Search Results - "Ju, Jianhua"

Genome Mining of Streptomyces atratus SCSIO ZH16: Discovery of Atratumycin and Identification of Its Biosynthetic Gene Cluster by Sun, Changli, Yang, Zhijie, Zhang, Chunyan, Liu, Zhiyong, He, Jianqiao, Liu, Qing, Zhang, Tianyu, Ju, Jianhua, Ma, Junying

“…Genome mining of the deep sea-derived Streptomyces atratus SCSIO ZH16 enabled the activation of a cyclodepsipeptide gene cluster and isolation of its cinnamic…”
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The roles of genes associated with regulation, transportation, and macrocyclization in desotamide biosynthesis in Streptomyces scopuliridis SCSIO ZJ46 by Ding, Wenjuan, Dong, Yuliang, Ju, Jianhua, Li, Qinglian

“…The deep-sea-derived microbe Streptomyces scopuliridis SCSIO ZJ46 produces desotamides A–D. Notably, desotamides A and B display antibacterial activities…”
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Inhibition of cellular inflammatory mediator production and amelioration of learning deficit in flies by deep sea Aspergillus-derived cyclopenin by Wang, Liyan, Li, Mengjie, Lin, Yinzhi, Du, Shuwen, Liu, Zhenyu, Ju, Jianhua, Suzuki, Hiromi, Sawada, Makoto, Umezawa, Kazuo

“…In the course of screening lipopolysaccharide (LPS)-induced nitric oxide (NO) production inhibitors, two related benzodiazepine derivatives, cyclopenol and…”
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Minimum Information about a Biosynthetic Gene cluster by Medema, Marnix H, Kottmann, Renzo, Yilmaz, Pelin, Cummings, Matthew, Blin, Kai, de Bruijn, Irene, Chooi, Yit Heng, Coates, R Cameron, Duddela, Srikanth, Edwards, Daniel J, Garg, Neha, Gomez-Escribano, Juan Pablo, Greule, Anja, Haines, Anthony S, Helfrich, Eric J N, Ishida, Keishi, Jones, Adam C, Jones, Carla S, Kegler, Carsten, Kim, Hyun Uk, Kötter, Peter, Masschelein, Joleen, Melnik, Alexey V, Mantovani, Simone M, Monroe, Emily A, Moss, Nathan, Nützmann, Hans-Wilhelm, Pan, Guohui, Reen, F Jerry, Rosconi, Federico, Tian, Zhenhua, Tobias, Nicholas J, Tsunematsu, Yuta, Wiemann, Philipp, Yan, Xiaohui, Xie, Yunchang, Aigle, Bertrand, Apel, Alexander K, Balibar, Carl J, Bechthold, Andreas, Bode, Helge B, Brady, Sean F, Brakhage, Axel A, Caffrey, Patrick, Cheng, Yi-Qiang, Donadio, Stefano, van der Donk, Wilfred A, Doyle, Sean, Driessen, Arnold J M, Entian, Karl-Dieter, Gerwick, Lena, Gerwick, William H, Gross, Harald, Gust, Bertolt, Hertweck, Christian, Ju, Jianhua, Katz, Leonard, Kaysser, Leonard, Klassen, Jonathan L, Keller, Nancy P, Kormanec, Jan, Kuipers, Oscar P, Kuzuyama, Tomohisa, Kyrpides, Nikos C, Kwon, Hyung-Jin, Lavigne, Rob, Lee, Chia Y, Linquan, Bai, Liu, Xinyu, Mahmud, Taifo, Metsä-Ketelä, Mikko, Moore, Bradley S, Moreira, Leonilde M, Müller, Rolf, Neilan, Brett A, O'Gara, Fergal, Oikawa, Hideaki, Osbourn, Anne, Ostash, Bohdan, Payne, Shelley M, Pernodet, Jean-Luc, Piel, Jörn, Raaijmakers, Jos M, Schmitt, Esther K, Scott, Barry, Seipke, Ryan F, Shen, Ben, Sherman, David H, Sosio, Margherita, Stegmann, Evi, Thomas, Christopher M, Tang, Yi, Walton, Jonathan D, Walsh, Christopher T, van Wezel, Gilles P, Wilkinson, Barrie, Wohlleben, Wolfgang, Wright, Gerard D, Ziemert, Nadine, Zhang, Changsheng

