Search Results - "Journal of investigative dermatology"

Classification of the Clinical Images for Benign and Malignant Cutaneous Tumors Using a Deep Learning Algorithm by Han, Seung Seog, Kim, Myoung Shin, Lim, Woohyung, Park, Gyeong Hun, Park, Ilwoo, Chang, Sung Eun

“…We tested the use of a deep learning algorithm to classify the clinical images of 12 skin diseases—basal cell carcinoma, squamous cell carcinoma,…”
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Treatment of Advanced Melanoma in 2020 and Beyond by Jenkins, Russell W., Fisher, David E.

“…The melanoma field has seen an unprecedented set of clinical advances over the past decade. Therapeutic efficacy for advanced or metastatic melanoma went from…”
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Atopic Dermatitis Is an IL-13–Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis by Tsoi, Lam C., Rodriguez, Elke, Degenhardt, Frauke, Baurecht, Hansjörg, Wehkamp, Ulrike, Volks, Natalie, Szymczak, Silke, Swindell, William R., Sarkar, Mrinal K., Raja, Kalpana, Shao, Shuai, Patrick, Matthew, Gao, Yilin, Uppala, Ranjitha, Perez White, Bethany E, Getsios, Spiro, Harms, Paul W., Maverakis, Emanual, Elder, James T., Franke, Andre, Gudjonsson, Johann E., Weidinger, Stephan

“…Atopic dermatitis (AD) affects up to 20% of children and adults worldwide. To gain a deeper understanding of the pathophysiology of AD, we conducted a…”
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The Burden of Atopic Dermatitis: Summary of a Report for the National Eczema Association by Drucker, Aaron M., Wang, Annie R., Li, Wen-Qing, Sevetson, Erika, Block, Julie K., Qureshi, Abrar A.

“…To assess the patient-level and societal burden of atopic dermatitis, we comprehensively reviewed the literature related to quality of life, social, economic,…”
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Atopic Dermatitis in America Study: A Cross-Sectional Study Examining the Prevalence and Disease Burden of Atopic Dermatitis in the US Adult Population by Chiesa Fuxench, Zelma C., Block, Julie K., Boguniewicz, Mark, Boyle, John, Fonacier, Luz, Gelfand, Joel M., Grayson, Mitchell H., Margolis, David J., Mitchell, Lynda, Silverberg, Jonathan I., Schwartz, Lawrence, Simpson, Eric L., Ong, Peck Y.

“…Population-based estimates on the prevalence of atopic dermatitis in adults vary widely. The objectives of this study were to determine the prevalence of…”
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Research Techniques Made Simple: Cutaneous Colorimetry: A Reliable Technique for Objective Skin Color Measurement by Ly, Bao Chau K., Dyer, Ethan B., Feig, Jessica L., Chien, Anna L., Del Bino, Sandra

“…Skin color evaluation contributes to assessment of an individual’s cutaneous phenotype. Skin color changes provide important clues to disease progression or…”
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Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations by Philippeos, Christina, Telerman, Stephanie B., Oulès, Bénédicte, Pisco, Angela O., Shaw, Tanya J., Elgueta, Raul, Lombardi, Giovanna, Driskell, Ryan R., Soldin, Mark, Lynch, Magnus D., Watt, Fiona M.

“…Previous studies have shown that mouse dermis is composed of functionally distinct fibroblast lineages. To explore the extent of fibroblast heterogeneity in…”
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Research Techniques Made Simple: Analysis of Collective Cell Migration Using the Wound Healing Assay by Grada, Ayman, Otero-Vinas, Marta, Prieto-Castrillo, Francisco, Obagi, Zaidal, Falanga, Vincent

“…Collective cell migration is a hallmark of wound repair, cancer invasion and metastasis, immune responses, angiogenesis, and embryonic morphogenesis. Wound…”
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The Global Burden of Skin Disease in 2010: An Analysis of the Prevalence and Impact of Skin Conditions by Hay, Roderick J., Johns, Nicole E., Williams, Hywel C., Bolliger, Ian W., Dellavalle, Robert P., Margolis, David J., Marks, Robin, Naldi, Luigi, Weinstock, Martin A., Wulf, Sarah K., Michaud, Catherine, J.L. Murray, Christopher, Naghavi, Mohsen

“…The Global Burden of Disease (GBD) Study 2010 estimated the GBD attributable to 15 categories of skin disease from 1990 to 2010 for 187 countries. For each of…”
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The Growing Burden of Invasive Melanoma: Projections of Incidence Rates and Numbers of New Cases in Six Susceptible Populations through 2031 by Whiteman, David C., Green, Adele C., Olsen, Catherine M.

