Search Results - "Journal of pineal research"

Melatonin as an antioxidant: under promises but over delivers by Reiter, Russel J., Mayo, Juan C., Tan, Dun-Xian, Sainz, Rosa M., Alatorre-Jimenez, Moises, Qin, Lilan

“…Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large number of circumstances. It achieves this action via a variety of…”
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Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation by Ali, Tahir, Rahman, Shafiq Ur, Hao, Qiang, Li, Weifen, Liu, Zizhen, Ali Shah, Fawad, Murtaza, Iram, Zhang, Zaijun, Yang, Xifei, Liu, Gongping, Li, Shupeng

“…Major depressive disorder (MDD) is a life‐threatening illness characterized by mood changes and high rates of suicide. Although the role of neuroinflammation…”
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Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice by Yin, Jie, Li, Yuying, Han, Hui, Chen, Shuai, Gao, Jing, Liu, Gang, Wu, Xin, Deng, Jinping, Yu, Qifang, Huang, Xingguo, Fang, Rejun, Li, Tiejun, Reiter, Russel J., Zhang, Dong, Zhu, Congrui, Zhu, Guoqiang, Ren, Wenkai, Yin, Yulong

“…Melatonin has been shown to improve lipid metabolism and gut microbiota communities in animals and humans; however, it remains to know whether melatonin…”
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Melatonin attenuates myocardial ischemia‐reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK‐OPA1 signaling pathways by Zhang, Ying, Wang, Yue, Xu, Junnan, Tian, Feng, Hu, Shunying, Chen, Yundai, Fu, Zhenhong

“…Optic atrophy 1 (OPA1)‐related mitochondrial fusion and mitophagy are vital to sustain mitochondrial homeostasis under stress conditions. However, no study has…”
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Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3/miR‐223/NLRP3 axis by Zhang, Yong, Liu, Xin, Bai, Xue, Lin, Yuan, Li, Zhange, Fu, Jiangbo, Li, Mingqi, Zhao, Tong, Yang, Huan, Xu, Ranchen, Li, Jiamin, Ju, Jin, Cai, Benzhi, Xu, Chaoqian, Yang, Baofeng

“…Atherosclerosis (AS) is an inflammatory disease linked to endothelial dysfunction. Melatonin is reported to possess substantial anti‐inflammatory properties,…”
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Melatonin and inflammation—Story of a double‐edged blade by Hardeland, Rüdiger

“…Melatonin is an immune modulator that displays both pro‐ and anti‐inflammatory properties. Proinflammatory actions, which are well documented by many studies…”
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Melatonin: an ancient molecule that makes oxygen metabolically tolerable by Manchester, Lucien C., Coto-Montes, Ana, Boga, Jose Antonio, Andersen, Lars Peter H., Zhou, Zhou, Galano, Annia, Vriend, Jerry, Tan, Dun-Xian, Reiter, Russel J.

“…Melatonin is remarkably functionally diverse with actions as a free radical scavenger and antioxidant, circadian rhythm regulator, anti‐inflammatory and…”
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Melatonin prevents Drp1‐mediated mitochondrial fission in diabetic hearts through SIRT1‐PGC1α pathway by Ding, Mingge, Feng, Na, Tang, Daishi, Feng, Jiahao, Li, Zeyang, Jia, Min, Liu, Zhenhua, Gu, Xiaoming, Wang, Yuemin, Fu, Feng, Pei, Jianming

“…Myocardial contractile dysfunction is associated with an increase in mitochondrial fission in patients with diabetes. However, whether mitochondrial fission…”
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Phytomelatonin receptor PMTR1‐mediated signaling regulates stomatal closure in Arabidopsis thaliana by Wei, Jian, Li, Dong‐Xu, Zhang, Jia‐Rong, Shan, Chi, Rengel, Zed, Song, Zhong‐Bang, Chen, Qi

“…Melatonin has been detected in plants in 1995; however, the function and signaling pathway of this putative phytohormone are largely undetermined due to a lack…”
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Melatonin protects cardiac microvasculature against ischemia/reperfusion injury via suppression of mitochondrial fission‐VDAC1‐HK2‐mPTP‐mitophagy axis by Zhou, Hao, Zhang, Ying, Hu, Shunying, Shi, Chen, Zhu, Pingjun, Ma, Qiang, Jin, Qinhua, Cao, Feng, Tian, Feng, Chen, Yundai

