Search Results - "Journal of neuropathology and experimental neurology"

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years by Braak, Heiko, Thal, Dietmar R, Ghebremedhin, Estifanos, Del Tredici, Kelly

“…Two thousand three hundred and thirty two nonselected brains from 1- to 100-year-old individuals were examined using immunocytochemistry (AT8) and Gallyas…”
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Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010 by Beach, Thomas G, Monsell, Sarah E, Phillips, Leslie E, Kukull, Walter

“…ABSTRACTThe neuropathologic examination is considered to provide the gold standard for Alzheimer disease (AD). To determine the accuracy of currently used…”
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Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury by McKee, Ann C, Cantu, Robert C, Nowinski, Christopher J, Hedley-Whyte, E. Tessa, Gavett, Brandon E, Budson, Andrew E, Santini, Veronica E, Lee, Hyo-Soon, Kubilus, Caroline A, Stern, Robert A

“…Since the 1920s, it has been known that the repetitive brain trauma associated with boxing may produce a progressive neurological deterioration, originally…”
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Limbic Predominant Age-Related TDP-43 Encephalopathy (LATE): Clinical and Neuropathological Associations by Besser, Lilah M, Teylan, Merilee A, Nelson, Peter T

“…Abstract Recently, a consensus working group provided new terminology for a common disease entity, limbic predominant age-related TDP-43 encephalopathy (LATE),…”
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Neuroanatomic Connectivity of the Human Ascending Arousal System Critical to Consciousness and Its Disorders by Edlow, Brian L, Takahashi, Emi, Wu, Ona, Benner, Thomas, Dai, Guangping, Bu, Lihong, Grant, Patricia Ellen, Greer, David M, Greenberg, Steven M, Kinney, Hannah C, Folkerth, Rebecca D

“…ABSTRACTThe ascending reticular activating system (ARAS) mediates arousal, an essential component of human consciousness. Lesions of the ARAS cause coma, the…”
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TDP-43 Proteinopathy and Motor Neuron Disease in Chronic Traumatic Encephalopathy by McKee, Ann C, Gavett, Brandon E, Stern, Robert A, Nowinski, Christopher J, Cantu, Robert C, Kowall, Neil W, Perl, Daniel P, Hedley-Whyte, E. Tessa, Price, Bruce, Sullivan, Chris, Morin, Peter, Lee, Hyo-Soon, Kubilus, Caroline A, Daneshvar, Daniel H, Wulff, Megan, Budson, Andrew E

“…Epidemiological evidence suggests that the incidence of amyotrophic lateral sclerosis is increased in association with head injury. Repetitive head injury is…”
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Peri-Infarct Upregulation of the Oxytocin Receptor in Vascular Dementia by McKay, Erin C, Beck, John S, Khoo, Sok Kean, Dykema, Karl J, Cottingham, Sandra L, Winn, Mary E, Paulson, Henry L, Lieberman, Andrew P, Counts, Scott E

“…Abstract Vascular dementia (VaD) is cognitive decline linked to reduced cerebral blood perfusion, yet there are few therapeutic options to protect cognitive…”
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The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases by Nelson, Peter T, Abner, Erin L, Patel, Ela, Anderson, Sonya, Wilcock, Donna M, Kryscio, Richard J, Van Eldik, Linda J, Jicha, Gregory A, Gal, Zsombor, Nelson, Ruth S, Nelson, Bela G, Gal, Jozsef, Azam, Md. Tofial, Fardo, David W, Cykowski, Matthew D

“…Abstract Over the course of most common neurodegenerative diseases the amygdala accumulates pathologically misfolded proteins. Misfolding of 1 protein in aged…”
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Biology of Microglia in the Developing Brain by Kaur, Charanjit, Rathnasamy, Gurugirijha, Ling, Eng-Ang

“…Abstract Microglia exist in different morphological forms in the developing brain. They show a small cell body with scanty cytoplasm with many branching…”
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Prognostic Value of Histopathological Features and Loss of H3K27me3 Immunolabeling in Anaplastic Meningioma: A Multicenter Retrospective Study by Gauchotte, Guillaume, Peyre, Matthieu, Pouget, Celso, Cazals-Hatem, Dominique, Polivka, Marc, Rech, Fabien, Varlet, Pascale, Loiseau, Hugues, Lacomme, Stéphanie, Mokhtari, Karima, Kalamarides, Michel, Bielle, Franck

“…Abstract The diagnosis of anaplastic meningioma (AM) (WHO grade III) is based on the presence of a high mitotic index (MI) and/or overt anaplasia. Only few…”
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Components of Myelin Damage and Repair in the Progression of White Matter Pathology After Mild Traumatic Brain Injury by Mierzwa, Amanda J., Marion, Christina M., Sullivan, Genevieve M., McDaniel, Dennis P., Armstrong, Regina C.

