Search Results - "Joyce, Eric F."

Cohesin promotes stochastic domain intermingling to ensure proper regulation of boundary-proximal genes by Luppino, Jennifer M., Park, Daniel S., Nguyen, Son C., Lan, Yemin, Xu, Zhuxuan, Yunker, Rebecca, Joyce, Eric F.

“…The human genome can be segmented into topologically associating domains (TADs), which have been proposed to spatially sequester genes and regulatory elements…”
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Condensin II drives large-scale folding and spatial partitioning of interphase chromosomes in Drosophila nuclei by Rosin, Leah F, Nguyen, Son C, Joyce, Eric F

“…Metazoan chromosomes are folded into discrete sub-nuclear domains, referred to as chromosome territories (CTs). The molecular mechanisms that underlie the…”
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Core Components of the Nuclear Pore Bind Distinct States of Chromatin and Contribute to Polycomb Repression by Gozalo, Alejandro, Duke, Ashley, Lan, Yemin, Pascual-Garcia, Pau, Talamas, Jessica A., Nguyen, Son C., Shah, Parisha P., Jain, Rajan, Joyce, Eric F., Capelson, Maya

“…Interactions between the genome and the nuclear pore complex (NPC) have been implicated in multiple gene regulatory processes, but the underlying logic of…”
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Co-depletion of NIPBL and WAPL balance cohesin activity to correct gene misexpression by Luppino, Jennifer M, Field, Andrew, Nguyen, Son C, Park, Daniel S, Shah, Parisha P, Abdill, Richard J, Lan, Yemin, Yunker, Rebecca, Jain, Rajan, Adelman, Karen, Joyce, Eric F

“…The relationship between cohesin-mediated chromatin looping and gene expression remains unclear. NIPBL and WAPL are two opposing regulators of cohesin…”
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Single-molecule super-resolution imaging of chromosomes and in situ haplotype visualization using Oligopaint FISH probes by Beliveau, Brian J., Boettiger, Alistair N., Avendaño, Maier S., Jungmann, Ralf, McCole, Ruth B., Joyce, Eric F., Kim-Kiselak, Caroline, Bantignies, Frédéric, Fonseka, Chamith Y., Erceg, Jelena, Hannan, Mohammed A., Hoang, Hien G., Colognori, David, Lee, Jeannie T., Shih, William M., Yin, Peng, Zhuang, Xiaowei, Wu, Chao-ting

“…Fluorescence in situ hybridization (FISH) is a powerful single-cell technique for studying nuclear structure and organization. Here we report two advances in…”
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Versatile design and synthesis platform for visualizing genomes with Oligopaint FISH probes by Beliveau, Brian J., Joyce, Eric F., Apostolopoulos, Nicholas, Yilmaz, Feyza, Fonseka, Chamith Y., McCole, Ruth B., Chang, Yiming, Li, Jin Billy, Senaratne, Tharanga Niroshini, Williams, Benjamin R., Rouillard, Jean-Marie, Wu, Chao-ting

“…A host of observations demonstrating the relationship between nuclear architecture and processes such as gene expression have led to a number of new…”
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Dynamic and Stable Cohesins Regulate Synaptonemal Complex Assembly and Chromosome Segregation by Gyuricza, Mercedes R., Manheimer, Kathryn B., Apte, Vandana, Krishnan, Badri, Joyce, Eric F., McKee, Bruce D., McKim, Kim S.

“…Assembly of the synaptonemal complex (SC) in Drosophila depends on two independent pathways defined by the chromosome axis proteins C(2)M and ORD. Because…”
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H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis by Poleshko, Andrey, Smith, Cheryl L, Nguyen, Son C, Sivaramakrishnan, Priya, Wong, Karen G, Murray, John Isaac, Lakadamyali, Melike, Joyce, Eric F, Jain, Rajan, Epstein, Jonathan A

“…Cell-type-specific 3D organization of the genome is unrecognizable during mitosis. It remains unclear how essential positional information is transmitted…”
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A Pathway for Synapsis Initiation during Zygotene in Drosophila Oocytes by Tanneti, Nikhila S., Landy, Kathryn, Joyce, Eric F., McKim, Kim S.