“…New melanoma therapies are being developed rapidly, complementing prevention and detection strategies for disease control. Estimating the future burden of…”
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The Genetics of Chronic Itch: Gene Expression in the Skin of Patients with Atopic Dermatitis and Psoriasis with Severe Itch by Nattkemper, Leigh A., Tey, Hong Liang, Valdes-Rodriguez, Rodrigo, Lee, Helen, Mollanazar, Nicholas K., Albornoz, Christian, Sanders, Kristen M., Yosipovitch, Gil

“…To identify itch-related mediators and receptors that are differentially expressed in pruritic skin, we used RNA sequencing to analyze the complete…”
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Connective Tissue and Fibroblast Senescence in Skin Aging by Wlaschek, Meinhard, Maity, Pallab, Makrantonaki, Evgenia, Scharffetter-Kochanek, Karin

“…There is increasing evidence that skin aging is significantly enforced by the accumulation of senescent dermal fibroblasts. Various stressors damaging…”
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Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans by Smith, Susan H., Jayawickreme, Channa, Rickard, David J., Nicodeme, Edwige, Bui, Thi, Simmons, Cathy, Coquery, Christine M., Neil, Jessica, Pryor, William M., Mayhew, David, Rajpal, Deepak K., Creech, Katrina, Furst, Sylvia, Lee, James, Wu, Dalei, Rastinejad, Fraydoon, Willson, Timothy M., Viviani, Fabrice, Morris, David C., Moore, John T., Cote-Sierra, Javier

“…Tapinarof (GSK2894512) is a naturally derived topical treatment with demonstrated efficacy for patients with psoriasis and atopic dermatitis, although the…”
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A MicroRNA-29 Mimic (Remlarsen) Represses Extracellular Matrix Expression and Fibroplasia in the Skin by Gallant-Behm, Corrie L., Piper, Joseph, Lynch, Joshua M., Seto, Anita G., Hong, Seok Jong, Mustoe, Thomas A., Maari, Catherine, Pestano, Linda A., Dalby, Christina M., Jackson, Aimee L., Rubin, Paul, Marshall, William S.

“…MicroRNA-29 (miR-29) negatively regulates fibrosis and is downregulated in multiple fibrotic organs and tissues, including in the skin. miR-29 mimics prevent…”
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Global Epidemiology of Psoriasis: A Systematic Review of Incidence and Prevalence by Parisi, Rosa, Symmons, Deborah P.M., Griffiths, Christopher E.M., Ashcroft, Darren M.

“…The worldwide incidence and prevalence of psoriasis is poorly understood. To better understand this, we performed a systematic review of published…”
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The Psychological Burden of Skin Diseases: A Cross-Sectional Multicenter Study among Dermatological Out-Patients in 13 European Countries by Dalgard, Florence J., Gieler, Uwe, Tomas-Aragones, Lucia, Lien, Lars, Poot, Francoise, Jemec, Gregor B.E., Misery, Laurent, Szabo, Csanad, Linder, Dennis, Sampogna, Francesca, Evers, Andrea W.M., Halvorsen, Jon Anders, Balieva, Flora, Szepietowski, Jacek, Romanov, Dmitry, Marron, Servando E., Altunay, Ilknur K., Finlay, Andrew Y., Salek, Sam S., Kupfer, Jörg

“…The contribution of psychological disorders to the burden of skin disease has been poorly explored, and this is a large-scale study to ascertain the…”
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Research Techniques Made Simple: Animal Models of Wound Healing by Grada, Ayman, Mervis, Joshua, Falanga, Vincent

“…Animal models have been developed to study the complex cellular and biochemical processes of wound repair and to evaluate the efficacy and safety of potential…”
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Environmentally-Induced (Extrinsic) Skin Aging: Exposomal Factors and Underlying Mechanisms by Krutmann, Jean, Schikowski, Tamara, Morita, Akimichi, Berneburg, Mark

“…As a barrier organ, the skin is an ideal model to study environmentally-induced (extrinsic) aging. In this review, we explain the development of extrinsic skin…”
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SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin by Tabib, Tracy, Morse, Christina, Wang, Ting, Chen, Wei, Lafyatis, Robert

“…Fibroblasts produce matrix, regulate inflammation, mediate reparative processes, and serve as pluripotent mesenchymal cells. Analyzing digested normal human…”
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Increasing Comorbidities Suggest that Atopic Dermatitis Is a Systemic Disorder by Brunner, Patrick M., Silverberg, Jonathan I., Guttman-Yassky, Emma, Paller, Amy S., Kabashima, Kenji, Amagai, Masayuki, Luger, Thomas A., Deleuran, Mette, Werfel, Thomas, Eyerich, Kilian, Stingl, Georg, Bagot, Martine, Hijnen, Dirk Jan, Ardern-Jones, Michael, Reynolds, Nick, Spuls, Phyllis, Taieb, Alain

“…Atopic dermatitis comorbidities extend well beyond the march to allergic conditions (food allergy, asthma, allergic rhinitis, allergic conjunctivitis, and…”
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