Search Results - "Jovcevski, Blagojce"

Discovery of an ʟ-amino acid ligase implicated in Staphylococcal sulfur amino acid metabolism by Pederick, Jordan L., Horsfall, Aimee J., Jovcevski‬, Blagojce, Klose, Jack, Abell, Andrew D., Pukala, Tara L., Bruning, John B.

“…Enzymes involved in Staphylococcus aureus amino acid metabolism have recently gained traction as promising targets for the development of new antibiotics,…”
Get full text

Stability of the octameric structure affects plasminogen-binding capacity of streptococcal enolase by Cork, Amanda J, Ericsson, Daniel J, Law, Ruby H P, Casey, Lachlan W, Valkov, Eugene, Bertozzi, Carlo, Stamp, Anna, Jovcevski, Blagojce, Aquilina, J Andrew, Whisstock, James C, Walker, Mark J, Kobe, Bostjan

“…Group A Streptococcus (GAS) is a human pathogen that has the potential to cause invasive disease by binding and activating human plasmin(ogen). Streptococcal…”
Get full text

Phosphomimics Destabilize Hsp27 Oligomeric Assemblies and Enhance Chaperone Activity by Jovcevski, Blagojce, Kelly, Megan A., Rote, Anthea P., Berg, Tracey, Gastall, Heidi Y., Benesch, Justin L.P., Aquilina, J. Andrew, Ecroyd, Heath

“…Serine phosphorylation of the mammalian small heat-shock protein Hsp27 at residues 15, 78, and 82 is thought to regulate its structure and chaperone function;…”
Get full text

C‑Phycocyanin from Spirulina Inhibits α‑Synuclein and Amyloid‑β Fibril Formation but Not Amorphous Aggregation by Liu, Yanqin, Jovcevski, Blagojce, Pukala, Tara L

“…Proteinopathies including cataracts and neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease, are characterized by a series of aberrant…”
Get full text

Profiling and optimized extraction of bioactive polyphenolic compounds from young, red-fleshed apple using eco-friendly deep eutectic solvents by Yu, Long, Jovcevski, Blagojce, Pukala, Tara L., Bulone, Vincent

“…[Display omitted] •Young, red-fleshed apples (RFA) are rich in bioactive polyphenolic compounds.•Natural deep eutectic solvents (NDES) efficiently extract…”
Get full text

Structural and mechanistic insights into amyloid‐β and α‐synuclein fibril formation and polyphenol inhibitor efficacy in phospholipid bilayers by Sanders, Henry M., Jovcevski, Blagojce, Marty, Michael T., Pukala, Tara L.

“…Under certain cellular conditions, functional proteins undergo misfolding, leading to a transition into oligomers which precede the formation of amyloid…”
Get full text

Fabrication of Piperazine Functionalized Polymeric Monolithic Tip for Rapid Enrichment of Glycopeptides/Glycans by Sajid, Muhammad Salman, Jovcevski, Blagojce, Pukala, Tara Louise, Jabeen, Fahmida, Najam-ul-Haq, Muhammad

“…Enrichment strategies are designed for the pretreatment of low-abundance glycans and glycopeptides prior to mass spectrometric (MS) analysis. Here, a tip-based…”
Get full text

Polyphenol Honokiol and Flavone 2′,3′,4′-Trihydroxyflavone Differentially Interact with α‑Synuclein at Distinct Phases of Aggregation by Jovcevski, Blagojce, Das, Sukanya, Smid, Scott, Pukala, Tara Louise

“…The association between protein aggregation and neurodegenerative diseases such as Parkinson’s disease continues to be well interrogated but poorly elucidated…”
Get full text

Nucleoside selectivity of Aspergillus fumigatus nucleoside‐diphosphate kinase by Nguyen, Stephanie, Jovcevski, Blagojce, Pukala, Tara L., Bruning, John B.

“…Aspergillus fumigatus nucleoside‐diphosphate kinase (NDK) exhibits nucleoside selectivity whereby adenine nucleosides are preferentially used and cytidine…”
Get full text

Designer D-peptides targeting the N-terminal region of α-synuclein to prevent parkinsonian-associated fibrilization and cytotoxicity by Horsley, John R., Jovcevski, Blagojce, Pukala, Tara L., Abell, Andrew D.