“…Formation of the synaptonemal complex (SC), or synapsis, between homologs in meiosis is essential for crossing over and chromosome segregation [1–4]. How SC…”
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Identification of genes that promote or antagonize somatic homolog pairing using a high-throughput FISH-based screen by Joyce, Eric F, Williams, Benjamin R, Xie, Tiao, Wu, C-Ting

“…The pairing of homologous chromosomes is a fundamental feature of the meiotic cell. In addition, a number of species exhibit homolog pairing in nonmeiotic,…”
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Multi-feature clustering of CTCF binding creates robustness for loop extrusion blocking and Topologically Associating Domain boundaries by Chang, Li-Hsin, Ghosh, Sourav, Papale, Andrea, Luppino, Jennifer M., Miranda, Mélanie, Piras, Vincent, Degrouard, Jéril, Edouard, Joanne, Poncelet, Mallory, Lecouvreur, Nathan, Bloyer, Sébastien, Leforestier, Amélie, Joyce, Eric F., Holcman, David, Noordermeer, Daan

“…Topologically Associating Domains (TADs) separate vertebrate genomes into insulated regulatory neighborhoods that focus genome-associated processes. TADs are…”
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An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype by Shah, Parisha P, Keough, Kathleen C, Gjoni, Ketrin, Santini, Garrett T, Abdill, Richard J, Wickramasinghe, Nadeera M, Dundes, Carolyn E, Karnay, Ashley, Chen, Angela, Salomon, Rachel E A, Walsh, Patrick J, Nguyen, Son C, Whalen, Sean, Joyce, Eric F, Loh, Kyle M, Dubois, Nicole, Pollard, Katherine S, Jain, Rajan

“…Association of chromatin with lamin proteins at the nuclear periphery has emerged as a potential mechanism to coordinate cell type-specific gene expression and…”
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The genome-wide multi-layered architecture of chromosome pairing in early Drosophila embryos by Erceg, Jelena, AlHaj Abed, Jumana, Goloborodko, Anton, Lajoie, Bryan R., Fudenberg, Geoffrey, Abdennur, Nezar, Imakaev, Maxim, McCole, Ruth B., Nguyen, Son C., Saylor, Wren, Joyce, Eric F., Senaratne, T. Niroshini, Hannan, Mohammed A., Nir, Guy, Dekker, Job, Mirny, Leonid A., Wu, C.-ting

“…Genome organization involves cis and trans chromosomal interactions, both implicated in gene regulation, development, and disease. Here, we focus on trans…”
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Recurrent Losses and Rapid Evolution of the Condensin II Complex in Insects by King, Thomas D, Leonard, Christopher J, Cooper, Jacob C, Nguyen, Son, Joyce, Eric F, Phadnis, Nitin

“…Abstract Condensins play a crucial role in the organization of genetic material by compacting and disentangling chromosomes. Based on studies in a few model…”
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Germline progenitors escape the widespread phenomenon of homolog pairing during Drosophila development by Joyce, Eric F, Apostolopoulos, Nicholas, Beliveau, Brian J, Wu, C-ting

“…Homolog pairing, which plays a critical role in meiosis, poses a potential risk if it occurs in inappropriate tissues or between nonallelic sites, as it can…”
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Chromosome territory formation attenuates the translocation potential of cells by Rosin, Leah F, Crocker, Olivia, Isenhart, Randi L, Nguyen, Son C, Xu, Zhuxuan, Joyce, Eric F

“…The formation and spatial arrangement of chromosome territories (CTs) in interphase has been posited to influence the outcome and frequency of genomic…”
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Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair by Joyce, Eric F, Pedersen, Michael, Tiong, Stanley, White-Brown, Sanese K, Paul, Anshu, Campbell, Shelagh D, McKim, Kim S

“…Ataxia telangiectasia-mutated (ATM) and ataxia telangiectasia-related (ATR) kinases are conserved regulators of cellular responses to double strand breaks…”
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Investigating the Interplay between Sister Chromatid Cohesion and Homolog Pairing in Drosophila Nuclei by Senaratne, T Niroshini, Joyce, Eric F, Nguyen, Son C, Wu, C-Ting

“…Following DNA replication, sister chromatids must stay connected for the remainder of the cell cycle in order to ensure accurate segregation in the subsequent…”
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Chromosome axis defects induce a checkpoint-mediated delay and interchromosomal effect on crossing over during Drosophila meiosis by Joyce, Eric F, McKim, Kim S

“…Crossovers mediate the accurate segregation of homologous chromosomes during meiosis. The widely conserved pch2 gene of Drosophila melanogaster is required for…”
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Large-Scale Topological Changes Restrain Malignant Progression in Colorectal Cancer by Johnstone, Sarah E., Reyes, Alejandro, Qi, Yifeng, Adriaens, Carmen, Hegazi, Esmat, Pelka, Karin, Chen, Jonathan H., Zou, Luli S., Drier, Yotam, Hecht, Vivian, Shoresh, Noam, Selig, Martin K., Lareau, Caleb A., Iyer, Sowmya, Nguyen, Son C., Joyce, Eric F., Hacohen, Nir, Irizarry, Rafael A., Zhang, Bin, Aryee, Martin J., Bernstein, Bradley E.

“…Widespread changes to DNA methylation and chromatin are well documented in cancer, but the fate of higher-order chromosomal structure remains obscure. Here we…”
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