Search Results - "Journal of neurochemistry"

Neuroinflammation: the devil is in the details by DiSabato, Damon J., Quan, Ning, Godbout, Jonathan P.

“…There is significant interest in understanding inflammatory responses within the brain and spinal cord. Inflammatory responses that are centralized within the…”
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The clinical symptoms of Parkinson's disease by Sveinbjornsdottir, Sigurlaug

“…In this review, the clinical features of Parkinson's disease, both motor and non‐motor, are described in the context of the progression of the disease. Also…”
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Mitochondrial dysfunction in Parkinson's disease by Bose, Anindita, Beal, M. Flint

“…Parkinson's disease (PD) is the second most common neurodegenerative disease. About 2% of the population above the age of 60 is affected by the disease. The…”
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The S100B story: from biomarker to active factor in neural injury by Michetti, Fabrizio, D'Ambrosi, Nadia, Toesca, Amelia, Puglisi, Maria Ausiliatrice, Serrano, Alessia, Marchese, Elisa, Corvino, Valentina, Geloso, Maria Concetta

“…S100B is a Ca2+‐binding protein mainly concentrated in astrocytes. Its levels in biological fluids (cerebrospinal fluid, peripheral and cord blood, urine,…”
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Brain aging and neurodegeneration: from a mitochondrial point of view by Grimm, Amandine, Eckert, Anne

“…Aging is defined as a progressive time‐related accumulation of changes responsible for or at least involved in the increased susceptibility to disease and…”
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α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities by Alam, Parvez, Bousset, Luc, Melki, Ronald, Otzen, Daniel E.

“…This review article provides an overview of the different species that α‐synuclein aggregates can populate. It also attempts to reconcile conflicting views…”
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The physiological role of α‐synuclein and its relationship to Parkinson’s Disease by Sulzer, David, Edwards, Robert H.

“…The protein α‐synuclein has a central role in the pathogenesis of Parkinson’s disease (PD). In this review, we discuss recent results concerning its primary…”
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Microglial phagocytosis of neurons in neurodegeneration, and its regulation by Butler, Claire A., Popescu, Alma S., Kitchener, Emily J. A., Allendorf, David H., Puigdellívol, Mar, Brown, Guy C.

“…There is growing evidence that excessive microglial phagocytosis of neurons and synapses contributes to multiple brain pathologies. RNA‐seq and genome‐wide…”
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A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Aβ oligomers from Alzheimer’s brain by Li, Shaomin, Selkoe, Dennis J.

“…It is increasingly accepted that early cognitive impairment in Alzheimer's disease results in considerable part from synaptic dysfunction caused by the…”
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Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics by Belaidi, Abdel A., Bush, Ashley I.

“…Brain iron homeostasis is increasingly recognized as a potential target for the development of drug therapies for aging‐related disorders. Dysregulation of…”
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Genetics in Parkinson disease: Mendelian versus non‐Mendelian inheritance by Hernandez, Dena G., Reed, Xylena, Singleton, Andrew B.

“…Parkinson's disease is a common, progressive neurodegenerative disorder, affecting 3% of those older than 75 years of age. Clinically, Parkinson's disease (PD)…”
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Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease by Jakaria, Md, Belaidi, Abdel Ali, Bush, Ashley I., Ayton, Scott

“…Alzheimer's disease (AD) is the most prevalent form of dementia, with complex pathophysiology that is not fully understood. While β‐amyloid plaque and…”
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Microglia and the aging brain: are senescent microglia the key to neurodegeneration? by Angelova, Dafina M., Brown, David R.

“…The single largest risk factor for etiology of neurodegenerative diseases like Alzheimer’s disease is increased age. Therefore, understanding the changes that…”
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How does adenosine control neuronal dysfunction and neurodegeneration? by Cunha, Rodrigo A.

“…The adenosine modulation system mostly operates through inhibitory A1 (A1R) and facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release…”
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The amyloid cascade hypothesis: are we poised for success or failure? by Karran, Eric, De Strooper, Bart

“…The first description of Alzheimer's disease (AD) was made in 1907 by Alois Alzheimer (Allgemeine Zeitschrift fur Psyciatrie und Psychisch‐Gerichtliche Medizin…”
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The energetic brain - A review from students to students by Bordone, Melina Paula, Salman, Mootaz M., Titus, Haley E., Amini, Elham, Andersen, Jens V., Chakraborti, Barnali, Diuba, Artem V., Dubouskaya, Tatsiana G., Ehrke, Eric, Espindola de Freitas, Andiara, Braga de Freitas, Guilherme, Gonçalves, Rafaella A., Gupta, Deepali, Gupta, Richa, Ha, Sharon R., Hemming, Isabel A., Jaggar, Minal, Jakobsen, Emil, Kumari, Punita, Lakkappa, Navya, Marsh, Ashley P. L., Mitlöhner, Jessica, Ogawa, Yuki, Kumar, Paidi Ramesh, Ribeiro, Felipe C., Salamian, Ahmad, Saleem, Suraiya, Sharma, Sorabh, Silva, Joana M., Singh, Shripriya, Sulakhiya, Kunjbihari, Tefera, Tesfaye Wolde, Vafadari, Behnam, Yadav, Anuradha, Yamazaki, Reiji, Seidenbecher, Constanze I.

“…The past 20 years have resulted in unprecedented progress in understanding brain energy metabolism and its role in health and disease. In this review, which…”
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Cholinergic modulation of the hippocampal region and memory function by Haam, Juhee, Yakel, Jerrel L.

“…Acetylcholine (ACh) plays an important role in memory function and has been implicated in aging‐related dementia, in which the impairment of…”
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MMP‐9 in translation: from molecule to brain physiology, pathology, and therapy by Vafadari, Behnam, Salamian, Ahmad, Kaczmarek, Leszek

“…Matrix metalloproteinase‐9 (MMP‐9) is a member of the metzincin family of mostly extracellularly operating proteases. Despite the fact that all of these…”
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Soluble Aβ oligomers and protofibrils induce NLRP3 inflammasome activation in microglia by Lučiūnaitė, Asta, McManus, Róisín M., Jankunec, Marija, Rácz, Ildikó, Dansokho, Cira, Dalgėdienė, Indrė, Schwartz, Stephanie, Brosseron, Frederic, Heneka, Michael T.

“…Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder causing memory loss, language problems and behavioural disturbances. AD is associated…”
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Current and experimental treatments of Parkinson disease: A guide for neuroscientists by Oertel, Wolfgang, Schulz, Jörg B.

“…Over a period of more than 50 years, the symptomatic treatment of the motor symptoms of Parkinson disease (PD) has been optimized using pharmacotherapy, deep…”
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