Search Results - "Jouvet, Nathalie"

The pancreas: Bandmaster of glucose homeostasis by Jouvet, Nathalie, Estall, Jennifer L.

“…The pancreas is a centralized organ vital for whole body metabolic control. Recent advances in the field of metabolism have reinforced its importance for…”
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Human Glyceraldehyde-3-phosphate Dehydrogenase Plays a Direct Role in Reactivating Oxidized Forms of the DNA Repair Enzyme APE1 by Azam, Sonish, Jouvet, Nathalie, Jilani, Arshad, Vongsamphanh, Ratsavarinh, Yang, Xiaoming, Yang, Stephen, Ramotar, Dindial

“…Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has diverse biological functions including its nuclear translocation in response to oxidative stress. We show…”
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Humanized mice for the study of infectious diseases by Brehm, Michael A, Jouvet, Nathalie, Greiner, Dale L, Shultz, Leonard D

“…Highlights • Humanized mice can be used to study human specific infectious agents in vivo. • Human HSC engrafted immunodeficient IL2rg null mice develop human…”
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PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments by Léveillé, Mélissa, Besse-Patin, Aurèle, Jouvet, Nathalie, Gunes, Aysim, Sczelecki, Sarah, Jeromson, Stewart, Khan, Naveen P., Baldwin, Cindy, Dumouchel, Annie, Correia, Jorge C., Jannig, Paulo R., Boulais, Jonathan, Ruas, Jorge L., Estall, Jennifer L.

“…The liver is regularly exposed to changing metabolic and inflammatory environments. It must sense and adapt to metabolic need while balancing resources…”
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PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids by Oropeza, Daniel, Jouvet, Nathalie, Bouyakdan, Khalil, Perron, Gabrielle, Ringuette, Lea-Jeanne, Philipson, Louis H, Kiss, Robert S, Poitout, Vincent, Alquier, Thierry, Estall, Jennifer L

“…Abstract Objectives Peroxisome proliferator-activated receptor γ coactivator 1 (PPARGCA1, PGC-1) transcriptional coactivators control gene programs important…”
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Searching for the [beta]-Cell Fountain of Youth by Jouvet, Nathalie, Estall, Jennifer L

“…Aging affects every species and tissue but not in equal ways. Human pancreatic [beta]-cells lose their ability to replicate, regenerate, and secrete insulin as…”
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Role of the Interaction Between NCK1 and PERK in Pancreatic Beta-cell Function and Survival by Monteillet, Laure, Jouvet, Nathalie, Baldwin, Cindy, Estall, Jennifer

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Peptide-based sequestration of the adaptor protein Nck1 in pancreatic β cells enhances insulin biogenesis and protects against diabetogenic stresses by Kefalas, George, Jouvet, Nathalie, Baldwin, Cindy, Estall, Jennifer L., Larose, Louise

“…One feature of diabetes is the failure of pancreatic β cells to produce insulin, but the molecular mechanisms leading to this failure remain unclear…”
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The Tetracycline-Controlled Transactivator (Tet-On/Off) System in β-Cells Reduces Insulin Expression and Secretion in Mice by Jouvet, Nathalie, Bouyakdan, Khalil, Campbell, Scott A, Baldwin, Cindy, Townsend, Shannon E, Gannon, Maureen A, Poitout, Vincent, Alquier, Thierry, Estall, Jennifer L

“…Controllable genetic manipulation is an indispensable tool in research, greatly advancing our understanding of cell biology and physiology. However in β-cells,…”
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Searching for the β-Cell Fountain of Youth by Jouvet, Nathalie, Estall, Jennifer L

“…Aging affects every species and tissue but not in equal ways. Human pancreatic β-cells lose their ability to replicate, regenerate, and secrete insulin as one…”
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Loss of Furin in β-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to β-Cell Dysfunction by Brouwers, Bas, Coppola, Ilaria, Vints, Katlijn, Dislich, Bastian, Jouvet, Nathalie, Van Lommel, Leentje, Segers, Charlotte, Gounko, Natalia V, Thorrez, Lieven, Schuit, Frans, Lichtenthaler, Stefan F, Estall, Jennifer L, Declercq, Jeroen, Ramos-Molina, Bruno, Creemers, John W M

