Futuristic Non-antibiotic Therapies to Combat Antibiotic Resistance: A Review

The looming problem of resistance to antibiotics in microorganisms is a global health concern. The drug-resistant microorganisms originating from anthropogenic sources and commercial livestock farming have posed serious environmental and health challenges. Antibiotic-resistant genes constituting the...

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Bibliographic Details
Published in:	Frontiers in microbiology Vol. 12; p. 609459
Main Authors:	Kumar, Manoj, Sarma, Devojit Kumar, Shubham, Swasti, Kumawat, Manoj, Verma, Vinod, Nina, Praveen Balabaskaran, Jp, Devraj, Kumar, Santosh, Singh, Birbal, Tiwari, Rajnarayan R
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 26-01-2021
Subjects:	alternative therapies antibiotic resistance drug-resistance gene transfer health problems Microbiology drug-resistance health problems gene transfer alternative therapies antibiotic resistance
Online Access:	Get full text
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Summary:	The looming problem of resistance to antibiotics in microorganisms is a global health concern. The drug-resistant microorganisms originating from anthropogenic sources and commercial livestock farming have posed serious environmental and health challenges. Antibiotic-resistant genes constituting the environmental "resistome" get transferred to human and veterinary pathogens. Hence, deciphering the origin, mechanism and extreme of transfer of these genetic factors into pathogens is extremely important to develop not only the therapeutic interventions to curtail the infections, but also the strategies to avert the menace of microbial drug-resistance. Clinicians, researchers and policymakers should jointly come up to develop the strategies to prevent superfluous exposure of pathogens to antibiotics in non-clinical settings. This article highlights the present scenario of increasing antimicrobial-resistance in pathogenic bacteria and the clinical importance of unconventional or non-antibiotic therapies to thwart the infectious pathogenic microorganisms.
Bibliography:	Edited by: Israel Castillo-Juárez, Colegio de Postgraduados (COLPOS), Mexico Reviewed by: José Rivera-Chávez, Universidad Nacional Autónoma de México, Mexico; Miguel Cocotl-Yañez, National Autonomous University of Mexico, Mexico This article was submitted to Antimicrobials, Resistance and Chemotherapy, a section of the journal Frontiers in Microbiology
ISSN:	1664-302X 1664-302X
DOI:	10.3389/fmicb.2021.609459