dictating Therapeutic Response to MAPK Pathway Inhibitors by Cheung, Lydia W.T., Yu, Shuangxing, Zhang, Dong, Li, Jie, Ng, Patrick K.S., Panupinthu, Nattapon, Mitra, Shreya, Ju, Zhenlin, Yu, Qinghua, Liang, Han, Hawke, David H., Lu, Yiling, Broaddus, Russell R., Mills, Gordon B.

“…PIK3R1 (p85α regulatory subunit of PI3K) is frequently mutated across cancer lineages. Herein, we demonstrate that the most common recurrent PIK3R1 mutation…”
Get full text

Adaptation and Changes in Actin Dynamics and Cell Motility as Early Responses of Cultured Mammalian Cells to Altered Gravitational Vector by Ju, Zhenlin, Thomas, Tamlyn N, Chiu, Yi-Jen, Yamanouchi, Sakuya, Yoshida, Yukari, Abe, Jun-Ichi, Takahashi, Akihisa, Wang, Jing, Fujiwara, Keigi, Hada, Megumi

“…Cultured mammalian cells have been shown to respond to microgravity (μG), but the molecular mechanism is still unknown. The study we report here is focused on…”
Get full text

Pla2g16 phospholipase mediates gain-of-function activities of mutant p53 by Xiong, Shunbin, Tu, Huolin, Kollareddy, Madhusudhan, Pant, Vinod, Li, Qin, Zhang, Yun, Jackson, James G., Suh, Young-Ah, Elizondo-Fraire, Ana C., Yang, Peirong, Chau, Gilda, Tashakori, Mehrnoosh, Wasylishen, Amanda R., Ju, Zhenlin, Solomon, Hilla, Rotter, Varda, Liu, Bin, El-Naggar, Adel K., Donehower, Lawrence A., Martinez, Luis Alfonso, Lozano, Guillermina

“…p53 ᴿ¹⁷²ᴴ/⁺ mice inherit a p53 mutation found in Li-Fraumeni syndrome and develop metastatic tumors at much higher frequency than p53 ⁺/⁻ mice. To explore the…”
Get full text

Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer by Lui, Vivian Wai Yan, Peyser, Noah D., Ng, Patrick Kwok-Shing, Hritz, Jozef, Zenga, Yan, Lu, Yiling, Li, Hua, Wang, Lin, Gilbert, Breean R., General, Ignacio J., Bahar, Ivet, Ju, Zhenlin, Wang, Zhenghe, Pendleton, Kelsey P., Xiao, Xiao, Yu Dua, Vries, John K., Hammerman, Peter S., Garraway, Levi A., Mills, Gordon B., Johnson, Daniel E., Grandis, Jennifer R.

“…The underpinnings of STAT3 hyperphosphorylation resulting in enhanced signaling and cancer progression are incompletely understood. Loss-of-function mutations…”
Get full text