Search Results - "Ju, Lining"

Receptor-mediated cell mechanosensing by Chen, Yunfeng, Ju, Lining, Rushdi, Muaz, Ge, Chenghao, Zhu, Cheng

“…Mechanosensing describes the ability of a cell to sense mechanical cues of its microenvironment, including not only all components of force, stress, and strain…”
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An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation by Chen, Yunfeng, Ju, Lining Arnold, Zhou, Fangyuan, Liao, Jiexi, Xue, Lingzhou, Su, Qian Peter, Jin, Dayong, Yuan, Yuping, Lu, Hang, Jackson, Shaun P., Zhu, Cheng

“…Integrins are membrane receptors that mediate cell adhesion and mechanosensing. The structure–function relationship of integrins remains incompletely…”
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Cooperative unfolding of distinctive mechanoreceptor domains transduces force into signals by Ju, Lining, Chen, Yunfeng, Xue, Lingzhou, Du, Xiaoping, Zhu, Cheng

“…How cells sense their mechanical environment and transduce forces into biochemical signals is a crucial yet unresolved question in mechanobiology. Platelets…”
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Micropipette-based biomechanical nanotools on living cells by Wang, Haoqing, Zhou, Fang, Guo, Yuze, Ju, Lining Arnold

“…Mechanobiology is an emerging field at the interface of biology and mechanics, investigating the roles of mechanical forces within biomolecules, organelles,…”
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Hemodynamic analysis for stenosis microfluidic model of thrombosis with refined computational fluid dynamics simulation by Zhao, Yunduo Charles, Vatankhah, Parham, Goh, Tiffany, Michelis, Rhys, Kyanian, Kiarash, Zhang, Yingqi, Li, Zhiyong, Ju, Lining Arnold

“…Disturbed blood flow has been increasingly recognized for its critical role in platelet aggregation and thrombosis. Microfluidics with hump shaped contractions…”
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Tensile and compressive force regulation on cell mechanosensing by Chen, Yunfeng, Li, Zhiyong, Ju, Lining Arnold

“…Receptor-mediated cell mechanosensing plays critical roles in cell spreading, migration, growth, and survival. Dynamic force spectroscopy (DFS) techniques have…”
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Protein disulfide isomerase cleaves allosteric disulfides in histidine-rich glycoprotein to regulate thrombosis by Lv, Keyu, Chen, Shuai, Xu, Xulin, Chiu, Joyce, Wang, Haoqing J., Han, Yunyun, Yang, Xiaodan, Bowley, Sheryl R., Wang, Hao, Tang, Zhaoming, Tang, Ning, Yang, Aizhen, Yang, Shuofei, Wang, Jinyu, Jin, Si, Wu, Yi, Schmaier, Alvin H., Ju, Lining A., Hogg, Philip J., Fang, Chao

“…The essence of difference between hemostasis and thrombosis is that the clotting reaction is a highly fine-tuned process. Vascular protein disulfide isomerase…”
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Novel Pressure-Regulated Deployment Strategy for Improving the Safety and Efficacy of Balloon-Expandable Transcatheter Aortic Valves by Snir, Afik, Wilson, Michael K., Ju, Lining A., Zhao, Yunduo, Wong, Sophia, Khor, Lynn, Naoum, Christopher, Wong, Kirby, Keech, Anthony, Celermajer, David S., Ng, Martin K.

“…The authors propose a novel pressure-regulated method for balloon-expandable transcatheter heart valve (THV) deployment, aimed at optimizing prosthesis-annulus…”
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Mechano-redox control of integrin de-adhesion by Passam, Freda, Chiu, Joyce, Ju, Lining, Pijning, Aster, Jahan, Zeenat, Mor-Cohen, Ronit, Yeheskel, Adva, Kolšek, Katra, Thärichen, Lena, Aponte-Santamaría, Camilo, Gräter, Frauke, Hogg, Philip J

“…How proteins harness mechanical force to control function is a significant biological question. Here we describe a human cell surface receptor that couples…”
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Fluorescence-coupled micropipette aspiration assay to examine calcium mobilization caused by red blood cell mechanosensing by Wang, Haoqing, Obeidy, Peyman, Wang, Zihao, Zhao, Yunduo, Wang, Yao, Su, Qian Peter, Cox, Charles D., Ju, Lining Arnold

“…Mechanical stimuli such as tension, compression, and shear stress play critical roles in the physiological functions of red blood cells (RBCs) and their…”
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Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis by Xu, Xiaohong Ruby, Wang, Yiming, Adili, Reheman, Ju, Lining, Spring, Christopher M., Jin, Joseph Wuxun, Yang, Hong, Neves, Miguel A. D., Chen, Pingguo, Yang, Yan, Lei, Xi, Chen, Yunfeng, Gallant, Reid C., Xu, Miao, Zhang, Hailong, Song, Jina, Ke, Peifeng, Zhang, Dan, Carrim, Naadiya, Yu, Si-Yang, Zhu, Guangheng, She, Yi-Min, Cyr, Terry, Fu, Wenbin, Liu, Guoqing, Connelly, Philip W., Rand, Margaret L., Adeli, Khosrow, Freedman, John, Lee, Jeffrey E., Tso, Patrick, Marchese, Patrizia, Davidson, W. Sean, Jackson, Shaun P., Zhu, Cheng, Ruggeri, Zaverio M., Ni, Heyu

