Search Results - "Ju, Dianwen"

Hedgehog Signaling Pathway and Autophagy in Cancer by Zeng, Xian, Ju, Dianwen

“…Hedgehog (Hh) pathway controls complex developmental processes in vertebrates. Abnormal activation of Hh pathway is responsible for tumorigenesis and…”
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Inflammasome: A Double-Edged Sword in Liver Diseases by Luan, Jingyun, Ju, Dianwen

“…Inflammasomes have emerged as critical innate sensors of host immune that defense against pathogen infection, metabolism syndrome, cellular stress and cancer…”
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Gene therapy for neurodegenerative disorders: advances, insights and prospects by Chen, Wei, Hu, Yang, Ju, Dianwen

“…Gene therapy is rapidly emerging as a powerful therapeutic strategy for a wide range of neurodegenerative disorders, including Alzheimer's disease (AD),…”
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Kidney protection effects of dihydroquercetin on diabetic nephropathy through suppressing ROS and NLRP3 inflammasome by Ding, Tao, Wang, Shaofei, Zhang, Xuyao, Zai, Wenjing, Fan, Jiajun, Chen, Wei, Bian, Qi, Luan, Jingyun, Shen, Yilan, Zhang, Yanda, Ju, Dianwen, Mei, Xiaobin

“…Diabetic nephropathy (DN), the leading cause of end-stage renal disease, is acknowledged as an independent risk factor for cardiovascular disease, which…”
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The role of interleukin-22 in lung health and its therapeutic potential for COVID-19 by Fang, Si, Ju, Dianwen, Lin, Yong, Chen, Wei

“…Although numerous clinical trials have been implemented, an absolutely effective treatment against coronavirus disease 2019 (COVID-19) is still elusive…”
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Cell Membrane-Derived Vesicle: A Novel Vehicle for Cancer Immunotherapy by Xu, Caili, Ju, Dianwen, Zhang, Xuyao

“…As nano-sized materials prepared by isolating, disrupting and extruding cell membranes, cellular vesicles are emerging as a novel vehicle for immunotherapeutic…”
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Mesoporous silica nanoparticles induced hepatotoxicity via NLRP3 inflammasome activation and caspase-1-dependent pyroptosis by Zhang, Xuyao, Luan, Jingyun, Chen, Wei, Fan, Jiajun, Nan, Yanyang, Wang, Yichen, Liang, Yanxu, Meng, Guangxun, Ju, Dianwen

“…Increased biomedical applications of mesoporous silica nanoparticles (MSNs) raise considerable attention concerning their toxicological effects; the toxicities…”
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Editorial: Community series in combinational immunotherapy of cancer: novel targets, mechanisms, and strategies, volume II by Xu, Caili, Ju, Dianwen, Zhang, Xuyao

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Editorial: Combinational immunotherapy of cancer: novel targets, mechanisms, and strategies by Nan, Yanyang, Ju, Dianwen, Zhang, Xuyao

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Protective effects of interleukin-22 on oxalate-induced crystalline renal injury via alleviating mitochondrial damage and inflammatory response by Gu, Yuting, Shen, Yilan, Chen, Wei, He, Haidong, Ma, Yulei, Mei, Xiaobin, Ju, Dianwen, Liu, Hongrui

“…Oxalate-induced crystalline kidney injury is one of the most common types of crystalline nephropathy. Unfortunately, there is no effective treatment to reduce…”
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Research progress of interleukin-15 in cancer immunotherapy by Cai, Menghan, Huang, Xuan, Huang, Xiting, Ju, Dianwen, Zhu, Yi Zhun, Ye, Li

“…Interleukin-15 (IL-15) is a cytokine that belongs to the interleukin-2 (IL-2) family and is essential for the development, proliferation, and activation of…”
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Amino Acid Degrading Enzymes and Autophagy in Cancer Therapy by Wang, Ziyu, Xie, Qinghong, Zhou, Haifeng, Zhang, Min, Shen, Jie, Ju, Dianwen