“…A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters…”
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Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin by Liu, Jun O, Schneider-Poetsch, Tilman, Ju, Jianhua, Eyler, Daniel E, Dang, Yongjun, Bhat, Shridhar, Merrick, William C, Green, Rachel, Shen, Ben

“…Cycloheximide is a natural product that cell biologists have used for decades as a tool to arrest protein synthesis in eukaryotes. Biochemical data now refine…”
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Identification of the Anti-Infective Aborycin Biosynthetic Gene Cluster from Deep-Sea-Derived Streptomyces sp. SCSIO ZS0098 Enables Production in a Heterologous Host by Shao, Mingwei, Ma, Juying, Li, Qinglian, Ju, Jianhua

“…Aborycin is a ribosomally synthesized member of the type I lasso peptide natural products. In the present study, aborycin was isolated and identified from the…”
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Genome Sequencing of Streptomyces olivaceus SCSIO T05 and Activated Production of Lobophorin CR4 via Metabolic Engineering and Genome Mining by Zhang, Chunyan, Ding, Wenjuan, Qin, Xiangjing, Ju, Jianhua

“…Marine-sourced actinomycete genus continues to be an important source of new natural products. Here we report the complete genome sequence of deep-sea-derived…”
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Discovery and Biosynthesis of Atrovimycin, an Antitubercular and Antifungal Cyclodepsipeptide Featuring Vicinal-dihydroxylated Cinnamic Acyl Chain by Liu, Qing, Liu, Zhiyong, Sun, Changli, Shao, Mingwei, Ma, Junying, Wei, Xiaoyi, Zhang, Tianyu, Li, Wenjun, Ju, Jianhua

“…Atrovimycin (1), a cyclodepsipeptide containing a unique vicinal-hydroxylated cinnamic acyl chain, was isolated and elucidated from Streptomyces atrovirens…”
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Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents by Ma, Junying, Huang, Hongbo, Xie, Yunchang, Liu, Zhiyong, Zhao, Jin, Zhang, Chunyan, Jia, Yanxi, Zhang, Yun, Zhang, Hua, Zhang, Tianyu, Ju, Jianhua

“…Tuberculosis remains one of the world’s deadliest communicable diseases, novel anti-tuberculosis agents are urgently needed due to severe drug resistance and…”
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Ilamycin C induces apoptosis and inhibits migration and invasion in triple-negative breast cancer by suppressing IL-6/STAT3 pathway by Xie, Qing, Yang, Zhijie, Huang, Xuanmei, Zhang, Zikang, Li, Jiangbin, Ju, Jianhua, Zhang, Hua, Ma, Junying

“…Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with poor prognosis, and its treatment remains a challenge due to few…”
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Natural Hydroxamate-Containing Siderophore Acremonpeptides A–D and an Aluminum Complex of Acremonpeptide D from the Marine-Derived Acremonium persicinum SCSIO 115 by Luo, Minghe, Zang, Ruochen, Wang, Xin, Chen, Ziming, Song, Xiaoxian, Ju, Jianhua, Huang, Hongbo

“…Four new hydroxamate-containing natural product cyclopeptides designated acremonpeptides A–D (1–4), together with Al­(III)–acremonpeptide D (5) were obtained…”
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Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities by Song, Yongxiang, Yang, Jiafan, Yu, Jianchen, Li, Jie, Yuan, Jie, Wong, Nai-Kei, Ju, Jianhua

