The effect of zinc doping on the cytocompatibility and antibacterial efficacy of hydroxyapatite nanoparticles for treatment of bone infection

The effect of zinc doping on the cytocompatibility and antibacterial efficacy of hydroxyapatite nanoparticles for treatment of bone infection

In the face of antibiotic resistance, new antibacterial methods are urgently needed for bone infections. Local delivery of therapeutic metal ions via osteogenic nanoparticles (NPs) is a viable alternative, but high concentrations risk toxicity to mammalian cells. In this study first four ions (Mg2+,...

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Bibliographic Details
Published in:Open ceramics Vol. 16; p. 100488
Main Authors: Cuypers, L.A.B., Bertsch, P., Wang, R., Harhangi, H.R., Joziasse, L.S., Walboomers, X.F., van Niftrik, L., Yang, F., Leeuwenburgh, S.C.G.
Format: Journal Article
Language:English
Published: Elsevier Ltd 01-12-2023
Elsevier
Subjects:
Antibacterial properties
Cytocompatibility
Hydroxyapatite
Metal ions
Staphylococcus aureus
Zinc
Hydroxyapatite
Antibacterial properties
Cytocompatibility
Staphylococcus aureus
Zinc
Metal ions
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Summary:In the face of antibiotic resistance, new antibacterial methods are urgently needed for bone infections. Local delivery of therapeutic metal ions via osteogenic nanoparticles (NPs) is a viable alternative, but high concentrations risk toxicity to mammalian cells. In this study first four ions (Mg2+, Sr2+, Cu2+, Zn2+) were assessed for cytocompatibility and antibacterial properties. Only zinc ions showed antibacterial effects at non-toxic levels. Subsequently, zinc-doped hydroxyapatite nanoparticles (ZnHA NPs) were synthesized with varying zinc content (0–20 mol%). ZnHA NPs were characterized on size, morphology, composition, and antibacterial activity, with 15 mol% ZnHA NPs exhibiting the optimal balance between cytocompatibility and antibacterial efficacy. These NPs show promise as deliverable biomaterials for bone infection treatment. [Display omitted] •A novel method is used to synthesize spherical zinc-doped hydroxyapatite nanoparticles.•Zinc ions are potential therapeutics in bone infection avoiding antibiotic resistance.•Zinc released from nanoparticles significantly delayed the bacterial log growth phase.•15 mol% nanoparticles were cytocompatible, while exhibiting antibacterial properties.
ISSN:2666-5395
2666-5395
DOI:10.1016/j.oceram.2023.100488