“…Recently, there has been renewed interest in metabolic therapy for cancer, particularly in amino acid deprivation by enzymes. L-asparaginase was approved for…”
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Targeting the autophagy promoted antitumor effect of T-DM1 on HER2-positive gastric cancer by Zhang, Jinghui, Fan, Jiajun, Zeng, Xian, Nie, Mingming, Chen, Wei, Wang, Yichen, Luan, Jingyun, Zhu, Zeguo, Chang, Xusheng, Ju, Dianwen, Feng, Li, Yin, Kai

“…Trastuzumab emtansine (T-DM1), an antibody-drug conjugate consisted of the HER2-targeted monoclonal antibody trastuzumab and the tubulin inhibitor emtansine,…”
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NOD-Like Receptor Protein 3 Inflammasome-Dependent IL-1β Accelerated ConA-Induced Hepatitis by Luan, Jingyun, Zhang, Xuyao, Wang, Shaofei, Li, Yubin, Fan, Jiajun, Chen, Wei, Zai, Wenjing, Wang, Sijia, Wang, Yichen, Chen, Mingkuan, Meng, Guangxun, Ju, Dianwen

“…Autoimmune hepatitis (AIH) is a progressive inflammatory disorders of unknown etiology, characterized by immune-mediated destruction of hepatocytes and massive…”
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Blocking the PD-1-PD-L1 axis by a novel PD-1 specific nanobody expressed in yeast as a potential therapeutic for immunotherapy by Xian, Zongshu, Ma, Linlin, Zhu, Min, Li, Guanghui, Gai, Junwei, Chang, Qing, Huang, Yuliang, Ju, Dianwen, Wan, Yakun

“…PD-1/PD-L1 pathway blocking with antibodies offers a vital and efficient therapeutic strategy to restore T cell-associated antitumor immunity and treats a…”
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Inhibition of autophagy overcomes the nanotoxicity elicited by cadmium-based quantum dots by Fan, Jiajun, Sun, Yun, Wang, Shaofei, Li, Yubin, Zeng, Xian, Cao, Zhonglian, Yang, Ping, Song, Ping, Wang, Ziyu, Xian, Zongshu, Gao, Hongjian, Chen, Qicheng, Cui, Daxiang, Ju, Dianwen

“…Abstract Cadmium-based quantum dots (QDs) have shown their values in disease diagnosis, cellular and molecular tracking, small-animal imaging, and therapeutic…”
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Therapeutic Opportunities of IL-22 in Non-Alcoholic Fatty Liver Disease: From Molecular Mechanisms to Clinical Applications by Zai, Wenjing, Chen, Wei, Liu, Hongrui, Ju, Dianwen

“…Nonalcoholic fatty liver disease (NAFLD) represents one of the most common liver disorders and can progress into a series of liver diseases, including…”
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Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment by Zhang, Jinghui, Fan, Jiajun, Zeng, Xian, Nie, Mingming, Luan, Jingyun, Wang, Yichen, Ju, Dianwen, Yin, Kai

“…The Hedgehog (HH) signaling pathway plays important roles in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment (TME). Aberrant HH…”
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Mechanisms and Clinical Implications of Human Gut Microbiota-Drug Interactions in the Precision Medicine Era by Wang, Shuaiqi, Ju, Dianwen, Zeng, Xian

“…The human gut microbiota, comprising trillions of microorganisms residing in the gastrointestinal tract, has emerged as a pivotal player in modulating various…”
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Modulating autophagy to boost the antitumor efficacy of TROP2-directed antibody-drug conjugate in pancreatic cancer by Xu, Caili, Huang, Xiting, Hu, Qinchao, Xue, Wenjing, Zhou, Kaicheng, Li, Xingxiu, Nan, Yanyang, Ju, Dianwen, Wang, Ziyu, Zhang, Xuyao

“…Pancreatic cancer, characterized by a dismal prognosis and limited treatment options, persists as a formidable challenge in oncology. Trophoblast cell surface…”
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