Search Results - "Journal of experimental & clinical cancer research"

Pyroptosis at the forefront of anticancer immunity by Loveless, Reid, Bloomquist, Ryan, Teng, Yong

“…Tumor resistance to apoptosis and the immunosuppressive tumor microenvironment are two major contributors to poor therapeutic responses during cancer…”
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Resistance to anti-EGFR therapies in metastatic colorectal cancer: underlying mechanisms and reversal strategies by Zhou, Jing, Ji, Qing, Li, Qi

“…Cetuximab and panitumumab are monoclonal antibodies (mAbs) against epidermal growth factor receptor (EGFR) that are effective agents for metastatic colorectal…”
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Exosomal miR-9 inhibits angiogenesis by targeting MDK and regulating PDK/AKT pathway in nasopharyngeal carcinoma by Lu, Juan, Liu, Qi-Hui, Wang, Fan, Tan, Jia-Jie, Deng, Yue-Qin, Peng, Xiao-Hong, Liu, Xiong, Zhang, Bao, Xu, Xia, Li, Xiang-Ping

“…Exosomes are small vesicles containing a wide range of functional proteins, mRNA and miRNA. Exosomal miRNAs from cancer cells play crucial roles in mediating…”
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Understanding the roles and regulation patterns of circRNA on its host gene in tumorigenesis and tumor progression by Wei, Jianxia, Li, Mengna, Xue, Changning, Chen, Shipeng, Zheng, Lemei, Deng, Hongyu, Tang, Faqing, Li, Guiyuan, Xiong, Wei, Zeng, Zhaoyang, Zhou, Ming

“…Circular RNAs (circRNAs) are a novel type of endogenous non-coding RNAs, which are covalently closed loop structures formed by precursor mRNAs (pre-mRNAs)…”
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Long noncoding RNA NEAT1 drives aggressive endometrial cancer progression via miR-361-regulated networks involving STAT3 and tumor microenvironment-related genes by Dong, Peixin, Xiong, Ying, Yue, Junming, Xu, Daozhi, Ihira, Kei, Konno, Yosuke, Kobayashi, Noriko, Todo, Yukiharu, Watari, Hidemichi

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BH3-mimetics: recent developments in cancer therapy by Townsend, Paul A, Kozhevnikova, Maria V, Cexus, Olivier N F, Zamyatnin, Jr, Andrey A, Soond, Surinder M

“…The hopeful outcomes from 30 years of research in BH3-mimetics have indeed served a number of solid paradigms for targeting intermediates from the apoptosis…”
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Current status of research on exosomes in general, and for the diagnosis and treatment of kidney cancer in particular by Mao, Weipu, Wang, Keyi, Wu, Zonglin, Xu, Bin, Chen, Ming

“…Kidney cancer is a common urological tumour. Owing to its high prevalence and mortality rate, it is the third most malignant tumour of the urinary system,…”
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Hypoxic exosomes facilitate angiogenesis and metastasis in esophageal squamous cell carcinoma through altering the phenotype and transcriptome of endothelial cells by Mao, Yu, Wang, Yimin, Dong, Lixin, Zhang, Yunjie, Zhang, Yanqiu, Wang, Chao, Zhang, Qiang, Yang, Sen, Cao, Liyan, Zhang, Xinyuan, Li, Xin, Fu, Zhanzhao

“…In cancer progression, hypoxia, or low oxygen tension, is a major regulator of tumor aggressiveness and metastasis. However, how cancer cells adapt to the…”
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Pharmacology-based ranking of anti-cancer drugs to guide clinical development of cancer immunotherapy combinations by Lemaire, Vincent, Shemesh, Colby S, Rotte, Anand

“…The success of antibodies targeting Programmed cell death protein 1 (PD-1) and its ligand L1 (PD-L1) in cancer treatment and the need for improving response…”
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Targeting strategies for oxaliplatin-induced peripheral neuropathy: clinical syndrome, molecular basis, and drug development by Yang, Yang, Zhao, Bing, Gao, Xuejiao, Sun, Jinbing, Ye, Juan, Li, Jun, Cao, Peng

