Search Results - "Journal of molecular medicine (Berlin, Germany)"

Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection by Li, Tianwen, Shao, Yongfu, Fu, Liyun, Xie, Yi, Zhu, Linwen, Sun, Weiliang, Yu, Rui, Xiao, Bingxiu, Guo, Junming

“…To observe the diagnostic values of circular RNAs (circRNAs), their expression profiles between gastric cancer patients’ plasma and healthy controls were first…”
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Transfer RNA-derived fragments and tRNA halves: biogenesis, biological functions and their roles in diseases by Shen, Yijing, Yu, Xiuchong, Zhu, Linwen, Li, Tianwen, Yan, Zhilong, Guo, Junming

“…The number of studies on non-coding RNAs has increased substantially in recent years owing to their importance in gene regulation. However, the biological…”
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Clinical implications of intratumor heterogeneity: challenges and opportunities by Ramón y Cajal, Santiago, Sesé, Marta, Capdevila, Claudia, Aasen, Trond, De Mattos-Arruda, Leticia, Diaz-Cano, Salvador J., Hernández-Losa, Javier, Castellví, Josep

“…In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and biological ramifications this phenomenon poses. Intratumoral…”
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HOX genes and their role in the development of human cancers by Bhatlekar, Seema, Fields, Jeremy Z., Boman, Bruce M.

“…In this review, we summarize published findings on the involvement of HOX genes in oncogenesis. HOX genes are developmental genes—they code for proteins that…”
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METTL1 overexpression is correlated with poor prognosis and promotes hepatocellular carcinoma via PTEN by Tian, Qiu-Hong, Zhang, Mei-Fang, Zeng, Jin-Sheng, Luo, Rong-Guang, Wen, Yang, Chen, Jun, Gan, Liu-Gen, Xiong, Jian-Ping

“…RNA methylation is emerging as an important regulator of gene expression. Dysregulation of methyltransferase that is essential for RNA modification contributes…”
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Mechanisms of foam cell formation in atherosclerosis by Chistiakov, Dimitry A., Melnichenko, Alexandra A., Myasoedova, Veronika A., Grechko, Andrey V., Orekhov, Alexander N.

“…Low-density lipoprotein (LDL) and cholesterol homeostasis in the peripheral blood is maintained by specialized cells, such as macrophages. Macrophages express…”
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Role of sirtuin-1 in diabetic nephropathy by Wang, Wanning, Sun, Weixia, Cheng, Yanli, Xu, Zhonggao, Cai, Lu

“…Diabetic nephropathy (DN) is a research priority for scientists around the world because of its high prevalence and poor prognosis. Although several mechanisms…”
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Stem cell-derived organoids and their application for medical research and patient treatment by Bartfeld, Sina, Clevers, Hans

“…3D culture has allowed the initiation and expansion of organ-like structures, called organoids, from either tissue-resident adult stem cells or pluripotent…”
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Non-coding RNAs regulating mitochondrial function in cardiovascular diseases by Ao, Xiang, Ding, Wei, Li, Xiaoge, Xu, Qingling, Chen, Xinhui, Zhou, Xuehao, Wang, Jianxun, Liu, Ying

“…Cardiovascular disease (CVD) is the leading cause of disease-related death worldwide and a significant obstacle to improving patients’ health and lives…”
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Disturbed lipid and amino acid metabolisms in COVID-19 patients by Masoodi, Mojgan, Peschka, Manuela, Schmiedel, Stefan, Haddad, Munif, Frye, Maike, Maas, Coen, Lohse, Ansgar, Huber, Samuel, Kirchhof, Paulus, Nofer, Jerzy-Roch, Renné, Thomas

“…The Coronavirus disease 2019 (COVID-19) pandemic is overwhelming the healthcare systems. Identification of systemic reactions underlying COVID-19 will lead to…”
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Cyclin D1, cancer progression, and opportunities in cancer treatment by Qie, Shuo, Diehl, J. Alan

“…Mammalian cells encode three D cyclins (D1, D2, and D3) that coordinately function as allosteric regulators of cyclin-dependent kinase 4 (CDK4) and CDK6 to…”
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AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan by Salminen, Antero, Hyttinen, Juha M. T., Kaarniranta, Kai

“…Adenosine monophosphate-activated protein kinase (AMPK) is a crucial regulator of energy metabolic homeostasis and thus a major survival factor in a variety of…”
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Ocular neovascularization by Campochiaro, Peter A.

“…Retinal and choroidal vascular diseases constitute the most common causes of moderate and severe vision loss in developed countries. They can be divided into…”
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Anti-oxidative effects of superoxide dismutase 3 on inflammatory diseases by Nguyen, Nguyen Hoai, Tran, Gia-Buu, Nguyen, Cuong Thach

“…Free radicals and other oxidants are critical determinants of the cellular signaling pathways involved in the pathogenesis of several human diseases including…”
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AMPK: a key regulator of energy stress and calcium-induced autophagy by Saikia, Rimpi, Joseph, Jomon

“…Autophagy is a well-known cell-survival strategy orchestrated by a conserved set of proteins. It equips the cells with mechanisms to attain homeostasis during…”
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Extracellular histones in tissue injury and inflammation by Allam, Ramanjaneyulu, Kumar, Santhosh V. R., Darisipudi, Murthy N., Anders, Hans-Joachim

“…Neutrophil NETosis is an important element of host defense as it catapults chromatin out of the cell to trap bacteria, which then are killed, e.g., by the…”
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Glycosylation is a key in SARS-CoV-2 infection by Reis, Celso A., Tauber, Rudolf, Blanchard, Véronique

“…SARS-CoV-2 causes the respiratory syndrome COVID-19 and is responsible for the current pandemic. The S protein of SARS-CoV-2-mediating virus binding to target…”
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A map of human circular RNAs in clinically relevant tissues by Maass, Philipp G., Glažar, Petar, Memczak, Sebastian, Dittmar, Gunnar, Hollfinger, Irene, Schreyer, Luisa, Sauer, Aisha V., Toka, Okan, Aiuti, Alessandro, Luft, Friedrich C., Rajewsky, Nikolaus

“…Cellular circular RNAs (circRNAs) are generated by head-to-tail splicing and are present in all multicellular organisms studied so far. Recently, circRNAs have…”
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Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders by Mahley, Robert W.

“…Apolipoprotein (apo) E was initially described as a lipid transport protein and major ligand for low density lipoprotein (LDL) receptors with a role in…”
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Layered defense: how mucus and tight junctions seal the intestinal barrier by Capaldo, Christopher T., Powell, Domonica N., Kalman, Daniel

“…The colonic mucosa provides a vital defensive barrier separating the body from the microbial populations residing in the intestinal lumen. Indeed, growing…”
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