“…Two new chlorinated bis -indole alkaloids, dionemycin ( 1 ) and 6-OMe-7′,7″-dichorochromopyrrolic acid ( 2 ), along with seven known analogs 3 – 9 , were…”
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Mathermycin, a Lantibiotic from the Marine Actinomycete Marinactinospora thermotolerans SCSIO 00652 by Chen, Erquan, Chen, Qi, Chen, Shaoming, Xu, Bing, Ju, Jianhua, Wang, Huan

“…Lantibiotics are antimicrobial peptides belonging to the family of ribosomally synthesized and posttranslationally modified peptides (RiPPs) and feature…”
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Structure-based molecular networking for the target discovery of novel germicidin derivatives from the sponge-associated streptomyces sp. 18A01 by Bai, Yan, Yi, Ping, Zhang, Yun, Hu, Jiangchun, Wang, Ying, Ju, Jianhua, Pan, Huaqi

“…Four new α -pyrone derivatives, named germicidins P-S ( 1 - 4 ) along with nine known analogues ( 5 - 13 ) were discovered from the sponge-associated…”
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Identification of the Actinomycin D Biosynthetic Pathway from Marine-Derived Streptomyces costaricanus SCSIO ZS0073 by Liu, Mengchan, Jia, Yanxi, Xie, Yunchang, Zhang, Chunyan, Ma, Junying, Sun, Changli, Ju, Jianhua

“…Bioactive secondary metabolites from are important sources of lead compounds in current drug development. SCSIO ZS0073, a mangrove-derived actinomycete,…”
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Complete genome sequence of the deep South China Sea-derived Streptomyces niveus SCSIO 3406, the producer of cytotoxic and antibacterial marfuraquinocins by Zhu, Qinghua, Cheng, Weige, Song, Yongxiang, He, Qing, Ju, Jianhua, Li, Qinglian

“…Streptomyces niveus SCSIO 3406 was isolated from a sediment sample collected from South China Sea at a depth of 3536 m. Four new sesquiterpenoid…”
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Deciphering the Biosynthetic Origin of l-allo-Isoleucine by Li, Qinglian, Qin, Xiangjing, Liu, Jing, Gui, Chun, Wang, Bo, Li, Jie, Ju, Jianhua

“…The nonproteinogenic amino acid l-allo-isoleucine (l-allo-Ile) is featured in an assortment of life forms comprised of, but not limited to, bacteria, fungi,…”
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Secondary Metabolites and Biosynthetic Gene Clusters Analysis of Deep-Sea Hydrothermal Vent-Derived Streptomyces sp. SCSIO ZS0520 by Zhang, Huaran, Chen, Yingying, Li, Yanqing, Song, Yongxiang, Ma, Junying, Ju, Jianhua

“…Streptomyces sp. SCSIO ZS0520 is a deep-sea hydrothermal vent-derived actinomycete. Our previous metabolism investigation showed that Streptomyces sp. SCSIO…”
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Characterization and heterologous expression of the neoabyssomicin/abyssomicin biosynthetic gene cluster from Streptomyces koyangensis SCSIO 5802 by Tu, Jiajia, Li, Siting, Chen, Jiang, Song, Yongxiang, Fu, Shaobin, Ju, Jianhua, Li, Qinglian

“…The deep-sea-derived microbe Streptomyces koyangensis SCSIO 5802 produces neoabyssomicins A-B (1-2) and abyssomicins 2 (3) and 4 (4). Neoabyssomicin A (1)…”
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Chemical Synthesis and Structure-Activity Relationship Study Yield Desotamide a Analogues with Improved Antibacterial Activity by Xu, Run, Song, Yongxiang, Li, Jun, Ju, Jianhua, Li, Qinglian

“…Desotamides A, a cyclohexapeptide produced by the deep-sea-derived Streptomyces scopuliridis SCSIO ZJ46, displays notable antibacterial activities against…”
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