Search Results - "Journal of ocular pharmacology"

The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options by Periman, Laura M, Perez, Victor L, Saban, Daniel R, Lin, Meng C, Neri, Piergiorgio

“…Homeostasis of the lacrimal functional unit is needed to ensure a well-regulated ocular immune response comprising innate and adaptive phases. When the ocular…”
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Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma by Lin, Cheng-Wen, Sherman, Bryan, Moore, Lori A, Laethem, Carmen L, Lu, Da-Wen, Pattabiraman, Padmanabhan P, Rao, Ponugoti Vasantha, deLong, Mitchell A, Kopczynski, Casey C

“…Rho-associated protein kinase (ROCK) inhibitors lower intraocular pressure (IOP) by increasing aqueous outflow through the trabecular meshwork (TM). The…”
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Ocular Adverse Events Associated with Antibody-Drug Conjugates in Human Clinical Trials by Eaton, Joshua Seth, Miller, Paul E, Mannis, Mark J, Murphy, Christopher J

“…This article reviews ocular adverse events (AEs) reported in association with administration of antibody-drug conjugates (ADCs) in human clinical trials…”
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Recent Advances in Topical Ocular Drug Delivery by Yellepeddi, Venkata Kashyap, Palakurthi, Srinath

“…Topical ocular drug delivery has been considered to be an ideal route of administration for treatment of ocular diseases related to the anterior segment of the…”
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Eyes on Lipinski's Rule of Five: A New "Rule of Thumb" for Physicochemical Design Space of Ophthalmic Drugs by Karami, Thomas K, Hailu, Shumet, Feng, Shaoxin, Graham, Richard, Gukasyan, Hovhannes J

“…The study objective was to investigate molecular thermodynamic properties of approved ophthalmic drugs and derive a framework outlining physicochemical design…”
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Mucus-Penetrating Particles and the Role of Ocular Mucus as a Barrier to Micro- and Nanosuspensions by Popov, Alexey

“…The ocular surface is naturally covered with a layer of mucus. Along with other functions, this mucus layer serves to trap and eliminate foreign substances,…”
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Effects of a Novel Selective EP2 Receptor Agonist, Omidenepag Isopropyl, on Aqueous Humor Dynamics in Laser-Induced Ocular Hypertensive Monkeys by Fuwa, Masahiro, Toris, Carol B, Fan, Shan, Taniguchi, Takazumi, Ichikawa, Masaki, Odani-Kawabata, Noriko, Iwamura, Ryo, Yoneda, Kenji, Matsugi, Takeshi, Shams, Naveed K, Zhang, Jin-Zhong

“…To investigate the mechanism of the intraocular pressure (IOP)-lowering effect of a novel selective prostaglandin E2 receptor 2 (EP2) receptor agonist,…”
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Relevance of Lipid-Based Products in the Management of Dry Eye Disease by Garrigue, Jean-Sébastien, Amrane, Mourad, Faure, Marie-Odile, Holopainen, Juha M, Tong, Louis

“…Components of the ocular surface synergistically contribute to maintaining and protecting a smooth refractive layer to facilitate the optimal transmission of…”
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Double-Masked, Randomized, Phase 2 Evaluation of Abicipar Pegol (an Anti-VEGF DARPin Therapeutic) in Neovascular Age-Related Macular Degeneration by Callanan, David, Kunimoto, Derek, Maturi, Raj K, Patel, Sunil S, Staurenghi, Giovanni, Wolf, Sebastian, Cheetham, Janet K, Hohman, Thomas C, Kim, Kimmie, López, Francisco J, Schneider, Susan

“…To evaluate safety and efficacy of the vascular endothelial growth factor binding protein abicipar pegol (abicipar) versus ranibizumab for neovascular…”
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Cytomegalovirus Retinitis: A Review by Port, Alexander D, Orlin, Anton, Kiss, Szilard, Patel, Sarju, D'Amico, Donald J, Gupta, Mrinali P

“…Cytomegalovirus (CMV) is a ubiquitous DNA herpes virus that causes significant morbidity and mortality in immunocompromised individuals. CMV retinitis is a…”
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Topical Losartan: Practical Guidance for Clinical Trials in the Prevention and Treatment of Corneal Scarring Fibrosis and Other Eye Diseases and Disorders by Wilson, Steven E