“…The cardiac microvascular system, which is primarily composed of monolayer endothelial cells, is the site of blood supply and nutrient exchange to…”
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Functions of melatonin in plants: a review by Arnao, Marino B., Hernández-Ruiz, Josefa

“…The number of studies on melatonin in plants has increased significantly in recent years. This molecule, with a large set of functions in animals, has also…”
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Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia‐reperfusion injury by improving mitochondrial quality control: Role of SIRT6 by Yu, Li‐Ming, Dong, Xue, Xue, Xiao‐Dong, Xu, Shu, Zhang, Xu, Xu, Yin‐Li, Wang, Zhi‐Shang, Wang, Yang, Gao, Hao, Liang, Yan‐Xiao, Yang, Yang, Wang, Hui‐Shan

“…Targeting mitochondrial quality control with melatonin has been found promising for attenuating diabetic cardiomyopathy (DCM), although the underlying…”
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Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection by Galano, Annia, Reiter, Russel J.

“…Oxidative stress (OS) represents a threat to the chemical integrity of biomolecules including lipids, proteins, and DNA. The associated molecular damage…”
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Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury‐induced ferroptosis by Rui, Tongyu, Wang, Haochen, Li, Qianqian, Cheng, Ying, Gao, Yuan, Fang, Xuexian, Ma, Xuying, Chen, Guang, Gao, Cheng, Gu, Zhiya, Song, Shunchen, Zhang, Jian, Wang, Chunling, Wang, Zufeng, Wang, Tao, Zhang, Mingyang, Min, Junxia, Chen, Xiping, Tao, Luyang, Wang, Fudi, Luo, Chengliang

“…Accumulating evidence demonstrates that ferroptosis may be important in the pathophysiological process of traumatic brain injury (TBI). As a major hormone of…”
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Effects of melatonin on fatty liver disease: The role of NR4A1/DNA‐PKcs/p53 pathway, mitochondrial fission, and mitophagy by Zhou, Hao, Du, Wenjuan, Li, Ye, Shi, Chen, Hu, Nan, Ma, Sai, Wang, Weihu, Ren, Jun

“…Mitochondrial dysfunction has been implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) through poorly defined mechanisms. Melatonin…”
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Melatonin alleviates inflammasome‐induced pyroptosis through inhibiting NF‐κB/GSDMD signal in mice adipose tissue by Liu, Zhenjiang, Gan, Lu, Xu, Yatao, Luo, Dan, Ren, Qian, Wu, Song, Sun, Chao

“…Pyroptosis is a proinflammatory form of cell death that is associated with pathogenesis of many chronic inflammatory diseases. Melatonin is substantially…”
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Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3‐dependent regulation of oxidative stress and apoptosis by Zhai, Mengen, Li, Buying, Duan, Weixun, Jing, Lin, Zhang, Bin, Zhang, Meng, Yu, Liming, Liu, Zhenhua, Yu, Bo, Ren, Kai, Gao, Erhe, Yang, Yang, Liang, Hongliang, Jin, Zhenxiao, Yu, Shiqiang

“…Sirtuins are a family of highly evolutionarily conserved nicotinamide adenine nucleotide‐dependent histone deacetylases. Sirtuin‐3 (SIRT3) is a member of the…”
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Melatonin protects mouse testes from palmitic acid‐induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1‐dependent manner by Xu, Dejun, Liu, Lingbin, Zhao, Yongju, Yang, Li, Cheng, Jianyong, Hua, Rongmao, Zhang, Zelin, Li, Qingwang

“…Palmitic acid (PA), the main component of dietary saturated fat, has been known to increase in patients with obesity, and PA‐induced lipotoxicity may…”
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Melatonin: a well-documented antioxidant with conditional pro-oxidant actions by Zhang, Hong-Mei, Zhang, Yiqiang

“…Melatonin (N‐acetyl‐5‐methoxytryptamine), an indoleamine produced in many organs including the pineal gland, was initially characterized as a hormone primarily…”
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Melatonin attenuates choroidal neovascularization by regulating macrophage/microglia polarization via inhibition of RhoA/ROCK signaling pathway by Xu, Yue, Cui, Kaixuan, Li, Jia, Tang, Xiaoyu, Lin, Jianqiang, Lu, Xi, Huang, Rong, Yang, Boyu, Shi, Yuxun, Ye, Dan, Huang, Jingjing, Yu, Shanshan, Liang, Xiaoling

“…Choroidal neovascularization (CNV) is an important characteristic of advanced wet age‐related macular degeneration (AMD) and leads to severe visual impairment…”
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