“…Platelet αIIbβ3 integrin and its ligands are essential for thrombosis and hemostasis, and play key roles in myocardial infarction and stroke. Here we show that…”
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Anisotropic functionalization of upconversion nanoparticles by Ren, Wei, Wen, Shihui, Tawfik, Sherif Abdulkader, Su, Qian P, Lin, Gungun, Ju, Lining A, Ford, Michael J, Ghodke, Harshad, van Oijen, Antoine M, Jin, Dayong

“…Despite significant advances toward accurate tuning of the size and shape of colloidal nanoparticles, the precise control of the surface chemistry thereof…”
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Biophysical nanotools for single-molecule dynamics by Su, Qian Peter, Ju, Lining Arnold

“…The focus of the cell biology field is now shifting from characterizing cellular activities to organelle and molecular behaviors. This process accompanies the…”
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Dual Biomembrane Force Probe enables single-cell mechanical analysis of signal crosstalk between multiple molecular species by Ju, Lining, Chen, Yunfeng, Li, Kaitao, Yuan, Zhou, Liu, Baoyu, Jackson, Shaun P., Zhu, Cheng

“…Conventional approaches for studying receptor-mediated cell signaling, such as the western blot and flow cytometry, are limited in three aspects: 1) The…”
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Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets by Ju, Lining, McFadyen, James D., Al-Daher, Saheb, Alwis, Imala, Chen, Yunfeng, Tønnesen, Lotte L., Maiocchi, Sophie, Coulter, Brianna, Calkin, Anna C., Felner, Eric I., Cohen, Neale, Yuan, Yuping, Schoenwaelder, Simone M., Cooper, Mark E., Zhu, Cheng, Jackson, Shaun P.

“…Diabetes is associated with an exaggerated platelet thrombotic response at sites of vascular injury. Biomechanical forces regulate platelet activation,…”
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A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis by Shen, Bo, Tasdogan, Alpaslan, Ubellacker, Jessalyn M., Zhang, Jingzhu, Nosyreva, Elena D., Du, Liming, Murphy, Malea M., Hu, Shuiqing, Yi, Yating, Kara, Nergis, Liu, Xin, Guela, Shay, Jia, Yuemeng, Ramesh, Vijayashree, Embree, Claire, Mitchell, Evann C., Zhao, Yunduo C., Ju, Lining A., Hu, Zhao, Crane, Genevieve M., Zhao, Zhiyu, Syeda, Ruhma, Morrison, Sean J.

“…Stromal cells in adult bone marrow that express leptin receptor (LEPR) are a critical source of growth factors, including stem cell factor (SCF), for the…”
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Dynamic control of β1 integrin adhesion by the plexinD1-sema3E axis by Choi, Young I., Duke-Cohan, Jonathan S., Chen, Wei, Liu, Baoyu, Rossy, Jérémie, Tabarin, Thibault, Ju, Lining, Gui, Jingang, Gaus, Katharina, Zhu, Cheng, Reinherz, Ellis L.

“…Plexins and semaphorins comprise a large family of receptorligand pairs controlling cell guidance in nervous, immune, and vascular systems. How plexin…”
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MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents by Samson, Andre L., Ju, Lining, Ah Kim, Hyun, Zhang, Shenpeng R., Lee, Jessica A. A., Sturgeon, Sharelle A., Sobey, Christopher G., Jackson, Shaun P., Schoenwaelder, Simone M.

“…The Open Field (OF) test is one of the most commonly used assays for assessing exploratory behaviour and generalised locomotor activity in rodents…”
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Fluorescence Biomembrane Force Probe: Concurrent Quantitation of Receptor-ligand Kinetics and Binding-induced Intracellular Signaling on a Single Cell by Chen, Yunfeng, Liu, Baoyu, Ju, Lining, Hong, Jinsung, Ji, Qinghua, Chen, Wei, Zhu, Cheng

“…Membrane receptor-ligand interactions mediate many cellular functions. Binding kinetics and downstream signaling triggered by these molecular interactions are…”
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Partial loss of actin nucleator actin‐related protein 2/3 activity triggers blebbing in primary T lymphocytes by Obeidy, Peyman, Ju, Lining A, Oehlers, Stefan H, Zulkhernain, Nursafwana S, Lee, Quintin, Galeano Niño, Jorge L, Kwan, Rain YQ, Tikoo, Shweta, Cavanagh, Lois L, Mrass, Paulus, Cook, Adam JL, Jackson, Shaun P, Biro, Maté, Roediger, Ben, Sixt, Michael, Weninger, Wolfgang

“…T lymphocytes utilize amoeboid migration to navigate effectively within complex microenvironments. The precise rearrangement of the actin cytoskeleton required…”
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