“…Losartan is an angiotensin II receptor blocker (ARB) that impedes transforming growth factor (TGF) beta signaling by inhibiting activation of signal…”
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LFA-1/ICAM-1 Interaction as a Therapeutic Target in Dry Eye Disease by Pflugfelder, Stephen C, Stern, Michael, Zhang, Steven, Shojaei, Amir

“…Dry eye disease (DED) is a common ocular disorder associated with inflammation of the lacrimal gland and ocular surface. The interaction of the integrin…”
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Recent Insights into the Etiopathogenesis of Diabetic Retinopathy and Its Management by Biswas, Arpon, Choudhury, Abhijit Deb, Agrawal, Sristi, Bisen, Amol Chhatrapati, Sanap, Sachin Nashik, Verma, Sarvesh Kumar, Kumar, Mukesh, Mishra, Anjali, Kumar, Shivansh, Chauhan, Mridula, Bhatta, Rabi Sankar

“…Diabetic retinopathy (DR) is a microvascular retinal disease associated with chronic diabetes mellitus, characterized by the damage of blood vessels in the…”
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Ophthalmic Drug Delivery Using Iontophoresis: Recent Clinical Applications by Perez, Victor L, Wirostko, Barbara, Korenfeld, Michael, From, Stephen, Raizman, Michael

“…Iontophoresis is a noninvasive delivery system designed to overcome barriers to ocular penetration of topical ophthalmic medications by employing a…”
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Pharmacotherapy of glaucoma by Schmidl, Doreen, Schmetterer, Leopold, Garhöfer, Gerhard, Popa-Cherecheanu, Alina

“…Glaucoma is a group of diseases involving the optic nerve and associated structures, which is characterized by progressive visual field loss and typical…”
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Targeting Lipid Metabolism for the Treatment of Age-Related Macular Degeneration: Insights from Preclinical Mouse Models by Landowski, Michael, Bowes Rickman, Catherine

“…Age-related macular degeneration (AMD) is a major leading cause of irreversible visual impairment in the world with limited therapeutic interventions…”
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Ocular Side Effects of Bisphosphonates: A Review of Literature by Chartrand, Nicholas A, Lau, Chap-Kay, Parsons, Mark T, Handlon, Jaiden J, Ronquillo, Yasmyne C, Hoopes, Phillip C, Moshirfar, Majid

“…In rare cases, bisphosphonates are well established to cause ocular inflammation, presenting as uveitis, episcleritis, scleritis, orbital inflammation, and/or…”
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Comprehensive Preclinical Assessment of ADVM-022, an Intravitreal Anti-VEGF Gene Therapy for the Treatment of Neovascular AMD and Diabetic Macular Edema by Gelfman, Claire M, Grishanin, Ruslan, Bender, Kristina Oresic, Nguyen, Aivan, Greengard, Judith, Sharma, Pallavi, Nieves, Julio, Kiss, Szilárd, Gasmi, Mehdi

“…Inhibition of vascular endothelial growth factor is the mode of action for several approved therapies, including aflibercept, for the treatment of neovascular…”
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Effects of Diquafosol Sodium Ophthalmic Solution on Tear Film Matrix Metallopeptidase-9 and Corneal Nerve Density in Patients with Type 2 Diabetic Dry Eye by Qin, Guanghao, Chen, Jiayan, Li, Liangzhe, Qi, Yifan, Chen, Yimeng, Zhang, Qing, Wu, Yi, You, Yue, Yang, Lanting, Guo, Naici, Moutari, Salissou, Bu, Shaochong, Moore, Jonathan E, Xu, Ling, He, Wei, Yu, Sile, He, Xingru, Pazo, Emmanuel Eric

“…Diabetes mellitus has been associated with increased dry eye disease (DED) and exacerbates DED's pathology. This preliminary short-term study aimed to evaluate…”
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Solanum nigrum Toxicity and Its Neuroprotective Effect Against Retinal Ganglion Cell Death Through Modulation of Extracellular Matrix in a Glaucoma Rat Model by Yadav, Karan Singh, Bisen, Amol Chhatrapati, Ishteyaque, Sharmeen, Sharma, Isha, Verma, Smriti, Sanap, Sachin Nashik, Verma, Shobhit, Washimkar, Kaveri R, Kumar, Akhilesh, Tripathi, Vineeta, Bhatta, Rabi Sankar, Mugale, Madhav Nilakanth

“…Glaucoma is a complex degenerative optic neuropathy characterized by loss of retinal ganglion cells (RGCs) leading to irreversible vision loss and blindness…”
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