“…White matter tracts are highly vulnerable to damage from impact-acceleration forces of traumatic brain injury (TBI). Mild TBI is characterized by a low density…”
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Blood–Brain Barrier Dysfunction as a Hallmark Pathology in Chronic Traumatic Encephalopathy by Doherty, Colin P., O’Keefe, Eoin, Wallace, Eugene, Loftus, Teresa, Keaney, James, Kealy, John, Humphries, Marian M., Molloy, Michael G., Meaney, James F., Farrell, Michael, Campbell, Matthew

“…Chronic traumatic encephalopathy (CTE) is a neurodegenerative condition associated with repetitive mild traumatic brain injury. In recent years, attention has…”
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Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex by Ansari, Mubeen A, Scheff, Stephen W

“…We investigated oxidative stress in human postmortem frontal cortexfrom individuals characterized as mild cognitive impairment (n= 8), mild/moderate Alzheimer…”
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Metabolomics of Human Brain Aging and Age-Related Neurodegenerative Diseases by Jové, Mariona, Portero-Otín, Manuel, Naudí, Alba, Ferrer, Isidre, Pamplona, Reinald

“…ABSTRACTNeurons in the mature human central nervous system (CNS) perform a wide range of motor, sensory, regulatory, behavioral, and cognitive functions. Such…”
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The Choroid Plexus in Healthy and Diseased Brain by Kaur, Charanjit, Rathnasamy, Gurugirijha, Ling, Eng-Ang

“…The choroid plexus is composed of epithelial cells resting on a basal lamina. These cells produce the cerebrospinal fluid (CSF), which has many functions…”
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Activation Status of Human Microglia Is Dependent on Lesion Formation Stage and Remyelination in Multiple Sclerosis by Peferoen, Laura A.N, Vogel, Daphne Y.S, Ummenthum, Kimberley, Breur, Marjolein, Heijnen, Priscilla D.A.M, Gerritsen, Wouter H, Peferoen-Baert, Regina M.B, van der Valk, Paul, Dijkstra, Christine D, Amor, Sandra

“…ABSTRACTSimilar to macrophages, microglia adopt diverse activation states and contribute to repair and tissue damage in multiple sclerosis. Using reverse…”
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Microglia of Prefrontal White Matter in Suicide by Schnieder, Tatiana P, Trencevska, Iskra, Rosoklija, Gorazd, Stankov, Aleksandr, Mann, J John, Smiley, John, Dwork, Andrew J

“…ABSTRACTImmune functions in the brain are associated with psychiatric illness and temporary alteration of mental state. Microglia, the principal brain…”
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Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy by Walker, Jamie M, Richardson, Timothy E, Farrell, Kurt, Iida, Megan A, Foong, Chan, Shang, Ping, Attems, Johannes, Ayalon, Gai, Beach, Thomas G, Bigio, Eileen H, Budson, Andrew, Cairns, Nigel J, Corrada, María, Cortes, Etty, Dickson, Dennis W, Fischer, Peter, Flanagan, Margaret E, Franklin, Erin, Gearing, Marla, Glass, Jonathan, Hansen, Lawrence A, Haroutunian, Vahram, Hof, Patrick R, Honig, Lawrence, Kawas, Claudia, Keene, C Dirk, Kofler, Julia, Kovacs, Gabor G, Lee, Edward B, Lutz, Mirjam I, Mao, Qinwen, Masliah, Eliezer, McKee, Ann C, McMillan, Corey T, Mesulam, M Marsel, Murray, Melissa, Nelson, Peter T, Perrin, Richard, Pham, Thao, Poon, Wayne, Purohit, Dushyant P, Rissman, Robert A, Sakai, Kenji, Sano, Mary, Schneider, Julie A, Stein, Thor D, Teich, Andrew F, Trojanowski, John Q, Troncoso, Juan C, Vonsattel, Jean-Paul, Weintraub, Sandra, Wolk, David A, Woltjer, Randall L, Yamada, Masahito, Yu, Lei, White, Charles L, Crary, John F

“…Abstract Primary age-related tauopathy (PART) is a neurodegenerative entity defined as Alzheimer-type neurofibrillary degeneration primarily affecting the…”
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Genomic Analysis of Dysembryoplastic Neuroepithelial Tumor Spectrum Reveals a Diversity of Molecular Alterations Dysregulating the MAPK and PI3K/mTOR Pathways by Surrey, Lea F, Jain, Payal, Zhang, Bo, Straka, Joshua, Zhao, Xiaonan, Harding, Brian N, Resnick, Adam C, Storm, Phillip B, Buccoliero, Anna Maria, Genitori, Lorenzo, Li, Marilyn M, Waanders, Angela J, Santi, Mariarita

“…Abstract Dysembryoplastic neuroepithelial tumors (DNT) lacking key diagnostic criteria are challenging to diagnose and sometimes fall into the broader category…”
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Differential Relationships of Reactive Astrocytes and Microglia to Fibrillar Amyloid Deposits in Alzheimer Disease by Serrano-Pozo, Alberto, Muzikansky, Alona, Gómez-Isla, Teresa, Growdon, John H, Betensky, Rebecca A, Frosch, Matthew P, Hyman, Bradley T

“…ABSTRACTAlthough it is clear that astrocytes and microglia cluster around dense-core amyloid plaques in Alzheimer disease (AD), whether they are primarily…”
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