“…The deposition of α-synuclein (αS) aggregates in the gut and the brain is ever present in cases of Parkinson's disease. While the central…”
Get full text

Structural insights into the antifungal drug target guanosine monophosphate synthase from Aspergillus fumigatus by Nguyen, Stephanie, Jovcevski, Blagojce, Pukala, Tara L., Bruning, John B.

“…Purine biosynthesis is a fundamental cellular process that sustains life by maintaining the intracellular pool of purines for DNA/RNA synthesis and signal…”
Get full text

Escherichia coli YgiC and YjfC Possess PeptideSpermidine Ligase Activity by Pederick, Jordan L., Klose, Jack, Jovcevski, Blagojce, Pukala, Tara L., Bruning, John B.

“…Polyamines and polyamine-containing metabolites are involved in many cellular processes related to bacterial cell growth and survival. In Escherichia coli, the…”
Get full text

A structural model of the human plasminogen and Aspergillus fumigatus enolase complex by Nguyen, Stephanie, Jovcevski, Blagojce, Truong, Jia Q., Pukala, Tara L., Bruning, John B.

“…The metabolic enzyme, enolase, plays a crucial role in the cytoplasm where it maintains cellular energy production within the process of glycolysis. The main…”
Get full text

Rationally designed peptide-based inhibitor of Aβ42 fibril formation and toxicity: a potential therapeutic strategy for Alzheimer's disease by Horsley, John R, Jovcevski, Blagojce, Wegener, Kate L, Yu, Jingxian, Pukala, Tara L, Abell, Andrew D

“…Amyloid beta peptide (Aβ42) aggregation in the brain is thought to be responsible for the onset of Alzheimer's disease, an insidious condition without an…”
Get more information

Biochemical and structural characterization of meningococcal methylenetetrahydrofolate reductase by Pantong, Wanita, Pederick, Jordan L., Maenpuen, Somchart, Tinikul, Ruchanok, Jayapalan, Jaime J., Jovcevski, Blagojce, Wegener, Kate L., Bruning, John B., Salaemae, Wanisa

“…Methylenetetrahydrofolate reductase (MTHFR) is a key metabolic enzyme in colonization and virulence of Neisseria meningitidis, a causative agent of…”
Get full text

Interrogating the higher order structures of snake venom proteins using an integrated mass spectrometric approach by Wang, C. Ruth, Bubner, Emily R., Jovcevski, Blagojce, Mittal, Parul, Pukala, Tara L.

“…Snake venoms contain complex mixtures of proteins vital for the survival of venomous snakes. Aligned with their diverse pharmacological activities, the protein…”
Get full text

Structural Study of Potent Triazole-Based Inhibitors of Staphylococcus aureus Biotin Protein Ligase by Stachura, Damian L., Nguyen, Stephanie, Polyak, Steven W., Jovcevski, Blagojce, Bruning, John B., Abell, Andrew D.

“…The rise of multidrug-resistant bacteria, such as Staphylococcus aureus, has highlighted global urgency for new classes of antibiotics. Biotin protein ligase…”
Get full text

Structural Analysis and Identity Confirmation of Anthocyanins in Brassica oleracea Extracts by Direct Injection Ion Mobility-Mass Spectrometry by Pachulicz, River J., Yu, Long, Jovcevski, Blagojce, Bulone, Vincent, Pukala, Tara L.

“…Anthocyanins are a subclass of plant-derived flavonoids that demonstrate immense structural heterogeneity which is challenging to capture in complex extracts…”
Get full text

Short Photoswitchable Antibacterial Peptides by Yeoh, Yuan Qi, Horsley, John R., Yu, Jingxian, Polyak, Steven W., Jovcevski, Blagojce, Abell, Andrew D.

“…Three photoswitchable tetrapeptides, based on a known synthetic antibacterial, were designed and synthesized to determine activity against Staphylococcus…”
Get full text

Evaluating the Effect of Phosphorylation on the Structure and Dynamics of Hsp27 Dimers by Means of Ion Mobility Mass Spectrometry by Jovcevski, Blagojce, Kelly, Megan A, Aquilina, J. Andrew, Benesch, Justin L. P, Ecroyd, Heath

“…The quaternary structure and dynamics of the human small heat-shock protein Hsp27 are linked to its molecular chaperone function and influenced by…”
Get full text