Search Results - "Journet, Michel"

Highly Efficient Synthesis of HIV NNRTI Doravirine by Gauthier, Donald R, Sherry, Benjamin D, Cao, Yang, Journet, Michel, Humphrey, Guy, Itoh, Tetsuji, Mangion, Ian, Tschaen, David M

“…The development of an efficient and robust process for the production of HIV NNRTI doravirine is described. The synthesis features a continuous aldol reaction…”
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Asymmetric Synthesis of Telcagepant, a CGRP Receptor Antagonist for the Treatment of Migraine by Xu, Feng, Zacuto, Michael, Yoshikawa, Naoki, Desmond, Richard, Hoerrner, Scott, Itoh, Tetsuji, Journet, Michel, Humphrey, Guy R, Cowden, Cameron, Strotman, Neil, Devine, Paul

“…A highly efficient, asymmetric synthesis of telcagepant (1), a CGRP receptor antagonist for the treatment of migraine, is described. This synthesis features…”
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Asymmetric Synthesis of a Potent HIV‑1 Integrase Inhibitor by Kuethe, Jeffrey T, Humphrey, Guy R, Journet, Michel, Peng, Zhihui, Childers, Karla G

“…The development of a practical asymmetric total synthesis of the potent HIV-1 integrase inhibitor 5 is described. Key transformations include construction of…”
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A Rapid Synthesis of 2-Aryl-5-substituted-2,3-dihydrobenzofurans by Kuethe, Jeffrey T, Wong, Audrey, Journet, Michel, Davies, Ian W

“…An effective strategy has been developed for the rapid and efficient one-pot synthesis of 2-aryl-5-substituted-2,3-dihydrobenzofurans from readily available…”
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Highly efficient and mild synthesis of variously 5-substituted-4-carbaldehyde-1,2,3-triazole derivatives by Journet, Michel, Cai, Dongwei, Kowal, Jason J, Larsen, Robert D

“…Synthesis of variously 5-substituted-4-carbaldehyde-1,2,3-triazole derivatives 2 was accomplished by reacting sodium azide with α,β-acetylenic aldehydes 1 in…”
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Functional analysis of the Pseudomonas aeruginosa autoinducer PAI by Passador, L, Tucker, K D, Guertin, K R, Journet, M P, Kende, A S, Iglewski, B H

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Radical cyclization of (bromomethyl)dimethylsilyl propargyl ethers. Regio-, chemo- and stereoselectivity by Journet, Michel, Malacria, Max

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The Evolving State of Continuous Processing in Pharmaceutical API Manufacturing: A Survey of Pharmaceutical Companies and Contract Manufacturing Organizations by McWilliams, J. Christopher, Allian, Ayman D, Opalka, Suzanne M, May, Scott A, Journet, Michel, Braden, Timothy M

“…This manuscript provides the results of an in-depth survey assessment of the capabilities, experience, and perspectives on continuous processing in the…”
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Preparation of Methyltriazolo[1,4]benzodiazepine via Oxidative Activation of a Thiolactam for the Synthesis of BET Inhibitor Molibresib by Erickson, Greg A, Hatcher, Mark A, Journet, Michel, Kowalski, John A, Lovelace, Tom C, Pink, Christopher J, Xie, Shiping

“…A novel oxidative activation of a thiolactam was developed for the preparation of methyltriazolo[1,4]benzodiazepine in a single step. A sulfenic acid (R-SOH)…”
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A New Rare Example of Cyclopropanation in Free-Radical Chemistry by Journet, Michel, Malacria, Max

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Asymmetric Synthesis of N‑Boc‑(R)‑Silaproline via Rh-Catalyzed Intramolecular Hydrosilylation of Dehydroalanine and Continuous Flow N‑Alkylation by Chung, John Y. L, Shevlin, Michael, Klapars, Artis, Journet, Michel

“…An asymmetric synthesis of a silicon-containing proline surrogate, N-Boc-(R)-silaproline (1), is described. Starting from N-Boc-dehydroalanine ester,…”
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Novel Ag(I)-catalysis of an intramolecular 1,3-dipolar cycloaddition by Kende, Andrew S., Journet, Michel