“…FURIN is a proprotein convertase (PC) responsible for proteolytic activation of a wide array of precursor proteins within the secretory pathway. It maps to the…”
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Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone by Oropeza, Daniel, Jouvet, Nathalie, Budry, Lionel, Campbell, Jonathan E, Bouyakdan, Khalil, Lacombe, Julie, Perron, Gabrielle, Bergeron, Valerie, Neuman, Joshua C, Brar, Harpreet K, Fenske, Rachel J, Meunier, Clemence, Sczelecki, Sarah, Kimple, Michelle E, Drucker, Daniel J, Screaton, Robert A, Poitout, Vincent, Ferron, Mathieu, Alquier, Thierry, Estall, Jennifer L

“…There is growing concern over confounding artifacts associated with β-cell-specific Cre-recombinase transgenic models, raising questions about their general…”
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Impact of the PGC-1α Gly482Ser Polymorphism on Mouse Metabolism by Jouvet, Nathalie, Courty, Émilie, Galipeau, Maria, Vandenbeek, Roxanne, Bouyakdan, Khalil, Alquier, Thierry, Estall, Jennifer

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The Gly482Ser Polymorphism Affects PGC-1α Stability in INS-1 β-Cells by Galipeau, Maria, Vandenbeek, Roxanne, Khan, Naveen, Screaton, Robert, Scott, Daniel, Jouvet, Nathalie, Oeffinger, Marlene, Estall, Jennifer

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Role of the Interaction Between Nck1 and PERK in Pancreatic Beta Cell Function and Survival by Monteillet, Laure, Courty, Émilie, Jouvet, Nathalie, Gasparrini, Marco, Baldwin, Cindy, Larose, Louise, Paraskevas, Steven, Estall, Jennifer

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299-OR: Molecular and Physiological Consequences of the Diabetes-Related PGC1A Gly482Ser Polymorphism by GALIPEAU, MARIA, JOUVET, NATHALIE, COURTY, EMILIE, VANDENBEEK, ROXANNE, KHAN, NAVEEN P., BOUYAKDAN, KHALIL, NIAN, CUILAN, IORIO, CATERINA, SCOTT, DANIEL D., FARAJ, MAY, OEFFINGER, MARLENE, LYNN, FRANCIS C., SCREATON, ROBERT A., ALQUIER, THIERRY, ESTALL, JENNIFER L.

“…Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1A) is a nuclear transcriptional coregulator that plays a major role in the control of…”
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73 - Characterization and Flaws of a New Potential β-Cell-Specific Mouse Line by Jouvet, Nathalie, Courty, Emilie, Bouyakdan, Khalil, Alquier, Thierry, Estall, Jennifer L.

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The Diabetes-Related Gly482Ser Polymorphism Affects PGC1A Stability and Glucose Metabolism by Galipeau, Maria, Jouvet, Nathalie, Courty, Emilie, Vandenbeek, Roxanne, Khan, Naveen, Bouyakdan, Khalil, Nian, Cuilan, Iorio, Cathy, Scott, Daniel, Faraj, May, Oeffinger, Marlene, Lynn, Francis, Screaton, Robert, Alquier, Thierry, Estall, Jennifer

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Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in Non-Alcoholic Fatty Liver Disease-Related Fibrosis by Abdelnabi, Mohamed N., Flores Molina, Manuel, Soucy, Geneviève, Quoc-Huy Trinh, Vincent, Bédard, Nathalie, Mazouz, Sabrina, Jouvet, Nathalie, Dion, Jessica, Tran, Sarah, Bilodeau, Marc, Estall, Jennifer L., Shoukry, Naglaa H.

“…Nonalcoholic fatty liver disease (NAFLD) is a major health problem with complex pathogenesis. Although sex differences in NAFLD pathogenesis have been…”
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Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in Non-Alcoholic Fatty Liver Disease-Related FibrosisSummary by Mohamed N. Abdelnabi, Manuel Flores Molina, Geneviève Soucy, Vincent Quoc-Huy Trinh, Nathalie Bédard, Sabrina Mazouz, Nathalie Jouvet, Jessica Dion, Sarah Tran, Marc Bilodeau, Jennifer L. Estall, Naglaa H. Shoukry

“…Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is a major health problem with complex pathogenesis. Although sex differences in NAFLD pathogenesis…”
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