“…Oxaliplatin (OHP)-induced peripheral neurotoxicity (OIPN) is a severe clinical problem and potentially permanent side effect of cancer treatment. For the…”
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CRISPR/Cas9 revitalizes adoptive T-cell therapy for cancer immunotherapy by Ghaffari, Sasan, Khalili, Nastaran, Rezaei, Nima

“…Cancer immunotherapy has gained attention as the supreme therapeutic modality for the treatment of various malignancies. Adoptive T-cell therapy (ACT) is one…”
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The CD112R/CD112 axis: a breakthrough in cancer immunotherapy by Zeng, Taofei, Cao, Yuqing, Jin, Tianqiang, Tian, Yu, Dai, Chaoliu, Xu, Feng

“…The recent discovery of immune checkpoint inhibitors is a significant milestone in cancer immunotherapy research. However, some patients with primary or…”
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The emerging role of ISWI chromatin remodeling complexes in cancer by Li, Yanan, Gong, Han, Wang, Pan, Zhu, Yu, Peng, Hongling, Cui, Yajuan, Li, Heng, Liu, Jing, Wang, Zi

“…Disordered chromatin remodeling regulation has emerged as an essential driving factor for cancers. Imitation switch (ISWI) family are evolutionarily conserved…”
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Poliovirus receptor (PVR)-like protein cosignaling network: new opportunities for cancer immunotherapy by Wu, Baokang, Zhong, Chongli, Lang, Qi, Liang, Zhiyun, Zhang, Yizhou, Zhao, Xin, Yu, Yang, Zhang, Heming, Xu, Feng, Tian, Yu

“…Immune checkpoint molecules, also known as cosignaling molecules, are pivotal cell-surface molecules that control immune cell responses by either promoting…”
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circPDE5A regulates prostate cancer metastasis via controlling WTAP-dependent N6-methyladenisine methylation of EIF3C mRNA by Ding, Lifeng, Wang, Ruyue, Zheng, Qiming, Shen, Danyang, Wang, Huan, Lu, Zeyi, Luo, Wenqin, Xie, Haiyun, Ren, Liangliang, Jiang, Minxiao, Yu, Chenhao, Zhou, Zhenwei, Lin, Yudong, Lu, Haohua, Xue, Dingwei, Su, Wenjing, Xia, Liqun, Neuhaus, Jochen, Cheng, Sheng, Li, Gonghui

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Restoration of the immune function as a complementary strategy to treat Chronic Lymphocytic Leukemia effectively by Moreno, Carol, Muñoz, Cecilia, Terol, María José, Hernández-Rivas, José-Ángel, Villanueva, Miguel

“…Chronic Lymphocytic Leukemia (CLL) is a hematological malignancy characterized by uncontrolled proliferation of B-cells and severe immune dysfunction…”
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The crosstalk between immune cells and tumor pyroptosis: advancing cancer immunotherapy strategies by Hu, Mengyuan, Deng, Fengying, Song, Xinlei, Zhao, Hongkun, Yan, Fei

“…Pyroptosis is a cell death process characterized by cell swelling until membrane rupture and release of intracellular contents. As an effective tumor treatment…”
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Cell death shapes cancer immunity: spotlighting PANoptosis by Gao, Lixia, Shay, Chloe, Teng, Yong

“…PANoptosis represents a novel type of programmed cell death (PCD) with distinctive features that incorporate elements of pyroptosis, apoptosis, and…”
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Hodgkin lymphoma and liquid biopsy: a story to be told by Velasco-Suelto, Jesús, Gálvez-Carvajal, Laura, Comino-Méndez, Iñaki, Rueda-Domínguez, Antonio

“…Hodgkin lymphoma (HL) represents a neoplasm primarily affecting adolescents and young adults, necessitating the development of precise diagnostic and…”
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Trastuzumab emtansine delays and overcomes resistance to the third-generation EGFR-TKI osimertinib in NSCLC EGFR mutated cell lines by La Monica, Silvia, Cretella, Daniele, Bonelli, Mara, Fumarola, Claudia, Cavazzoni, Andrea, Digiacomo, Graziana, Flammini, Lisa, Barocelli, Elisabetta, Minari, Roberta, Naldi, Nadia, Petronini, Pier Giorgio, Tiseo, Marcello, Alfieri, Roberta

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