“…Acetylenic α-diazoketones, bearing gem-dimethyl substituents in the α′ position, were found to undergo an intramolecular 1,3-dipolar cycloaddition reaction in…”
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Dehydration of an Insoluble Urea Byproduct Enables the Condensation of DCC and Malonic Acid in Flow by O’Brien, Alexander G, Ricci, Eric M, Journet, Michel

“…A procedure for the preparation of N,N′-dicyclohexylbarbituric acid from DCC and malonic acid is described. Addition of phosphorus oxychloride to the reaction…”
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Controlled Semihydrogenation of Aminoalkynes Using Ethylenediamine as a Poison of Lindlar's Catalyst by Campos, Kevin R., Cai, Dongwei, Journet, Michel, Kowal, Jason J., Larsen, Robert D., Reider, Paul J.

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Development of a Multikilogram Scale Synthesis of a TRPV1 Antagonist by Kuethe, Jeffrey T, Journet, Michel, Peng, Zhihui, Zhao, Dalian, McKeown, Arlene, Humphrey, Guy R

“…A highly efficient, regioselective five-step synthesis of the TRPV1 antagonist 1 is described. The coupling of piperazine 7 with dichloropyrimidine 8 proceeded…”
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Selective Continuous Flow Iodination Guided by Direct Spectroscopic Observation of Equilibrating Aryl Lithium Regioisomers by Dunn, Anna L, Leitch, David C, Journet, Michel, Martin, Michael, Tabet, Elie A, Curtis, Neil R, Williams, Glynn, Goss, Charles, Shaw, Tony, O’Hare, Bernie, Wade, Charles, Toczko, Matthew A, Liu, Peng

“…The iodination of 4-fluoro-2-(trifluoromethyl)­benzonitrile via C–H lithiation and subsequent treatment with iodine under continuous flow conditions is…”
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Synthesis of Vaniprevir (MK-7009): Lactamization To Prepare a 22-Membered Macrocycle by Song, Zhiguo J, Tellers, David M, Journet, Michel, Kuethe, Jeffrey T, Lieberman, David, Humphrey, Guy, Zhang, Fei, Peng, Zhihui, Waters, Marjorie S, Zewge, Daniel, Nolting, Andrew, Zhao, Dalian, Reamer, Robert A, Dormer, Peter G, Belyk, Kevin M, Davies, Ian W, Devine, Paul N, Tschaen, David M

“…Development of a practical synthesis of MK-7009, a 22-membered macrocycle, is described. A variety of ring-closing strategies were evaluated, including…”
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Preparation of 4-Allylisoindoline via a Kumada Coupling with Allylmagnesium Chloride by Zacuto, Michael J, Shultz, C. Scott, Journet, Michel

“…A practical, cost-effective Kumada coupling for the preparation of 4-allylisoindoline has been developed. The first catalyst screen for this reaction with…”
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A Highly Regioselective Amination of 6-Aryl-2,4-dichloropyrimidine by Peng, Zhi-Hui, Journet, Michel, Humphrey, Guy

“…A highly regioselective amination of 6-aryl-2,4-dichloropyrimidine with aliphatic secondary amines and aromatic amines has been developed which strongly favors…”
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Synthesis of Bis-Macrocyclic HCV Protease Inhibitor MK-6325 via Intramolecular sp 2–sp 3 Suzuki–Miyaura Coupling and Ring Closing Metathesis by Li, Hongmei, Scott, Jeremy P, Chen, Cheng-yi, Journet, Michel, Belyk, Kevin, Balsells, Jaume, Kosjek, Birgit, Baxter, Carl A, Stewart, Gavin W, Wise, Christopher, Alam, Mahbub, Song, Zhiguo Jake, Tan, Lushi

“…A practical asymmetric synthesis of the complex fused bis-macrocyclic HCV protease inhibitor MK-6325 (1) is described. Through the combination of a high…”
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